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Mechanism of emergence of new influenza viruses and their control

Research Project

Project/Area Number 18002014
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

KAWAOKA Yoshihiro  東京大学, 医科学研究所, 教授 (70135838)

Co-Investigator(Kenkyū-buntansha) SHINYA Kyoko  神戸大学, 医学部, 准教授 (90374925)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥578,500,000 (Direct Cost: ¥445,000,000、Indirect Cost: ¥133,500,000)
Fiscal Year 2010: ¥115,700,000 (Direct Cost: ¥89,000,000、Indirect Cost: ¥26,700,000)
Fiscal Year 2009: ¥115,700,000 (Direct Cost: ¥89,000,000、Indirect Cost: ¥26,700,000)
Fiscal Year 2008: ¥115,700,000 (Direct Cost: ¥89,000,000、Indirect Cost: ¥26,700,000)
Fiscal Year 2007: ¥115,700,000 (Direct Cost: ¥89,000,000、Indirect Cost: ¥26,700,000)
Fiscal Year 2006: ¥115,700,000 (Direct Cost: ¥89,000,000、Indirect Cost: ¥26,700,000)
Keywordsインフルエンザ / 抗ウイルス薬 / 薬剤耐性ウイルス / レセプター / ウイルス粒子形成 / オセルタミビル / タミフル
Research Abstract

We studied the mechanisms by which H5N1 avian influenza viruses are transmitted to humans. We identified several amino acids that support efficient avian virus replication in mammals, and determined the distribution of avian-type receptors in the human airway. In 2009, during the term of this project, an influenza pandemic occurred. We therefore analyzed the mechanisms of the emergence of drug-resistant pandemic (H1N1) 2009 and H5N1 viruses. The data we obtained were and continue to be critical to the proper usage of influenza drugs in the clinical setting. We also analyzed the packaging mechanism of the influenza viral genome, and elucidated the three-dimensional structure of ribonucleoprotein complexes within progeny virions. The information obtained from these studies is critical for not only the prevention of future pandemics but also the development of new strategies to combat seasonal and pandemic influenza.

Report

(10 results)
  • 2016 Abstract(Follow-up Assessment) ( PDF )   Self-evaluation (Follow-up Assessment) ( PDF )   Comments (Follow-up Assessment) ( PDF )
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (180 results)

All 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article (99 results) (of which Peer Reviewed: 68 results) Presentation (36 results) Book (6 results) Remarks (39 results)

  • [Journal Article] Three-dimensional analysis of ribonucleoprotein complexes in influenza A virus2012

    • Author(s)
      Noda T, Sugita Y, Aoyama K, Hirase A, Kawakami E, Miyazawa A, Sagara H, Kawaoka Y.
    • Journal Title

      Nat Commun

      Volume: 3 Pages: 639-639

    • Related Report
      2010 Final Research Report
  • [Journal Article] Three-dimensional analysis of ribonucleoprotein complexes in influenza A virus2012

    • Author(s)
      Noda T, et al
    • Journal Title

      Nat Commun

      Volume: 3 Pages: 639-639

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA2011

    • Author(s)
      Kawakami E, et al
    • Journal Title

      J Virol Methods

      Volume: 173 Pages: 1-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks2011

    • Author(s)
      Song J, et al
    • Journal Title

      J Virol

      Volume: 85 Pages: 2180-2188

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pandemic Swine-Origin H1N1 Influenza A Isolates Show Heterogeneous Virulence in Macaques2011

    • Author(s)
      Safronetz D, et al
    • Journal Title

      J Virol

      Volume: 85 Pages: 1214-1223

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of Siva-1 for replication of influenza A virus through apoptosis induction2011

    • Author(s)
      Shiozaki T, et al
    • Journal Title

      J Gen Virol

      Volume: 92 Pages: 315-325

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-based design of NS2 mutants for attenuated influenza A virus vaccines2011

    • Author(s)
      Akarsu H, et al
    • Journal Title

      Virus Res

      Volume: 155 Pages: 240-248

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses2011

    • Author(s)
      Shinya K, et al
    • Journal Title

      Virol J

      Volume: 8 Pages: 97-97

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-705 (favipiravir) activity against lethal H5N1 influenza A viruses2010

    • Author(s)
      Kiso M, Takahashi K, Sakai-Tagawa Y, Shinya K, Sakabe S, Le QM, Ozawa M, Furuta Y, Kawaoka Y.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107 Pages: 882-887

    • Related Report
      2010 Final Research Report
  • [Journal Article] Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses2010

    • Author(s)
      Kiso M, Kubo S, Ozawa M, Le QM, Nidom CA, Yamashita M, Kawaoka Y.
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Final Research Report
  • [Journal Article] The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets2010

    • Author(s)
      Imai H, Shinya K, Takano R, Kiso M, Muramoto Y, Sakabe S, Murakami S, Ito M, Yamada S, Le MQ, Nidom CA, Sakai-Tagawa Y, Takahashi K, Omori Y, NodaT, Shimojima M, Kakugawa S, Goto H, Iwatsuki-Horimoto K, Horimoto T, Kawaoka Y.
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses2010

    • Author(s)
      Kiso M, Shinya K, Shimojima M, Takano R, Takahashi K, Katsura H, Kakugawa S, Le MQ, Yamashita M, Furuta Y, Ozawa M, Kawaoka Y.
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Final Research Report
  • [Journal Article] Biological and structural characterization of a host-adapting amino acid in influenza virus2010

    • Author(s)
      Yamada S, Hatta M, Staker BL, Watanabe S, Imai M, Shinya K, Sakai-Tagawa Y, Ito M, Ozawa M, Watanabe T, Sakabe S, Li C, Kim JH, Myler PJ, Phan I, Raymond A, Smith E, Stacy R, Nidom CA, Lank SM, Wiseman RW, Bimber BN, O’Connor DH, Neumann G, Stewart LJ, Kawaoka Y.
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence2010

    • Author(s)
      Li C, Hatta M, Nidom CA, Muramoto Y, Watanabe S, Neumann G, Kawaoka Y.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107 Pages: 4687-4692

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice2010

    • Author(s)
      Kim JH, et al
    • Journal Title

      J Gen Virol

      Volume: 91 Pages: 1284-1289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mutation in H5 hemagglutinin that conferred human receptor recognition is not stably maintained during duck passage2010

    • Author(s)
      Shinya K, et al
    • Journal Title

      J Gen Virol

      Volume: 91 Pages: 1461-1463

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses2010

    • Author(s)
      Kiso M, et al
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence2010

    • Author(s)
      Li C, et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 4687-4692

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses2010

    • Author(s)
      Sakai-Tagawa Y, et al
    • Journal Title

      J Clin Microbiol

      Volume: 48 Pages: 2872-2877

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human antibodies reveal a protective epitope that is highly conserved among human and non-human influenza A viruses2010

    • Author(s)
      Grandea III AG, et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 12658-12663

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological and structural characterization of a host-adapting amino acid in influenza virus2010

    • Author(s)
      Yamada S, et al
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans from 2003 to 2008 in Northern Vietnam2010

    • Author(s)
      Le MQ, et al
    • Journal Title

      J Gen Virol

      Volume: 91 Pages: 2485-2490

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] H5N1 influenza viruses from pigs in Indonesia2010

    • Author(s)
      Nidom CA, et al
    • Journal Title

      Emerg Infect Dis

      Volume: 16 Pages: 1515-1523

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses2010

    • Author(s)
      Kiso M, et al
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses2010

    • Author(s)
      Octaviani CP, et al
    • Journal Title

      J Virol

      Volume: 84 Pages: 10918-10922

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets2010

    • Author(s)
      Imai H, et al
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral replication rate regulates clinical outcome and CD8 T cell responses during highly pathogenic H5N1 influenza virus infection in mice2010

    • Author(s)
      Hatta Y, et al
    • Journal Title

      PLoS Pathog

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 12010

    • Author(s)
      Iwai A, et al
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 32064-32074

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dogs are highly susceptible to H5N1 avian influenza virus2010

    • Author(s)
      Chen Y, et al
    • Journal Title

      Virology

      Volume: 405 Pages: 15-19

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of TNF-alpha in human macrophages by avian and human influenza viruses2010

    • Author(s)
      Monteerarat Y, et al
    • Journal Title

      Arch Virol

      Volume: 155 Pages: 1273-1279

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cross-reactive neutralizing monoclonal antibody protects mice from H5N1 and pandemic (H1N1) 2009 virus infection2010

    • Author(s)
      Sakabe S, et al
    • Journal Title

      Antiviral Res

      Volume: 88 Pages: 249-255

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The low-pH stability discovered in neuraminidase of 1918 pandemic influenza A virus enhances virus replication2010

    • Author(s)
      Takahashi T, et al
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-705(favipiravir)activity against lethal H5N1 influenza A viruses2010

    • Author(s)
      Kiso M, et al.
    • Journal Title

      Proc Natl Acad Sci USA 107

      Pages: 882-887

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses2009

    • Author(s)
      Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y.
    • Journal Title

      Nature

      Volume: 460 Pages: 1021-1025

    • Related Report
      2010 Final Research Report
  • [Journal Article] Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets.2009

    • Author(s)
      Watanabe T, Watanabe S, Shinya K, Kim JH, Hatta M, Kawaoka Y.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 106 Pages: 588-592

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host2009

    • Author(s)
      Gao Y, et al.
    • Journal Title

      PLoS Pathog 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ostrich involvement in the selection of H5N1 influenza virus possessing mammalian-type amino acids in the PB2 protein2009

    • Author(s)
      Shinya K, et al.
    • Journal Title

      J Virol 83

      Pages: 13015-13018

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses2009

    • Author(s)
      Itoh Y, et al.
    • Journal Title

      Nature 460

      Pages: 1021-1025

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of conserved amino acids in the influenza A virus nucleoprotein2009

    • Author(s)
      Li Z, et al.
    • Journal Title

      J Virol 83

      Pages: 4153-4162

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The incorporation of influenza A virus genome Segments Does Not Absolutely Require Wild-Type Sequences2009

    • Author(s)
      Fujii K, et al.
    • Journal Title

      J Gen Virol 90

      Pages: 1734-1740

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The region required for protein expression from the stop-start pentanucleotide in the M gene of influenza B virus2009

    • Author(s)
      Hatta M, et al.
    • Journal Title

      J Virol 83

      Pages: 5939-5942

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia2009

    • Author(s)
      Takano R, et al.
    • Journal Title

      Arch Virol 154

      Pages: 677-681

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oseltamivir-Resistant Influenza A Viruses Circulating in Japan2009

    • Author(s)
      Tamura D, et al.
    • Journal Title

      J Clin Micro 47

      Pages: 1424-1427

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influenza A virus lacking M2 protein as a live attenuated vaccine2009

    • Author(s)
      Watanabe T., et al.
    • Journal Title

      J Virol 83

      Pages: 5947-5950

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selection of H5N1 influenza virus PB2 during replication in humans2009

    • Author(s)
      Le QM, et al.
    • Journal Title

      J Virol 83

      Pages: 5278-5281

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RuvB-like 2 protein is a suppressor of influenza A virus polymerases2009

    • Author(s)
      Kakugawa S, et al.
    • Journal Title

      J Virol 83

      Pages: 6429-6434

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice2009

    • Author(s)
      Fan S, et al.
    • Journal Title

      Virology 384

      Pages: 28-32

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection2009

    • Author(s)
      Kakugawa S, et al.
    • Journal Title

      J Virol 83

      Pages: 2510-2517

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleotide sequence requirements at the 5' end of the influenza A virus M RNA segment for efficient virus replication2009

    • Author(s)
      Ozawa M, et al.
    • Journal Title

      J Virol 83

      Pages: 3384-3388

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets2009

    • Author(s)
      Watanabe T, et al.
    • Journal Title

      Proc Natl Acad Sci USA 106

      Pages: 588-592

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells.J Virol 82:10502-10509, 20092009

    • Author(s)
      Murakami S, et al.
    • Journal Title

      J Virol 83

      Pages: 6429-6434

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets.2009

    • Author(s)
      Watanabe T, Watanabe S, Shinya K, Kim JH, Hatta M, Kawaoka Y.
    • Journal Title

      Proc Natl Acad Sci U S A 106

      Pages: 588-592

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Drosophila RNAi screen identifies host genes important for influenza virus replication2008

    • Author(s)
      Hao L, Sakurai A, Watanabe T, Sorensen E, Nidom CA, Newton MA, Ahlquist P, Kawaoka Y.
    • Journal Title

      Nature

      Volume: 454 Pages: 890-893

    • Related Report
      2010 Final Research Report
  • [Journal Article] Drosophila RNAi screen identifies host genes important for influenza virus replication.2008

    • Author(s)
      Hao L, Sakurai A, Watanabe T, Sorensen E, Nidom CA, Newton MA, Ahlquist P, Kawaoka Y.
    • Journal Title

      Nature 454

      Pages: 890-893

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] A single amino acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice2008

    • Author(s)
      Jiao P, et.al.
    • Journal Title

      Journal of Virology 82

      Pages: 1146-1154

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of canine RNA polymerase I-driven reverse genetics for influenza A virus : its application for H5N1 vaccine production2008

    • Author(s)
      Murakami S, et.al.
    • Journal Title

      Journal of Virology 82

      Pages: 1605-1609

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens2008

    • Author(s)
      Zhu Q, et.al.
    • Journal Title

      Journal of Virology 82

      Pages: 220-228

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cvnomolEus macaaues2008

    • Author(s)
      Itho, et.al.
    • Journal Title

      Vaccine 26

      Pages: 562-572

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel approach to the development of effective H5N1 influenza A virus vaccines : the use of M2 cytoplasmic tail mutants2008

    • Author(s)
      Watanabe T, et.al.
    • Journal Title

      Journal of Virology 82

      Pages: 2486-2492

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limited compatibility between the RNA polymerase components of influenza virus type A and B2008

    • Author(s)
      Iwatsuki-Horimoto K, et.al.
    • Journal Title

      Virus Research 135

      Pages: 161-165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A vaccine prepared from a non-pathogenic H7N7 virus isolated from natural reservoir conferred protective immunity against the challenge with lethal dose of highly pathogenic avian influenza virus in chickens2008

    • Author(s)
      Sakabe S, et.al.
    • Journal Title

      Vaccine 26

      Pages: 2127-2134

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin2008

    • Author(s)
      Sawai T, et.al.
    • Journal Title

      Immunology 124

      Pages: 155-165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children2008

    • Author(s)
      Sugaya N, et.al.
    • Journal Title

      Clin Infect Dis 47

      Pages: 339-345

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila RNAi screen identifies host genes important for influenza virus replication2008

    • Author(s)
      Hao L, et.al.
    • Journal Title

      Nature 454

      Pages: 890-893

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model2008

    • Author(s)
      Murakami S, et.al.
    • Journal Title

      Vaccine 26

      Pages: 6398-6404

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza2008

    • Author(s)
      Marsolais D, et.al.
    • Journal Title

      Mol Pharmacol 74

      Pages: 896-903

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons2008

    • Author(s)
      Jia B, et.al.
    • Journal Title

      Arch Virol 153

      Pages: 1821-1826

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compatibility among polymerase subunit proteins is a restricting factor in reassortment between equine H7N7 and human H3N2 influenza viruses2008

    • Author(s)
      Li C, at.al.
    • Journal Title

      Journal of Virology 82

      Pages: 11880-11888

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus2007

    • Author(s)
      Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y, Kim JH, Halfmann P, Hatta M, Feldmann F, Alimonti JB, Fernando L, Li Y, Katze MG, Feldmann H, Kawaoka Y.
    • Journal Title

      Nature

      Volume: 445 Pages: 319-323

    • Related Report
      2010 Final Research Report
  • [Journal Article] Emergence of influenza B viruses with reduced sensitibity to neuraminidase inhibitors2007

    • Author(s)
      Hatakeyama S, Sugaya N, Ito M, Yamazaki M, Ichikawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Koike K, Mitamura K, Kawaoka Y.
    • Journal Title

      JAMA

      Volume: 297 Pages: 1435-1442

    • Related Report
      2010 Final Research Report
  • [Journal Article] Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice2007

    • Author(s)
      Hatta M, Hatta Y, Kim JH, Watanabe S, Shinya K, Kawaoka Y.
    • Journal Title

      PLoS Pathog

      Volume: 3 Pages: 1374-1379

    • Related Report
      2010 Final Research Report
  • [Journal Article] Emergence of influenza B viruses with reduced sensitibity to neuraminidase inhibitors.2007

    • Author(s)
      Hatakeyama S, Sugaya N, Ito M, Yamazaki M, Ichikawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Koike K, Mitamura K, Kawaoka Y.
    • Journal Title

      JAMA 297

      Pages: 1435-1442

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.2007

    • Author(s)
      Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y, Kim JH, Halfmann P, Hatta M, Feldmann F, Alimonti JB, Fernando L, Li Y, Katze MG, Feldmann H, Kawaoka Y.
    • Journal Title

      Nature 445

      Pages: 319-323

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice PLoS Pathog2007

    • Author(s)
      Hatta M, Hatta Y, Kim JH, Watanabe S, Shinya K, Kawaoka Y.
    • Journal Title

      3

      Pages: 1374-1379

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Contributions of two nuclear localization signals of influenza A virus nucleoprotein to viral replication.2007

    • Author(s)
      Ozawa M., et. al.
    • Journal Title

      Journal of Virology 81

      Pages: 30-41

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient vagina-to-lower respiratory tract immune trafficking in a murine model of influenza A virus infection.2007

    • Author(s)
      Garulli B., et. al.
    • Journal Title

      Virology 361

      Pages: 274-282

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children.2007

    • Author(s)
      Sugaya N., et. al.
    • Journal Title

      Clin. Infect. Dis. 44

      Pages: 197-202

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced growth of seed viruses for H5N1 influenza vaccines.2007

    • Author(s)
      Horimoto T., et. al.
    • Journal Title

      Virology 366

      Pages: 23-27

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An adenoviral vector-mediated reverse genetics system for influenza A virusgeneration.2007

    • Author(s)
      Ozawa M., et. al.
    • Journal Title

      Journal of Virology 81

      Pages: 9556-9559

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.2007

    • Author(s)
      Hatta M., et. al.
    • Journal Title

      PLoS Pathog. 3

      Pages: 1374-1379

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pneumo- and Neurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice.2007

    • Author(s)
      Rigoni M., et. al.
    • Journal Title

      Virology 364

      Pages: 28-55

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The quail and chicken intestine have sialyl-galactose sugar chainsresponsible for the binding of influenza A viruses to human type receptors.2007

    • Author(s)
      Guo CT., et. al.
    • Journal Title

      Glycobiology 17

      Pages: 713-724

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influenza viral hemagglutinin complicated shape is advantageous to its binding affinity for sialosaccharide receptor.2007

    • Author(s)
      Sawada T., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 355

      Pages: 6-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of an H7N7 equine influenza A virus in mice.2007

    • Author(s)
      Shinya K., et. al.
    • Journal Title

      J. Gen. Virol. 88

      Pages: 547-532

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishement of canine RNA polymerase I-driven reverse genetics for influenza A virus: its application for H5N1 vaccine production.2007

    • Author(s)
      Murakami S., et. al.
    • Journal Title

      Journal of Virology 82

      Pages: 1605-1609

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single amino acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice.2007

    • Author(s)
      Jiao P., et. al.
    • Journal Title

      Journal of Virology 82

      Pages: 1146-1154

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.2007

    • Author(s)
      Kobasa D., et al.
    • Journal Title

      Nature 445

      Pages: 319-323

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Emergence of influenza B viruses with reduced sensitibity to neuraminidase inhibitors.2007

    • Author(s)
      Hatakeyama, S. et al.
    • Journal Title

      Journal of the American Medical Association 297

      Pages: 1435-1442

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Avian flu: Influenza virus receptors in the human airway2006

    • Author(s)
      Shinya K, Ebina M, Yamada S, Ono M, Kasai N, Kawaoka Y.
    • Journal Title

      Nature

      Volume: 440 Pages: 435-436

    • Related Report
      2010 Final Research Report
  • [Journal Article] Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors2006

    • Author(s)
      Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y.
    • Journal Title

      Nature

      Volume: 444 Pages: 378-382

    • Related Report
      2010 Final Research Report
  • [Journal Article] Avian flu: Influenza virus receptors in the human airway.2006

    • Author(s)
      Shinya K, Ebina M, Yamada S, Ono M, Kasai N, Kawaoka Y.
    • Journal Title

      Nature 440

      Pages: 435-436

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.2006

    • Author(s)
      Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y.
    • Journal Title

      Nature 444

      Pages: 378-382

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Highly pathogenic H5N1 influenza virus causes coagulopathy in Chikens.2006

    • Author(s)
      Muramoto Y., et al.
    • Journal Title

      Microbiol. Immunol. 50

      Pages: 73-81

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Architecture of ribonucleoprotein complexes in influenza A virus particles.2006

    • Author(s)
      Noda T., et al.
    • Journal Title

      Nature 439

      Pages: 490-492

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hierarchy among vRNA segments in their role in vRNA incorporation into influenza A virions.2006

    • Author(s)
      Muramoto Y., et al.
    • Journal Title

      Journal of Virology 80

      Pages: 2318-2325

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly.2006

    • Author(s)
      Iwatsuki-Horimoto K., et al.
    • Journal Title

      Journal of Virology 80

      Pages: 5233-5240

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China.2006

    • Author(s)
      Chen H., et al.
    • Journal Title

      Journal of Virology 80

      Pages: 5976-5983

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Avian flu : Influenza virus receptors in the human airway.2006

    • Author(s)
      Shinya K., et al.
    • Journal Title

      Nature 440

      Pages: 435-436

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.2006

    • Author(s)
      Yamada S., et al.
    • Journal Title

      Nature 444

      Pages: 378-382

    • Related Report
      2006 Annual Research Report
  • [Presentation] Pandemic Influenza2010

    • Author(s)
      河岡義裕
    • Organizer
      Pandemic Influenza
    • Place of Presentation
      ワシントン(招待講演)
    • Year and Date
      2010-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Pandemic Influenza2010

    • Author(s)
      Kawaoka Y
    • Organizer
      Influenza : Translating basic insights
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Systems Biology Approaches to Viral Pathogenesis and Immunity2010

    • Author(s)
      河岡義裕
    • Organizer
      Pacific Northwest regional Center of Excellence
    • Place of Presentation
      ポートランド(招待講演)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Systems Biology Approaches to Viral Patthogenesis and Immunity2010

    • Author(s)
      Kawaoka Y
    • Organizer
      Pacific Northwest Regional Center of Excellence
    • Place of Presentation
      Portland, USA
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular Determinants of Transmission and Virulence2010

    • Author(s)
      河岡義裕
    • Organizer
      Option for the Control Influenza VII
    • Place of Presentation
      香港(招待講演)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular Determinants of Transmission and Virulence2010

    • Author(s)
      Kawaoka Y
    • Organizer
      Option for the Control Influenza VII
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 2009 Pandemic Influenza2010

    • Author(s)
      河岡義裕
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 2009 Pandemic Influenza2010

    • Author(s)
      Kawaoka Y
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pandemic Influenza2010

    • Author(s)
      河岡義裕
    • Organizer
      American Society for Microbiology, 110^<th> General Meeting
    • Place of Presentation
      サンディエゴ(招待講演)
    • Year and Date
      2010-05-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Pandemic Influenza2010

    • Author(s)
      Kawaoka Y
    • Organizer
      American Society for Microbiology, 110th General Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 2009 Pandemic Influenza2010

    • Author(s)
      河岡義裕
    • Organizer
      European Society for Virology
    • Place of Presentation
      チェルノッビオ(招待講演)
    • Year and Date
      2010-04-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 2009 Pandemic Influenza2010

    • Author(s)
      Kawaoka Y
    • Organizer
      European Society for Virology
    • Place of Presentation
      Cernobbio, Italy
    • Year and Date
      2010-04-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] New Insights from studies on influenza2010

    • Author(s)
      河岡義裕
    • Organizer
      XII International Symposium on Respiratory Viral Infection
    • Place of Presentation
      台北(招待講演)
    • Year and Date
      2010-03-11
    • Related Report
      2010 Final Research Report
  • [Presentation] New Insights from studies on influenza2010

    • Author(s)
      河岡義裕
    • Organizer
      XII International Symposium on Respiratory Viral Infection
    • Place of Presentation
      台北、中国
    • Year and Date
      2010-03-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新型インフルエンザ-本当の姿2010

    • Author(s)
      河岡義裕
    • Organizer
      再生医療・創薬 新しい医療の確立を目指して
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-02-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 新型インフルエンザ―本当の姿2010

    • Author(s)
      河岡義裕
    • Organizer
      再生医療・創薬 新しい医療の確立を目指して
    • Place of Presentation
      神戸、日本
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Keynote Speech2010

    • Author(s)
      河岡義裕
    • Organizer
      JUNBA 2010 Symposium
    • Place of Presentation
      サンフランシスコ(招待講演)
    • Year and Date
      2010-01-12
    • Related Report
      2010 Final Research Report
  • [Presentation] KEYNOTE SPEECH2010

    • Author(s)
      河岡義裕
    • Organizer
      JUNBA 2010 Symposium
    • Place of Presentation
      サンフランシスコ、米国
    • Year and Date
      2010-01-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Why influenza kills and will kill again2009

    • Author(s)
      河岡義裕
    • Organizer
      China-Japan Research Collaboration on Emerging and Reemerging Infections: First Five Years and Future
    • Place of Presentation
      北京(招待講演)
    • Year and Date
      2009-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Why influenza kills and will kill again2009

    • Author(s)
      河岡義裕
    • Organizer
      China-Japan Research Collaboration on Emerging and Reemerging Infections : First Five Years and Future
    • Place of Presentation
      北京・中国
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Insights into Influenza Pathogenesis and Prevention2009

    • Author(s)
      河岡義裕
    • Organizer
      International Symposium on Respiratory Viral Infections
    • Place of Presentation
      バンコク(招待講演)
    • Year and Date
      2009-02-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Insights into Influenza Pathogenesis and Prevention2009

    • Author(s)
      Kawaoka Y
    • Organizer
      International Symposium on Respiratory Viral Infections
    • Place of Presentation
      バンコク
    • Year and Date
      2009-02-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] パンデミック・インフルエンザ-過去と未来-2008

    • Author(s)
      河岡義裕
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2008-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] パンデミック・インフルエンザ-過去と未来-2008

    • Author(s)
      河岡義裕
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] パンデミック・インフルエンザ2008

    • Author(s)
      河岡義裕
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山(招待講演)
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] パンデミック・インフルエンザ2008

    • Author(s)
      河岡義裕
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1918 and H5N1 viruses2008

    • Author(s)
      河岡義裕
    • Organizer
      XIV. International Congress of Virology
    • Place of Presentation
      イスタンブール(招待講演)
    • Year and Date
      2008-08-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 1918 and H5N1 viruses2008

    • Author(s)
      Kawaoka Y
    • Organizer
      XIV. International Congress of Virology
    • Place of Presentation
      イスタンブール
    • Year and Date
      2008-08-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Influenza: Recent findings2008

    • Author(s)
      河岡義裕
    • Organizer
      4^<th> China-Japan Bilateral Symposium on Avian Influenza
    • Place of Presentation
      北京(招待講演)
    • Year and Date
      2008-04-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Influenza : Recent findings2008

    • Author(s)
      Kawaoka Y
    • Organizer
      4^<th> China-Japan Bilateral Symposium on Avian Influenza
    • Place of Presentation
      北京
    • Year and Date
      2008-04-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Influenza Pandemic: Past and Future2007

    • Author(s)
      河岡義裕
    • Organizer
      5^<th> International Conference on Emerging Zoonosis
    • Place of Presentation
      パリ(招待講演)
    • Year and Date
      2007-11-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Influenza Pandemic: Past and Future2007

    • Author(s)
      河岡義裕
    • Organizer
      5th International Conference on Emerging Zoonoses
    • Place of Presentation
      パリ(フランス)
    • Year and Date
      2007-11-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Why influenza kills and kill again2007

    • Author(s)
      河岡義裕
    • Organizer
      Options for the Control of Influenza VI
    • Place of Presentation
      トロント(招待講演)
    • Year and Date
      2007-06-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Why influenza kills and kill again.2007

    • Author(s)
      河岡義裕
    • Organizer
      Options for the Control of Influenza VI
    • Place of Presentation
      トロント(カナダ)
    • Year and Date
      2007-06-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Enigmas of influenza2007

    • Author(s)
      河岡義裕
    • Organizer
      1^<st> Max Planck Symposium "Virology"
    • Place of Presentation
      ベルリン(招待講演)
    • Year and Date
      2007-04-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Enigmas of influenza2007

    • Author(s)
      河岡義裕
    • Organizer
      1st Max Planck Symposium "Virology"
    • Place of Presentation
      ベルリン(ドイツ)
    • Year and Date
      2007-04-13
    • Related Report
      2007 Annual Research Report
  • [Book] 闘う!ウイルス・バスターズ2011

    • Author(s)
      河岡義裕、渡辺登喜子
    • Total Pages
      264
    • Publisher
      朝日新書(出版)
    • Related Report
      2010 Final Research Report
  • [Book] 闘う!ウイルス・バスターズ2011

    • Author(s)
      河岡義裕、渡辺登喜子
    • Total Pages
      264
    • Publisher
      朝日新書
    • Related Report
      2010 Annual Research Report
  • [Book] 新型インフルエンザ 本当の姿2009

    • Author(s)
      河岡義裕
    • Total Pages
      185
    • Publisher
      集英社新書(出版)
    • Related Report
      2010 Final Research Report
  • [Book] インフルエンザパンデミック2009

    • Author(s)
      河岡義裕、堀本研子
    • Total Pages
      238
    • Publisher
      講談社新書(出版)
    • Related Report
      2010 Final Research Report
  • [Book] 新型インフルエンザ 本当の姿2009

    • Author(s)
      河岡義裕
    • Total Pages
      185
    • Publisher
      集英社
    • Related Report
      2009 Annual Research Report
  • [Book] インフルエンザ パンデミック2009

    • Author(s)
      河岡義裕、堀本研子
    • Total Pages
      238
    • Publisher
      講談社
    • Related Report
      2009 Annual Research Report
  • [Remarks] 朝日新聞:平成24年1月25日夕刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 読売新聞:平成22年8月7日朝刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 朝日新聞:平成22年8月6日朝刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 朝日新聞:平成22年8月5日朝刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 日経新聞:平成22年2月26日夕刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 朝日新聞:平成22年2月26日夕刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 毎日新聞:平成22年2月27日朝刊 新聞掲載

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  • [Remarks] 読売新聞:平成22年2月27日夕刊 新聞掲載

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  • [Remarks] 日経新聞:平成21年12月22日朝刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 読売新聞:平成21年12月22日夕刊 新聞掲載

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  • [Remarks] 毎日新聞:平成21年7月14日朝刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 朝日新聞:平成21年7月14日朝刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 産経新聞:平成21年7月14日朝刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 読売新聞:平成21年7月14日朝刊 新聞掲載

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      2010 Final Research Report
  • [Remarks] 日経新聞:平成21年7月14日朝刊 新聞掲載

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  • [Remarks] 毎日新聞:平成21年6月16日朝刊 新聞掲載

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  • [Remarks] 朝日新聞:平成21年6月15日夕刊 新聞掲載

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    • Related Report
      2010 Final Research Report
  • [Remarks] 毎日新聞:平成18年11月16日朝刊 新聞掲載

    • Related Report
      2010 Final Research Report
  • [Remarks] 日経新聞:平成18年11月16日朝刊 新聞掲載

    • Related Report
      2010 Final Research Report
  • [Remarks] 読売新聞:平成18年11月16日夕刊 新聞掲載

    • Related Report
      2010 Final Research Report
  • [Remarks] 読売新聞:平成18年10月20日朝刊 新聞掲載

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/virology/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/virology/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/virology/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks] 読売新聞:平成18年10月20日朝刊

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 日経新聞:平成18年11月16日朝刊

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 毎日新聞:平成18年11月16日朝刊

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 読売新聞:平成18年11月16日夕刊

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 朝日新聞:平成18年12月1日夕刊

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 読売新聞:平成19年4月4日夕刊

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 朝日新聞:平成19年4月21日朝刊

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 毎日新聞:平成19年10月7日朝刊

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 朝日新聞:平成21年1月12日朝刊

    • Related Report
      2008 Self-evaluation Report

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Published: 2006-04-01   Modified: 2018-03-28  

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