Elucidation of analgesic mechanism in spinal dorsal horn of beta-alanine
| Project/Area Number |
17K16725
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Niigata University |
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Principal Investigator |
Seino Yutaka 新潟大学, 医歯学総合病院, 医員 (50771200)
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| Research Collaborator |
Ohashi Nobuko
Kohno Tatsuro
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | βアラニン / β-アラニン / 脊髄後角 / 疼痛管理学 |
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| Outline of Final Research Achievements |
In this study, we performed electrophysiological experiments in the spinal dorsal horn of β-alanine. We found that β-alanine is involved in inhibitory synaptic transmission in the spinal dorsal horn. We also found that this effect was concentration dependent. We also investigated the receptors involved, and revealed that β-alanine acts through the Cl channel, and that it is not involved in the GABA A receptor but through the glycine receptor.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、βアラニンが抑制性シナプス伝達に関与しており、脊髄後角において鎮痛制御に関与している可能性を明らかにした。
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Report
(3 results)
Research Products
(5 results)
