Research of emission and international comparison of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in Pan-Japan Sea cities

• Project/Area Number: 18256002
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Environmental pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: HAYAKAWA Kazuichi Kanazawa University, 薬学系, 教授 (40115267)
• Co-Investigator(Kenkyū-buntansha): TORIBA Akira 金沢大学, 薬学系, 准教授 (50313680) ; KAMEDA Takayuki 金沢大学, 薬学系, 助教 (50398426) ; TOU Nei 金沢大学, 薬学系, 助教 (90372490) ; 田村 憲治 (独)国立環境研究所, 環境健康研究領域 疫学・国際保健研究室, 主任研究員 (10179898)
• Co-Investigator(Renkei-kenkyūsha): TAMURA Kenji (独)国立環境研究所, 環境健康研究領域・疫学・国際保健研究室, 主任研究員 (10179898)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000); Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2007: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2006: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
• Keywords: 多環芳香族炭化水素 / ニトロ多環芳香族炭化水素 / 発生源 / 長距離輸送 / 毒性 / 曝露 / 代謝 / 中国 / 組成比 / 石炭燃焼 / 自動車 / 代謝物 / 個人曝露 / フッ素イオン / 変異原性 / 活性酸素 / 大気浮遊粉じん / 石炭 / 日本海

Research Abstract

本研究では, 環日本海域の主要大気汚染物質の一つである多環芳香族炭化水素(PAH)及びニトロ多環芳香族炭化水素(NPAH)について次の成果を得た。1) 大気中のガス状と粒子状とを分別捕集する装置を開発し, 実大気中の存在状態を明らかにした。2) 能登半島先端の大気中PAH及びフッ素の一部が中国から長距離輸送され, 前者は中国の冬季の石炭暖房, 後者は黄砂嵐が主発生要因であることを明らかにした。3) 最近の環日本海域の大気汚染傾向と毒性の強さ及びPAH,NPAH濃度との関係を明らかにした。4) ヒトのNPAHの曝露を, 尿中代謝物を用いて明らかにするLC-MS/MS分析法を開発した。これを用いて, 中国瀋陽市の住民(学童)の尿中1-NP代謝物は日本人より高いことを明らかにした。

Research Products

• [Journal Article] Exposures to particulate air pollution and nitro-polycyclic aromatic hydrocarbons amongst taxi drivers in Shenyang, China (2009)
  • Author(s): Miller-Schlze, J. P., Toriba, A., Tang, N., Hayakawa, K., Tamura, K., Dong, L., Simpson, C. D.
  • Journal Title: Environ Sci. Technol 27
  • URL: http://pubs.acs.orgonFeb
  • Peer Reviewed
• [Journal Article] Analysis of atmospheric polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in gas/particle phases separately collected by a high-volume air sampler equipped with a column packed with XAD-4 resin (2009)
  • Author(s): Araki, Y., Tang, N., Ohno, M., Kameda, T., Toriba, A., Hayakawa, K.
  • Journal Title: J. Health Sci 55(1) Pages: 77-85
  • NAID: 110007055928
  • Peer Reviewed
• [Journal Article] Study of solid extraction for the determination of sequestering agensts in river water by high-performance liquid chromatography. (2009)
  • Author(s): Kemmei, Tomoko
  • Journal Title: Journal of Chromatography A 1216 Pages: 1109-1114
  • Peer Reviewed
• [Journal Article] Analysis of Atmospheric Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Aromatic Hydrocarbons in Gas/Particle Phases Separately Collected by a High-volume Air Sampler Equipped with a Column Packedwith XAD-4 Resin. (2009)
  • Author(s): Araki, Yuki
  • Journal Title: Journal of Health Science 55 Pages: 77-85
  • Peer Reviewed
• [Journal Article] A facile method for the detection of aldehydes in oxidized lipids using solid-phase microextraction fiber and gas chromatograph equipped with a septum-free iniector. (2009)
  • Author(s): Arato, Shingo
  • Journal Title: Journal of Oleo Science 58 Pages: 17-22
  • Peer Reviewed
• [Journal Article] 環境汚染物質の分解・処理について (2009)
  • Author(s): 早川和一
  • Journal Title: 薬学雑誌 129 Pages: 35-43
  • NAID: 110007028555
  • Peer Reviewed
• [Journal Article] Interaction of hydroxylated polycyclic aromatic hydrocarbons to estrogen receptor. Polycycl (2008)
  • Author(s): Hayakawa, K., Onoda, Y., Tachikawa, C., Yoshita, M., Toriba, A., Kameda, T., Tang, N.
  • Journal Title: Aromat. Comp 28(4) Pages: 382-391
  • Peer Reviewed
• [Journal Article] Cigrette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line (2008)
  • Author(s): Shizu, M., Itoh, Y., Sunahara, R., Chujo, S., Hayashi, H., Ide, Y., Takii, T., Koshiko, M., Chung, S. W., Hayakawa, K., Miyazawa, K., Hirose, K., Onozaki, K.
  • Journal Title: J. Interferon Cytokine Res.,August 28(8) Pages: 509-522
  • Peer Reviewed
• [Journal Article] Direct measurement of the glucuronide conjugate of 1-hydroxypyrene in human urine by using liquid chromatography with tandem mass spectrometry (2008)
  • Author(s): Kakimoto, K., Toriba, A., Ohno, T., Ueno, M., Kameda, T., Tang, N., Hayakawa, K
  • Journal Title: J. Chromatogr. B 867 Pages: 259-263
  • NAID: 10028001109
  • Peer Reviewed
• [Journal Article] Evaluation of endocrine disrupting activities of monohydroxylated derivatives of 1-nitropyrene by yeast two-hybrid assay (2008)
  • Author(s): Kameda, T., Akiyama, A., Toriba, A., Tachikawa, C., Yoshita, M., Tang, N., Hayakawa, K.
  • Journal Title: J. Health Sci 54(1) Pages: 18-22
  • NAID: 110006570814
  • Peer Reviewed
• [Journal Article] PAH, NPAH, 変異原性および活性酸素種生成能から見た北九州と鉄嶺の大気汚染の比較 (2008)
  • Author(s): 戸次加奈江, 唐 寧, 鳥羽 陽, 早川和二
  • Journal Title: 産業医科大学雑誌 30(1) Pages: 39-45
  • Peer Reviewed
• [Journal Article] Thin layer chromatography/fluorescence detection of 3, 4-methylenedioxy-methamphetamine and related compounds (2008)
  • Author(s): Kato, Noriyuki
  • Journal Title: Journal of Forensic Sciences 53 Pages: 1367-1371
  • Peer Reviewed
• [Journal Article] Determination of adulteration in apple juice by HPLC with novel optical rotation detector. (2008)
  • Author(s): Yamamoto, Atsushi
  • Journal Title: Journal of Agricultural and Food Chemistry 56 Pages: 7302-7304
  • Peer Reviewed
• [Journal Article] A fast and simple analysis of glyphosate in tea beverages by capillary electrophoresis with on-line copper (II)-glyphosate complex formation. (2008)
  • Author(s): Kodama, Shinji
  • Journal Title: Journal of Health Science 54 Pages: 602-606
  • Peer Reviewed
• [Journal Article] A-Clean-up Method by Photocatalysis for HPLC Analysis of Iprodione in Dry Basil. (2008)
  • Author(s): Maeda, Osamu
  • Journal Title: Analytical Sciences 24 Pages: 1053-1055
  • Peer Reviewed
• [Journal Article] Direct measurement of the glucuronide conjugate of 1-hydroxypyrene in human urine by using liquid chromatography with tandem mass spectrometrv. (2008)
  • Author(s): Kakimoto, Kensaku
  • Journal Title: Journal of Chromatography B 867 Pages: 259-263
  • Peer Reviewed
• [Journal Article] An Optical Rotatory Detecter for High-Performance Liquid Chromatography Using Polarization Modulation. (2008)
  • Author(s): Yamamoto, Atsushi
  • Journal Title: Analytical Sciences 24 Pages: 361-364
  • Peer Reviewed
• [Journal Article] Evaluation of Endocrine Disrupting Activities of Monohydroxylated Derivatives of 1-Nitropyrene by Yeast Two-hybrid Assay. (2008)
  • Author(s): Kameda, Takayuki
  • Journal Title: Journal of Health Science 54 Pages: 118-122
  • NAID: 110006570814
  • Peer Reviewed
• [Journal Article] 東アジアの有害大気汚染-多環芳香族炭化水素とニトロ多環芳香族炭化水素- (2008)
  • Author(s): 早川和一
  • Journal Title: ぶんせき 6 Pages: 278-284
  • NAID: 120006338341
  • Peer Reviewed
• [Journal Article] PAH, NPAH,変異原性および活性酸素種生成能から見た北九州と鉄嶺の大気汚染の比較 (2008)
  • Author(s): 戸次 加奈江
  • Journal Title: 産業医科大学雑誌 30 Pages: 39-45
  • Peer Reviewed
• [Journal Article] Activation of 5-lipoxygenase and NF-κB in the action of acenaphthenequinone by modulation of oxidative stress (2007)
  • Author(s): Chung, S.-W., Toriba, A., Chung, H.-Y., Yu, B.-P., Kameda, T., Tang, N., Kizu, R., Hayakawa, K.
  • Journal Title: Toxicol. Sci 101(1) Pages: 152-158
  • Peer Reviewed
• [Journal Article] Identification of estrogenic/anti-estrogenic compounds in diesel exhaust particulate extract (2007)
  • Author(s): Noguchi, K., Toriba, A., Chung, S.-W., Kizu, R., Hayakawa, K.
  • Journal Title: Biomed. Chromatogr 21(11) Pages: 1135-1142
  • Peer Reviewed
• [Journal Article] Estrogenic/antiestrogenic activities of polycyclic aromatic hydrocarbons and their monohydroxylated derivatives by Yeast two-hybrid assay (2007)
  • Author(s): Hayakawa, K., Onoda, Y., Tachikawa, C., Hosoi, S., Yoshita, M., Chung, S.-W., Kizu, R., Toriba, A., Kameda, T., and Tang, N.
  • Journal Title: J. Health Sci 53(5) Pages: 562-570
  • NAID: 110006402642
  • Peer Reviewed
• [Journal Article] Analysis of 1-nitropyrene in air particulate matter standard reference materials by using two-dimensional high performance liquid chromatography with online reduction and tandem mass spectrometry detection (2007)
  • Author(s): Miller-Schulze, J. P., Paulsen, M., Toriba, A., Hayakawa, K., Simpson, C. D.
  • Journal Title: J. Chromatogr. A 1167 Pages: 154-160
  • Peer Reviewed
• [Journal Article] Identification and quantification of 1-Nitropyrene Metabolites in human urine as a proposed biomarker for exposure to diesel exhaust (2007)
  • Author(s): Toriba, A., Kitaoka, H., Dills, R., Mizukami, S., Tanabe, K., Takeuchi, N., Ueno, M., Kameda, T., Tang, N., Hayakawa, K., Simpson, C.
  • Journal Title: Chem. Res. Toxicol 20(7) Pages: 999-1007
  • Peer Reviewed
• [Journal Article] Long-range transportation of polycyclic aromatic hydrocarbons (PAHs) from the eastern Asian continent to Kanazawa, Japan with Asian dust (2007)
  • Author(s): Tamamura, S., Sato, T., Ota, Y., Wang, X., Tang, N., Hayakawa, K.
  • Journal Title: Atmos. Environ 41(12) Pages: 2580-2593
  • Peer Reviewed
• [Journal Article] Long-Range transportation of polycyclic aromatic hydrocarbons from China to Japan (2007)
  • Author(s): Yang, X.-Y., Okada, Y., Tang, N., Matsunaga, S., Tamura, K., Lin, J-M., Kameda,T., Toriba, A., Hayakawa, K.
  • Journal Title: Atmos. Environ 41(13) Pages: 2710-2718
  • Peer Reviewed
• [Journal Article] Profiles of particulate-bound polycyclic aromatic hydrocarbons and their nitrated derivatives in three typical cities (2007)
  • Author(s): Hattori, T., Tang, N., Tamura, K., Hokoda, A., Yang, X.-Y., Igarash K., Ohno, M., Okada, Y., Kameda, T., Toriba, A., Hayakawa, K.
  • Journal Title: liaoning province, China, Environ. Forensics 8(1&2) Pages: 165-172
  • Peer Reviewed
• [Journal Article] Analysis of 1-nitropyrene in air particulate matter standard reference materials by using two-dimensional high performance liquid chromatography with online reduction and tandem mass spectrometry detection (2007)
  • Author(s): Miller-Schlze, J. P.
  • Journal Title: J. Chromatogr. A 1167 Pages: 154-160
  • Peer Reviewed
• [Journal Article] Identification and quantification of 1-nitropyrene metabolites in human urine as a proposed biomarker for exposure to diesel exhaust (2007)
  • Author(s): Toriba, Akira
  • Journal Title: Chem. Res. Toxicol 20 Pages: 999-1007
  • Peer Reviewed
• [Journal Article] Degradation of benzo[a]pyrene using TiO_2 and Ag-loaded BiVO_4 photocatalysts: Evaluation by the Ames Test (2007)
  • Author(s): Kohtani, Shigeru
  • Journal Title: J. Adv. Oxidation Technol 10 Pages: 381-386
  • Peer Reviewed
• [Journal Article] Minireview: Bionmarkers of exposure to polycyclic aromatic hydrocarbons and related compounds (2007)
  • Author(s): Toriba, Akira
  • Journal Title: Biomed. Chromatogr 53 Pages: 631-638
  • Peer Reviewed
• [Journal Article] 分析化学総説:有害性ニトロ多環芳香族炭化水素類を対象とする分析法の開発と環境動態解析 (2007)
  • Author(s): 早川 和一
  • Journal Title: 分析化学 56 Pages: 905-920
  • Peer Reviewed
• [Journal Article] 総説:経気道曝露化学物質とヒトの健康 (2007)
  • Author(s): 早川 和一
  • Journal Title: 薬学雑誌 127 Pages: 429-436
  • Peer Reviewed
• [Journal Article] Review: Development of analytical methods for polycyclic aromatic hydrocarbon compounds (PAHs) in airborne particulates. (2007)
  • Author(s): Liu, Li-bin
  • Journal Title: J. Envirn. Sci 19 Pages: 1-11
  • Peer Reviewed
• [Journal Article] 多環芳香族炭化水素及びニトロ多環芳香族炭化水素から見た中国東北地方の大気環境 (2007)
  • Author(s): 唐 寧, 田村憲治, 楊 小陽, 亀田 貴之, 鳥羽 陽, 早川和一
  • Journal Title: J.Ecotech.Res. 13・1 Pages: 35-42
  • NAID: 130004956006
• [Journal Article] Study on atmospheric polycyclic aromatic hydrocarbons at a background site of Ishikawa prefecture, Japan. (2007)
  • Author(s): Yang, X.-Y, Okada, Y, Tang, N, Toriba, A, Hayakawa K.
  • Journal Title: J.Ecotech.Res. 13・1 Pages: 5-9
  • NAID: 130004956004
• [Journal Article] Deposition analysis of non sea-salt sulfate and nitrate along to the northwest winter monsoon in Hokuriku district by a snow boring core and bulk samples. (2007)
  • Author(s): Honoki, H, Watanabe, K, Iida, H, Kawada, K, Hayakawa, K.
  • Journal Title: Bull. Glaciological Res. 24 Pages: 23-28
  • NAID: 10018709868
• [Journal Article] Specific Separation of Polar Analytes on a Medium Polar Stationary Phase by Gas Chromatography with CalTier Gas Containing vaporous Modifiers. (2007)
  • Author(s): Ito, H, Murase, A, Kodama, S, Yamamoto, A, Hayakawa, K, et al.
  • Journal Title: Chromatography 28・1 Pages: 25-28
• [Journal Article] Profiles of Particulate-Bound Polycyclic Aromatic Hydrocarbons and Their Nitrated Delivatives in Three Typical Cities, Liaoning Province, China. (2007)
  • Author(s): Hattori, T, Tang, N, Tamum, K, Toriba, A, Hayakawa, K, et al.
  • Journal Title: Environ.Foreisic Sci. 8・1-2 Pages: 165-172
• [Journal Article] Rapid and sensitive determination of tryptophan,serotonin and psychoactive tryptamines by thin-layer chromatography/fluorescence detection. (2007)
  • Author(s): Kato, N, Toriba, A, Nishimura, H, Hayakawa K, et al.
  • Journal Title: J. Chromatogr, A 1145・1-2 Pages: 229-233
• [Journal Article] Bisphenol A(BPA)and its source in foods in Japanese markets. (2007)
  • Author(s): Sajiki, J, Miyamoto, F, Fukata, H, Mori, C, Yonekubo, J, Hayakawa,K.
  • Journal Title: Food Addit. Contam. 24・1 Pages: 103-112
• [Journal Article] Occurrence of Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls in Shark Liver Oil Supplements. (2007)
  • Author(s): Akutsu, K, Tanaka, Y, Hayakawa, K.
  • Journal Title: Food Addit. Contam. 23・12 Pages: 1323-1329
• [Journal Article] Determination of 1-nitropyrene metabolites by HPLC with chemiluminescence detection and its application to human urine as a new biomarker of exposure to diesel exhaust (2006)
  • Author(s): Hayakawa, K., Toriba, A., Lu, C., Mizukami, S., Kameda, T., Tang, N.
  • Journal Title: Luminescence 21(6) Pages: 321-322
  • Peer Reviewed
• [Journal Article] Simultaneous determination of urinary hydrxylated metabolites of naphthalene, fluorine, phenanthrene, fluoranthene and pyrene as multiple biomarkers of exposure to polycyclic aromatic hydrocarbons (2006)
  • Author(s): Chetiyanukornkul, T., Toriba, A., Kameda, T., Tang, N., Hayakawa, K.
  • Journal Title: Anal. Bioanal. Chem 386 Pages: 712-718
  • Peer Reviewed
• [Journal Article] Determination of 1-nitropyrene metabolites by high performance liquid chromatography with chemiluminescence detection (2006)
  • Author(s): Hayakawa, K., Lu, C., Mizukami, S., Toriba, A., Tang, N.
  • Journal Title: J. Chromatogr. A 1107 Pages: 286-289
  • Peer Reviewed
• [Journal Article] Determination of 1-nitropyrene metabolites by HPLC with chemnuminescence detection and its appncation to human urine as a new biomarker of exposule to diesel exhaust. (2006)
  • Author(s): Hayakawa, K, Toriba, A, Lu, C, Mizukami, S, Kameda, T, Tang,N.
  • Journal Title: Luminescence 21・6 Pages: 320-386
• [Journal Article] Chiral Capnlaly Electrophoresis ofAmphetamine-type Stimulants. (2006)
  • Author(s): Chinaka, S, Iio, R, Tilkayama, N, Kodama, S, Hayakawa,K.
  • Journal Title: J.Health Science 52・6 Pages: 649-654
• [Journal Article] Simultaneous determination of urinary hydrxylated metabolites of naphthalene, fluorine, phenanthrene, fluoranthene and pyrene as multiple biomarkers ofexposure to polycyclic aromatic hydrocarbons. (2006)
  • Author(s): Chetiyanukomkul, T, Toriba, A, Kameda, T, Tang, N, Hayakawa,K
  • Journal Title: Anal.Bioanal.Chem. 386 Pages: 712-718
• [Journal Article] Development of Septum-Free lnjector for Gas Chromatography and Its Appncation to The Sample with a High Boiling Point. (2006)
  • Author(s): Ito, H, Hayakawa, K, Yamamoto, A, Hayakawa, K, Inoue Y., et al.
  • Journal Title: J. Chromatogr. A 1132 Pages: 256-259
• [Journal Article] Chiral Capillary Electrophoresis of Agrochemicals in Real Samples. (2006)
  • Author(s): Kodama, S, Saito, Y, Chinaka, S, Yamamoto, A, Hayakawa,K.
  • Journal Title: J.Health Science 52・5 Pages: 489-494
  • NAID: 110004809603
• [Journal Article] Components of diesel exhaust particles differentially affect Th1/Th2 response in a murine model of allergic airway inflammation. (2006)
  • Author(s): Yanagisawa, R, Yoshino, S, Yamaki, K, Yoshikawa, T, Hayakawa, K., et al.
  • Journal Title: Clin. Exp. Allergy 36 Pages: 386-395
• [Journal Article] A new On-line Sample Preparation System for the Liquid Chromatography/Time-of-Flight Mass Spectrometly Simultaneous Analysis of Pestisides in River Water. (2006)
  • Author(s): Sasaki, H, Yoneklibo, J, Hayakawa, K.
  • Journal Title: Anal.Sci. 22・6 Pages: 835-840
• [Journal Article] Atmospheric Deposition of Polychlorinated Dibenzo-p-dioxins (PCDDs)and Polyclorinated Dibenzonfurans (PCDFs)in Kanazawa, Japan. (2006)
  • Author(s): Oka, H, Kakimoto, H, Kyudoh, H, Kizu, R, Hayakawa, K. et al.
  • Journal Title: J.Health Science 52・3 Pages: 300-307
• [Journal Article] Thymic involution produced by diesel exhaust particles and their constituents in mice. (2006)
  • Author(s): Tomita, S, Kizu, R, Hayakawa, K, Koremaga, T, Takahama, Y., et al.
  • Journal Title: Toxicol.Environ.Chemi. 88・1 Pages: 113-124
• [Journal Article] Homologue and isomer distribution of dioxins observed in water samples collected from Kahokugata Lagoon and inflowing rivers, Japan. (2006)
  • Author(s): Kakimoto, H, Oka, H, Tonba, A, Kizu, R, Hayakawa, K., et al.
  • Journal Title: Water Res. 40・10 Pages: 1929-1940
• [Journal Article] Seasonal Change of Gas/Particle Partitioning of Atmospheric Dioxins. (2006)
  • Author(s): Oka, H, Tang, N, Toriba A, Kizu, R, Hayakawa, K., at al.
  • Journal Title: J.Health Sci. 52・1 Pages: 50-57
  • NAID: 110006163214
• [Journal Article] Comparison of traditional cloud-point extraction and on-line flow-injection cloud-point extraction with a chemiluminescence method using benzo[α]pyrene as a marler. (2006)
  • Author(s): Song, Q.G, Lu, C, Hayakawa, K, Lin, J-M.
  • Journal Title: Anal.Bioanal.Chem. 384 Pages: 1007-1012
• [Journal Article] Damage to and recovery of coastlines polluted with C-heavy oil spilled from Nakhodka. (2006)
  • Author(s): Hayakawa, K, Kawanishi, T, Toriba, A, Kizu, R, Tamiya, E., et al.
  • Journal Title: Water Res 40・5 Pages: 981-989
• [Journal Article] Determination of 1-nitropyrene metabolites by high performance liquid chromatography with chemiluminescence detection. (2006)
  • Author(s): Hayakawa, K, Lu, C, Mizukami, S, Toriba, A, Tang, N.
  • Journal Title: J.Chromatogr. A 1107 Pages: 286-289
• [Journal Article] 大気中の多環芳香族炭化水素類の計測法とその発生・動態解析研究の進歩 (2006)
  • Author(s): Kameda, T, Hayakawa, K.
  • Journal Title: 自動車研究 28・12 Pages: 653-657
• [Journal Article] Long-range transport of fluoride in East Asia monitored at Noto Penninsula
  • Author(s): Yang, X.-Y., Yamada, M., Tang, N., Lin J.-M., Kameda, T., Toriba, A., Hayakawa, K
  • Journal Title: Japan, Sci., Total Environ (in press)
  • Peer Reviewed
• [Journal Article] Determination of 1-nitropyrene in low volume anbient air samples by high-performance liquid chromatograph with fluorescence detection
  • Author(s): Ohno, T., Toriba, A., Kameda, T., Tang, N., Hayakawa, K
  • Journal Title: J. Chromatogr. A (in press)
  • Peer Reviewed
• [Journal Article] Development of septum-free injector for gas chromatography and its application to the samples with a high boiling point.
  • Author(s): Ito, H, Yamamoto, A, Murase, A, Hayakawa, K, Kino, M, Inoue, Y., et al.
  • Journal Title: Anal.Sci. (in press)
• [Journal Article] Long-range transportation of polycyclic aromatic hydrocarbons (PAHs)from the eastern Asian continent to Kanazawa, Japan with Asian dust.
  • Author(s): Tamamura, S, Sato, T, Ota, Y, Wang, X, Tang, N, Hayakawa,K.
  • Journal Title: Atmos.Environ. (in press)
• [Journal Article] A Determination Method for Nitrocatecholamines in Rat Brain with High-Performance Liquid Chromatography-Peroxyoxalate Chemiluminescence Detection.
  • Author(s): Tsimoda, M, Uchino, E, Imai, K, Hayakawa, K, Funatsu,T.
  • Journal Title: Chromatographia (in press)
• [Journal Article] Long-Range Transportation of Polycyclic Aromatic Hydrocarbons from China to Japan.
  • Author(s): Yallg, X.-Y, 0kada, Y, Tang, N, Matsunaga, S, Tamura, K, Kameda, T, Toriba, A, Hayakawa,K.
  • Journal Title: Atmos.Environ. (in press)
• [Journal Article] Environmental quinoid polycyclic aromatic hydrocarbon, acenaththenequinone, modulates COX expression through ROS genemtion and NF-_KB activation in A549 cells.
  • Author(s): Chung, S.-W, Chung, H.-Y, Tonba, A, Hayakawa, K.
  • Journal Title: Toxicol.Sci. (in press)
• [Presentation] 固相抽出-HPLC法による海水中のEDTA分析 (2009)
  • Author(s): 健名智子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 京都
• [Presentation] LC-MS/MSによる尿中ベンソ[α]ピレン代謝物分析法の開発 (2009)
  • Author(s): 鳥羽陽
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 京都
• [Presentation] 尿直接導入キャピラリー電気泳動/質量分析(CE/MS)法による抱合体を含む覚せい剤代謝物の定量 (2009)
  • Author(s): 飯尾麗子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 京都
• [Presentation] 光反応によって二次生成するニトロピレン水酸化体の大気内動態 (2009)
  • Author(s): 亀田貴之
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 京都
• [Presentation] インライン還元-蛍光検出HPLC法を用いた実大気粒子中多環芳香族炭化水素キノン類の測定 (2009)
  • Author(s): 後藤知子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 京都
• [Presentation] 光触媒を用いた農薬含有食品試料の精製法の検討 (2009)
  • Author(s): 前田理
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 京都
• [Presentation] LC-MS/MSによる尿中ベンゾ[α]ピレン代謝物の検出 (2008)
  • Author(s): 上野真利子
  • Organizer: 日本薬学会北陸支部第119回例会
  • Place of Presentation: 金沢
  • Year and Date: 2008-11-09
• [Presentation] 中国瀋陽市における大気中多環芳香族炭化水素類の汚染現状と推移 (2008)
  • Author(s): 徳田貴裕
  • Organizer: 日本薬学会北陸支部第118回例会
  • Place of Presentation: 富山
  • Year and Date: 2008-07-05
• [Presentation] Atmospheric Behaviors of Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Aromatic Hydrocarbons in East Asia. (2008)
  • Author(s): Hayakawa, Kazuichi
  • Organizer: Environmental Research of Young Researcher's Symposium in the Pan-Japan Sea
  • Place of Presentation: Kanazawa, Japan
  • Year and Date: 2008-01-16
• [Presentation] Behaviors and toxicities of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons (2008)
  • Author(s): Hayakawa, K., Tang, N., Kameda, T., Toriba, A.
  • Organizer: 12^<th> Asia Pacific Confederation of Chemical Engineering Congress
  • Place of Presentation: Dalian, China
• [Presentation] 人為燃焼粉じん中硫黄多環芳香族化合物の比較と都市大気汚染への寄与 (2008)
  • Author(s): 大野敬典
  • Organizer: フォーラム2008 : 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
• [Presentation] ディーゼル排ガス曝露指標を指向したヒト尿中1-ニトロピレン(1-NP)代謝物の定量-中国・上海市及び瀋陽市における小学生を対象とする曝露調査- (2008)
  • Author(s): 竹内直樹
  • Organizer: フォーラム2008 : 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
• [Presentation] 人為発生燃焼粉じん中多環芳香族炭化水素の組成及び変異原性の比較 (2008)
  • Author(s): 楊小陽
  • Organizer: フォーラム2008 : 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
• [Presentation] Urinary 1-Nitropyrene Metabolites in Taxi Drivers in Shenyang (2008)
  • Author(s): Toriba, Akira
  • Organizer: China. 2008 Joint ISEE-ISEA Conference : Exposure and Health in a Global Environment
  • Place of Presentation: Pasadena, USA
• [Presentation] 瀋陽における大気粉じん中多環芳香族炭化水素の比較 (2008)
  • Author(s): 唐寧
  • Organizer: 第49回大気環境学会年会
  • Place of Presentation: 金沢
• [Presentation] 固相抽出-HPLC法による環境水中金属イオン封鎖剤の定量 (2008)
  • Author(s): 健名智子
  • Organizer: 日本分析化学会第57年会
  • Place of Presentation: 福岡
• [Presentation] オンライン銅錯体形成を利用した茶飲料混入グリホサートの迅速キャピラリー電気泳動分析 (2008)
  • Author(s): 小玉修嗣
  • Organizer: 日本分析化学会第57年会
  • Place of Presentation: 福岡
• [Presentation] Environment and Pharmaceuticals (2008)
  • Author(s): Hayakawa, Kazuichi
  • Organizer: 68^<th> International Congress of FIP
  • Place of Presentation: Basel, Switzerland
• [Presentation] ジオール基導入化学修飾キャピラリーを用いたキャピラリー電気泳動法による覚せい剤類の迅速で泳動時間再現性の高い尿直接導入光学異性体分析 (2008)
  • Author(s): 岩室嘉晃
  • Organizer: 日本法中毒学会第27年会
  • Place of Presentation: 東京
• [Presentation] 環日本海域諸国における多環芳香族炭化水素及びニトロ多環芳香族炭化水素の挙動と健康影響 (2008)
  • Author(s): 早川和一
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸
• [Presentation] 日本海表層水におけるPAHs・POPsの調査結果について (2008)
  • Author(s): 川西啄也
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸
• [Presentation] ヒドロキシー1-ニトロピレンの内分泌かく乱作用および大気環境中動態 (2008)
  • Author(s): 亀田貴之
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸
• [Presentation] Study on atmospheric fluoride ion at Wajima on the Noto peninsula, Japan (2008)
  • Author(s): Yang, Xiaoyang
  • Organizer: Agenda for Environmental Forensics Conference
  • Place of Presentation: Qingdao, China
• [Presentation] 光触媒を用いた乾燥食品中のイプロジオンの定量法の開発 (2008)
  • Author(s): 前田理
  • Organizer: 第69回分析化学討論会
  • Place of Presentation: 名古屋
• [Presentation] 大気中二次生成2-ニトロフルオランテンと2-ニトロピレンの同時分析法の改良と応用 (2008)
  • Author(s): 佐藤紘介
  • Organizer: 第69回分析化学討論会
  • Place of Presentation: 名古屋
• [Presentation] 大気中多環芳香族炭化水素類の様態別捕集・分析法の開発 (2008)
  • Author(s): 荒木裕樹
  • Organizer: 第69回分析化学討論会
  • Place of Presentation: 名古屋
• [Presentation] 多環芳香族炭化水素類の有害性と環境動態の追跡 (2008)
  • Author(s): 早川 和一
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
• [Presentation] 環境汚染物質の分解・処理について (2008)
  • Author(s): 早川 和一
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
• [Presentation] 多環芳香族炭化水素類キノン化合物の構造と活性酸素生成能 (2008)
  • Author(s): 本山 ユミ
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
• [Presentation] 能登半島輪島における大気中フッ化物イオン実態調査 (2008)
  • Author(s): 楊 小陽
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
• [Presentation] Polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in urban air and their long-lange transportation. (2008)
  • Author(s): Hayakawa, Kazuichi
  • Organizer: International Conference on Chemistry Chem 05 "Green and Sustainable Chemistry for Developing Countries
  • Place of Presentation: Cairo, Egypt
• [Presentation] Atmospheric behaviors and health effects of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in East Asias (2007)
  • Author(s): Hayakawa, K.
  • Organizer: International Forum for Public Health, Shanghai 2007
  • Place of Presentation: Shanghai, China
• [Presentation] Monitoring and atmospheric behaviors of carrcinogenic/endocrine disrupting chemicals in East Asias : Polycyclic aromatic hydrocarbons and nitropolycyclic derivatives (2007)
  • Author(s): Hayakawa, K., Tang, N., Kameda, T., Toriba, A.
  • Organizer: 4th Asian-Pacific international conference on pollutants' analysis and control
  • Place of Presentation: Beijing, China
• [Presentation] Atmospheric behaviors of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in East Asia (2007)
  • Author(s): Hayakawa, K., Tang, N., Kameda, T., Toriba, A.
  • Organizer: The 2007 Environmental Societies Joint Conference
  • Place of Presentation: Busan, Korea
• [Presentation] Atmospheric Behaviors and Health Effects of Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Aromatic Hydrocarbons in East Asia (2007)
  • Author(s): Hayakawa, Kazuichi
  • Organizer: International Forum for Public Health, Shanghai 2007
  • Place of Presentation: Shanghai, China
• [Presentation] アジア大陸起源のフッ化物イオンの日本への長距離輸送 (2007)
  • Author(s): 楊 小陽
  • Organizer: 第24回イオンクロマトグラフィー討論会
  • Place of Presentation: 名古屋
• [Presentation] The Environmental Carcinogen of Burning-drived Particulate Exhausts of Mutagenicity and Reactive Oxygen Species (2007)
  • Author(s): Bekki, Kanae
  • Organizer: 1st Asian Conference on Environmental Mutagens/36th Annual Meeting of The Japanese Environmental Mutagen Society
  • Place of Presentation: Kitakyushu, Japan
• [Presentation] アジア大陸起源の水溶性フッ化物イオンの日本への長距離輸送 (2007)
  • Author(s): 楊 小陽
  • Organizer: フォーラム2007:衛生薬学・環境トキシコロジー
  • Place of Presentation: 大阪
• [Presentation] ヒト尿中に排泄される1-ニトロピレン代謝物の基礎的検討 (2007)
  • Author(s): 竹内 直樹
  • Organizer: フォーラム2007:衛生薬学・環境トキシコロジー
  • Place of Presentation: 大阪
• [Presentation] LC-MS/MSによるベンゾ[a]ピレンDNA付加体の検出 (2007)
  • Author(s): 上野 真利子
  • Organizer: フォーラム2007:衛生薬学・環境トキシコロジー
  • Place of Presentation: 大阪
• [Presentation] Monitoring and Atmospheric Behaviors of Carrcinogenic/Endocrine Disrupting Chemicals in East Asis: Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Derivatives (2007)
  • Author(s): Hayakawa, Kazuichi
  • Organizer: 4th Asian-Pacific Ihternational Conference on Pollutants' Analysis and Control
  • Place of Presentation: Beijing, China
• [Presentation] Long-range transport of fluoride from the Asian Continent to Japan. (2007)
  • Author(s): Yang, X. -Y.
  • Organizer: 第48回大気環境学会年
  • Place of Presentation: 岡山
• [Presentation] 大気浮遊粒子およびディーゼル排気粒子中ヒドロキシニトロピレンの測定(2):捕集時における分解およびその補正法の検討 (2007)
  • Author(s): 秋山 鮎子
  • Organizer: 第48回大気環境学会年
  • Place of Presentation: 岡山
• [Presentation] 人為発生燃焼粉じん中の多環芳香族炭化水素類の組成と変異原性の比較 (2007)
  • Author(s): 唐 寧
  • Organizer: 第48回大気環境学会年
  • Place of Presentation: 岡山
• [Presentation] 大気バイオエアロゾル測定に向けたパーティクルカウンターの開発 (2007)
  • Author(s): 山田 丸
  • Organizer: 第48回大気環境学会年
  • Place of Presentation: 岡山
• [Presentation] 尿中1-ヒドロキシピレングルクロニドをバイオマーカーとする多環芳香族炭化水素の曝露評価 (2007)
  • Author(s): 鳥羽 陽
  • Organizer: 第48回大気環境学会年
  • Place of Presentation: 岡山
• [Presentation] Long-Range Transport of Fluoride from China to Japan (2007)
  • Author(s): Yang, X-Y.
  • Organizer: 5th Asian Aerosol Conference
  • Place of Presentation: Kaohsiung, Taiwan
• [Presentation] Mutagenicities of Burning-Derived Particulate Extracts and Contributions of Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Aromatic Hydrocarbons (2007)
  • Author(s): Bekki, Kanae
  • Organizer: 13th International Symposium on Toxicity Assessment
  • Place of Presentation: Toyama, Japan
• [Presentation] Indentification and Quantification of 1-Nitropyrene Metabohlites in Human Urine as a Proposed Biomarker for Exposure to Diesel Exhaust (2007)
  • Author(s): Toriba, Akira
  • Organizer: International Symposium of Polyaromatic Compounds meeting (ISPAC 21)
  • Place of Presentation: Trondheim, Norway
• [Presentation] 個人曝露評価のための粉じん中1-nitropyrene分析法の確立 (2007)
  • Author(s): 大野 敬典
  • Organizer: 第14回クロマトグラフィーシンポジウム
  • Place of Presentation: 富山
• [Presentation] Compositional and mutagenic difference of polycylcic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in burning-derived particulates (2007)
  • Author(s): Igarashi, Kazuhiko
  • Organizer: KOSAE-JSAE Joint Symposium
  • Place of Presentation: Busan, Korea
• [Book] その自然と文化を探るビスターリヒマラヤ (2009)
  • Author(s): 早川和一(分担執筆)御影雅幸(編著)
  • Total Pages: 230
  • Publisher: 京都廣川書店
• [Book] Past, Present and Future Environments of Pan-Japan Sea Region (2006)
  • Author(s): Hayakawa, K., Editorial Supervisor, Iwasaka, Y., Kanaoka, C., Kimura, S., Kizu, R., Toriba, A., Ibusuki, T., Komura, K., Yamamoto, M., Tazaki, K., Kawanishi, T., Arai S., Kato, M., Yatomi, C., Kamiya, T., Tsukawaki , S., Kashiwaya, K., Sato, T., Hasebe, N., Nakamura, K., Mikage, M., Sasayama, K., Kamata, N., Tnag, N.
  • Publisher: (Chief Editor), Maruzen, Tokyo
• [Book] ナホトカ号重油流出事故から10年 私たちは何を学んだか? (2006)
  • Author(s): 田崎和江, 早川和一
  • Total Pages: 98
  • Publisher: 金沢大学21世紀COEプログラム
• [Book] Past,Present and Future Environments of Pan-Japan Sea Region. (2006)
  • Author(s): Hayakawa, K, Editorial Supervisor
  • Total Pages: 605
  • Publisher: Maruzen