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Ancient Chinese : their Genetic Diversity and Life History

Research Project

Project/Area Number 18107007
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Anthropology
Research InstitutionThe University of Tokyo

Principal Investigator

UEDA Shintaroh  東京大学, 大学院・理学系研究科, 教授 (20143357)

Co-Investigator(Kenkyū-buntansha) KUROSAKI Kunihiko  東邦大学, 医学部, 教授 (60240701)
OOTA Hiroki  北里大学, 医学部, 准教授 (40401228)
YONEDA Minoru  東京大学, 大学院・新領域創成科学研究科, 准教授 (30280712)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥105,690,000 (Direct Cost: ¥81,300,000、Indirect Cost: ¥24,390,000)
Fiscal Year 2010: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2009: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2008: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2007: ¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000)
Fiscal Year 2006: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Keywords古代DNA / 古人骨 / 遺伝的多様性 / 中国 / 次世代シーケンサ / 人類進化 / 国際研究者交流 / 分子人類学 / 分子考古学 / 炭化米 / 遺伝的様性 / イネ / 金沙遺跡 / コメ
Research Abstract

To explore further our previous findings that drastic spatio-temporal changes in the genetic structure of Chinese people had occurred during the past 2, 500 years, we analyzed ancient DNA of human remains excavated from the 3, 000-and 3, 500-year-old sites in the Central Plain of China. We obtained the following results :(1) drastic spatio-temporal changes had occurred also between 3, 500 and 3, 000 years ago, and(2) the population of 3, 500 years ago showed a genetic similarity with present-day Han Chinese.

Report

(5 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2008 Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (49 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (31 results) (of which Peer Reviewed: 8 results) Presentation (5 results) Book (7 results) Remarks (6 results)

  • [Journal Article] Elevatedevolutionary rate in genes with homopolymeric amino acid repeats constituting non-disorderedstructure2011

    • Author(s)
      J. Gojobori and S. Ueda
    • Journal Title

      Mol Biol Evol

      Volume: 28 Pages: 543-550

    • Related Report
      2010 Final Research Report
  • [Journal Article] Determination of dextromethorphan in human plasma using pipettetip solid-phase extraction and gaschromatography. Mass spectrometry2011

    • Author(s)
      C. Hasegawa, et al
    • Journal Title

      Anal Bioanal Chem

      Volume: 401 Pages: 2215-2223

    • Related Report
      2010 Final Research Report
  • [Journal Article] Elevated evolutionary rate in genes with homopolymeric amino acid repeats constituting non-disordered structure2011

    • Author(s)
      Gojobor J.
    • Journal Title

      Molecular Biology and Evolution

      Volume: 28 Pages: 543-550

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geneticdiversity and evolutionary relationaships in genusoryza revealed by using highly variable regionsof chloroplast DNA2010

    • Author(s)
      M. Kumagai, L. Wang, and S. Ueda
    • Journal Title

      Gene

      Volume: 462 Pages: 44-51

    • Related Report
      2010 Final Research Report
  • [Journal Article] A Genetic Analysis ofthe Sakishima Islanders Reveals No Relationshipwith Taiwan Aborigines but Shared Ancestrywith Ainu and Main-island Japanese2010

    • Author(s)
      H. Matsukusa, H. Oota, K. Haneji, T. Toma, S. Kawamura, and H. Ishida
    • Journal Title

      AmericanJournal of Physical Anthropology

      Volume: 142 Pages: 211-23

    • Related Report
      2010 Final Research Report
  • [Journal Article] Population-specificsusceptibility to Crohn's disease and ulcerativecolitis ; dominant and recessive relative risks inthe Japanese population2010

    • Author(s)
      S. Nakagome, et al
    • Journal Title

      Ann Hum Genet

      Volume: 74 Pages: 126-36

    • Related Report
      2010 Final Research Report
  • [Journal Article] Evolutionarily informative sites in the chloroplast genome of rice and their application to the phylogeny of Oryza species2010

    • Author(s)
      Kumagai M.
    • Journal Title

      Gene

      Volume: 462 Pages: 44-51

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alu-mediated acquisition of unstable ATTCT pentanucleotide repeats in the human ATXN10 gene2009

    • Author(s)
      T. Kurosaki, T. Matsuura, K. Ohno, and S. Ueda
    • Journal Title

      Mol Biol Evol

      Volume: 26 Pages: 2573-2579

    • Related Report
      2010 Final Research Report
  • [Journal Article] Anticancereffects of phenoxazine derivatives revealed byinhibition of cell growth and viability, disregulation of cell cycle, andapoptosisinduction in HTLV-1-positive leukemiacells2009

    • Author(s)
      N. Miyano-Kurosaki, et al
    • Journal Title

      J Pharmacol Sci

      Volume: 110 Pages: 87-97

    • Related Report
      2010 Final Research Report
  • [Journal Article] Origin and dispersal ofatypical aldehyde dehydrogenase ALDH2487Lys2009

    • Author(s)
      H. R. Luo, et al
    • Journal Title

      Gene

      Volume: 435 Pages: 96-103

    • Related Report
      2010 Final Research Report
  • [Journal Article] A commonvariation in EDAR is a genetic determinant ofshovel-shaped incisors2009

    • Author(s)
      R. Kimura, et al
    • Journal Title

      American Journal ofHuman Genetics

      Volume: 85 Pages: 528-535

    • Related Report
      2010 Final Research Report
  • [Journal Article] Long-range PCR for the diagnosis of spinocerebellar ataxia type 102008

    • Author(s)
      T. Kurosaki, T. Matsuura, K. Ohno, and S. Ueda
    • Journal Title

      Neurogenetics

      Volume: 9 Pages: 151-152

    • Related Report
      2010 Final Research Report
  • [Journal Article] Temporal andspatial variations of radiocarbon in japan Sea Bottom Water2008

    • Author(s)
      Y. Kumamoto, et al
    • Journal Title

      Journal of Oceanography

      Volume: 64 Pages: 429-441

    • Related Report
      2010 Final Research Report
  • [Journal Article] Severe developmentaldefects of enamel in a human skeleton of the Final Jomon age from the Nakazawahama sell-mound2008

    • Author(s)
      J. Sawada, T. Suzuki, M. Yoneda, M. Sat, K. Hirata, and Y. Dodo
    • Journal Title

      Anthropological Science

      Volume: 116 Pages: 105-121

    • Related Report
      2010 Final Research Report
  • [Journal Article] Dental diseases of human skeletal remains from the early-modern period of Kumejima island, Okinawa2008

    • Author(s)
      K. Irei, et al
    • Journal Title

      Japan. Anthropological Science

      Volume: 116 Pages: 149-159

    • Related Report
      2010 Final Research Report
  • [Journal Article] Determination of 14C/12C of acetaldehyde in indoor air by compound specific radiocarbon analysis2008

    • Author(s)
      Y. Kato, et al
    • Journal Title

      Atmospheric Environment

      Volume: 42 Pages: 1049-1056

    • Related Report
      2010 Final Research Report
  • [Journal Article] Morphological Change Caused by Loss of the Taxon-Specific Polyalanine Tract in Hoxd-132007

    • Author(s)
      N. Anan, et al
    • Journal Title

      Mol Biol Evol

      Volume: 24 Pages: 281-287

    • Related Report
      2010 Final Research Report
  • [Journal Article] Conservative evolution in duplicated genes of the primate Class I ADH cluster2007

    • Author(s)
      H. Oota, et al
    • Journal Title

      Gene

      Volume: 392 Pages: 64-76

    • Related Report
      2010 Final Research Report
  • [Journal Article] Evidence of positive selection on a Class I ADH locus2007

    • Author(s)
      Y. Han, et al
    • Journal Title

      American Journal of Human Genetics

      Volume: 80 Pages: 441-456

    • Related Report
      2010 Final Research Report
  • [Journal Article] Radiocarbon marine reservoir ages in the western Pacific estimated by pre-bomb molluscan shells2007

    • Author(s)
      M. Yoneda, et al
    • Journal Title

      Nuclear Instrumentsand Methods in Physics Research B

      Volume: 259 Pages: 432-437

    • Related Report
      2010 Final Research Report
  • [Journal Article] Morphological change caused by loss of the taxon-specific polyalanine tract in Hoxd-132007

    • Author(s)
      Anan K., Yoshida N., Kataoka Y., Sato M., Anan K., Yoshida N., Kataoka Y., Sato M., and Ueda S.
    • Journal Title

      Molecular Biology and Evolution 24

      Pages: 281-287

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Evidence of positive selection on a Class I ADH locus2007

    • Author(s)
      Han Y., Gu S., Oota H., Osier M.V., Pakstis A.J., Speed W.C., Kidd J.R., Kidd, K.K.
    • Journal Title

      American Journal of Human Genetics 80

      Pages: 441-456

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] ゲノム科学と人類学-世界の動向と今後の展望-2007

    • Author(s)
      太田博樹
    • Journal Title

      人類学雑誌 115

      Pages: 73-83

    • NAID

      10020274399

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Role of nitric oxide system in hydroxyl radical generation in tat striatum due to carbon monoxide poisoning,as determined by microdialysis2007

    • Author(s)
      Hara, S.
    • Journal Title

      Toxicology 239

      Pages: 136-143

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence of positive selection on a Class I ADH locus2007

    • Author(s)
      Han, Y.
    • Journal Title

      American Journal of Human Genetics 80

      Pages: 441-456

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conservative evolution in duplicated genes of the primate Class I ADH cluster2007

    • Author(s)
      Oota, H.
    • Journal Title

      Gene 392

      Pages: 64-76

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary scenario for acquisition of CAG repeats in human SCA1 gene2006

    • Author(s)
      T. Kurosaki, A. Ninokata, L. Wang, and S. Ueda
    • Journal Title

      Gene

      Volume: 373 Pages: 23-27

    • Related Report
      2010 Final Research Report
  • [Journal Article] Rapid and simple analysis of oxazolobenzodiazepine drugs in sera by wide-bore capillary gas chromatography with nitrogen-phosphorus detection using on-column methylation2006

    • Author(s)
      M. Terada, T. Shinozuka, E. Tanaka, K. Honda, and K. Kurosaki
    • Journal Title

      Forensic Toxicol

      Volume: 24 Pages: 58-64

    • Related Report
      2010 Final Research Report
  • [Journal Article] Rapid and simple analysis of oxazolobenzodiazepine drugs in sera by wide-bore capillary gas chromatography with nitrogen-phosphorus detection using on-column methylation2006

    • Author(s)
      Terada M., Shinozuka T., Tanaka E., Honda K., Kurosaki K.
    • Journal Title

      Forensic Toxicology 24

      Pages: 58-64

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Autosomal and Y-chromosomal STR markers reveal a close relationship between Hokkaido Ainu and Ryukyu islanders

    • Author(s)
      K. Koganebuchi, et al
    • Journal Title

      Anthropol Sci

      Volume: (in press)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of anAsian-specific nonsynonymous EDAR variant onmultiple dental traits

    • Author(s)
      J-H. Park, et al
    • Journal Title

      J Hum Genet

      Volume: (in press)

    • Related Report
      2010 Final Research Report
  • [Presentation] Construction of rice chloroplast DNA reference data and its application for DNA analysis of over 2,000 year old rice seed remains2011

    • Author(s)
      Kumagai M.
    • Organizer
      Molecular Biology and Evolution 2011
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-07-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Construction of rice chloroplast DNA referencedata and its application for ancient DNA analysisof over 2, 000 years old rice seed remains2011

    • Author(s)
      M. Kumagai, L. Wang, and S. Ueda
    • Organizer
      The Society for Molecular Biology and Evolution Annual Meeting
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] How should we think of "population" in population genetics? Japan-based Global Study of Racial Representation International Workshop2011

    • Author(s)
      H. Oota
    • Organizer
      The Interface of Humanities and Genomics
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Evolutionarily informative sites in the chloroplast genome of rice and their application to the phylogeny of Oryza species2009

    • Author(s)
      M. Kumagai, L. Wang, and S. Ueda
    • Organizer
      Internationalsymposium on wild rice 2009
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2010 Final Research Report
  • [Presentation] 栽培イネの起源と古代イネDNA分析2007

    • Author(s)
      熊谷 真彦
    • Organizer
      日本人類学会
    • Place of Presentation
      日本歯科大学
    • Year and Date
      2007-10-06
    • Related Report
      2007 Annual Research Report
  • [Book] 「イネの遺伝的多様性DNA分析による研究」、考古学を科学する2011

    • Author(s)
      熊谷真彦、植田信太郎
    • Publisher
      臨川書店
    • Related Report
      2010 Final Research Report
  • [Book] Effects of HumanMigration on Genome Diversity in East Asia2011

    • Author(s)
      H. Oota, and M. Stoneking
    • Publisher
      KyotoUniversity Press(Kyoto, Japan) and TransPacific Press(Melbourne, Australia)
    • Related Report
      2010 Final Research Report
  • [Book] イネの遺伝的多様性DNA分析による研究2011

    • Author(s)
      熊谷真彦(共著)
    • Publisher
      臨川書店
    • Related Report
      2010 Annual Research Report
  • [Book] 中世総合資料学論集2008

    • Author(s)
      植田 信太郎
    • Publisher
      塙書房(印刷中)
    • Related Report
      2007 Annual Research Report
  • [Book] 「古代DNA」、進化学・第2巻:遺伝子とゲノムの進化2006

    • Author(s)
      植田信太郎
    • Publisher
      岩波書店
    • Related Report
      2010 Final Research Report
  • [Book] 進化学(第2巻・第5章)「古代DNA」2006

    • Author(s)
      植田信太郎
    • Publisher
      岩波書店
    • Related Report
      2008 Self-evaluation Report
  • [Book] 進化学「第2巻 : 遺伝子とゲノムの進化」2006

    • Author(s)
      植田, 信太郎
    • Total Pages
      285
    • Publisher
      岩波書店
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/shinka/lab.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ddbj.nig.ac.jp/aDNA/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/shinka/lab.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ddbj.nig.ac.jp/aDNA/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks] 「古代DNAデータベース」の構築に参画Ancient Genome Encyclopedia (Ancient DNA DataBase)

    • URL

      http://www.ddbj.nig.ac.jp/aDNA/index.html

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/shinka/lab.html

    • Related Report
      2008 Self-evaluation Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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