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Novel Mechanisms of the Regulation of Reproduction by Novel Brain Hormones

Research Project

Project/Area Number 18107002
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Morphology/Structure
Research InstitutionWaseda University

Principal Investigator

TSUTSUI Kazuyoshi  Waseda University, 教育・総合科学学術院, 教授 (20163842)

Co-Investigator(Kenkyū-buntansha) MINAKATA Hiroyuki  サントリー生物有機科学研究所, 部長研究員 (90150143)
UKENA Kazuyoshi  広島大学, 大学院・総合科学研究科, 准教授 (10304370)
TANAKA Shigeyasu  静岡大学, 創造科学技術大学院, 教授 (90146233)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥107,770,000 (Direct Cost: ¥82,900,000、Indirect Cost: ¥24,870,000)
Fiscal Year 2010: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2009: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2008: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2007: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2006: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Keywords視床下部ホルモン / 脳下垂体ホルモン / 発現制御 / シグナル伝達 / 生殖 / 分子進化
Research Abstract

We discovered a novel avian hypothalamic neuropeptide inhibiting gonadotropin release, named gonadotropin-inhibitory hormone (GnIH). We demonstrated that GnIH acts on gonadotropes and GnRH neurons via GPR147 to inhibit gonadal development and maintenance by decreasing gonadotropin release and synthesis. We further demonstrated that GnIH has an evolutionarily conserved role in controlling reproduction across vertebrate species.

Report

(6 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (290 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (198 results) (of which Peer Reviewed: 158 results) Presentation (50 results) Book (30 results) Remarks (10 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Light-dependent and circadian clock-regulated activation of SREBP, XBP1 and HSF pathways.2011

    • Author(s)
      M.Hatori(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 108巻

      Pages: 4868-4869

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification, localization and expression of LPXRFamide peptides, and melatonin-dependent induction of their precursor mRNA in the newt brain.2011

    • Author(s)
      V.S.Chowdhury, T.Ubuka, T.Osugi, T.Shimura, K.Tsutsui
    • Journal Title

      J.Endocrinol. 209巻

      Pages: 1-12

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of gonadotropin-inhibitory hormone on folliculogenesis and steroidogenesis of cyclic mice.2011

    • Author(s)
      P.Singh, A.Krishna, K.Tsutsui
    • Journal Title

      Fertil.Steril. 95巻

      Pages: 1397-1404

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates : Discovery and comparative aspects.2011

    • Author(s)
      K.Ukena, H.Vaudry, J.Leprince, K.Tsutsui
    • Journal Title

      Cell Tissue Res. 343巻

      Pages: 475-481

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photoperiod and reproductive condition are associated with changes in RFamide-related peptide (RFRP) expression in Syrian hamsters (Mesocricetus auratus).2010

    • Author(s)
      A.O.Mason(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      J.Biol.Rhythm. 25巻

      Pages: 176-185

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification, localization and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, GPR103.2010

    • Author(s)
      K.Ukena(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology 151巻

      Pages: 2255-2264

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolactin increases the synthesis of 7α-hydroxypregnenolone, a key factor for induction of locomotor activity, in breeding male newts.2010

    • Author(s)
      S.Haraguchi(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology 151巻

      Pages: 2211-2222

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.2010

    • Author(s)
      M.Doi(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Nature Medicine 16巻

      Pages: 67-74

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] RFamide-related peptide (RFRP) and mRNA expression in mammalian testis : Association with the spermatogenic cycle.2010

    • Author(s)
      S.Zhao(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology 151巻

      Pages: 617-627

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal phase relation of circadian neural oscillations alters RFamide-related peptide-3 (RFRP-3), a mammalian gonadotropininhibitory hormone (GnIH) homolog, and testicular function in the mouse (Mumusculus).2010

    • Author(s)
      S.Sethi, K.Tsutsui, C.M.Chaturvedi
    • Journal Title

      Neuroendocrinology 91巻

      Pages: 189-199

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : 7α-Hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates : Identification, mode of action and functional significance.2010

    • Author(s)
      K.Tsutsui(筆頭著者), S.Haraguchi, et al.
    • Journal Title

      Front. Endocrinol. 1巻

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Recent studies of gonadotropininhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads.2010

    • Author(s)
      G.E.Bentley, K.Tsutsui, L.J.Kriegsfeld
    • Journal Title

      Brain Res. 1364巻

      Pages: 62-71

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Discovery and evolutionary history of GnIH and kisspeptin : New key neuropeptides controlling reproduction.2010

    • Author(s)
      K.Tsutsui(筆頭著者), G.E.Bentley, et al.
    • Journal Title

      J.Neuroendocrinol. 22巻

      Pages: 716-727

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : The roles of RFamide-related peptide-3 (RFRP-3) in mammalian reproductive function and behaviour.2010

    • Author(s)
      L.J.Kriegsfeld(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      J.Neuroendocrinol. 22巻

      Pages: 692-700

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function.2010

    • Author(s)
      K.Tsutsui(筆頭著者), G.E.Bentley, et al.
    • Journal Title

      Front.Neuroendocrinol. 31巻

      Pages: 284-295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Phylogenetic aspects of gonadotropin-inhibitory hormone (GnIH) and its homologs in vertebrates.2010

    • Author(s)
      筒井和義
    • Journal Title

      Ann.N.Y.Acad.Sci. 1200巻

      Pages: 75-84

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 総説:性周期とニューロペプチド:GnIH2010

    • Author(s)
      筒井和義・産賀崇由
    • Journal Title

      特集「ニューロペプチド」Hormone Frontier in Gynecologyメディカルレビュー社 第17巻

      Pages: 25-29

    • Related Report
      2010 Final Research Report
  • [Journal Article] Photoperiod and reproductive condition are associated with changes in RF amide-related peptide(RFRP)expression in Syrian hamsters(Mesocricetus auratus)2010

    • Author(s)
      A.O.Mason, et al.
    • Journal Title

      J.Biol.Rhythm. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of gonadotropin-inhibitory hormone on folliculogenesis and steroidogenesis of cyclic mice2010

    • Author(s)
      P.Singh, K.Tsutsui
    • Journal Title

      Fertil.Steril. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Phylogenetic aspects of gonadotropin-inhibitory hormone(GnIH)and its homologs in vertebrates2010

    • Author(s)
      筒井和義
    • Journal Title

      Ann.N.Y.Acad.Sci. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 総説:性周期とニューロペプチド:GnIH特集「ニューロペプチド」Hormone Frontier in Gynecology2010

    • Author(s)
      筒井和義・産賀崇由
    • Journal Title

      メディカルレビュー社 第17巻(in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, localization and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, GPR1032010

    • Author(s)
      K.Ukena, et al.
    • Journal Title

      Endocrinology (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolactin increases the synthesis of 7α-hydroxypregnenolone, a key factor for induction of locomotor activity, in breeding male newts2010

    • Author(s)
      S.Haraguchi, et al.
    • Journal Title

      Endocrinology (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of gonadotropin-inhibitory hormone in the zebra finch(Taeniopygia guttata) : peptide isolation, cDNA cloning and brain distribution2010

    • Author(s)
      Y.Tobari, et al.
    • Journal Title

      Peptides (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone(GnIH)and its control of central and peripheral reproductive function2010

    • Author(s)
      筒井和義, et al.
    • Journal Title

      Front. Neuroendocrinol. (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Identification of 7α-hydroxypregnenolone, novel bioactive amphibian neurosteroid stimulating locomotor activity, and its physiological roles in the regulation of locomotion2010

    • Author(s)
      筒井和義, et al.
    • Journal Title

      Gen.Comp.Endocrinol. (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b62010

    • Author(s)
      M.Doi, et al.
    • Journal Title

      Nature Medicine 16

      Pages: 67-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RFamide-related peptide(RFRP)and mRNA expression in mammalian testis : Association with the spermatogenic cycle2010

    • Author(s)
      S.Zhao, et al.
    • Journal Title

      Endocrinology 151

      Pages: 617-627

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GnIHによるゴナドトロピン分泌制御 特集/生殖機能調節の新しい視点 産科と婦人科2010

    • Author(s)
      筒井和義
    • Journal Title

      Obstet. Gynecol.; 診断と治療社 77

      Pages: 252-258

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus2010

    • Author(s)
      V.S.Chowdhury, et al.
    • Journal Title

      Endocrinology 151

      Pages: 271-280

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal phase relation of circadian neural oscillations alters RFamide-related peptide-3(RFRP-3), amammalian gonadotropin-inhibitory hormone(GnIH)2010

    • Author(s)
      S.Sethi, et al.
    • Journal Title

      Neuroendocrinology 91

      Pages: 189-199

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of gonadotropininhibitory hormone by the avian hypothalamus.2009

    • Author(s)
      V.S.Chowdhury(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology Endocrine news 151巻 Vol. 34 No.12

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of human gonadotropin-inhibitory hormone homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.2009

    • Author(s)
      T.Ubuka(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      PLoS ONE 4巻

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain.2009

    • Author(s)
      T.Ubuka(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      J.Comp.Neurol. 517巻

      Pages: 841-855

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates.2009

    • Author(s)
      Y.R.Lee(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology 150巻

      Pages: 2837-2846

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis : enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides.2009

    • Author(s)
      J.L.Do Rego(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Front.Neuroendocrinol. 30巻

      Pages: 259-301

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) : Biosynthesis, mode of action and functional significance.2009

    • Author(s)
      筒井和義
    • Journal Title

      Prog.Neurobiol. 88巻

      Pages: 76-88

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis and action in the Purkinje cell.2009

    • Author(s)
      筒井和義
    • Journal Title

      J.Exp.Neurosci. 2巻

      Pages: 1-12

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) in birds : discovery, progress and prospect (review).2009

    • Author(s)
      K.Tsutsui(筆頭著者), E.Saigoh, et al.
    • Journal Title

      J.Neuroendocrinol. 21巻

      Pages: 271-275

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] GnIH : Amultifunctional neuropeptide (review).2009

    • Author(s)
      G.E.Bentley(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      J.Neuroendocrinol. 21巻

      Pages: 276-281

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Octopus GnRH (oct-GnRH), a multifunctional peptide in the endocrine and nervous systems of the cephalopod (review).2009

    • Author(s)
      H.Minakata, S.Shigeno, N.Kano, S.Haraguchi, T.Osugi, K.Tsutsui
    • Journal Title

      J.Neuroendocrinol. 21巻

      Pages: 322-326

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary origin and divergence of GnIH and its homologous peptides (review).2009

    • Author(s)
      K.Tsutsui, T.Osugi
    • Journal Title

      Gen.Comp.Endocrinol. 161巻

      Pages: 30-33

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] メラトニンとGnIHの光周性「光周性の分子生物学」海老原・井澤編2009

    • Author(s)
      筒井和義
    • Journal Title

      シュプリンガー

      Pages: 149-157

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] メラトニンに関する最近の話題:メラトニンとGnIH Annual Review糖尿病・代謝・内分泌 20092009

    • Author(s)
      筒井和義
    • Journal Title

      中外医学社, V.生殖医学

      Pages: 190-195

    • Related Report
      2010 Final Research Report
  • [Journal Article] Review : Proximate and ultimate mechanisms driving circadian control of neuroendocrine function : Lessons from the young and old2009

    • Author(s)
      W.P.Williams III, et al.
    • Journal Title

      Integr.Comp.Biol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of human gonadotropin-inhibitory hormone homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis2009

    • Author(s)
      T.Ubuka, et al.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone identification. cDNA cloning, and distribution in rhesus macaque brain2009

    • Author(s)
      T.Ubuka, et al.
    • Journal Title

      J.Comp.Neurol. 517

      Pages: 841-855

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates2009

    • Author(s)
      Y.R.Lee, et al.
    • Journal Title

      Endocrinology 150

      Pages: 2837-2846

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal changes in the synthesis of 7α-hydroxypregnenolone stimulating locomotor activity in newts2009

    • Author(s)
      T.Koyama, et al.
    • Journal Title

      Ann.N.Y.Acad.Sci. 1163

      Pages: 444-447

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal changes in the synthesis of 7α-hydroxypregnenolone stimulating locomotor activity in newts2009

    • Author(s)
      S.Haraguchi, et al.
    • Journal Title

      Ann.N.Y.Acad.Sci. 1163

      Pages: 410-413

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis : enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides2009

    • Author(s)
      J.L.Do Rego, et al.
    • Journal Title

      Front.Neuroendocrinol. 30

      Pages: 259-301

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Discovery of a novel avian neurosteroid, 7α-hydroxypregnenoIone, and its role in the regulation of the diurnal rhythm of locomotor activity in Japanese quail2009

    • Author(s)
      筒井和義, et al.
    • Journal Title

      Gen.Comp.Endocrinol. 163

      Pages: 117-122

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone(GnIH) : Biosynthesis, mode of action and functional significance2009

    • Author(s)
      筒井和義
    • Journal Title

      Prog.Neurobiol. 88

      Pages: 76-88

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis and action in the Purkinje cell2009

    • Author(s)
      筒井和義
    • Journal Title

      J.Exp.Neurosci. 2

      Pages: 1-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone(GnIH)in birds : discovery, progress and prospect(review)2009

    • Author(s)
      筒井和義, et al.
    • Journal Title

      J.Neuroendocrinol. 21

      Pages: 271-275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GnIH : A Multifunctional Neuropeptide(review)2009

    • Author(s)
      G.E.Bentley, et al.
    • Journal Title

      J.Neuroendocrinol 21

      Pages: 276-281

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Octopus GnRH(oct-GnRH), a multifunctional peptide in the endocrine and nervous systems of the cephalopod(review)2009

    • Author(s)
      H.Minakata, et al.
    • Journal Title

      J.Neuroendocrinol. 21

      Pages: 322-326

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary origin and divergence of GnIH and its homologous peptides(review)2009

    • Author(s)
      筒井和義, T.Osugi
    • Journal Title

      Gen.Comp.Endocrinol. 161

      Pages: 30-33

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, biosynthesis and function of 7α-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in non-mammals(review)2009

    • Author(s)
      筒井和義, et al.
    • Journal Title

      Ann.N.Y.Acad.Sci. 1163

      Pages: 308-315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hormone-mediated reproductive behavior in the red-bellied newt(review)2009

    • Author(s)
      S.Kikuyama, et al.
    • Journal Title

      Ann.N.Y.Acad.Sci. 1163

      Pages: 179-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steroid biosynthesis within the frog brain : A model of neuroendocrine regulation(review)2009

    • Author(s)
      J.L.Do Rego, et al.
    • Journal Title

      Ann.N.Y.Acad.Sci. 1163

      Pages: 83-92

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メラトニンに関する最近の話題:メラトニンとGnIH Annual Review 糖尿病・代謝・内分泌20092009

    • Author(s)
      筒井和義
    • Journal Title

      中外医学社V.生殖医学

      Pages: 190-195

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates2009

    • Author(s)
      Y. R. Lee (筆頭), K. Tsutsui (最終), et.al. (著者13名)
    • Journal Title

      Endocrinology (印刷中)

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Review : A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) : Biosynthesis, mode of action and functional significance2009

    • Author(s)
      K. Tsutsui (単独)
    • Journal Title

      Prog. Neurobiol (印刷中)

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates.2009

    • Author(s)
      Y. R. Lee, et al.
    • Journal Title

      Endocrinology Epub ahead of print

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal changes in the synthesis of 7aIpha-hydroxypregnenolone stimulating locomotor activity in newts2009

    • Author(s)
      T. Koyama, et al.
    • Journal Title

      Ann. N. Y. Acad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal changes in the synthesis of 7aIpha-hydroxypregnenoIone stimulating Iocomotor activity in newtS.2009

    • Author(s)
      S. Haraguchi, et al.
    • Journal Title

      Ann. N. Y. Aoad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurosteroid biosynthesis : enzymatic pathways and neuroendoorine regulation by neurotransmitters and n europeptides.2009

    • Author(s)
      J. L. Do Rego, et al.
    • Journal Title

      Front. Neuroendocrinol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Discovery of a novel avian neurosteroid, 7alpha-hydroxypregnenolone, and its role in the regulation of the diurnal rhythm of locomotor activity in Japanese quail.2009

    • Author(s)
      K. Tsutsui, et al.
    • Journal Title

      Gen. Comp. Endocrinol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Proximate and ultimate mechanisms driving circadian control of neuroendoorine function : Lessons from the young and old.2009

    • Author(s)
      W. P. Williams III, et al.
    • Journal Title

      Integr. Comp. Biol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone(GnlH) and its homologous peptides in vertebrates : discovery, mode of action and functional significance.2009

    • Author(s)
      K. Tsutsui.
    • Journal Title

      Prog. Neurobiol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone(GnlH) in birds : disc overy, progress and prospect (review).2009

    • Author(s)
      K. Tsutsui, et al.
    • Journal Title

      J. Neuroendocrinol. 21

      Pages: 271-275

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GnIH : A Multifunctional Neuropeptide (review).2009

    • Author(s)
      G. E. Bentley, et al.
    • Journal Title

      J. Neuroendocrinol. 21

      Pages: 276-281

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Octopus GnRH (oot-GnRH), a multifunctional peptide in the endocrine and nervous systems of the cephalo pod (review).2009

    • Author(s)
      H. Minakata, et al.
    • Journal Title

      J. Neuroendocrinol. 21

      Pages: 322-326

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary origin and divergence of GnlH and its homologous peptides (review).2009

    • Author(s)
      K. Tsutsui, T. Osugi.
    • Journal Title

      Gen. Comp. Endocrinol. 161

      Pages: 30-33

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, biosynthesis and function of 7alpha-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in non-mammals (review).2009

    • Author(s)
      K. Tsutsui, et al.
    • Journal Title

      Ann. N. Y. Aoad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hormone-mediated reproductive behavior in the red-bellied newt (review).2009

    • Author(s)
      S. Kikuyama, et al.
    • Journal Title

      Ann. N. Y. Acad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steroid Biosynthesis within the frog brain : A model of neuroendocrine regulation (review).2009

    • Author(s)
      J. L. Do Rego, et al.
    • Journal Title

      Ann. N. Y. Acad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メラトニンとGnlHの光周性2009

    • Author(s)
      筒井和義
    • Journal Title

      光周性の分子生物学海老原・井澤編 (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メラトニンに関する最近の話題 : メラトニンとGnlH2009

    • Author(s)
      筒井和義
    • Journal Title

      中外医学社V. 生殖医学

      Pages: 190-195

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in GnRH I, bradykinin and their receptors and GnIH in the ovary of Calotes versicolor during reproductive cycle.2008

    • Author(s)
      P.Singh, A.Krishna, R.Sridaran, K.Tsutsui
    • Journal Title

      Gen.Comp.Endocrinol. 159巻

      Pages: 158-169

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in RFamiderelated peptide expression are coordinated with the preovulatory luteinizing hormone surge.2008

    • Author(s)
      E.M.Gibson(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology 149巻

      Pages: 4958-4969

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potent action of RFRP-3 on pituitary gonadotropes indicative of an hypophysiotropic role in the negative regulation of gonadotropin secretion.2008

    • Author(s)
      I.J.Clarke(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology 149巻

      Pages: 5811-5821

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypophysiotropic role of RFamide-related peptide-3 RFRP-3 in the inhibition of LH secretion in female rats.2008

    • Author(s)
      M.Murakami(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      J.Endocrinol. 199巻

      Pages: 105-112

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 7α-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms.2008

    • Author(s)
      K.Tsutsui(筆頭著者), K.Inoue, et al.
    • Journal Title

      J.Neurosci. 28巻

      Pages: 2158-2167

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog growth hormone-releasing peptide (fGRP) and its related peptide-2 (fGRP-RP-2) in the amphibian hypothalamus.2008

    • Author(s)
      V.S.Chowdhury(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology 149巻

      Pages: 962-970

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system.2008

    • Author(s)
      G.Bentley(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Gen.Comp.Endocrinol. 156巻

      Pages: 34-43

    • NAID

      10020188345

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auditory stimulation of reproductive function in male Rufous-winged Sparrows, Aimophila carpalis.2008

    • Author(s)
      T.W.Small(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Horm.Behav. 53巻

      Pages: 28-39

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellum, a target for hormonal signaling.2008

    • Author(s)
      N.Koibuchi, J.Kimura-Kuroda, Y.Ikeda, K.Tsutsui
    • Journal Title

      Cerebellum 7巻

      Pages: 499-504

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique form and osmoregulatory function of a neurohypophysial hormone in a urochordate.2008

    • Author(s)
      K. Ukena, E. Iwakoshi-Ukena, A Hikosaka
    • Journal Title

      Endocrinology 149巻

      Pages: 5254-5261

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH) : biosynthesis, mode of action and functional significance in birds.2008

    • Author(s)
      K.Tsutsui, G.E.Bentley
    • Journal Title

      Avian Biol.Res. 1巻

      Pages: 175-186

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroids in the Purkinje cell : Biosynthesis, mode of action and functional significance.2008

    • Author(s)
      筒井和義
    • Journal Title

      Mol.Neurobiol. 37巻

      Pages: 116-125

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Recent advances in reproductive neuroendocrinology : A role for the RFamide peptides in seasonal reproduction?2008

    • Author(s)
      T.J.Greives(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Proc.R.Soc.B. 275巻

      Pages: 1943-1951

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Progesterone biosynthesis and action in the developing neuron.2008

    • Author(s)
      筒井和義
    • Journal Title

      Endocrinology 149巻

      Pages: 2757-2761

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (Review). In : a special issue for "Cerebellum, a target for hormonal signaling".2008

    • Author(s)
      筒井和義
    • Journal Title

      Cerebellum 7巻

      Pages: 502-504

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] GnIHとGnIH同属ペプチド(LPXRFamide ペプチド): 構造と機能の普遍性と多様性2008

    • Author(s)
      筒井和義
    • Journal Title

      生化学 80巻

      Pages: 849-854

    • NAID

      10022594510

    • Related Report
      2010 Final Research Report
  • [Journal Article] Review : Neurosteroids in the Purkinje cell : Biosynthesis, mode of action and functional significance2008

    • Author(s)
      K. Tsutsui (単独)
    • Journal Title

      Mol. Neurobiol 37

      Pages: 116-125

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 7α-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms2008

    • Author(s)
      K. Tsutsui (筆頭) et.al. (著者5名)
    • Journal Title

      J. Neurosci 28

      Pages: 2158-2167

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog growth hormone-releasing peptide (fGRP) and its related peptide2008

    • Author(s)
      V. S. Chowdhury (筆頭), K. Tsutsui (最終) et.al. (著者6名)
    • Journal Title

      Endocrinology 149

      Pages: 962-970

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain2008

    • Author(s)
      T. Ubuka (筆頭), K. Tsutsui (8番目) et.al. (著者9名)
    • Journal Title

      Endocrinology 149

      Pages: 268-278

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Changes in GnRH I, bradykinin and their receptors and GnlH in the ovary of Calotes versicolor during reproductive cycle.2008

    • Author(s)
      P. Singh, et al.
    • Journal Title

      Gen. Comp. Endocrinol. 159

      Pages: 158-169

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge.2008

    • Author(s)
      E. M. Gibson, et al.
    • Journal Title

      Endocrinology 149

      Pages: 4958-4969

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potent action of RFRP-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion.2008

    • Author(s)
      I. J. Clarke, et al.
    • Journal Title

      Endocrinology 149

      Pages: 5811-5821

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats.2008

    • Author(s)
      M. Murakami, et al.
    • Journal Title

      J. Endocrinol. 199

      Pages: 105-112

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical detection and biological activities of CYP17 (P450c17) in the indifferent gonad of the frog Rana rugosa.2008

    • Author(s)
      N. Sakurai, et al.
    • Journal Title

      J. Steroid Biochem. Mol. Biol. 112

      Pages: 5-12

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 7alpha-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms.2008

    • Author(s)
      K. Tsutsui, et al.
    • Journal Title

      J. Neuroscience 28

      Pages: 2158-2167

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MeIatonin stimulates the release of growth hormone and proIactin by inducing the expression of frog growth hormone-releasing peptide and its related peptide-2 in the amphibian hypothalamus.2008

    • Author(s)
      V. S. Chowdhury, et al.
    • Journal Title

      Endocrinology 149

      Pages: 962-970

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-l and -lI neurons in European starling brain.2008

    • Author(s)
      T. Ubuka, et al.
    • Journal Title

      Endocrinology 149

      Pages: 268-278

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system.2008

    • Author(s)
      G. Bentley, et al.
    • Journal Title

      Gen. Comp. Endocrinol. 156

      Pages: 34-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoperiod-independent hypothalamic regulation of luteinizing hormone secretion in a free-living Sono ran desert bird, the Rufous-winged Sparrow (Aimophila carpalis).2008

    • Author(s)
      T. W. Small, et al.
    • Journal Title

      Brain Behav. Evol. 71

      Pages: 127-142

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory stimulation of reproductive function in male Rufous-winged Sparrows, Aimophila carpalis.2008

    • Author(s)
      T. W. Small, et al.
    • Journal Title

      Horm. Behav. 53

      Pages: 28-39

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The orexigenic effect of GnlH is mediate by central opioid receptors in chicks.2008

    • Author(s)
      T. Tachibana, et al.
    • Journal Title

      Comp. Biochem. Physiol. A Mol. Integr. Physiol. 150

      Pages: 21-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellum, a target for hormonal signaling.2008

    • Author(s)
      N. Koibuchi, et al.
    • Journal Title

      Cerebellum 7

      Pages: 499-504

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone (GnlH) : biosynthesis, mode of action and functional significance in birds.2008

    • Author(s)
      K. Tsutsui, G. E. Bentley.
    • Journal Title

      Avian Biol. Res. 1

      Pages: 175-186

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroids in the Purkinje cell : Biosynthesis, mode of action and functional significance.2008

    • Author(s)
      K. Tsutsui.
    • Journal Title

      Mol. Neurobiol. 37

      Pages: 116-125

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Recent advances in reproductive neuroendocrinology : A role for the RFamide peptides in seasonaI reproduction?2008

    • Author(s)
      T. J. Greives, et al.
    • Journal Title

      Proc. R. Soc. B. 275

      Pages: 1943-1951

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Progesterone biosynthesis and action in the developing neuron.2008

    • Author(s)
      K. Tsutsui.
    • Journal Title

      Endocrinology 149

      Pages: 2757-2761

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (review).2008

    • Author(s)
      K. Tsutsui.
    • Journal Title

      Cerebellum 7

      Pages: 502-504

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Expression, Iocalization and possible actions of 25-Dx, a membrane-associated putative progest erone-binding protein. in the developing Purkinje cell of the cerbellurn.2008

    • Author(s)
      H. Sakamoto, et al.
    • Journal Title

      Cerebellum 7

      Pages: 18-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生殖神経内分泌学の新たな展開 : GnIHとキスペプチンの発見2008

    • Author(s)
      筒井和義
    • Journal Title

      増刊号「ホルモンの病態異常と臨床検査」臨床検査Journal of Medical Technology (医学書院) 52

      Pages: 1207-1207

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GnIHとGnIH同属ペプチド(LPXRFamideペプチド) : 構造と機能の普遍性と多様性2008

    • Author(s)
      筒井和義
    • Journal Title

      生化学 80

      Pages: 849-854

    • NAID

      10022594510

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 総説 : ステロイドのnon-genomic action 特集 : 合成ステロイドホルモン-最新の基礎・臨床研究-2008

    • Author(s)
      徳元 俊伸, 筒井 和義
    • Journal Title

      日本臨床 66

      Pages: 70-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 7alpha-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms.2008

    • Author(s)
      K.Tsutsui, et. al.
    • Journal Title

      J Neuroscience 28

      Pages: 2158-2167

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog growth hormone-releasing peptide and its related peptide-2 in the amphibian hypothalamus.2008

    • Author(s)
      V.S.Chowdhury, et. al.
    • Journal Title

      Endocrinology 149

      Pages: 962-970

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain.2008

    • Author(s)
      T.Ubuka, et. al.
    • Journal Title

      Endocrinology 149

      Pages: 268-278

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system.2008

    • Author(s)
      G.E.Bentley, et. al.
    • Journal Title

      Gen.Comp.Endocrinol 156

      Pages: 34-43

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoperiod-independent hypothalamic regulation of luteinizing hormone secretion in a free-living Sonoran desert bird, the Rufous-winged Sparrow(Aimophila carpalis).2008

    • Author(s)
      T.W.Small, et. al.
    • Journal Title

      Brain Behav.Evol. 71

      Pages: 127-142

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory stimulation of reproductive function in male Rufous-winged Sparrows,Aimophila carpalis.2008

    • Author(s)
      T.W.Small, et. al.
    • Journal Title

      Horm.Behav. 53

      Pages: 28-39

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The orexigenic effect of GnIH is mediate by central opioid receptors in chicks.2008

    • Author(s)
      T.Tachibana, et. al.
    • Journal Title

      Comp.Biochem.Physiol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review:Neurosteroids in the Purkinje cell:Biosynthesis,mode of action and functional significance.2008

    • Author(s)
      K.Tsutsui
    • Journal Title

      Mol.Neurobiol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review:Recent advances in reproductive neuroendocrinology:A role for the RFamide peptides in seasonal reproduction?2008

    • Author(s)
      T.J.Greives, et. al.
    • Journal Title

      Proc.R.Soc.B (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: Progesterone biosynthesis and action in the developing neuron.2008

    • Author(s)
      K.Tsutsui
    • Journal Title

      Endocrinology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellum,a target for hormonal signaling.2008

    • Author(s)
      N.Koibuchi, et. al.
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: Expression,localization and possible actions of 25-Dx,a membrane-associated putative progesterone-binding protein,in the developing Purkinie cell of the cerebellum.2008

    • Author(s)
      H.Sakamoto, et. al.
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurosteroid synthesis and action in the cerebellum during development(Review).2008

    • Author(s)
      K.Tsutsui
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain.2007

    • Author(s)
      T.Ubuka (筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Endocrinology Endocrine news 149巻

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mode of action and functional significance of estrogen inducing dendritic growth, spinogenesis and synaptogenesis in the developing Purkinje cell.2007

    • Author(s)
      K.Sasahara(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      J.Neurosci. 27巻

      Pages: 7408-7417

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat.2007

    • Author(s)
      M.A.Johnson, K.Tsutsui, G.S. Fraley
    • Journal Title

      Horm.Behav. 51巻

      Pages: 171-180

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Discovery of gonadotropin-inhibitory hormone in a domesticated bird, its mode of action and functional significance.2007

    • Author(s)
      K.Tsutsui(筆頭著者), K.Ukena, etal.
    • Journal Title

      J.Ornithol. 148巻(Suppl 2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone in seasonally-breeding songbirds : Neuroanatomy and functional biology.2007

    • Author(s)
      G.E.Bentley(筆頭著者), K.Ukena, K.Tsutsui, et al.
    • Journal Title

      J.Ornithol. 148巻(Suppl 2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative reproductive neuroendocrinology.2007

    • Author(s)
      P.J.Sharp, K.Tsutsui
    • Journal Title

      Gen.Comp.Endocrinol. 153巻

      Pages: 344-345

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : The general and comparative biology of gonadotropininhibitory hormone (GnIH).2007

    • Author(s)
      K.Tsutsui(筆頭著者), K.Ukena, et al.
    • Journal Title

      Gen.Comp.Endocrinol. 153巻

      Pages: 365-370

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 総説:GnIH特集/中枢内分泌の最新知見とその異常,産科と婦人科2007

    • Author(s)
      筒井和義
    • Journal Title

      Obstet. Gynecol.;診断と治療社 74巻

      Pages: 904-913

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mode of action and functional significance of estrogen inducing dendritic growth, spinogenesis and synaptogenesis in the developing Purkinje cell2007

    • Author(s)
      K. Sasahara (筆頭), K. Tsutsui (最終) et.al.(著者7名)
    • Journal Title

      J. Neurosci 27

      Pages: 7408-7417

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Mode of action and functional significance of estrogen inducing dendritic growth, spinogenesis and synaptogenesis in the develoaing Purkinie cell.2007

    • Author(s)
      K.Sasahara, et. al.
    • Journal Title

      J Neuroscience 27

      Pages: 7408-7417

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion,and has variable effects on sex behavior in the adult male rat.2007

    • Author(s)
      M.A.Johnson, et. al.
    • Journal Title

      Horm Behav. 51

      Pages: 171-180

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review:Discovery of gonadotropin-inhibitory hormone in a domesticated bird,its mode of action and functional significance.2007

    • Author(s)
      K.Tsutsui, et. al.
    • Journal Title

      J.Ornithol. 148

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review:Gonadotropin-inhibitory hormone in seasonally-breeding songbirds:Neuroanatomy and functional biology.2007

    • Author(s)
      G.E.Bentley, et. al.
    • Journal Title

      J.Ornithol. 148

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative reproductive neuroendocrinology.2007

    • Author(s)
      P.J.Sharp, et. al.
    • Journal Title

      Gen.Comp.Endocrinol. 153

      Pages: 344-345

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review:The general and comparative biology of gonadotropin-inhibitory hormone(GnIH).2007

    • Author(s)
      K.Tsutsui, et. al.
    • Journal Title

      Gen.Comp.Endocrinol. 153

      Pages: 365-370

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellum, a target for hormonal signaling.2007

    • Author(s)
      N.Koibuchi et al.
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat.2007

    • Author(s)
      M.A.Johnson et al.
    • Journal Title

      Horm Behav. 51

      Pages: 171-180

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (Review).2007

    • Author(s)
      K.Tsutsui
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Discovery of gonadotropin-inhibitory hormone in a domesticated bird, and its mode of action and functional significance.2007

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      J. Ornithol. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Gonadotropin-inhibitory hormone in seasonally-breeding songbirds : Neuroanatomy and functional biology.2007

    • Author(s)
      G.E.Bentley et al.
    • Journal Title

      J. Ornithol. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : The general and comparative biology of gonadotropin-inhibitory hormone (GnIH).2007

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      Gen. Comp. Endocrinol. Epub ahead of print

    • Related Report
      2006 Annual Research Report
  • [Journal Article] membrane of water-permeable epithelial cells in osmoregulatoryorgans of the tree frog.2007

    • Author(s)
      G.Akabane et al.
    • Journal Title

      Am. J. Physiol. Regul. Integr. Comp. Physiol. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cloning and expression of the vacuolar proton-pumping ATPase subunits in the follicular epithelium of bullfrog endolymphatic Sac.2007

    • Author(s)
      S.Yajima et al.
    • Journal Title

      Zool. Sci. 24

      Pages: 147-157

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ocemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages.2007

    • Author(s)
      M.Nagasawa et al.
    • Journal Title

      J. Cell Physiol. 210

      Pages: 692-701

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Amphibian aquaporins and adaptation to terrestrial environments : A review.2007

    • Author(s)
      M.Suzuki et al.
    • Journal Title

      Comp. biochem. Physiol. A Mol. Integr. Physiol. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family : Insights from novel lamprey RFamide peptides.2006

    • Author(s)
      T.Osugi K.Ukena, S.A.Sower, H.Kawauchi, K.Tsutsui
    • Journal Title

      FEBS J. 273巻

      Pages: 1731-1743

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH).2006

    • Author(s)
      G.E.Bentley(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      Horm.Behav. 49巻

      Pages: 550-555

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail.2006

    • Author(s)
      T.Ubuka, K.Ukena, P.J.Sharp, G.E.Bentley, K.Tsutsui
    • Journal Title

      Endocrinology 147巻

      Pages: 1187-1194

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel fish hypothalamic neuropeptides stimulate the release of gonadotropins and growth hormone from the pituitary of sockeye salmon.2006

    • Author(s)
      M.Amano(筆頭著者), K.Ukena, K.Tsutsui, et al.
    • Journal Title

      J.Endocrinol. 188巻

      Pages: 417-423

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals.2006

    • Author(s)
      L.J.Kriegsfeld(筆頭著者), K.Ukena, K.Tsutsui, et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103巻

      Pages: 2410-2415

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje cell.2006

    • Author(s)
      筒井和義
    • Journal Title

      J.Steroid Biochem.Mol.Biol. 102巻

      Pages: 187-194

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity.2006

    • Author(s)
      K.Tsutsui, K.Ukena
    • Journal Title

      Peptides 27巻

      Pages: 1121-1129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH) : A review.2006

    • Author(s)
      K.Tsutsui(筆頭著者), K.Ukena, et al.
    • Journal Title

      J.Exp.Zool. 305A巻

      Pages: 801-806

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Interactions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) in birds and mammals.2006

    • Author(s)
      G.E.Bentley(筆頭著者), K.Ukena, K.Tsutsui, et al.
    • Journal Title

      J.Exp.Zool. 305A巻

      Pages: 807-814

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structures and diverse functions of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs) : A review.2006

    • Author(s)
      K.Ukena(筆頭著者), K.Tsutsui, et al.
    • Journal Title

      J.Exp.Zool. 305A巻

      Pages: 815-821

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroids in the brain neuron : Biosynthesis, action and medicinal impact on neurodegenerative disease.2006

    • Author(s)
      K.Tsutsui, S.H.Mellon
    • Journal Title

      Central Nerv.Syst.Agents Med.Chem. 6巻

      Pages: 73-82

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release2006

    • Author(s)
      T. Ubuka (筆頭), K. Tsutsui (最終) et.al. (著者5名)
    • Journal Title

      Endocrinology 47

      Pages: 1187-1194

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals2006

    • Author(s)
      L. J. Kriegsfeld (筆頭), K. Tsutsui (5番目) et.al. (著者6名)
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 2410-2415

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormoneinhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail.2006

    • Author(s)
      T.Ubuka et al.
    • Journal Title

      Endocrinology 147

      Pages: 1187-1194

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals.2006

    • Author(s)
      L.J.Kriegsfeld et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 2410-2415

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel fish hypothalamic neuropeptides stimulate the release of gonadotropins and growth hormone from the pituitary of sockeye salmon.2006

    • Author(s)
      M.Amano et al.
    • Journal Title

      J. endocrinology 188

      Pages: 417-423

    • Related Report
      2006 Annual Research Report
  • [Journal Article] peptides in the RF amide peptide family : Insights from novel lamprey RF amide peptides.2006

    • Author(s)
      T.Osugi et al.
    • Journal Title

      FEBS Journal 273

      Pages: 1731-1743

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis.2006

    • Author(s)
      T.Sakamoto et al.
    • Journal Title

      Peptides 27

      Pages: 3347-3351

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rapid inhibition of female sexual behavior bu gonadotropin-inhibitory hormone (GnIH).2006

    • Author(s)
      G.E.Bentley et al.
    • Journal Title

      Horm. Behav. 49

      Pages: 550-555

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Control of luteinizing hormone and testosterone secretion in a flexibly breeding male passerine, the Rufous-winged Sparrow, Aimophila carpalis.2006

    • Author(s)
      P.J.Deviche et al.
    • Journal Title

      Gen. Comp. Endocrinol. 149

      Pages: 226-235

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gonadotropin-nhibitory hormone in birds : possible mode of action.2006

    • Author(s)
      G.E.Bentley et al.
    • Journal Title

      Acta Zool Sinica. 52

      Pages: 178-182

    • Related Report
      2006 Annual Research Report
  • [Journal Article] and the suprachiasmatic nucleus with the paraventricular organ in the Japanese grass lizard (Takydromus tachydromoides).2006

    • Author(s)
      E.Kawano et la.
    • Journal Title

      zool Sci. 23

      Pages: 277-287

    • Related Report
      2006 Annual Research Report
  • [Journal Article] eview : Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje ell.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      J. Steroid Biochem. Mol. Biol. 102

      Pages: 187-194

    • Related Report
      2006 Annual Research Report
  • [Journal Article] review : Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      Cerebellum 5

      Pages: 89-96

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity.2006

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      Peptides 27

      Pages: 1121-1129

    • Related Report
      2006 Annual Research Report
  • [Journal Article] review : Gonadotropin-Inhibitory Hormone (GnIH) : Discovery, Progress and Perspective.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      K. Tsutsui 43

      Pages: 191-198

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mode of action and functional signifcance of avian gonadotropin-inhibitory hormone (GnIH) : A review.2006

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      K. Tsutsui et al. 305A

      Pages: 801-806

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Revuew : ubteractuibs if gibaditrioub0rekeasubg girnibe (GnRH) and gonadotropin-inhibitory hormone (GnIH) in birds and mammals.2006

    • Author(s)
      G.E.Bentley et al.
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 807-814

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structures and diverse functions of frog growth hormone-releasing releasing peptide (fGRP) and its related peptides (fGRP-RPs) : A review.2006

    • Author(s)
      K.Ukena et al.
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 815-821

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurosteroid biosynthesis in the quail brain : A review.2006

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 733-742

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Neurosteroids in the brain neuron : Biosynthesis, action and medicinal impact on neurodegenerative disease.2006

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      Central Nervous System Agents in Medicinal Chemistry 6

      Pages: 73-82

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Isolation and characterization of a novel small cardioactive peptide-related peptide from the brain of Octopus vulgaris.2006

    • Author(s)
      A.Kanda et al.
    • Journal Title

      Peptides 27

      Pages: 1755-1761

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gonadotropin-releasing-hormone receptor isolated from the common octopus (Octopus vulgaris).2006

    • Author(s)
      A.Kanda et al.
    • Journal Title

      Biochem. J. 395

      Pages: 125-135

    • Related Report
      2006 Annual Research Report
  • [Journal Article] effect of placental restriction on the development of subpopulations of corticotrophs in the fetal sheep pituitary during late gestation.2006

    • Author(s)
      K.Farrand et al.
    • Journal Title

      Endocrinology 147

      Pages: 4762-4771

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexua development in Schizosaccharomyces pombe.2006

    • Author(s)
      A.Nakashima et al.
    • Journal Title

      Curr. Genet. 49

      Pages: 403-413

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular and cellular characterization of a new aquaporin, AQP-x5, specifically expressed in the small granular glands of Xenopus skin.2006

    • Author(s)
      M.Kubota et al.
    • Journal Title

      J. Exp. Biol. 209

      Pages: 3199-3208

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gene expression of vascular growth factor-A in the pituitary during formation of the vascular system in the hypothalamic-pituitary axis of the rat.2006

    • Author(s)
      T.Nakakura et al.
    • Journal Title

      Cell Tissue Res. 324

      Pages: 87-95

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Balancing reproduction by the inhibitory regulator GnIH and the stimulatory regulator kisspeptin. Trends Neurosci.

    • Author(s)
      K.Tsutsui(筆頭著者), G.E.Bentley, et al.
    • Journal Title

      Cell Press (in press)

    • Related Report
      2010 Final Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH), a new key neurohormone controlling vertebrate reproduction : Biosynthesis, mode of action and functional significance.2011

    • Author(s)
      筒井和義
    • Organizer
      The 2011 International Biomodulation Symposium on 'Biomaterials and Biomodelling for Translational Research'
    • Place of Presentation
      Seoul National University, Seoul, Korea.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Putting the brakes on reproduction. Implications for conservation? Global climate change?2010

    • Author(s)
      J.C.Wingfield, K.Tsutsui
    • Organizer
      Howard Bern Lecture at the Society of Integrative and Comparative Biology (SICB) meeting 2011
    • Place of Presentation
      Salt Lake City, USA.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel molecular mechanisms underlying diurnal locomotor rhythms in birds : Coordination of melatonin with 7α-hydroxypregnenolone, a newly discovered avian neurosteroid.2010

    • Author(s)
      筒井和義
    • Organizer
      The 25th International Ornithological Congress
    • Place of Presentation
      Campos do Jordao, Brazil.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Discovery and evolutionary history of GnIH and kisspeptin, new key neuropeptides controlling reproduction.2010

    • Author(s)
      筒井和義
    • Organizer
      The 7th International Congress of Neuroendocrinology
    • Place of Presentation
      Rouen, France.(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Discovery of GnIH : First identification in birds and conservation in mammals.2010

    • Author(s)
      筒井和義
    • Organizer
      The Symposium "Gonadotropin inhibitory hormone (GnIH) functions in mammals " at The Endocrine Society's 92nd Annual Meeting
    • Place of Presentation
      San Diego, California, USA.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Discovery and functional significance of gonadotropin-inhibitory hormone (GnIH) in vertebrates : From comparative to general.2010

    • Author(s)
      筒井和義
    • Organizer
      The 14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan.(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Discovery and functional significance of gonadotropin-inhibitory hormone(GnIH)in vertebrates : From comparative to general2010

    • Author(s)
      筒井和義
    • Organizer
      The 14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] The President Address : Future Progress of the AOSCE2010

    • Author(s)
      筒井和義
    • Organizer
      The 6th AOSCE
    • Place of Presentation
      Palmerston North, New Zealand
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規脳ホルモンの探索と生理機能の解析2009

    • Author(s)
      筒井和義
    • Organizer
      埼玉大学学術講演会
    • Place of Presentation
      埼玉市
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生殖機能を制御する新規生理活性ペプチドGnIH2009

    • Author(s)
      筒井和義
    • Organizer
      平成21年度日本内分泌学会サマーセミナー
    • Place of Presentation
      坂井市
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生殖腺刺激ホルモン放出抑制ホルモン(GnIH)による生殖機能の制御2009

    • Author(s)
      筒井和義
    • Organizer
      第82回日本内分泌学会学術総会サテライトシンポジウム
    • Place of Presentation
      群馬県
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phylogenetic aspects of gonadotropin-inhibitory hormone (GnIH) and its homologs in vertebrates.2009

    • Author(s)
      筒井和義
    • Organizer
      Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Yakushima, Japan.(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] New neuropeptides and neurosteroids in vertebrates : Discovery, progress and prospects.2009

    • Author(s)
      筒井和義
    • Organizer
      The 16th International Congress of Comparative Endocrinolog
    • Place of Presentation
      Hong Kong, China.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Phylogenetic aspects of gonadotropin-inhibitory hormone(GnIH)and its homologs in vertebrates2009

    • Author(s)
      筒井和義
    • Organizer
      Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Yakushima, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of a novel bioactive amphibian neurosteroid, 7α-hydroxypregnenolone, and its role in the regulation of the diurnal rhythm of locomotor activity in newts2009

    • Author(s)
      筒井和義
    • Organizer
      The 6th ISAREN
    • Place of Presentation
      Berlin. Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] New neuropeptides and neurosteroids in vertebrates : Discovery, progress and prospects2009

    • Author(s)
      筒井和義
    • Organizer
      The 16th International Congress of Comparative Endocrinology
    • Place of Presentation
      Hong Kong
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect.2008

    • Author(s)
      筒井和義
    • Organizer
      The 5th International Symposium on Molecular Endocrinology
    • Place of Presentation
      Hormone Research Center, Gwangju, Korea.(基調講演)
    • Year and Date
      2008-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect2008

    • Author(s)
      K. Tsutsui
    • Organizer
      The 5th International Symposium on Molecular Endocrinology(基調講演)
    • Place of Presentation
      Gwangju, Korea
    • Year and Date
      2008-04-04
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect.2008

    • Author(s)
      K. Tsutsui.
    • Organizer
      The 5th International Symposium on Molecular Endocrinology
    • Place of Presentation
      Gwangju, Korea
    • Year and Date
      2008-04-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] The novel neurosteroid 7alpha-hydroxypregnenolone is a key factor inducing sex-dependent locomotor activity2008

    • Author(s)
      K. Tsutsui
    • Organizer
      第85日本生理学会シンポジウム「性差の分子メカニズムMolecular Mechanisms of Sexual Differences)
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] GnlHとGnlH同族ペプチドの多様性と分子進化2008

    • Author(s)
      筒井 和義
    • Organizer
      基礎生物学研究所研究会「生殖生物学の歴史と展望」
    • Place of Presentation
      岡崎カンファレンス
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Discovery of gonadotropininhibitory hormone (GnIH), and its mode of action and functional significance.2008

    • Author(s)
      筒井和義
    • Organizer
      US/Japan International Symposium on Neurosteroids
    • Place of Presentation
      Gifu, Japan.(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification, biosynthesis and function of 7α-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity.2008

    • Author(s)
      筒井和義
    • Organizer
      The 24th Conference European Comparative Endocrinologists
    • Place of Presentation
      Genova, Italy.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] The novel avian neurosteroid 7α-hydroxypregnenolone mediates melatonin ction underlying diurnal locomotor rhythms.2008

    • Author(s)
      筒井和義
    • Organizer
      The 9th International Symposium on Avian Endocrinology
    • Place of Presentation
      Leuven, Belgium.(Farner Medal 受賞講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Evolutionary origin and divergence of GnIH and its homologous peptides.2008

    • Author(s)
      筒井和義
    • Organizer
      The 6th International Symposium on Fish Endocrinology and Neuroendocrinology
    • Place of Presentation
      Calgary, Canada.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] The novel avian neurosteroid 7α-hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms2008

    • Author(s)
      K. Tsutsui
    • Organizer
      The 9th International Symposium on Avian Endocrinology(Farner Medal 受賞講演)
    • Place of Presentation
      Leuven, Belgium
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Evolutionary origin and divergence of GnIH and its homologous peptides2008

    • Author(s)
      K. Tsutsui
    • Organizer
      The 6th International Symposium on Fish Endocrinology and Neuroendocrinology(基調講演)
    • Place of Presentation
      Calgary, Canada
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Novel molecular mechanism inducing sex difference in locmotor activity by 7alpha-hydroxypregnenolone, a newly discovered neurosteroid.2008

    • Author(s)
      K. Tsutsui.
    • Organizer
      International Symposium for Gonad and Brain Sex Differentiation
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Discovery of gonadotropin-inhibitory hormone (GnIH), and its mode of action and functional significance.2008

    • Author(s)
      K. Tsutsui.
    • Organizer
      US/Japan International Symposium on Neurosteroids
    • Place of Presentation
      Gifu, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rapid stimulation of Iocomotor activity by 7alpha-hydroxypregnenolone identified as a novel neuronal a otivator.2008

    • Author(s)
      S. Haraguchi, K. Tsutsui.
    • Organizer
      US/Japan International Symposium on Neurosteroids
    • Place of Presentation
      Gifu, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification, biosynthesis and function of 7alpha-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity.2008

    • Author(s)
      K. Tsutsui.
    • Organizer
      The 24th Conference European Comparative Endocrinologists
    • Place of Presentation
      Genova, Italy
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hormone-mediated reproductive behavior in the newt.2008

    • Author(s)
      S. Kikuyama, K. Tsutsui.
    • Organizer
      The 24th Conference European Comparative Endocrinologists
    • Place of Presentation
      Genova, Italy
    • Related Report
      2008 Annual Research Report
  • [Presentation] The novel avian neurosteroid 7alpha-hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms.2008

    • Author(s)
      K. Tsutsui.
    • Organizer
      The 9th International Symposium on Avian Endocrinology
    • Place of Presentation
      Leuven, Belgium
    • Related Report
      2008 Annual Research Report
  • [Presentation] Evolutionary origin and divergence of GnIH and its homologous peptides.2008

    • Author(s)
      K. Tsutsui.
    • Organizer
      The 6th International Symposium on Fish Endocrinology and Neuroendocrinology
    • Place of Presentation
      Calgary, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neurosteroid synthesis and action in the cerebellar Purkinje cell2007

    • Author(s)
      K. Tsutsui
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会シンポジウム「局所ステロイドの合成と機能」
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] イモリから同定した新規ニューロステロイドの生理作用2007

    • Author(s)
      筒井 和義
    • Organizer
      日本動物学会第78回大会シンポジウム「両生類はワンダーランド」
    • Place of Presentation
      弘前大学
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニューロステロイド合成の日周性とメラトニンによる調節2007

    • Author(s)
      筒井 和義
    • Organizer
      第29回日本比較生理生化学会シンポジウム「生体リズムにおける振動制御機構と出力機構〜研究の現状と新展開〜」
    • Place of Presentation
      岡山大学
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 烏類から発見された生殖腺刺激ホルモン放出抑制ホルモン(GnlH)とその受容体2007

    • Author(s)
      筒井 和義
    • Organizer
      第4回GPCR研究会シンポジウム「GPCRと内分泌・生殖機能」
    • Place of Presentation
      日本科学未来館
    • Year and Date
      2007-05-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) in a new reproductive axis.2007

    • Author(s)
      筒井和義
    • Organizer
      The 6th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Siliguri, India.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, mode of action, functional significance and prospective application to reproductive dysfunction.2007

    • Author(s)
      筒井和義
    • Organizer
      The 5th Anniversary Congress of International Drug Discovery Science and Technology (IDDST)-2007
    • Place of Presentation
      Xi'an, China.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Structures, diverse actions and functional significance of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs).2007

    • Author(s)
      筒井和義
    • Organizer
      International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
    • Place of Presentation
      Conference Center at the Berkeley Marina, Berkeley, California, USA.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Gonadotropin-inhibitory hormone(GnIH)in a new reproductive axis2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 6th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Siliguri,India
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gonadotropin-inhibitory hormone(GnIH): discovery,mode of action,functional significance and prospective application to reproductive dysfunction2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 5th Anniversary Congress of Internationa l Drug Discovery Science and Technology (IDDST)-2007
    • Place of Presentation
      Xi'an,China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Melatonin regulates the production of 7alpha-hydroxvpregnenolone identified as an active neurosteroid stimulating locomotor activity in vertebrates2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 2nd World Congress of Chronobiology
    • Place of Presentation
      Tokyo,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] The comparative biology of gonadotrophin-inhibitory hormone (GnIH) and its homologous peptides.2006

    • Author(s)
      筒井和義
    • Organizer
      The 23rd Conference of European Comparative Endocrinologists
    • Place of Presentation
      The University of Manchester, Manchester, UK. (基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Discovery of gonadotropininhibitory hormone in a domesticated bird, its mode of action and functional significance.2006

    • Author(s)
      筒井和義
    • Organizer
      The 24th International Ornithological Congress
    • Place of Presentation
      Hamburg, Germany.(基調講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje cell.2006

    • Author(s)
      筒井和義
    • Organizer
      The 17th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology
    • Place of Presentation
      Seefeld, Tyrol, Austria.(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Discovery of gonadotropininhibitory hormone in a domesticated bird, its mode of action and functional significance2006

    • Author(s)
      K. Tsutsui
    • Organizer
      The 24th International Ornithological Congress(基調講演)
    • Place of Presentation
      Hamburg, Germany
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] The comparative biology of gonadotrophin-inhibitory hormone (GnIH) and its homologous peptides

    • Author(s)
      K. Tsutsui
    • Organizer
      The 23rd Conference of European Comparative Endocrinologists(基調講演)
    • Place of Presentation
      Manchester, UK
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] その他42件

    • Related Report
      2007 Annual Research Report
  • [Book] Handbook of Cerebellum and Cerebellar Disorders2011

    • Author(s)
      筒井和義
    • Publisher
      Springer(in press)
    • Related Report
      2010 Final Research Report
  • [Book] Phylogenetic Aspects of Neuropeptides : From Invertebrates to Humans2010

    • Author(s)
      筒井和義
    • Publisher
      Blackwell, Boston, Massachusetts
    • Related Report
      2010 Final Research Report
  • [Book] Melatonin : From Molecules to Therapy2007

    • Author(s)
      K.Tsutsui, T.Ubuka, G.E.Bentley
    • Publisher
      Nova Science Publishers, New York
    • Related Report
      2010 Final Research Report
  • [Book] Hormone Biotechnology2007

    • Author(s)
      筒井和義
    • Publisher
      Daya Publishing House, Delhi
    • Related Report
      2010 Final Research Report
  • [Book] Evolutionary Molecular Strategies and Plasticity2007

    • Author(s)
      筒井和義
    • Publisher
      Research Signpost Publishers,Trivandrum, India
    • Related Report
      2010 Final Research Report
  • [Book] ホルモンハンドブック新訂eBook版(日本比較内分泌学会編)2007

    • Author(s)
      筒井和義
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] シリーズ21世紀の動物科学10内分泌と生命現象2007

    • Author(s)
      筒井和義,浮穴和義,南方宏之
    • Publisher
      培風館
    • Related Report
      2010 Final Research Report
  • [Book] Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain. Melatonin : From Molecules to Therapy, (S.R. Pandi-Perumal and D. P. Cardinali)2007

    • Author(s)
      K. Tsutsui, T. Ubuka and G. E. Bentley
    • Total Pages
      14
    • Publisher
      Nova Science Publishers, New York
    • Related Report
      2008 Self-evaluation Report
  • [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain. Hormone Biotechnology, (S.K. Maitra)2007

    • Author(s)
      K. Tsutsui
    • Total Pages
      7
    • Publisher
      Daya Publishing House, Delhi
    • Related Report
      2008 Self-evaluation Report
  • [Book] Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain.In:Melatonin:From Molecules to Therapy.2007

    • Author(s)
      K.Tsutsui, et. al.
    • Total Pages
      14
    • Publisher
      Nova Science Publishers,New York
    • Related Report
      2007 Annual Research Report
  • [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain.In: Hormone Biotechnology.2007

    • Author(s)
      K.Tsutsui
    • Total Pages
      7
    • Publisher
      Daya Publishing House,Delhi
    • Related Report
      2007 Annual Research Report
  • [Book] Neuronal neurosteroidogenesis and organizing actions of neurosteroids during cerebellar development.In:Evolutionary Molecular Strategies and Plasticity.2007

    • Author(s)
      K.Tsutsui
    • Total Pages
      18
    • Publisher
      Research Signpost Publishers,Trivandrum
    • Related Report
      2007 Annual Research Report
  • [Book] 脳ホルモンの新領域シリーズ21世紀の動物科学10内分泌と生命現象第5章脳ホルモンの新領域長浜嘉孝・井口泰泉共編2007

    • Author(s)
      筒井 和義, et. al.
    • Total Pages
      39
    • Publisher
      培風館
    • Related Report
      2007 Annual Research Report
  • [Book] ホルモンハンドブック新訂eBook版2章ペプチドとタンパク質(無脊椎動物)日本比較内分泌学会編2007

    • Author(s)
      松島 治, et. al.
    • Total Pages
      27
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report
  • [Book] ホルモンハンドブック新訂eBook版2章ペプチドとタンパク質(無脊椎動物)日本比較内分泌学会編2007

    • Author(s)
      南方 宏之
    • Total Pages
      99
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report
  • [Book] ホルモンハンドブック新訂eB00k版脂溶性情報分子(細胞内受容体結合分子ファミリー)日本比較内分泌学会編2007

    • Author(s)
      筒井 和義
    • Total Pages
      130
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report
  • [Book] Melatonin actio on neuropeptide induction through receptor-mediated mechanisms in the brain.2007

    • Author(s)
      K.Tsutsui et al.
    • Publisher
      In : Melatonin : From Molecules to Therapy, S.R. Pandi-Perumal and D. P. Cardinali (eds) Nova Serence Publishers, New York(in press)
    • Related Report
      2006 Annual Research Report
  • [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain.2007

    • Author(s)
      K.Tsutsui
    • Total Pages
      7
    • Publisher
      In : Hormone Biotechnology, S. K. Maitra (ed), Daya Publishing House, Delhi
    • Related Report
      2006 Annual Research Report
  • [Book] Neuronal neurosteroidogenesis and organizing actions of neurosteroids during cerebellar development.2007

    • Author(s)
      K.Tsutsui
    • Total Pages
      18
    • Publisher
      In : Evolutionary Molecular Strategies and Plasticity, M. Canonaco and R. M. Facciolo (eds) Research Signpost Publishers, Trivandrum, India
    • Related Report
      2006 Annual Research Report
  • [Book] 動物のアクアポリンの多様性と比較内分泌的展望 特集 新しい内分泌現象 日本比較内分泌学会ニュース1242007

    • Author(s)
      田中滋康 et al.
    • Total Pages
      16
    • Publisher
      日本比較内分泌学会
    • Related Report
      2006 Annual Research Report
  • [Book] Reproductive Biology and Phylogeny of Birds2006

    • Author(s)
      G.E.Bentley, K.Tsutsui, J.C.Wingfield
    • Publisher
      Science Publishers, Enfield, USA
    • Related Report
      2010 Final Research Report
  • [Book] The Handbook of Biologically Active Peptides2006

    • Author(s)
      N.Chartrel, K.Tsutsui, J.Costentin, H.Vaudry.
    • Publisher
      Elsevier publisher
    • Related Report
      2010 Final Research Report
  • [Book] Endocrinology of reproduction. Reproductive Biology and Phylogeny of Birds, (Barrie G. M. Jamieson)2006

    • Author(s)
      G. E. Bentley, K. Tsutsui and J. C. Wingfield.
    • Total Pages
      62
    • Publisher
      Bentley Science Publishers, Enfield, USA
    • Related Report
      2008 Self-evaluation Report
  • [Book] Endocrinology of reproduction.2006

    • Author(s)
      G.E.Bentley et al.
    • Total Pages
      62
    • Publisher
      In : Reproductive Biology and Phylogeny of Birds, Barrie G. M. Jamieson (ed) Science Publishers, Enfield, USA
    • Related Report
      2006 Annual Research Report
  • [Book] Avian gonadotropin-inhibitory hormone (GnIH) : Identification, mode of action and functional significance.2006

    • Author(s)
      K.Tsutsui
    • Total Pages
      5
    • Publisher
      In : Comparative Endocrinology and Biodiversity in Asia and Oceania, P. Tangpraprutgul et al. (eds) Chulalongkorn University Press, Bangkok
    • Related Report
      2006 Annual Research Report
  • [Book] Melatonin action on the induction of gonadotropin-inhibitory hormone in the avian brain.2006

    • Author(s)
      v.S.Chowdhury et al.
    • Total Pages
      4
    • Publisher
      In : Comparative Endocrinology and Biodiversity in Asia and Oceania, P. Tangpraprutgul et al. (eds) Chulalongkorn University Press, Bangkok
    • Related Report
      2006 Annual Research Report
  • [Book] The RF amide-related peptides.2006

    • Author(s)
      N.Chartrel et al.
    • Total Pages
      8
    • Publisher
      In : The Handbook of Biologically Active Peptides, A. J. Kastin (ed) Elsevier publisher
    • Related Report
      2006 Annual Research Report
  • [Book] オキシトシン/バソプレッシンスーパーファミリーの進化「生物進化の分子マップ」生体の科学,57巻2006

    • Author(s)
      南方宏之
    • Total Pages
      2
    • Publisher
      (財)金原一郎記念医学医療振興財団/医学書院
    • Related Report
      2006 Annual Research Report
  • [Book] 免疫染色& in situハイブリダイゼーション 最新プロトコール(野地澄晴編)2006

    • Author(s)
      田中英明 et al.
    • Total Pages
      28
    • Publisher
      羊土社
    • Related Report
      2006 Annual Research Report
  • [Book] 甲状腺の分化に関連sる遺伝子Nkx.2.1の分子進化In : 生物進化の分子マップ,生体の科学 572006

    • Author(s)
      鈴木雅一 et al.
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2006 Annual Research Report
  • [Remarks] プレスリリース

    • Related Report
      2010 Final Research Report
  • [Remarks] 2009年12月24日読売新聞掲載

    • Related Report
      2010 Final Research Report
  • [Remarks] 2008年3月2日読売新聞掲載

    • Related Report
      2010 Final Research Report
  • [Remarks] 2008年3月2日YOMIURI ONLINE掲載

    • Related Report
      2010 Final Research Report
  • [Remarks] 2007年9月10日asahi.com OPINION(朝日新聞社報)掲載

    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2009 Annual Research Report
  • [Remarks] Farner Medal, International Society for Avian Endocrinology, 2008

    • URL

      http://www.f.waseda.jp/k-tsutsui/index.html

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.f.waseda.jp/k-tsutsui/fworks.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規メタスチン同族体およびその用途2008

    • Inventor(s)
      筒井和義
    • Industrial Property Rights Holder
      筒井和義
    • Filing Date
      2008-09-30
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 新規メタスチン同族体およびその用途2008

    • Inventor(s)
      筒井和義
    • Industrial Property Rights Holder
      筒井和義
    • Industrial Property Number
      2008-253859
    • Filing Date
      2008-09-30
    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report

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Published: 2006-04-01   Modified: 2016-04-21  

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