Development of safe liver transplantation by modulation of transcription factor, nuclear factor kappa B (NF-kB)
| Project/Area Number |
18209041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
藤堂 省 Hokkaido University, 大学院・医学研究科, 教授 (60136463)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Michitaka 北海道大学, 大学院・医学研究科, 特任教授 (80256510)
梅澤 一夫 慶應義塾大学, 理工学部, 教授 (70114402)
岸野 吏志 明治薬科大学, 薬学部, 教授 (90373026)
古川 博之 北海道大学, 大学院・医学研究科, 特任教授 (70292026)
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| Co-Investigator(Renkei-kenkyūsha) |
UMEZAWA Umezawa 慶應義塾大学, 理工学部, 教授 (70114402)
KISHINO Satoshi 明治薬科大学, 薬学部, 教授 (90373026)
FURUKAWA Hiroyuki 北海道大学, 大学院・医学研究科, 特任教授 (70292026)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000)
Fiscal Year 2008: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2007: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2006: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
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| Keywords | NF-kB / 免疫抑制 / 臓器保存 / 虚血再灌流障害 / 臓器移植 / 肝移植 / 拒絶反応 / NF kappa B / 虚血再灌流 / NF-KB / DHMEQ / 虚血・再かん流障害 |
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| Research Abstract |
移植後の拒絶反応と炎症を軽減するために、新規NF-kB阻害剤Qの効果、投与法、剤型を検討した。拒絶、炎症に関わる免疫担当細胞の抑制や、小動物の肝、小腸、心、膵島細胞移植および虚血再灌流で有効性が確認された。また、新規臓器保存液を試作し、肝および多くの細胞や心移植における冷保存障害の軽減に成功した。臨床開発に不可欠な生体~細胞での有効性が確認され、新たな臓器保護法の実用化が期待される。
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] A Novel Fully Human Anti-CD40 Monoclonal Antibody, 4D11, for Kidney Transplantation in Cynomolgus Monkeys2007
Author(s)
Imai A, Suzuki T, Sugitani A, Itoh T, Ueki S, Aoyagi T, Yamashita K, Taniguchi M, Takahashi N, Miura T, Shimamura T, FurukawaH, Todo S
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Journal Title
Transplantation 84(8)
Pages: 1020-1028
Related Report
Peer Reviewed
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[Journal Article] Control of allograft rejection by applying a novel NF-kB inhibitor, dehydroxymethylepoxyquinomicin.2006
Author(s)
Shinya Ueki, Kenichiro Yamashita, Takeshi Aoyagi, Sanae Haga, Tomomi Suzuki, Tomoo Itoh, Masahiko Taniguchi, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
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Journal Title
Transplantation 82・12
Pages: 1720-1727
Related Report
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[Journal Article] The novel NF-kB inhibitor, Dehydroxymethylepoxyquinomicin(DHMEQ)prevents local and remote organ injury following intestinal ischemia/reperfusion in rats.
Author(s)
Tomomi Suzuki, Kenichiro Yamashita, Wataru Jomen, Shinya Ueki, Takeshi Aoyagi, Moto Fukai, Hiroyuki Furukawa, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo
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Journal Title
Related Report
Peer Reviewed
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[Presentation] "THE IMMUNOMODULATORY EFFECT OF DONOR SPECIFIC TRANSFUSION PLUS NF-kB BLOCKADE BY UTILIZING A NOVEL INHIBITOR, DHMEQ.2008
Author(s)
Ryoichi Goto, Kenichiro Yamashita, Takeshi Aoyagi, Shinya Ueki, Rumi Igarashi, Motohiro Uno, Tetsu Oura, Masaaki Watanabe, Tomohiro Shibata, Masahiko Taniguchi, Tomomi Suzuki, Tsuyoshi Shimamura, Hiroyuki furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
Organizer
8th international conference
Place of Presentation
Berlin, Germany Intercontinental Berlin hotel
Related Report
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[Presentation] "EFFECT OF A NOVEL NF-kB INHIBITOR, DEHYDROXYMETHYLEPOXYQUINOMICIN IN COMBINATION WITH DONOR SPECIFIC TRANSFUSION IN MOUSE HEART TRANSPLANTATION.2007
Author(s)
Ryoichi Goto, Kenichiro Yamashita, Takeshi Aoyagi, Motohiro Uno, Shinya Ueki, Tomoo Itoh, Masahiko Taniguchi, Tomomi Suzuki, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
Organizer
American Transplant Congress
Place of Presentation
San Francisco, CA Moscone West Convention Cneter
Related Report
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