| Budget Amount *help |
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2007: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2006: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
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| Research Abstract |
Risk assessment system for radiation has been well developed, so defining the radiation equivalent dose for chemical agents could place in the order of their risk. As well as the radiation, benzene causes leukemia to humans. Therefore, we evaluated the radiation equivalent dose for benzene based on its metabolites and low-dose rate radiation induced chromosome aberrations using CD34+ cells from human bone marrow, which is the target organ of benzene induced leukemia. As a result, the leukemia risk attributable to 1ppm of benzene inhalation was estimated 3.5×10-4-8.5×10-4, and that to 1μg/m3 of benzene inhalation was estimated 1.2×10-7-2.8×10-7. These values were better estimates than those in a previous study using human peripheral blood lymphocytes. We can perform more reliable risk assessment by using the proper experimental condition depending on the end points.
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