Creating reference genomes of lactic acid bacteria and Bifidobacteria
| Project/Area Number |
17K19248
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Agricultural chemistry and related fields
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
Arita Masanori 国立遺伝学研究所, 情報研究系, 教授 (10356389)
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| Co-Investigator(Kenkyū-buntansha) |
川島 武士 国立遺伝学研究所, 情報研究系, 助教 (10378531)
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| Project Period (FY) |
2017-06-30 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | バイオインフォマティクス / 比較ゲノム / 微生物 / ビフィズス菌 / ピロリ菌 / ゲノム / 糖質加水分解酵素 / 糖転移酵素 / 食生活 / 乳酸菌 / 全ゲノム解析 / データベース / オープンデータ |
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| Outline of Final Research Achievements |
By comparing publicly available genomes of Helicobacter pylori, we identified geographical region-specific or universally shared genomic rearrangements. We also identified a reference strain in terms of the ordering of core genes.
Through the survey of glyco-enzymes within publicly available genomes of Bifidobacterium species, we identified the relationship between the dietary habits and contents of host animals and the metabolic capability of polysaccharides.
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| Academic Significance and Societal Importance of the Research Achievements |
公共データベースには多種多様な微生物のゲノムが公開されており、同じ種であっても含まれる遺伝子の内訳が菌株毎に数百も異なりうる。そのように類似したゲノムが数百以上あたえられた際、それらを効率よく比較して共通する機能や特徴を見出す作業は「種とはなにか」「なぜ種にわかれるのか」を考える上で重要である。その具体例として、ゲノム構造を比較したり糖代謝能を比較する方法論を見出し、実データに応用した。
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Bifidobacterium jacchi sp. nov., isolated from the faeces of a baby common marmoset (Callithrix jacchus)2019
Author(s)
Modesto M, Watanabe K, Arita M, Satti M, Oki K, Sciavilla P, Patavino C, Camma C, Michelini S, Sgorbati B, Mattarelli P
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Journal Title
International Journal of Systematic and Evolutionary Microbiology
Volume: 69
Issue: 8
Pages: 2477-2485
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Alloscardovia theropitheci sp. nov., isolated from the faeces of gelada baboon, the 'bleeding heart' monkey (Theropithecus gelada)2019
Author(s)
Modesto M, Satti M, Watanabe K, Sciavilla P, Felis GE, Sandri C, Spiezio C, Arita M, Mattarelli P
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Journal Title
International Journal of Systematic and Evolutionary Microbiology
Volume: 69
Issue: 10
Pages: 3041-3048
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Characterization of Bifidobacterium species in feaces of the Egyptian fruit bat: Description of B. vespertilionis sp. nov. and B. rousetti sp. nov.2019
Author(s)
Modesto M, Satti M, Watanabe K, Puglisi E, Morelli L, Huang CH, Liou JS, Miyashita M, Tamura T, Saito S, Mori K, Huang L, Sciavilla P, Sandri C, Spiezio C, Vitali F, Cavalieri D, Perpetuini G, Tofalo R, Bonetti A, Arita M, Mattarelli P
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Journal Title
Systematic and Applied Microbiology
Volume: 42
Issue: 6
Pages: 126017-126017
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Lactobacillus paragasseri sp. nov., a sister taxon of Lactobacillus gasseri, based on whole-genome sequence analyses2018
Author(s)
Tanizawa Y, Tada I, Kobayashi H, Endo A, Maeno S, Toyoda A, Arita M, Nakamura Y, Sakamoto M, Ohkuma M, Tohno M
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Journal Title
Int J Syst Evol Microbiol
Volume: 68
Issue: 11
Pages: 3512-3517
DOI
Related Report
Peer Reviewed
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