| Co-Investigator(Kenkyū-buntansha) |
EMOTO Noriaki 神戸薬科大学, 薬学部, 教授 (30294218)
MASUBUCHI Satoru 北海道, 医学研究科, 特任准教授 (80362771)
DOI Masao 京都大学, 大学院・薬学研究科, 准教授 (20432578)
IIGO Masayuki 宇都宮大学, 農学部, 准教授 (10232109)
NAKAHARA Daiichiro 浜松医科大学, 医学部, 教授 (80128389)
NAKAO Kazuki 独立行政法人理化学研究所, 動物資源開発室動物実験支援ユニット, 研究員 (20217657)
YAMAGUCHI Yoshiaki 京都大学, 大学院・薬学研究科, 助教 (30467427)
MATSUO Masahiro 京都大学, 大学院・薬学研究科, 助教 (70456838)
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| Budget Amount *help |
¥580,580,000 (Direct Cost: ¥446,600,000、Indirect Cost: ¥133,980,000)
Fiscal Year 2010: ¥99,190,000 (Direct Cost: ¥76,300,000、Indirect Cost: ¥22,890,000)
Fiscal Year 2009: ¥97,240,000 (Direct Cost: ¥74,800,000、Indirect Cost: ¥22,440,000)
Fiscal Year 2008: ¥101,790,000 (Direct Cost: ¥78,300,000、Indirect Cost: ¥23,490,000)
Fiscal Year 2007: ¥104,130,000 (Direct Cost: ¥80,100,000、Indirect Cost: ¥24,030,000)
Fiscal Year 2006: ¥178,230,000 (Direct Cost: ¥137,100,000、Indirect Cost: ¥41,130,000)
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| Research Abstract |
The discovery of clock genes at 1997 and the following study of the molecular machinery of clock genes, have enabled “biological time” as a research object. We begin the present study as a project of post-cloning age. We clarified the G-protein mediated novel cellular communications in the suprachiasmatic nucleus. We synthesized an artificial transcriptional factor regulating the clock gene transcriptions. We also clarified a timing mechanism of nucleic acid metabolism in the liver, miturition rhythm in the urinary bladder, and further, we identified a novel steroid synthetic enzyme, which links between circadian clock and hypertension, in the adrenal gland.
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