Development of a taxis model of cells: application for medicine and evolutionary biology
| Project/Area Number |
17KK0080
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2018 – 2021
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Keywords | 微生物 / バイオメカニクス / 数理モデル / シミュレーション / バイオテクノロジー / モデル化 |
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| Outline of Final Research Achievements |
The research methodology of the parent project includes the step of "innovating theoretical and analytical methods" for microbial biomechanics. In this study, therefore, the mathematical model of phototaxis of microalgae (Gonium) was developed by combining the experimental and mathematical results of the Goldstein Laboratory at the University of Cambridge with the applicant's simulation technology. We have also conducted swimming and feeding analyses of groups of collar flagellates, the origin of multicellular animals, and has expanded microbial biomechanics into evolutionary biology. Besides, we collaborated with Professors Pedley and Lauga of the same department to analyze the stability of microbial swimming and mathematical modeling of microbial suspensions. These results were published in a total of six refereed journal papers, including two in J Fluid Mech, one in Phys Rev E, and one in J Comp Phys.
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| Academic Significance and Societal Importance of the Research Achievements |
微細藻ゴニウムの走光性を数理モデル化した成果は、光環境下の微細藻集団の振る舞いを予測する際の核となる技術である。将来的に有害赤潮藻の行動予測などにもつながる重要な知見である。２体干渉の数値解析で用いた繊毛遊泳モデルは、細胞表面の速度の付着条件と繊毛打による推力を表す新しいものであり、流体力学的に有用な成果である。微生物懸濁液のレオロジー特性を解明した成果は、マクロな連続体スケールの数理モデル化に貢献する成果である。ケンブリッジ大学のGoldstein教授、Pedley教授、Lauga教授と国際共同研究を推進して共著論文を執筆できたことは、日本の微生物バイオメカニクスの国際化に役立つ成果である。
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Report
(5 results)
Research Products
(17 results)
