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Neural basis of memory errors

Research Project

Project/Area Number 18300087
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cognitive science
Research InstitutionTohoku University

Principal Investigator

FUJII Toshikatsu  Tohoku University, 大学院・医学系研究科, 准教授 (70271913)

Co-Investigator(Kenkyū-buntansha) 麦倉 俊司  東北大学, 病院, 助教 (20375017)
奥田 次郎  玉川大学, 脳科学研究所, 嘱託教員 (80384725)
森 悦朗 (森 悦郎)  東北大学, 大学院・医学系研究科, 教授 (30368477)
鈴木 麻希  サイクロトン・ラジオアイソトープセンター, 講師(研究機関研究員) (80422145)
Co-Investigator(Renkei-kenkyūsha) MORI Etsuro  東北大学, 大学院・医学系研究科, 教授 (30368477)
SUZUKI Maki  東北大学, サイクロトロン・ラジオアイソトープセンター, 講師 (80422145)
MUGIKURA Shunji  東北大学, 大学病院, 助教 (20375017)
OKUDA Jiro  京都産業大学, コンピュ-タ理工学部, 准教授 (80384725)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥13,880,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥4,000,000 (Direct Cost: ¥4,000,000)
Keywords脳認知科学 / 記憶錯誤 / 脳機能画像法 / 神経心理学 / 認知神経科学 / PET / f MRI / 内側側頭葉 / 前頭前野 / fMRI
Research Abstract

ヒトの記憶については心理学的・神経科学的な研究が数多く行われてきていたが、記憶の間違い-つまり、記憶として想起はできるものの内容が正確ではない場合-のメカニズムについては不明な点が多い。本研究ではヒトの脳活動を間接的に測定することができる脳機能画像法と、脳損傷患者を対象とした神経心理学的研究によって、ヒトの脳でどのように誤った記憶情報が表象されるのかを検討した。記憶を司る内側側頭葉に対して、記憶を制御する前頭前野が影響を与えていることや、内側側頭葉と感覚情報を処理する感覚皮質の関連が明らかとなった。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (39 results)

All 2008 2007 2006

All Journal Article (20 results) (of which Peer Reviewed: 11 results) Presentation (14 results) Book (5 results)

  • [Journal Article] Neural correlates of true memory, false memory, and deception2008

    • Author(s)
      Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T
    • Journal Title

      Cerebral Cortex 18

      Pages: 2811-2819

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of true memory, false memory, and deception2008

    • Author(s)
      Abe, et.al.
    • Journal Title

      Cerebral Cortex 18(12)

      Pages: 2811-2819

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] fMRI2008

    • Author(s)
      鈴木麻希, ら
    • Journal Title

      神経内科 68 Suppl.5

      Pages: 37-44

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 記憶障害-概論2008

    • Author(s)
      菊池大一, ら
    • Journal Title

      神経内科 68 Suppl.5

      Pages: 484-493

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 遂行機能障害の画像診断2008

    • Author(s)
      深津玲子, ら
    • Journal Title

      Journal of Clinical Rehabilitation 17

      Pages: 26-31

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information : a positron emission tomography study2007

    • Author(s)
      Ueno A, Abe N, Suzuki M, Hirayama K, Mori E, Tashiro M, Itoh M, Fujii T
    • Journal Title

      Neuroimage 34

      Pages: 1292-1298

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deceiving others : distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions2007

    • Author(s)
      Abe N, Suzuki M, Mori E, Itoh M, Fujii T
    • Journal Title

      Journal of Cognitive Neuroscience 19

      Pages: 287-295

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential involvement of regions of rostral prefrontal cortex (Brodmann area 10) in time-and event-based prospective memory2007

    • Author(s)
      Okuda J, Fujii T, Ohtake H, Tsukiura T, Yamadori A, Frith CD, Burgess PW
    • Journal Title

      International Journal of Psychophysiology 64

      Pages: 233-246

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective impairment in the retrieval of family relationships in person identification : a case study of delusional misidentification2007

    • Author(s)
      Abe N, Ishii H, Fujii T, Ueno A, Lee E, Ishioka T, Mori E
    • Journal Title

      Neuropsychologia 45

      Pages: 2902-2909

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pure word deafness and pure anarthria in a patient with frontotemporal dementia2007

    • Author(s)
      Iizuka O, Suzuki K, Endo K, Fujii T, Mori E
    • Journal Title

      European Journal of Neurology 14

      Pages: 473-475

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective impairment in the retrieval of family relationships in person identification: a case study of delusional misidentification2007

    • Author(s)
      Abe, et. al.
    • Journal Title

      Neuropsychologia 45

      Pages: 2902-2909

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential involvement of regions of rostral prefrontal cortex(Brodmann area 10)in time-and event-based prospective memory2007

    • Author(s)
      Okuda, et. al.
    • Journal Title

      International Journal of Psychophysiology 64

      Pages: 233-246

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deceiving others : distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions2007

    • Author(s)
      Abe, et al.
    • Journal Title

      Journal of Cognitive Neuroscience 19(2)

      Pages: 287-295

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information : a positron emission tomography study2007

    • Author(s)
      Ueno, et al.
    • Journal Title

      Neuroimage 34(3)

      Pages: 1292-1298

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pure word deafness and pure anarthria in a patient with frontotemporal dementia2007

    • Author(s)
      Iizuka, et al.
    • Journal Title

      European Journal of Neurology 14(4)

      Pages: 473-475

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dissociable roles of prefrontal and anterior cingulate cortices in deception2006

    • Author(s)
      Abe N, Suzuki M, Tsukiura T, Mori E, Yamaguchi K, Itoh M, Fujii T
    • Journal Title

      Cerebral Cortex 16

      Pages: 192-199

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dissociable roles of the bilateral anterior temporal lobe in face-name associations : an event-related fMRI study2006

    • Author(s)
      Tsukiura T, Mochizuki-Kawai H, Fujii T
    • Journal Title

      Neuroimage 30

      Pages: 617-626

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dissociable roles of prefrontal and anterior cingulate cortices in deception2006

    • Author(s)
      Abe, et al.
    • Journal Title

      Cerebral Cortex 16(2)

      Pages: 192-199

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dissociable roles of the bilateral anterior temporal lobe in face-name associations : an event-related fMRI study2006

    • Author(s)
      Tsukiura, et al.
    • Journal Title

      Neuroimage 30(2)

      Pages: 617-626

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 記憶障害.特集II失語・失行・失認・記憶障害.2006

    • Author(s)
      藤井俊勝, ら
    • Journal Title

      神経内科 65

      Pages: 291-296

    • Related Report
      2006 Annual Research Report
  • [Presentation] Activity in the medial temporal lobes predicts realization of intentions for future actions2008

    • Author(s)
      Okuda J, Abe N, Suzuki M, Fujii T
    • Organizer
      14th Annual meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] Neural mechanisms for the retrieval of time duration of past events2008

    • Author(s)
      Suzuki M, Abe N, Mugikura S, Ueno A, Shigemune Y, Shoki Takahashi S, Fujii T
    • Organizer
      15^<th> Cognitive Neuroscience Society Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Reactivation of medial temporal lobe and area MT/V5 during the retrieval of motion information : a PET study2008

    • Author(s)
      Ueno A, Abe N, Suzuki M, Shigemune Y, Hirayama K, Mori E, Tashiro M, Itoh M, Fujii T
    • Organizer
      15^<th> Cognitive Neuroscience Society Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of emotion and reward motivation on neural activity associated with episodic memory encoding : a PET study2008

    • Author(s)
      Shigemune Y, Abe N, Suzuki M, Ueno A, Mori E, Tashiro M, Itoh M, Fujii T
    • Organizer
      15^<th> Cognitive Neuroscience Society Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Recollection failure increases false recognition in patients with Alzheimer's disease2008

    • Author(s)
      Abe N, Fujii T, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Takagi M, Hiraoka K, Yamasaki H, Hirayama K, Choi H, Mori E
    • Organizer
      15^<th> Cognitive Neuroscience Society Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Roles of the medial frontal cortex and hippocampus in memory-guided future planning2008

    • Author(s)
      Okuda J, Watanabe M, Fujii T, Suzuki M, Abe N, Tsukada M
    • Organizer
      15^<th> Cognitive Neuroscience Society Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] The neural network for temporal order memory retrieval : evidence from lesion and PET studies2007

    • Author(s)
      Suzuki M, Hashimoto R, Hirayama K, Abe N, Ueno A, Tashiro M, Mori E, Itoh M, Fujii T
    • Organizer
      International Neuropsychological Society Mid-Year Meeting 2007
    • Place of Presentation
      Bilbao, Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] A peculiar form of delusional misidentification : a neuropsychological case study providing a window on person identification2007

    • Author(s)
      Abe N, Ishii H, Fujii T, Ueno A, Lee EJ, Ishioka T, Mori E
    • Organizer
      International Neuropsychological Society Mid-Year Meeting 2007
    • Place of Presentation
      Bilbao, Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] Brain mechanisms underlying dissociative retrograde amnesia : an fMRI study2007

    • Author(s)
      Kikuchi H, Fujii T, Abe N, Suzuki M, Mugikura S, Takahashi S, Mori E
    • Organizer
      International Neuropsychological Society Mid-Year Meeting 2007
    • Place of Presentation
      Bilbao, Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] Distinct medial temporal lobe activations associated with the retrieval of different types of information attached with items : an fMRI study2006

    • Author(s)
      Fujii T, Suzuki M, Abe N, Mugikura S, Ueno A, Mori E, Takahashi S
    • Organizer
      The 4^<th> International Conference on Memory
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] Neural basis of the retrieval of temporal order memory of experienced events : A PET study2006

    • Author(s)
      Suzuki M, Abe N, Ueno A, Tashiro M, Mori E, Itoh M, Fujii T
    • Organizer
      The 4^<th> International Conference on Memory
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] Brain activities associated with false memory and deception : an fMRI investigation2006

    • Author(s)
      Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T
    • Organizer
      The 4^<th> International Conference on Memory
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] Reactivation of medial temporal lobe and occipital lobe during retrieval of color information : a PET study2006

    • Author(s)
      Ueno A, Abe N, Suzuki M, Mori E, Tashiro M, Itoh M, Fujii T
    • Organizer
      12th Annual meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Florence, Italy
    • Related Report
      2008 Final Research Report
  • [Presentation] Neural correlates of successful retrieval of 'person' as an information source of episodic memory : an event-related fMRI study2006

    • Author(s)
      Mugikura S, Abe N, Suzuki M, Ueno A, Higano S, Takahashi S, Fujii T
    • Organizer
      12th Annual meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Florence, Italy
    • Related Report
      2008 Final Research Report
  • [Book] ヒトの海馬の機能イメ-ジング. 比較海馬学(渡辺茂, 岡市広成)2008

    • Author(s)
      藤井俊勝, 鈴木麻希
    • Publisher
      ナカニシヤ出版
    • Related Report
      2008 Final Research Report
  • [Book] The basal forebrain and episodic memory. In : Huston JP(ed) : Handbook of Behavioral Neuroscience Handbook of Episodic Memory, Dere E, Easton A, Nadel L, Huston JP(eds). Elsevier2008

    • Author(s)
      Fujii T
    • Publisher
      The Netherlands
    • Related Report
      2008 Final Research Report
  • [Book] Handbook of Behavioral Neuroscience, Vol. 18, Handbook of Episodic Memory2008

    • Author(s)
      Fuiii T
    • Publisher
      The basal forebrain and episodic memory
    • Related Report
      2008 Annual Research Report
  • [Book] ヒトの海馬の機能イメージングIn:『比較海馬学』渡辺茂、岡市広成編2008

    • Author(s)
      藤井俊勝、鈴木麻希
    • Publisher
      ナカニシヤ出版
    • Related Report
      2007 Annual Research Report
  • [Book] 嘘とだましの心理学-戦略的なだましからあたたかい嘘まで-(嘘の脳内メカニズム-脳機能画像研究を中心に In : )(箱田裕司, 仁平義明編)2006

    • Author(s)
      阿部修士, 藤井俊勝
    • Publisher
      有斐閣(東京)
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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