Novel Risk assessment method for chemicals using Radiation Equivalent coefficients
| Project/Area Number |
18206057
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Civil and environmental engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
MORISAWA Shinsuke Kyoto University, 工学研究科, 教授 (50026340)
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| Co-Investigator(Kenkyū-buntansha) |
YONEDA Minoru 京都大学, 工学研究科, 教授 (40182852)
NAKAYAMA Aki 京都大学, 工学研究科, 助教 (10335200)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2007: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2006: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
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| Keywords | 放射線等価係数 / 健康リスク / ベンゼン / 放射線 / 白血病 / DDT / 肝臓癌 / マイクロアレイ / カテコール / γ線 / 遺伝子発現 / 個人差 / リスク評価 / 染色体異常 / 体内動態モデル / ベンゼン代謝生成物 / バイオマーカー / タンパク質 |
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| Research Abstract |
Risk assessment system for radiation has been well developed, so defining the radiation equivalent dose for chemical agents could place in the order of their risk. As well as the radiation, benzene causes leukemia to humans. Therefore, we evaluated the radiation equivalent dose for benzene based on its metabolites and low-dose rate radiation induced chromosome aberrations using CD34+ cells from human bone marrow, which is the target organ of benzene induced leukemia. As a result, the leukemia risk attributable to 1ppm of benzene inhalation was estimated 3.5×10-4-8.5×10-4, and that to 1μg/m3 of benzene inhalation was estimated 1.2×10-7-2.8×10-7. These values were better estimates than those in a previous study using human peripheral blood lymphocytes. We can perform more reliable risk assessment by using the proper experimental condition depending on the end points.
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Report
(6 results)
Research Products
(25 results)
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[Journal Article] Benzene Risk Estimation using Radiation Equivalent Coefficients2009
Author(s)
Nakayama, A., Isono, I., Kikucni, I., Ohnishi I., Igarashi J., Yoneda, M., Morisawa S
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Journal Title
Risk Analysis 29
Pages: 380392-380392
Related Report
Peer Reviewed
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