Development of new therapy for joint contractures using percutaneous carbon dioxide application.

• Project/Area Number: 17K19908
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Health science and related fields
• Research Institution: Kobe University
• Principal Investigator: Akisue Toshihiro 神戸大学, 保健学研究科, 教授 (90379363)
• Co-Investigator(Kenkyū-buntansha): 森山 英樹 神戸大学, 保健学研究科, 教授 (10438111) ; 河本 旭哉 神戸大学, 医学研究科, 特命講師 (30420558) ; 原 仁美 神戸大学, 医学部附属病院, 助教 (40437489) ; 新倉 隆宏 神戸大学, 医学研究科, 准教授 (40448171) ; 酒井 良忠 神戸大学, 医学研究科, 特命教授 (90397802)
• Project Period (FY): 2017-06-30 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 炭酸ガス / 関節拘縮 / 中枢性麻痺 / 関節固定 / 変形性関節症 / 拘縮 / リハビリテーション

Outline of Final Research Achievements

Joint contractures are a major complication following injuries in central nervous system or joint immobilization. However, no effective treatment has been developed so far. In the present study, we aimed to develop a novel therapeutic approach for joint contractures using transcutaneous carbon dioxide absorption. Our findings indicate that transcutaneous carbon dioxide may improve knee range of motion after injuries central nervous system or joint immobilization. We also revealed that transcutaneous carbon dioxide decreases muscular and articular fibrosis, thereby improving knee joint contracture.

Academic Significance and Societal Importance of the Research Achievements

本研究により得られた知見から、炭酸ガス経皮吸収が、関節拘縮に対する新たな非侵襲的治療戦略になる可能性をもつことが示された。従来、関節拘縮の治療に用いられてきた物理療法やストレッチ等と、この治療法を併用することで、より優れた治療法となる可能性を秘めている。

Research Products

• [Journal Article] Transcutaneous application of carbon dioxide improves contractures after immobilization of rat knee joint (2020)
  • Author(s): INOUE Shota、MORIYAMA Hideki、WAKIMOTO Yoshio、LI Changxin、HATAKEYAMA Junpei、WAKIGAWA Taisei、SAKAI Yoshitada、AKISUE Toshihiro
  • Journal Title: Physical Therapy Research Volume: 23 Issue: 2 Pages: 113-122
  • DOI: 10.1298/ptr.E10023
  • NAID: 130007958548
  • ISSN: 2189-8448
  • Year and Date: 2020-12-20
  • Peer Reviewed / Open Access
• [Journal Article] 経皮的炭酸ガス吸収療法が関節可動域に及ぼす効果 (2020)
  • Author(s): 畠山隼平, 森山英樹, 伊藤拓海, 李昌欣, 脇本祥夫, 井上翔太, 脇川大誠, 椿俊 哉, 木下沙英, 野村将人, 酒井良忠, 秋末敏宏
  • Journal Title: 専門リハビリテーション Volume: 19 Pages: 21-28
  • NAID: 40022680494
  • Peer Reviewed
• [Journal Article] Transcutaneous Carbon Dioxide Improves Contractures After Spinal Cord Injury in Rats (2019)
  • Author(s): Inoue Shota、Moriyama Hideki、Yakuwa Takumi、Mizuno Eriko、Suzuki Ryota、Nomura Masato、Sakai Yoshitada、Akisue Toshihiro
  • Journal Title: Clinical Orthopaedics and Related Research Volume: 477 Issue: 8 Pages: 1934-1946
  • DOI: 10.1097/corr.0000000000000808
  • NAID: 120006786959
  • Peer Reviewed
• [Presentation] ラット変形性膝関節症に対する経皮的炭酸ガス療法の効果 (2020)
  • Author(s): 李昌欣, 脇本祥夫, 井上翔太, 畠山隼平, 脇川大誠, 椿俊哉, 木下沙英, 酒井良忠, 秋末敏宏, 森山英樹
  • Organizer: 第25回日本基礎理学療法学会学術大会
• [Presentation] 炭酸ガスペースト(ディレコート)による人工Bohr 効果の検証 (2020)
  • Author(s): 米田誉武, 秋末敏宏, 中西智輝
  • Organizer: 第25回日本基礎理学療法学会学術大会
• [Presentation] Transcutaneous carbon dioxide improves contractures after spinal cord injury in rat. (2019)
  • Author(s): Li C, Nomura M, Wakimoto Y, Yakuwa T, Inoue S, Kinoshita S, Tsubaki T, Wakigawa T, Hatakeyama J, Sakai Y, Akisue T, Moriyama H.
  • Organizer: 13th International Society of Physical and Rehabilitation Medicine (ISPRM) World Congress
  • Int'l Joint Research
• [Presentation] Effects of botulinum toxin therapy on muscles and joint components responsible for contractures after spinal cord injuries. (2019)
  • Author(s): Tsubaki T, Ozawa J, Yakuwa T, Inoue S, Nomura M, Wakimoto Y, Li C, Hatakeyama J, Kinoshita S, Wakigawa T, Kito K, Sakai Y, Akisue T, Moriyama H.
  • Organizer: World Confederation for Physical Therapy (WCPT) Congress 2019
  • Int'l Joint Research
• [Presentation] Effects of transcutaneous carbon dioxide therapy on alterations in muscles and joint components after spinal cord injury in rats. (2019)
  • Author(s): Hatakeyama J, Inoue S, Yakuwa T, Nomura M, Wakimoto Y, Li C, Wakigawa T, Tsubaki T, Kinoshita S, Sakai Y, Akisue T, Moriyama H.
  • Organizer: World Confederation for Physical Therapy (WCPT) Congress 2019
  • Int'l Joint Research
• [Presentation] Carbon dioxide therapy improves contractures following joint immobilization. (2019)
  • Author(s): Wakigawa T, Inoue S, Yakuwa T, Nomura M, Wakimoto Y, Li C, Hatakeyama J, Tsubaki T, Kinoshita S, Sakai Y, Akisue T, Moriyama H.
  • Organizer: World Confederation for Physical Therapy (WCPT) Congress 2019
  • Int'l Joint Research
• [Presentation] 経皮的炭酸ガス吸収療法がヒト骨格筋および関節可動域に及ぼす影響. (2019)
  • Author(s): 李昌欣, 井上翔太, 脇本祥夫, 畠山隼平, 椿俊哉, 脇川大誠, 酒井良忠, 秋末敏宏, 森山英樹.
  • Organizer: 第24回日本基礎理学療法学会学術大会
• [Presentation] Carbon dioxide therapy improved contractures after joint immobilization in rats. (2018)
  • Author(s): Sakitani N, Moriyama H, Miyamoto R, Nomura M, Suzuki R, Kohara Y, Mizuno E, Wakimoto Y, Yakuwa T, Inoue S, Shimaya S, Iwasawa H, Ueha T, Sakai Y, Akisue T
  • Organizer: 8th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] 関節固定後の関節拘縮に対する経皮的炭酸ガス吸収療法の予防・治療効果 (2018)
  • Author(s): 井上翔太, 野村将人, 鈴木崚太, 水野絵里子, 八鍬匠, 脇本祥夫, 李昌欣, 秋末敏宏, 酒井良忠, 森山英樹
  • Organizer: 第6回日本運動器理学療法学術大会
• [Presentation] 炭酸ガス経皮膚吸収療法による関節拘縮の予防・治療効果 (2018)
  • Author(s): 崎谷直義、森山英樹、酒井良忠、秋末敏宏
  • Organizer: 炭酸ガス治療研究会第３回研究集会
• [Presentation] 中枢性麻痺後に生じる関節拘縮に対する経皮的炭酸ガス吸収療法の効果の検討 (2017)
  • Author(s): 髙野祥子、崎谷直義 、島谷俊亮、野村将人、脇本祥夫、小原雄太、上羽岳志、秋末敏宏、酒井良忠、森山英樹
  • Organizer: 第52回日本理学療法学術大会