Molecular mechanism of APOBEC-mediated HPV carcinogenesis and its application as prognosis factor
| Project/Area Number |
17K16839
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Institute of Infectious Diseases (2018)
Kanazawa University (2017) |
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Principal Investigator |
Wakae Kousho 国立感染症研究所, ウイルス第二部, 主任研究官 (70638303)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | APOBEC / HPV / 子宮頸癌 / 遺伝子変異 / hypermutation |
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| Outline of Final Research Achievements |
We clarified the mechanism how oncogenic host factors, APOBECs, are induced in HPV infected cells. We demonstrated that, differentiation of an HPV16(+) cervical keratinocyte induces APOBEC3A and 3B, as well as mutates host genome (Wakae, Sci. Rep. 2018). In addition, host gene mutations were detected from HPV-associated cancers, including cervical and oropharyngeal cancers, and were correlated with APOBEC3B expression. These results suggested that differentiation of HPV-infected host cells induces APOBECs and mutates their own genome.
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| Academic Significance and Societal Importance of the Research Achievements |
子宮頸がんや中咽頭癌の原因ウイルスであるヒトパピローマウイルス(HPV)が、どのような状況で発癌因子APOBECを発現し、遺伝情報を改変するのか、機序の一端を解明した。ウイルス学的・分子生物学的に重要な発見であると共に、HPV-APOBECによる発現機構を解明する事で、HPV関連癌の新しい予防・治療戦略の創出に貢献すると考えられる。
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Report
(3 results)
Research Products
(12 results)
