Creation of Space Immunology by space and ground experiments
| Project/Area Number |
17K19537
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathology, Infection/Immunology, and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
Kamimura Daisuke
Arima Yasunobu
Shirakawa Masaki
Shiba Dai
Yumoto Akane
Ueda Hiroki
Tainaka Kazuki
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 炎症 / ゲートウェイ反射 / 宇宙 / 重力 / 炎症アンプ / 免疫学 / 炎症回路 / 宇宙免疫学 |
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| Outline of Final Research Achievements |
We have reported that gravity stimulation induces regional neural activations to create an immune cell gateway to the CNS via alteration of specific vessels, a phenomenon called the gateway reflex. In this study, we aimed to study a relation between gravity and inflammatory diseases by a combination of ground and space experiments, and develop a research field of the space immunology. We have performed feasibility studies including the establishment of pathogenic T cell clones, overcome of time lag till sampling, and effects of over-gravity and impact during launch, with successful results. Although the space experiment was originally scheduled within the research term, it was postponed, which will be conducted in 2019.
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| Academic Significance and Societal Importance of the Research Achievements |
地球の重力は、地上生物にとって避けられない刺激であり、進化的にも保存された何らかの免疫学的な応答機構が存在する可能性が高く、それらを研究することは、重力と言う環境要因が我々の健康へどのように関連するのかを探る点でも、さらに、将来的な宇宙開発を進める点でも重要な意義をもつ。
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Bmi1 Regulates IκBα Degradation via Association with the SCF Complex.2018
Author(s)
Okuyama Y, Tanaka Y, Jiang JJ, Kamimura D, Nakamura A, Ota M, Ohki T, Higo D, Ogura H, Ishii N, Atsumi T, Murakami M.
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Journal Title
J Immunol.
Volume: 201(8)
Issue: 8
Pages: 2264-2272
DOI
Related Report
Peer Reviewed
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[Journal Article] Presenilin 1 Regulates NF-κB Activation via Association with Breakpoint Cluster Region and Casein Kinase II.2018
Author(s)
Tanaka Y, Sabharwal L, Ota M, Nakagawa I, Jiang JJ, Arima Y, Ogura H, Okochi M, Ishii M, Kamimura D, Murakami M.
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Journal Title
J Immunol.
Volume: 201(8)
Issue: 8
Pages: 2256-2263
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit.2017
Author(s)
Arima, Y., T. Ohki, N. Nishikawa, K. Higuchi, M. Ota, Y. Tanaka, J. Nio-Kobayashi, M. Elfeky, R. Sakai, Y. Mori, T. Kawamoto, A. Stofkova, Y. Sakashita, Y. Morimoto, M. Kuwatani, T. Iwanaga, Y. Yoshioka, N. Sakamoto, A. Yoshimura, M. Takiguchi, S. Sakoda, M. Prinz, D. Kamimura, M. Murakami.
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Journal Title
eLife
Volume: 6:e25517
Pages: 1-27
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Rbm10 regulates inflammation development via alternative splicing of Dnmt3b.2017
Author(s)
Atsumi T, Suzuki H, Jiang JJ, Okuyama Y, Nakagawa I, Ota M, Tanaka Y, Ohki T, Katsunuma K, Nakajima K, Hasegawa Y, Ohara O, Ogura H, Arima Y, Kamimura D, Murakami M.
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Journal Title
Int Immunol.
Volume: 29(12)
Issue: 12
Pages: 581-591
DOI
Related Report
Peer Reviewed / Open Access
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