Development of enzymatic sensor and drug release system based on BSA gel and lipid bilayers
| Project/Area Number |
17K19022
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nano/Micro science and related fields
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| Research Institution | Ibaraki University |
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Principal Investigator |
Yamaguchi Akira 茨城大学, 理工学研究科(理学野), 教授 (10359531)
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 酵素センサー / BSAゲル / メソポーラスシリカ |
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| Outline of Final Research Achievements |
The primary purpose of this study is development of new-generation non-invasive glucose sensor composed of BSA hydrogel, lipid bilayers, glucose oxidase, and mesoporous silica. Our developed sensor exhibited good reproducibility, large dynamic range, and high sensitivity, for the detection of glucose in various non-invasive samples. In addition, a hybrid material composed of BSA hydrogel and mesoporous silica nanoparticle could be applied for drug release system upon addition of a biological substance.
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| Academic Significance and Societal Importance of the Research Achievements |
簡易診断技術は予防医療・テーラーメイド医療の進展を支える基盤技術の一つである。酵素センサーは，酵素の基質選択的触媒特性を利用した信頼性の高い簡易診断技術であるが，センサー応答（感度・ダイナミックレンジ）や長期安定性に関する技術的障壁がある。本研究では，適切なナノ材料を複合化したセンサーを開発し，実用化への展望を実証することができた。また，用いた複合材料については，ガン治療などで開発が進む薬物送達システム（DDS）への適用性も確認された。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] High-performance bioelectrocatalysts created by immobilization of an enzyme into carbon-coated composite membranes with nano-tailored structures2017
Author(s)
Tetsuji Itoh, Yuuta Shibuya, Akira Yamaguchi, Yasuto Hoshikawa, Osamu Tanaike, Tatsu Tsunoda, Taka-aki Hanaoka, Satoshi Hamakawa, Fujio Mizukami, Akari Hayashi, Takashi Kyotani, Galen D.Stucky
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Journal Title
J. Mater. Chem. A
Volume: 5
Issue: 38
Pages: 20244-20251
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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