Spatiotemporal control of cell functions by Rho GTPases ; mechanisms and physiological roles

• Project/Area Number: 18002015
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: NARUMIYA Shuh Kyoto University, 医学研究科, 教授 (70144350)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥641,160,000 (Direct Cost: ¥493,200,000、Indirect Cost: ¥147,960,000); Fiscal Year 2010: ¥110,240,000 (Direct Cost: ¥84,800,000、Indirect Cost: ¥25,440,000); Fiscal Year 2009: ¥113,880,000 (Direct Cost: ¥87,600,000、Indirect Cost: ¥26,280,000); Fiscal Year 2008: ¥136,630,000 (Direct Cost: ¥105,100,000、Indirect Cost: ¥31,530,000); Fiscal Year 2007: ¥143,780,000 (Direct Cost: ¥110,600,000、Indirect Cost: ¥33,180,000); Fiscal Year 2006: ¥136,630,000 (Direct Cost: ¥105,100,000、Indirect Cost: ¥31,530,000)
• Keywords: Rho / アクチン / 微小管 / 細胞周期 / 細胞質分裂 / mDia / ROCK / 個体発生 / 癌化 / 神経細胞 / 細胞運動 / 細胞骨格 / Rho GTPase / 癌 / 細胞分裂 / Rho GTPases / ROCk / 細胞移動 / 細胞接着 / 免疫 / がん / 神経 / 遺伝子欠損マウス / 収縮環 / 核輸送 / がん化

Research Abstract

The small GTPase Rho functions as a molecular switch of cell morphogenesis, adhesion, migration and division by acting on downstream signaling molecules. Here we studied the spatiotemoral role of this signaling in cultured cells and the body. We revealed the role and mechanism of the Rho signaling in cell migration and cell division in cultured cells and further found that this pathway plays an essential role in development such as embryo vasculogenesis and proper path finding of axon, and that this pathway is exploited by oncogenes in cell transformation and tumorigenesis.

Research Products

• [Journal Article] Rotational movement of the formin mDia1 along the double helical strand of an actin filament. (2011)
  • Author(s): Mizuno H, Higashida C, Yuan Y, Ishizaki T, Narumiya S, Watanabe N.
  • Journal Title: Science. 331 Pages: 80-83
  • Peer Reviewed
• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases : Novel insights from knockout mouse studies. (2011)
  • Author(s): Tanizaki H., et al
  • Journal Title: Pharmacol Ther.2011 Feb;129(2):195-205 Volume: 116 Pages: 5875-5884
  • Peer Reviewed
• [Journal Article] Rotational movement of mDial along the double helical strand of actin filament. (2011)
  • Author(s): Mizuno H., et al
  • Journal Title: Science Volume: 331 Pages: 80-83
  • Peer Reviewed
• [Journal Article] Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway. (2011)
  • Author(s): Eguchi M., et al
  • Journal Title: Clin Exp Immunol.2011 Feb;163(2):260-9 Volume: 116 Pages: 5875-5884
  • Peer Reviewed
• [Journal Article] Fever, inflammation, pain and beyond : prostanoid receptor research during these 25 years. (2011)
  • Author(s): Narumiya S., et al
  • Journal Title: FASEB J. Volume: 25 Pages: 813-818
  • Peer Reviewed
• [Journal Article] Stress responses : the contribution of prostaglandin E(2) and its receptors. (2011)
  • Author(s): Furuyashiki T., et al
  • Journal Title: Nat Rev Endocrinol. Volume: 7 Pages: 163-175
  • Peer Reviewed
• [Journal Article] PGE(2)-EP(2) receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB. (2011)
  • Author(s): Aoki T., et al
  • Journal Title: Br J Pharmacol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression. (2011)
  • Author(s): Soontrapa K., et al
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 108 Pages: 6668-6673
  • Peer Reviewed
• [Journal Article] Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain. (2011)
  • Author(s): Johansson T., et al
  • Journal Title: Neurosci Lett Volume: (In press)
  • Peer Reviewed
• [Journal Article] Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells. (2010)
  • Author(s): Tanizaki H, Egawa G, Inaba K, Honda T, Nakajima S, Moniaga CS, Otsuka A, Ishizaki T, Tomura M, Watanabe T, Miyachi Y, Narumiya S, Okada T, Kabashima K.
  • Journal Title: Blood. 116 Pages: 5875-5884
  • Peer Reviewed
• [Journal Article] Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. (2010)
  • Author(s): Esaki Y, Li Y, Sakata D, Yao C, Segi-Nishida E, Matsuoka T, Fukuda K, Narumiya S.
  • Journal Title: Proc Natl Acad Sci USA. 107 Pages: 12233-12238
  • Peer Reviewed
• [Journal Article] Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. (2010)
  • Author(s): Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y.
  • Journal Title: Cell Stem Cell. 7 Pages: 225-239
  • Peer Reviewed
• [Journal Article] mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion. (2010)
  • Author(s): Tanji M, Ishizaki T, Ebrahimi S, Tsuboguchi Y, Sukezane T, Akagi T, Frame MC, Hashimoto N, Miyamoto S, Narumiya S.
  • Journal Title: Mol Cell Biol. 19 Pages: 4604-4615
  • Peer Reviewed
• [Journal Article] Rho and anillin-dependent control of mDia2localization and function in cytokinesis. (2010)
  • Author(s): Watanabe S, Okawa K, Miki T, Sakamoto S, Morinaga T, Segawa K, Arakawa T, Kinoshita M, Ishizaki T, Narumiya S.
  • Journal Title: Mol Biol Cell. 21 Pages: 3193-3204
  • Peer Reviewed
• [Journal Article] Localization mechanisms of a Rho effector, mDia2, in cytokinesis. (2010)
  • Author(s): Watanabe S., et al
  • Journal Title: Molecular Biology of the Cell Volume: 21 Pages: 3193-3204
  • Peer Reviewed
• [Journal Article] mDial Targets v-Src to Cell Periphery and Facilitates Cell Transformation, Tumorigenesis and Invasion. (2010)
  • Author(s): Tanji M, et al
  • Journal Title: Molecular and Cellular Biology Volume: 30 Pages: 4604-4615
  • Peer Reviewed
• [Journal Article] Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells (2010)
  • Author(s): Ohgushi M., et al
  • Journal Title: Cell Stem Cell Volume: 7 Pages: 225-239
  • Peer Reviewed
• [Journal Article] Rho-mDial pathway is required for adhesion, migration, and T cell stimulation in dendritic cells (2010)
  • Author(s): Tanizaki H., et al
  • Journal Title: Blood Volume: 116 Pages: 5875-5884
  • Peer Reviewed
• [Journal Article] COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. (2010)
  • Author(s): Katoh H, et al
  • Journal Title: Am J Pathol. Volume: 176 Pages: 1469-1483
  • Peer Reviewed
• [Journal Article] Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model. (2010)
  • Author(s): Terada N, et al
  • Journal Title: Cancer Res. Volume: 15 Pages: 1606-1615
  • Peer Reviewed
• [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling. (2010)
  • Author(s): Nakajima S., et al
  • Journal Title: J Immunol. Volume: 15 Pages: 5595-5603
  • Peer Reviewed
• [Journal Article] Prostacyclin receptor suppresses cardiac fibrosis : role of CREB phosphorylation. (2010)
  • Author(s): Chan EC., et al
  • Journal Title: J Mol Cell Cardiol. Volume: 49 Pages: 176-185
  • Peer Reviewed
• [Journal Article] Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. (2010)
  • Author(s): Esaki Y., et al
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107 Pages: 12233-12238
  • Peer Reviewed
• [Journal Article] The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke. (2010)
  • Author(s): Ahmad M, et al
  • Journal Title: Exp Transl Stroke Med. Volume: 2 Pages: 12-12
  • Peer Reviewed
• [Journal Article] Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia. (2010)
  • Author(s): Saleem S., et al
  • Journal Title: Neuroscience. Volume: 17 Pages: 317-323
  • Peer Reviewed
• [Journal Article] Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. (2010)
  • Author(s): Ahmad AS, et al
  • Journal Title: Age (Dordr) Volume: 32 Pages: 271-282
  • Peer Reviewed
• [Journal Article] Selective activation of the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation. (2010)
  • Author(s): Kuriyama S., et al
  • Journal Title: Thromb Haemost.2010 Oct;104(4):796-803 Volume: 7 Pages: 225-239
  • Peer Reviewed
• [Journal Article] Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying. (2010)
  • Author(s): Mizuguchi S., et al
  • Journal Title: Am J Physiol Gastrointest Liver Physiol.2010 Nov;299(5):G1078-86 Volume: 116 Pages: 5875-5884
  • Peer Reviewed
• [Journal Article] Identification of EP4 as a potential target for the treatment of castration-resistan prostate cancer using a novel xenograft model. (2010)
  • Author(s): Terada N, et al.
  • Journal Title: Cancer Res. 70 Pages: 1606-1615
  • Peer Reviewed
• [Journal Article] COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal roangtogemc microenvironment via CXCL12-CXCR4 chemokine systems. (2010)
  • Author(s): Katoh, et al.
  • Journal Title: Am J.Pathol 176 Pages: 1469-1483
  • Peer Reviewed
• [Journal Article] Prostaglandin E(2), an immunoactivator. (2010)
  • Author(s): Sakata D, et al.
  • Journal Title: J Pharmacol Sci. 112 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis (2010)
  • Author(s): Kubo H, et al.
  • Journal Title: Biomed Pharmacother. 64 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Recruiteddbonedmarrow cells expressing the EP3 prostaglandin Ereceptor subtype enhance angiogenesis during chronic inflammation. (2010)
  • Author(s): Ueno T, et al.
  • Journal Title: Biomed Pharmacother. 64 Pages: 93-100
  • Peer Reviewed
• [Journal Article] Central control of fever and female body temperature by RANKL/RANK. (2009)
  • Author(s): Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi N, von Haeseler A, Bader M, Kilic SS, Ueta Y, Pifl C, Narumiya S,Penninger JM.
  • Journal Title: Nature. 462 Pages: 505-509
  • Peer Reviewed
• [Journal Article] Prostaglandin F(2a) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta. (2009)
  • Author(s): Oga T, Matsuoka T, Yao C, Nonomura K, Kitaoka S, Sakata D, Kita Y, Tanizawa K, Taguchi Y, Chin K, Mishima M, Shimizu T, Narumiya S.
  • Journal Title: Nat Med. 15 Pages: 1426-1430
  • Peer Reviewed
• [Journal Article] Imatinib mesylate (STI571)-induced cell edge translocation of kinase-active and kinase-defective Abelson kinase: requirements of myristoylation and src homology 3 domain. (2009)
  • Author(s): Fujita A, Shishido T, Yuan Y, Inamoto E, Narumiya S, Watanabe N.
  • Journal Title: Mol Pharmacol. 75 Pages: 75-84
  • Peer Reviewed
• [Journal Article] Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. (2009)
  • Author(s): Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, Kuroiwa K, Sugimoto Y, Narumiya S.
  • Journal Title: Nat Med. 15 Pages: 633-640
  • Peer Reviewed
• [Journal Article] RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly. (2009)
  • Author(s): Yodoi R, Tamba S, Morimoto K, Segi-Nishida E, Nishihara M, Ichikawa A, Narumiya S, Sugimoto Y.
  • Journal Title: Endocrinology. 150 Pages: 3345-3352
  • Peer Reviewed
• [Journal Article] Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis. (2009)
  • Author(s): Monypenny J, Zicha D, Higashida C, Oceguera-Yanez F, Narumiya S, Watanabe N.
  • Journal Title: Mol Cell Biol. 29 Pages: 2730-2747
  • Peer Reviewed
• [Journal Article] mDia2shuttles between the nucleus and the cytoplasm through the importin-{a}/{b}- and CRM1-mediated nuclear transport mechanism. (2009)
  • Author(s): Miki T, Okawa K, Sekimoto T, Yoneda Y, Watanabe S, Ishizaki T, Narumiya S.
  • Journal Title: J Biol Chem. 284 Pages: 5753-5762
  • Peer Reviewed
• [Journal Article] Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum. (2009)
  • Author(s): Tanaka Y, et al
  • Journal Title: Eur J Neurosci. 30 Pages: 2338-2346
  • Peer Reviewed
• [Journal Article] Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-inducedpulmonary fibrosis indeendenty of transforming growth factor-beta. (2009)
  • Author(s): Oga T., et al.
  • Journal Title: Nat Med 15 Pages: 1426-1430
  • Peer Reviewed
• [Journal Article] Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord. (2009)
  • Author(s): Duffy P
  • Journal Title: J Neurosci. 29 Pages: 15266-15276
  • Peer Reviewed
• [Journal Article] Migration without a clutch. (2009)
  • Author(s): Narumiya S, et al
  • Journal Title: Nat.Cell Biol. 11 Pages: 1394-1396
• [Journal Article] Central control of fever and female body temperature by RANKL/RANK. (2009)
  • Author(s): Hanada R, et al.
  • Journal Title: Nature 26 Pages: 505-509
  • Peer Reviewed
• [Journal Article] Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metallop roteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. (2009)
  • Author(s): Amano H, et al
  • Journal Title: Cancer Sci. 100 Pages: 2318-2324
  • Peer Reviewed
• [Journal Article] Effect of EP4 agonist(ONO-4819CD)for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates : A randomized phase II, placebo controlled trial. (2009)
  • Author(s): Nakase H, et al.
  • Journal Title: Inflamm Bowel Dis. 16 Pages: 731-733
  • Peer Reviewed
• [Journal Article] Prostanoids and inflammation : a new concept arising from receptor knockout mice. (2009)
  • Author(s): Narumiya S
  • Journal Title: J Mol Med. 87 Pages: 1015-1022
  • Peer Reviewed
• [Journal Article] Prostaglandin E(2)-EP(3)signaling suppresses skin inflammation in murine contact hypersensitivity. (2009)
  • Author(s): Honda T, et al
  • Journal Title: J Allergy Clin Immunol. 124
  • Peer Reviewed
• [Journal Article] Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. (2009)
  • Author(s): Yao C, et al.
  • Journal Title: Nat. Med. 15 Pages: 633-640
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. (2009)
  • Author(s): Hoshino T, et al.
  • Journal Title: J Biol Chem 284 Pages: 18493-18502
  • Peer Reviewed
• [Journal Article] PGF(2alpha)FP receptor contributes to brain damage following transient focal brain ischemia. (2009)
  • Author(s): Saleem S., et al.
  • Journal Title: Neurotox Res. 15 Pages: 62-70
  • Peer Reviewed
• [Journal Article] RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly. (2009)
  • Author(s): Yodoi R, et al.
  • Journal Title: Endocrinology 150 Pages: 3345-3352
  • Peer Reviewed
• [Journal Article] Bone marrow derived EP3-expressing stromal cells enhance tumor associated angiogenesis and tumor growth. (2009)
  • Author(s): Ogawa Y, et al.
  • Journal Title: Biochem Biophys Res Commun. 382 Pages: 720-725
  • Peer Reviewed
• [Journal Article] An order of magnitude faster AIP1-associated actin disruption than nucleation by the Arp2/3 complex in lamellipodia (2009)
  • Author(s): Tsuji T, et al.
  • Journal Title: PLoS One. 4
  • Peer Reviewed
• [Journal Article] Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis. (2009)
  • Author(s): Monypenny J, et al.
  • Journal Title: Mol Cell Biol. 29 Pages: 2730-2747
  • Peer Reviewed
• [Journal Article] Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia. (2009)
  • Author(s): Saleem S., et al.
  • Journal Title: J Neuroimmunol. 208 Pages: 87-93
  • Peer Reviewed
• [Journal Article] Rho signaling,ROCK and mDial,in transformation, metastasis and invasion. (2009)
  • Author(s): Narumiya S., et al.
  • Journal Title: Cancer Metastasis Rev. 28 Pages: 87-93
• [Journal Article] Roles of prostaglandin E receptors in stress responses. (2009)
  • Author(s): Furuyashiki T., et al
  • Journal Title: Cuff Opin Pharmacol. 9 Pages: 31-38
• [Journal Article] Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice. (2009)
  • Author(s): Popp L., et al
  • Journal Title: Eur J Pain. 13 Pages: 691-703
  • Peer Reviewed
• [Journal Article] Imatinib mesylate(STI571)-induced cell edge translocation of kinase-active and kinase-defective Abelson kinase : requirements of myristoylation and src homology 3 domain. (2009)
  • Author(s): Fujita A., et al.
  • Journal Title: Mol Pharmacol. 75 Pages: 87-93
  • Peer Reviewed
• [Journal Article] mDia2 shuttles between the nucleus and the cytoplasm through the importin-α/β- and CRM1-mediated nuclear transport mechanism. (2009)
  • Author(s): Miki, T., Okawa, K., Sekimoto, T., Yoneda, Y., Watanabe, S., Ishizaki, T. & Narumiya, S.
  • Journal Title: J. Biol. Chem. 284 Pages: 5753-5762
• [Journal Article] Rho signaling, ROCK and mDial, in transformation, metastasisand invasion (2009)
  • Author(s): Narumiya, S., et.al.
  • Journal Title: Cancer Metastasis Rev 28 Pages: 65-76
• [Journal Article] Roles of prostaglandin E receptors in stress responses (2009)
  • Author(s): Furuyashiki, T., et.al.
  • Journal Title: Curr. Opin. Pharmacol 9 Pages: 31-38
• [Journal Article] Imatinib mesylate (SII571)-induced cell edge translocation of kinase-active and kinase-defective Abelson kinase : requirements of myristoylation and src homology 3 domain (2009)
  • Author(s): Fujita, A., et.al.
  • Journal Title: Mol. Pharmacol 75 Pages: 75-84
  • Peer Reviewed
• [Journal Article] The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. (2008)
  • Author(s): Takeya R, Taniguchi K, Narumiya S, Sumimoto H.
  • Journal Title: EMBO J. 27 Pages: 618-628
  • Peer Reviewed
• [Journal Article] G-actin regulates rapid induction of actin nucleation by mDia1 to restore cellular actin polymers. (2008)
  • Author(s): Higashida C, Suetsugu S, Tsuji T, Monypenny J, Narumiya S, Watanabe N.
  • Journal Title: J Cell Sci. 121 Pages: 3403-3412
  • Peer Reviewed
• [Journal Article] mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells. (2008)
  • Author(s): Watanabe S, Ando Y, Yasuda S, Hosoya H, Watanabe N, Ishizaki T, Narumiya S.
  • Journal Title: Mol Biol Cell. 19 Pages: 2328-2338
  • Peer Reviewed
• [Journal Article] mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells. (2008)
  • Author(s): Watanabe, S., Ando, Y., Yasuda, S., Hosoya, H., Watanabe, N., Ishizaki, T., and Narumiya, S.
  • Journal Title: Mol. Biol. Cell 19 Pages: 2328-2338
• [Journal Article] Prostacyclin prevents murine lung cancer independent of the membrane receptor byactivation of peroxisomal proliferator activated receptor gamma (2008)
  • Author(s): Nemenoff, R, et.al.
  • Journal Title: Gancer Prev. Res. (Phila Pa) 1 Pages: 349-356
  • Peer Reviewed
• [Journal Article] mDia2 shuttles between the nucleus and the cytoplasm through the importin-α/β- and CRM1-mediated nuclear transport mechanism (2008)
  • Author(s): Miki, T., et.al.
  • Journal Title: T. Biol. Chem 284 Pages: 5753-5762
  • Peer Reviewed
• [Journal Article] Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo (2008)
  • Author(s): Murata, T., et.al.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A 105 Pages: 20009-20014
  • Peer Reviewed
• [Journal Article] Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulateslate-phase reaction of experimental allergic conjunctivitis (2008)
  • Author(s): Ueta, M., et.al.
  • Journal Title: J Allergy Clin. Immunol 123 Pages: 466-471
  • Peer Reviewed
• [Journal Article] G-actin regulates rapid induction of actin nucleation by mDialto restore cellular actin polymers (2008)
  • Author(s): Higashida, C., et.al.
  • Journal Title: J. Cell Sci 121 Pages: 3403-3412
  • Peer Reviewed
• [Journal Article] TNF-alpha induces thromboxane receptor signaling-dependent microcirculatory dysfunction in mouse liver (2008)
  • Author(s): Katagiri, H., et.al.
  • Journal Title: Shock 30 Pages: 463-467
  • Peer Reviewed
• [Journal Article] Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization (2008)
  • Author(s): Tamba, S., et.al.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A 105 Pages: 14539-14544
  • Peer Reviewed
• [Journal Article] Prostacyclin receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery occlusion in mouse (2008)
  • Author(s): Wei, G., et.al.
  • Journal Title: Neuroscience 156 Pages: 1111-1117
  • Peer Reviewed
• [Journal Article] The roles of prostanoids in infection and sickness behaviors (2008)
  • Author(s): Matsuoka, T., et.al.
  • Journal Title: J. Infect. Chemother 14 Pages: 270-278
• [Journal Article] UNothelium EP1 receptor facilitates the dicturition reflex inmice (2008)
  • Author(s): Wang, X., et.al.
  • Journal Title: Biomed. Res 29 Pages: 105-111
  • Peer Reviewed
• [Journal Article] mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells (2008)
  • Author(s): Watanabe, S., et.al.
  • Journal Title: Mol. Biol. Cell 19 Pages: 2328-2338
  • Peer Reviewed
• [Journal Article] Prostaglandin 12 Plays a Key Role in Zymosan-Induced Mouse Pleurisy (2008)
  • Author(s): Yuhki, KI., et.al.
  • Journal Title: J. Pharmacol. Exp. Ther 325 Pages: 601-609
  • Peer Reviewed
• [Journal Article] The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells (2008)
  • Author(s): Takeya, R., et.al.
  • Journal Title: EMBO J. 27 Pages: 618-628
  • Peer Reviewed
• [Journal Article] Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors (2008)
  • Author(s): Koyanagi, M., et.al.
  • Journal Title: J Neurosci Res 86 Pages: 270-280
  • Peer Reviewed
• [Journal Article] Prostaglandin D2 Inhibits the Pioduction of IFN-γ by Invariant NK T Cells : Consequences in the Control of B16 Melanoma (2008)
  • Author(s): Torres, D., et.al.
  • Journal Title: J. Immunol 180 Pages: 783-792
  • Peer Reviewed
• [Journal Article] mDia2 induces tne actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells. (2008)
  • Author(s): Watanabe, S., et. al.
  • Journal Title: Mol. Biol. Cell (ahead of print)
  • Peer Reviewed
• [Journal Article] Prostaglandin D2 Inhibits the Production of IFN-γ by Invariant NK T Cells: Consequences in the Control of B16 Melanoma. (2008)
  • Author(s): Torres, D., et. al.
  • Journal Title: J. Immunol. 180 Pages: 783-792
  • Peer Reviewed
• [Journal Article] Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. (2008)
  • Author(s): Koyanagi, M., et. al.
  • Journal Title: J Neurosci Res. 86 Pages: 270-280
  • Peer Reviewed
• [Journal Article] Prostaglandin I2 Plays a Key Role in Zymosan-Induced Mouse Pleurisy. J. Pharmacol. (2008)
  • Author(s): Yuhki, KI., et. al.
  • Journal Title: J. Pharmacol. Exp. Ther. (ahead of print)
  • Peer Reviewed
• [Journal Article] Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. (2007)
  • Author(s): Nagamachi M, Sakata D, Kabashima K, Furuyashiki T, Murata T, Segi-Nishida E, Soontrapa K, Matsuoka T, Miyachi Y, Narumiya S.
  • Journal Title: J Exp Med. 204 Pages: 2865-2874
  • Peer Reviewed
• [Journal Article] Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. (2007)
  • Author(s): Sakata D, Taniguchi H, Yasuda S, Adachi-Morishima A, Hamazaki Y, Nakayama R, Miki T, Minato N, Narumiya S.
  • Journal Title: J Exp Med. 204 Pages: 2031-2038
  • Peer Reviewed
• [Journal Article] Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells. (2007)
  • Author(s): Ando Y, Yasuda S, Oceguera-Yanez F, Narumiya S.
  • Journal Title: Mol Biol Cell. 18 Pages: 3752-3763
  • Peer Reviewed
• [Journal Article] Inactivation of Rho GTPases with Clostridium difficile Toxin B Impairs Centrosomal Activation of Aurora-A in G2/M Transition of HeLa Cells. (2007)
  • Author(s): Ando, Y., Yasuda, S., Oceguera-Yanez F. and Narumiya, S.
  • Journal Title: Mol. Cell Biol. 18 Pages: 3752-3763
• [Journal Article] Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein (2007)
  • Author(s): Sakata, D., Taniguchi, H., Yasuda, S., Adachi-Morishima, A., Hamazaki, Y., Nakayama, R., Miki, T., Minato, N. and Narumiya, S.
  • Journal Title: mDia1. J. Exp. Med. 204 Pages: 2031-2038
• [Journal Article] ROCK2 and its alternatively spliced isoform ROCK2mpositively control the maturation of the mvogenic program. (2007)
  • Author(s): Pelosi M., et. al.
  • Journal Title: Mol Cell Biol. 27(17) Pages: 6163-6176
  • Peer Reviewed
• [Journal Article] Inactivation of Rho GTPases with Clostridium difficile Toxin B Impairs Centrosomal Activation of Aurora-A in G2/M Transition of Hela Cells. (2007)
  • Author(s): Ando, Y., et. al.
  • Journal Title: Mol Biol Cell 18 Pages: 3752-3763
  • Peer Reviewed
• [Journal Article] Genetic and Pharmacological Inhibition of Rho-associated Kinase II Enhances Adipogenesis. (2007)
  • Author(s): 3. Noguchi, M., et. al.
  • Journal Title: J Biol Chem. 282 Pages: 29574-29583
  • Peer Reviewed
• [Journal Article] Impaired T liympnocyte trafficking in mice deficient in an actin-nucleating protein, mDial. (2007)
  • Author(s): Sakata, D., et. al.
  • Journal Title: J. Exp. Med. 204 Pages: 2031-2038
  • Peer Reviewed
• [Journal Article] The RhoA effector mDiaphanous regulates MyoD expression and cell cycle progression via SRF-dependent and SRF-independent pathways. (2007)
  • Author(s): Gopinath SD., et. al.
  • Journal Title: J Cell Sci. 120 Pages: 3086-3098
  • Peer Reviewed
• [Journal Article] The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. (2007)
  • Author(s): Takeya, R., et. al.
  • Journal Title: EMBO J. 27(4) Pages: 618-628
  • Peer Reviewed
• [Journal Article] Prostaglandin E receptors. (2007)
  • Author(s): Sugimoto, Y., et. al.
  • Journal Title: J Biol Chem. 282 Pages: 11613-11617
  • Peer Reviewed
• [Journal Article] Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice. (2007)
  • Author(s): Andoh, T., et. al.
  • Journal Title: J Invest Dermatol. 127 Pages: 2042-2047
  • Peer Reviewed
• [Journal Article] Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. (2007)
  • Author(s): Taniguchi, H., et. al.
  • Journal Title: J. Neurosci. 27 Pages: 4303-4312
  • Peer Reviewed
• [Journal Article] PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury. (2007)
  • Author(s): Saleem S., et. al.
  • Journal Title: Eur J Neurosci. 26 Pages: 73-78
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase. (2007)
  • Author(s): Hristovska AM, et. al.
  • Journal Title: Hypertension 50 Pages: 525-530
  • Peer Reviewed
• [Journal Article] Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. (2007)
  • Author(s): Hoshino, T., et. al.
  • Journal Title: J Biol Chem. 282 Pages: 32676-32688
  • Peer Reviewed
• [Journal Article] Facilitation of Th1-mediated immune response by prostaglandin Ereceptor EP1. (2007)
  • Author(s): Nagamachi, M., et. al.
  • Journal Title: J. Exp. Med. 204 Pages: 2865-2874
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum. (2007)
  • Author(s): Kitaoka, S., et. al.
  • Journal Title: J. Neurosci. 27 Pages: 12900-12907
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase. (2007)
  • Author(s): Hristovska AM,
  • Journal Title: Hypertension 50 Pages: 525-530
  • Peer Reviewed
• [Journal Article] Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. (2006)
  • Author(s): Honda T, Segi-Nishida E, Miyachi Y, Narumiya S.
  • Journal Title: J Exp Med. 203 Pages: 325-335
  • Peer Reviewed
• [Journal Article] The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. (2006)
  • Author(s): Yamana N, Arakawa Y, Nishino T, Kurokawa K, Tanji M, Itoh RE, Monypenny J, Ishizaki T, Bito H, Nozaki K, Hashimoto N, Matsuda M, Narumiya S.
  • Journal Title: Mol Cell Biol. 26 Pages: 6844-6858
  • Peer Reviewed
• [Journal Article] Rho-mDia1 Pathway Regulates Cell Polarity and Focal Adhesion Turnover in Migrating Cells Through Mobilizing APC and c-Src. (2006)
  • Author(s): Yamana, N., Arakawa, Y., Nishino, T., Kurokawa, K., Tanji, M., Monypenny, J., Ishizaki, T., Bito, H., Nozaki, K., Hashimoto, N., Matsuda, M., and Narumiya, S.
  • Journal Title: Mol. Cell Biol. 26 Pages: 6844-6858
• [Journal Article] Measurement of activity of Rho GTPases during mitosis (2006)
  • Author(s): Oceguera-Yanez, F, Narumiya, S.
  • Journal Title: Methods Enzymol. 406 Pages: 332-345
• [Journal Article] Rho GTPases in animal cell mitosis. (2006)
  • Author(s): Narumiya, S., Yasuda, S.
  • Journal Title: Curr Opin Cell Biol. 18 Pages: 199-205
• [Journal Article] Molecular identification and characterization of a family of kinases with homology to CaMKI/CaMKIV. (2006)
  • Author(s): Ohmae, S., et al.
  • Journal Title: J. Biol. Chem. 281 Pages: 20427-20439
• [Journal Article] An essential role of Cdc42-like GTPases in mitosis of HeLa cells. (2006)
  • Author(s): Yasuda, S., et al.
  • Journal Title: FEBS Lett. 580 Pages: 3375-3380
• [Journal Article] Rho-mDial Pathway Regulates Cell Polarity and Focal Adhesion Turnover in Migrating Cells Through Mobilizing APC and c-Src. (2006)
  • Author(s): Yamana, N., et al.
  • Journal Title: Mol. Cell Biol. 26 Pages: 6844-6858
• [Journal Article] Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network : evidence of frequent filament severing. (2006)
  • Author(s): Miyoshi, T., et al.
  • Journal Title: J. Cell Biol. 175 Pages: 947-955
• [Presentation] Prostaglandins, Inflammation and respiratory diseases (2010)
  • Author(s): 成宮周
  • Organizer: Pacifichem 2010 Conference
  • Place of Presentation: Hawaii, USA(招待講演)
  • Year and Date: 2010-12-17
• [Presentation] Phenotype Analysis of Mice Deficient in Actin Nucleator, mDia (2010)
  • Author(s): 成宮周
  • Organizer: 4^<th> Mechanobiology Wiorkshop and Biophysical Society Meeting
  • Place of Presentation: Singapore(招待講演)
  • Year and Date: 2010-11-11
• [Presentation] (2010)
  • Author(s): 成宮周
  • Organizer: INSINET Symposium on Receptors, Signaling Network and Disease
  • Place of Presentation: Madrid, Spain(招待講演)
  • Year and Date: 2010-09-24
• [Presentation] 神経発生におけるRho標的分子mDiaの役割 (2010)
  • Author(s): 篠原亮太
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-02
• [Presentation] Prostanoids and Immune Inflammation (2010)
  • Author(s): 成宮周
  • Organizer: Bioactive Lipids : Biochemistry and Diseases on Keystone Symposia
  • Place of Presentation: Kyoto, Japan(招待講演)
  • Year and Date: 2010-06-11
• [Presentation] Physiology and Pathophysiology of Prostanoid receptors (2010)
  • Author(s): 成宮周
  • Organizer: The 14^<th> nternational Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-28
• [Presentation] Phenotype Analysis of Mice Deficient in Actin Nucleator, mDia (2010)
  • Author(s): Narumiya S.
  • Organizer: 4th Mechanobiology Workshop and Biophysical Society Meeting
  • Place of Presentation: Singapore
• [Presentation] Binding of anillin and mDia2 is required for mDia2 localization in the cleavage furrow of dividing cells. (2010)
  • Author(s): 渡邉定則
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪市
• [Presentation] Rho and anillin-dependent control of an actin nucleator, mDia2, in cytokinesis. (2010)
  • Author(s): 渡邉定則
  • Organizer: The 4th Mechanobiology Workshop and Biophysical
  • Place of Presentation: シンガポール
• [Presentation] Rho and anillin-dependent control of mDia2 localization and function in cytokinesis. (2010)
  • Author(s): 渡邉定則
  • Organizer: The American Society for Cell Biology 50th Annual meeting
  • Place of Presentation: アメリカ合衆国
• [Presentation] Binding of anillin and mDia2 is required for mDia2 localization in the cleavage furrow of dividing cells. (2009)
  • Author(s): 渡邊定則
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: Yokohama
  • Year and Date: 2009-12-10
• [Presentation] Prostaglandins and Inflammation ; A new concept from receptor KO mice studies (2009)
  • Author(s): 成宮周
  • Organizer: Nobel Forum China
  • Place of Presentation: Beijing, China
  • Year and Date: 2009-12-07
• [Presentation] Prostaglandins, a linker between immunity and inflammation (2009)
  • Author(s): 成宮周
  • Organizer: The 39^<th> Amumal Meeting of the Japanese Immunolgy Society
  • Place of Presentation: Osaka, Japan.
  • Year and Date: 2009-12-04
• [Presentation] Prostaglandins and Inflammation ; A new concept from receptor KO mice studies. (2009)
  • Author(s): 成宮周
  • Organizer: The 43^<rd> Annual Scientific Meeting of the Australasian Society of clinical anc Experimental Pharmacologists and Toxicologists (ASCEPT).
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2009-11-30
• [Presentation] Rho標的分子mDia2の細胞質分裂における時空間的制御機構の解析 (2009)
  • Author(s): 渡邉定則
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: Kobe
  • Year and Date: 2009-10-23
• [Presentation] Physiology, Pathophysiology of Prostanoids ; Novel roles revealed by receptor KO mouse studies (2009)
  • Author(s): 成宮周
  • Organizer: The 9^<th> Intemational Symposium on VIP, PACAP and related peptides
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2009-10-07
• [Presentation] Prostanoid Receptors ; Pathophysiological. roles and drug development (2009)
  • Author(s): 成宮周
  • Organizer: Special lecture, the 129th Annual Meeting of, the Pharmaceutical Society of Japan
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-03-27
• [Presentation] Prostanoid receptors in diseases and drug development (2009)
  • Author(s): 成宮周
  • Organizer: 日本薬学会特別講演
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-03-27
• [Presentation] Rho-mDia pathway, Src and cell transformation (2009)
  • Author(s): 成宮周
  • Organizer: Special Lecture, The 24th Annual Conference of Biomedical Science
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2009-03-21
• [Presentation] Roles of Prostaglandins in diseases ; Lessons from receptor-KO mice (2009)
  • Author(s): 成宮周
  • Organizer: 微小循環学会
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2009-02-20
• [Presentation] Functions of the Rho-mDia pathway in the body; lessons from knockout mice (2009)
  • Author(s): Narumiya S.
  • Organizer: The Gordon Research Conference on "Mechanisms of Cell Signaling"
  • Place of Presentation: Magdalene College, Oxoford, U.K.
• [Presentation] Prostanoids in inflammation ; a new concept arising from receptor-knockout mouse studies (2009)
  • Author(s): 成宮周
  • Organizer: The 9^<th> World Congress on Inflammation
  • Place of Presentation: Tokyo
• [Presentation] Functions of the Rho-mDia pathway in the body ; lessonsfrom knockout mice (2009)
  • Author(s): 成宮周
  • Organizer: The Gordon Research Conference on "Mechanisms of Cell Signaling
  • Place of Presentation: Magdalene College, Oxoford, U.K.
• [Presentation] Prostanoid Receptors : Physiology, Pathophysiology and Therapeutic Implications (2009)
  • Author(s): 成宮周
  • Organizer: Symposium on "From animal models to Clinical Application", World Health Summit
  • Place of Presentation: Charite Berlin, Berlin, Germany
• [Presentation] 神経発生におけるRho標的分子mDiaの役割 (2009)
  • Author(s): 篠原亮太
  • Organizer: 日本神経科学大会
  • Place of Presentation: Nagoya
• [Presentation] Roles of mDia, a Rho effector, in neural development (2009)
  • Author(s): 篠原亮太
  • Organizer: International Symposium on Cellular Signaling
  • Place of Presentation: Tsukuba
• [Presentation] Roles of mDia isoforms, a Rho effector, in neural development (2009)
  • Author(s): 篠原亮太
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: Yokohama
• [Presentation] Activation of drug discovery research and industry-academia-government cooperation (2009)
  • Author(s): 成宮周
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: Yokohama, Japan
• [Presentation] Dissecting the role of putative mDia-binding protein (2009)
  • Author(s): 坂本智子
  • Organizer: 第32回日本薬理学会年会
  • Place of Presentation: Yokohama, Japan
• [Presentation] Nitric oxide(NO) plays a role in inflammatory tachycaidia (2009)
  • Author(s): Asako Kanai
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: Yokohama, Japan
• [Presentation] The Prostaglandin E2-EP3/EP4 receptor signalings as targets for controlling lymphangiogenesis in chronic inflammation (2009)
  • Author(s): Kanako Hosono
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: Yokohama, Japan
• [Presentation] Prostaglandin E receptor subtypes EP2 and EP4 promote Thl cell differentiation and Th17 cell expansion through different signaling modules (2009)
  • Author(s): 坂田大治
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: Yokohama, Japan
• [Presentation] Effect of prostaglandin D2(PGD2) on IgE-dependent histaminerelease from mouse bone marrow-derived mast cells(BMMCs) (2009)
  • Author(s): Takeshi Murata
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: Yokohama, Japan
• [Presentation] Participation of metabotropic glutamate receptors in nentetrazol-induced kindling in mice (2009)
  • Author(s): Yusuke Watanabe
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: Yokohama, Japan
• [Presentation] Rho-mDia pathway, Src and cell transformation (2008)
  • Author(s): 成宮周
  • Organizer: 臨床分子医学会
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2008-07-25
• [Presentation] Prostanoid receptors: From physiology, Molecular Biology to Translational Research (2008)
  • Author(s): 成宮 周
  • Organizer: The Lecture at the 12oth Aniversary of Siriraj Hospital
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2008-03-21
• [Presentation] アクチン重合促進蛋白質mDia1欠損マウスにおけるTリンパ球の遊走能の減弱 (2008)
  • Author(s): 坂田 大治
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] Dissecting the role of putative mDia-binding protein in neuron (2008)
  • Author(s): 坂本 智子
  • Organizer: 第81回日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] Rho-mDia pathway, Src and cell transformation (2008)
  • Author(s): Narumiya S.
  • Organizer: Gordon Conference on Phosphorylation and G-protein mediated Signaling Networks
  • Place of Presentation: University of New England, Maine, U.S.A.
• [Presentation] The Rho-mDia Pathway in Cell Transformaiton and Migration (2008)
  • Author(s): Narumiya S.
  • Organizer: The AACR Special Conference in Cancer Researh on Cytoskeleotn Signaling in Cancer
  • Place of Presentation: San Diego, U.S.A.
• [Presentation] Physiology and Clinical Application of the Prostanoid Receptors (2008)
  • Author(s): 成宮周
  • Organizer: The Keystone Symposium on G protein-coupled Receptors : New Insights in Functional Regulation and Clinical Application
  • Place of Presentation: The Keystone Symposium on G protein-coupled Receptors : New Insights in Functional Regulation and Clinical Application
• [Presentation] Rho -mDia pathway, Src and cell transformation (2008)
  • Author(s): 成宮周
  • Organizer: Gordon Conference on Phosphorylation and G-protein mediated Signaling Networks
  • Place of Presentation: University of New England,, Maine,. U.S.A
• [Presentation] Physiology and Clinical Application of the Prostanoid Receptor (2008)
  • Author(s): 成宮周
  • Organizer: 京都大学国際シンポジウム
  • Place of Presentation: 副旦大学, Shanhai, China
• [Presentation] Liprin-a sequesters mDia through direct binding and critically regulates actin polymerization in cultured cells (2008)
  • Author(s): 坂本智子
  • Organizer: 48th annual Meeting ASCB
  • Place of Presentation: San Francisco, U.S.A
• [Presentation] 細胞質分裂を司る多様な全子メカニズム (2008)
  • Author(s): 渡邊定則
  • Organizer: BMB 2008
  • Place of Presentation: Kobe, Japan
• [Presentation] Analysisof the function and rekulation of mDia2 in Mammaliancell cytokinesis (2008)
  • Author(s): 渡邊定則
  • Organizer: 第60回日本細胞生物学会
  • Place of Presentation: Yokohama, Japan
• [Presentation] 胚発生におけるRho標的蛋白質Rho-associated kinase(ROCK)の役割 (2008)
  • Author(s): 石崎敏理
  • Organizer: BMB2008
  • Place of Presentation: Kobe, Japan
• [Presentation] The formin-homology protein Fhos/FHOD : mechanisms of action and physiological functions (2008)
  • Author(s): Ryu Takeya
  • Organizer: BMB2008
  • Place of Presentation: Kobe, Japan
• [Presentation] Rapid actin polymer restoration mechanism by mDial and other actin nucleators regulated by concentration fluctuation of G-actin (2008)
  • Author(s): 渡邊直樹
  • Organizer: BMB2008
  • Place of Presentation: Kobe, Japan
• [Presentation] 複数のプロスタグランジン受容体を介した子宮収縮は分娩に必須である (2008)
  • Author(s): 川崎友紀子
  • Organizer: BMB2008
  • Place of Presentation: Kobe, Japan
• [Presentation] Prostanoid receptors in signaling network of chronic inflammation", The Keystone Symposium on Eicosanoids and Other Lipid Mediators of Chronic Inflammation (2008)
  • Author(s): 成宮 周
  • Organizer: The Keystone Symposium on Eicosanoids and Other Lipid Mediators of Chronic Inflammation
  • Place of Presentation: Big Sky Resort, Montana, U.S.A.
• [Presentation] The Rho-mDial pathway in cell transformation and migration. (2008)
  • Author(s): 成宮 周
  • Organizer: An AACR special Conference in Cancer Research "Cytoskeleton Signaling in Cancer
  • Place of Presentation: San Diego, U.S.A.
• [Presentation] ToxinBによるRho GTPasesの阻害はG2/M期におけるcentrisomeでのAurora-Aの活性化を減弱させる (2008)
  • Author(s): 安藤 義和
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Prostaglandin E2 Acts on EP1 Receptor and Amplifies Both Dopamine D1 and D2 Receptor Signaling in the Striatum (2008)
  • Author(s): 北岡 志保
  • Organizer: 第81回日本薬理学会
  • Place of Presentation: 横浜
• [Presentation] Rho effector mDialの細胞の悪性化への関与 (2007)
  • Author(s): 丹治 正大
  • Organizer: BMB 2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] ROCKの個体初期発生における役割 (2007)
  • Author(s): 上條 博史
  • Organizer: BMB 2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] Dissecting the role of putative mDia-binding protein Liprin-α3 in cell motility (2007)
  • Author(s): 坂本 智子
  • Organizer: BMB 2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] アクチン重合促進蛋白質mDia1欠損マウスにおけるTリンパ球の遊走能の減弱 (2007)
  • Author(s): 坂田 大治
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] プロスタノイド受容体:cDNAクローニングから探索臨床まで (2007)
  • Author(s): 成宮 周
  • Organizer: 第48回日本脈管学会総会教育講演
  • Place of Presentation: 松本
  • Year and Date: 2007-10-25
• [Presentation] Dissecting the role of putative mDia-binding protein (2007)
  • Author(s): 坂本 智子
  • Organizer: Gordon research conferences
  • Place of Presentation: Oxford, UK
  • Year and Date: 2007-09-18
• [Presentation] 炎症・アレルギー・免疫・プロスタノイド (2007)
  • Author(s): 成宮 周
  • Organizer: 第28回日本炎症・再生医学会 特別講演
  • Place of Presentation: 東京京王プラザホテル
  • Year and Date: 2007-08-02
• [Presentation] 「毒素と化合物;機能解析ツールとしての有用性と薬物開発へのポテンシャル」 (2007)
  • Author(s): 成宮 周
  • Organizer: 日本ケミカルバイオロジー研究会 特別講演
  • Place of Presentation: 京都大学
  • Year and Date: 2007-05-09
• [Presentation] Rho signaling : Roles and Mechanism in Cell Morphogenesis and Movement (2007)
  • Author(s): Narumiya S.
  • Organizer: Dana-Farber Cancer Institute Seminars in Oncology
  • Place of Presentation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, U.S.A.
  • Year and Date: 2007-04-03
• [Presentation] mDia Isoforms Mediate Delivery of c-Src and Spindle Orientation through Actin Cytoskeleton; A Conserved Mechanism from Yeast to Mammals (2007)
  • Author(s): Narumiya S.
  • Organizer: ASCB-ECF Summer Meeting Dynamic Interplay Between Cytoskeletal and Membrane Systems, Dijon Congrexpo
  • Place of Presentation: Dijon, France.
• [Presentation] Rho GTPases in Cell Division; From G2/M Transiiton to Cytokinesis. (2007)
  • Author(s): 成宮 周
  • Organizer: The Gordon Research Conference on Mchanism of Cell Signaling
  • Place of Presentation: Magdalen Collese, Oxford, U.K.
• [Presentation] mDia Isoforms Mediate Delivery of c-Src and Spindle Orientation through Actin Cytoskeleton; A Conserved Mechanism from Yeast to Mammals? (2007)
  • Author(s): 成宮 周
  • Organizer: 2007 ASCB-ECF Summer Meeting Dynamic Interplay Between Cytoskeletal and Membrane Systems, Di jon Congrexpo
  • Place of Presentation: Di jon, France
• [Presentation] プロスタグランジン:シグナル伝達と位置づけ (2007)
  • Author(s): 成宮 周
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会合同大会シンポジウム
  • Place of Presentation: 横浜
• [Presentation] Inactivation of Rho GTPases with Clostridium difficile toxinB impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells (2007)
  • Author(s): 安藤 義和
  • Organizer: Gordon research conference -mechanisms of cell signaling
  • Place of Presentation: Oxford, UK
• [Presentation] ToxinBによるRho GTPasesの阻害はG2/M期におけるcentrisomeでのAurora-Aの活性化を減弱させる (2007)
  • Author(s): 安藤 義和
  • Organizer: 第80回日本分子生物学会年会、第80回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] mDia2 regulates assembly of the contractile ring during cytokinesis in NIH3T3cells (2007)
  • Author(s): 渡邉 定則
  • Organizer: Gordon research conferences
  • Place of Presentation: Oxford, UK
• [Presentation] mDia2 induces the actin scaffold for the contractile ring and stabilices in NIH3T3cells (2007)
  • Author(s): 渡邉 定則
  • Organizer: BME 2007
  • Place of Presentation: 横浜
• [Presentation] Rho GTPases in animal cell mitosis (2006)
  • Author(s): Narumiya S.
  • Organizer: FASEB Summer Research Conference on Regulation & Function of Small GTPases
  • Place of Presentation: Vermont Academy, Vermont, U.S.A.
• [Presentation] Cytoskeleton Remodeling by Rho GTPases and Effectors in cell morphogenesis, migration and mitosis.The Symposium on Cytoskeleon: dynamics and structural basis of cytoskeleton assembly (2006)
  • Author(s): Narumiya S.
  • Organizer: The 20th IUBMB International Congress of Biochemistry and Molecular Biology and the 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan.
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