Establishing Systems Biology of Obesity Based on Spatio-temporal Multi-omics Data of the Hypothalamus
Project/Area Number |
17KT0126
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 特設分野 |
Research Field |
Complex Systems Disease Theory
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Research Institution | Nagoya City University |
Principal Investigator |
Tanaka Tomohiro 名古屋市立大学, 医薬学総合研究院(医学), 准教授 (20402894)
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Project Period (FY) |
2017-07-18 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 肥満症 / 生体恒常性 / 臓器連関 / システム医学 / オミクス / 分子栄養学 / 病期分類 |
Outline of Final Research Achievements |
In this study, we have analyzed the systemic traits that underlie the molecular pathology of the hypothalamic energy center of the brain. Using minute microdissected hypothalamic nuclei, we have found that 1) by lipidomic profiling, we could differenciate brain areas, 2) by transcriptomic profiling, "Stages" of obesity has been recognized, with different temporal patterns of gene expression corresponding to different stages of obesity.
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Academic Significance and Societal Importance of the Research Achievements |
肥満症の研究の中でシステム医学的なアプローチは必ずしもこれまでなされてこなかった。本研究により、肥満症が“脳の”病気であり、病態生理と密接に関連した脳の分子病態により説明できる病期で規定されるものであることを明らかにした。この成果は肥満症に対するスティグマの克服のためにも重要な知見であり、肥満症の医学の進歩に大きく貢献しうるものと考えている。
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Pemafibrate, a selective PPARα modulator, and fenofibrate suppress microglial activation through distinct PPARα and SIRT1-dependent pathways2020
Author(s)
Ogawa K, Yagi T, Guo T, Takeda K, Ohguchi H, Koyama H, Aotani D, Imaeda K, Kataoka H, Tanaka T
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 524(2)
Issue: 2
Pages: 385-391
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A combination of dietary fat intake and nicotine exposure enhances CB1 endocannabinoid receptor expression in hypothalamic nuclei in male mice2020
Author(s)
Guo T*, Tanaka T*, Matsumoto M, Kaneko K, Unzai T, Ogino Y, Aotani D, Kusakabe T, Iwakura H, Miyazawa T, Sawamoto K, Minokoshi Y, Masuzaki H, Inagaki N, Nakao K. *Equally contributed senior authors
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Journal Title
Neuroscience Letters
Volume: 714
Pages: 13455-13455
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Rationale, Design, and Methods of the Study of Comparison of Canagliflozin vs. Teneligliptin Against Basic Metabolic Risks in Patients with Type 2 Diabetes Mellitus (CANTABILE study): Protocol for a Randomized, Parallel-Group Comparison Trial2020
Author(s)
C. Son*, Kasahara M*, Tanaka T *, Satoh-Asahara N, Kusakabe T, Nishimura K, Miyamoto Y, Kasama S, Hosoda K. *Equally contributed senior authors
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Journal Title
Diabetes Therapy
Volume: 11(1)
Issue: 1
Pages: 347-358
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] MAPK Erk5 in leptin receptor-expressing neurons controls body weight and systemic energy homeostasis in female mice.2019
Author(s)
Horie T, Park G, Inaba Y, Hashiuchi E, Iezaki T, Tokumura K, Fukasawa K, Yamada T, HiraiwaM, Kitaguchi Y, Kamada H, Kaneda K, Tanaka T, Inoue H, Hinoi E.
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Journal Title
Endocrinology
Volume: 160
Issue: 12
Pages: 2837-2848
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Case of Euthyroid Graves’ Ophthalmopathy in a Patient Sero-Negative for TSH Receptor Autoantibody2018
Author(s)
A. Hotta, T. Tanaka, H. Kato, S. Kakoi, Y. Shimizu, C. Hasegawa, A. Hayakawa, S. Yasuda, K. Ogawa, S. Ito, H. Ohguchi, T. Yagi, H. Koyama, M. Kawamura, K. Sugitani, Y. Ogura, T. Joh, and K. Imaeda. (Corresponding author)
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Journal Title
Case Rep Endocrinol,
Volume: 1707959
Pages: 1-6
DOI
Related Report
Peer Reviewed
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[Journal Article] CLICK: one-step generation of conditional knockout mice.2018
Author(s)
Miyasaka Y, Uno Y, Yoshimi K, Kunihiro Y, Yoshimura T, Tanaka T, Ishikubo H, Hiraoka Y, Takemoto N, Tanaka T, Ooguchi Y, Skehel P, Aida T, Takeda J, Mashimo T.
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Journal Title
BMC Genomics.
Volume: 19
Issue: 1
Pages: 318-318
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] An Autopsy Case of Pulmonary Tumor Thrombotic Microangiopathy Due to Rapidly Progressing Colon Cancer in a Patient with Type 2 Diabetes.2018
Author(s)
H. Oguchi, K. Imaeda, A. Hotta, S. Kakoi, S. Yasuda, Y. Shimizu, A. Hayakawa, H. Mishima, C. Hasegawa, S. Ito, K. Ogawa, Y. Yagi, H. Koyama, T. Tanaka, H. Kato, S.Takahashi, T. Joh
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Journal Title
Internal Medicine
Volume: 印刷中
NAID
Related Report
Peer Reviewed
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[Presentation] Spatio-Temporal Signatures of Hypothalamic Transcriptome/Metabolome in Obesity2017
Author(s)
T. Tanaka, T. Sonoyama, K.Kaneko, T. Unzai, Y.Ogino, T. Guo, K.Kobayashi, H. Koyama, D. Aotani, K. Inada, K.Nakao.
Organizer
The Obesity Society 2017
Related Report
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