Neural basis of memory errors

• Project/Area Number: 18300087
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cognitive science
• Research Institution: Tohoku University
• Principal Investigator: FUJII Toshikatsu Tohoku University, 大学院・医学系研究科, 准教授 (70271913)
• Co-Investigator(Kenkyū-buntansha): 麦倉 俊司 東北大学, 病院, 助教 (20375017) ; 奥田 次郎 玉川大学, 脳科学研究所, 嘱託教員 (80384725) ; 森 悦朗 (森 悦郎) 東北大学, 大学院・医学系研究科, 教授 (30368477) ; 鈴木 麻希 サイクロトン・ラジオアイソトープセンター, 講師(研究機関研究員) (80422145)
• Co-Investigator(Renkei-kenkyūsha): MORI Etsuro 東北大学, 大学院・医学系研究科, 教授 (30368477) ; SUZUKI Maki 東北大学, サイクロトロン・ラジオアイソトープセンター, 講師 (80422145) ; MUGIKURA Shunji 東北大学, 大学病院, 助教 (20375017) ; OKUDA Jiro 京都産業大学, コンピュ-タ理工学部, 准教授 (80384725)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥13,880,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2006: ¥4,000,000 (Direct Cost: ¥4,000,000)
• Keywords: 脳認知科学 / 記憶錯誤 / 脳機能画像法 / 神経心理学 / 認知神経科学 / PET / f MRI / 内側側頭葉 / 前頭前野 / fMRI

Research Abstract

ヒトの記憶については心理学的・神経科学的な研究が数多く行われてきていたが、記憶の間違い-つまり、記憶として想起はできるものの内容が正確ではない場合-のメカニズムについては不明な点が多い。本研究ではヒトの脳活動を間接的に測定することができる脳機能画像法と、脳損傷患者を対象とした神経心理学的研究によって、ヒトの脳でどのように誤った記憶情報が表象されるのかを検討した。記憶を司る内側側頭葉に対して、記憶を制御する前頭前野が影響を与えていることや、内側側頭葉と感覚情報を処理する感覚皮質の関連が明らかとなった。

Research Products

• [Journal Article] Neural correlates of true memory, false memory, and deception (2008)
  • Author(s): Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T
  • Journal Title: Cerebral Cortex 18 Pages: 2811-2819
  • Peer Reviewed
• [Journal Article] Neural correlates of true memory, false memory, and deception (2008)
  • Author(s): Abe, et.al.
  • Journal Title: Cerebral Cortex 18(12) Pages: 2811-2819
  • Peer Reviewed
• [Journal Article] fMRI (2008)
  • Author(s): 鈴木麻希, ら
  • Journal Title: 神経内科 68 Suppl.5 Pages: 37-44
• [Journal Article] 記憶障害-概論 (2008)
  • Author(s): 菊池大一, ら
  • Journal Title: 神経内科 68 Suppl.5 Pages: 484-493
• [Journal Article] 遂行機能障害の画像診断 (2008)
  • Author(s): 深津玲子, ら
  • Journal Title: Journal of Clinical Rehabilitation 17 Pages: 26-31
• [Journal Article] Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information : a positron emission tomography study (2007)
  • Author(s): Ueno A, Abe N, Suzuki M, Hirayama K, Mori E, Tashiro M, Itoh M, Fujii T
  • Journal Title: Neuroimage 34 Pages: 1292-1298
  • Peer Reviewed
• [Journal Article] Deceiving others : distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions (2007)
  • Author(s): Abe N, Suzuki M, Mori E, Itoh M, Fujii T
  • Journal Title: Journal of Cognitive Neuroscience 19 Pages: 287-295
  • Peer Reviewed
• [Journal Article] Differential involvement of regions of rostral prefrontal cortex (Brodmann area 10) in time-and event-based prospective memory (2007)
  • Author(s): Okuda J, Fujii T, Ohtake H, Tsukiura T, Yamadori A, Frith CD, Burgess PW
  • Journal Title: International Journal of Psychophysiology 64 Pages: 233-246
  • Peer Reviewed
• [Journal Article] Selective impairment in the retrieval of family relationships in person identification : a case study of delusional misidentification (2007)
  • Author(s): Abe N, Ishii H, Fujii T, Ueno A, Lee E, Ishioka T, Mori E
  • Journal Title: Neuropsychologia 45 Pages: 2902-2909
  • Peer Reviewed
• [Journal Article] Pure word deafness and pure anarthria in a patient with frontotemporal dementia (2007)
  • Author(s): Iizuka O, Suzuki K, Endo K, Fujii T, Mori E
  • Journal Title: European Journal of Neurology 14 Pages: 473-475
  • Peer Reviewed
• [Journal Article] Selective impairment in the retrieval of family relationships in person identification: a case study of delusional misidentification (2007)
  • Author(s): Abe, et. al.
  • Journal Title: Neuropsychologia 45 Pages: 2902-2909
  • Peer Reviewed
• [Journal Article] Differential involvement of regions of rostral prefrontal cortex(Brodmann area 10)in time-and event-based prospective memory (2007)
  • Author(s): Okuda, et. al.
  • Journal Title: International Journal of Psychophysiology 64 Pages: 233-246
  • Peer Reviewed
• [Journal Article] Deceiving others : distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions (2007)
  • Author(s): Abe, et al.
  • Journal Title: Journal of Cognitive Neuroscience 19(2) Pages: 287-295
• [Journal Article] Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information : a positron emission tomography study (2007)
  • Author(s): Ueno, et al.
  • Journal Title: Neuroimage 34(3) Pages: 1292-1298
• [Journal Article] Pure word deafness and pure anarthria in a patient with frontotemporal dementia (2007)
  • Author(s): Iizuka, et al.
  • Journal Title: European Journal of Neurology 14(4) Pages: 473-475
• [Journal Article] Dissociable roles of prefrontal and anterior cingulate cortices in deception (2006)
  • Author(s): Abe N, Suzuki M, Tsukiura T, Mori E, Yamaguchi K, Itoh M, Fujii T
  • Journal Title: Cerebral Cortex 16 Pages: 192-199
  • Peer Reviewed
• [Journal Article] Dissociable roles of the bilateral anterior temporal lobe in face-name associations : an event-related fMRI study (2006)
  • Author(s): Tsukiura T, Mochizuki-Kawai H, Fujii T
  • Journal Title: Neuroimage 30 Pages: 617-626
  • Peer Reviewed
• [Journal Article] Dissociable roles of prefrontal and anterior cingulate cortices in deception (2006)
  • Author(s): Abe, et al.
  • Journal Title: Cerebral Cortex 16(2) Pages: 192-199
• [Journal Article] Dissociable roles of the bilateral anterior temporal lobe in face-name associations : an event-related fMRI study (2006)
  • Author(s): Tsukiura, et al.
  • Journal Title: Neuroimage 30(2) Pages: 617-626
• [Journal Article] 記憶障害.特集II失語・失行・失認・記憶障害. (2006)
  • Author(s): 藤井俊勝, ら
  • Journal Title: 神経内科 65 Pages: 291-296
• [Presentation] Activity in the medial temporal lobes predicts realization of intentions for future actions (2008)
  • Author(s): Okuda J, Abe N, Suzuki M, Fujii T
  • Organizer: 14th Annual meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Melbourne, Australia
• [Presentation] Neural mechanisms for the retrieval of time duration of past events (2008)
  • Author(s): Suzuki M, Abe N, Mugikura S, Ueno A, Shigemune Y, Shoki Takahashi S, Fujii T
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] Reactivation of medial temporal lobe and area MT/V5 during the retrieval of motion information : a PET study (2008)
  • Author(s): Ueno A, Abe N, Suzuki M, Shigemune Y, Hirayama K, Mori E, Tashiro M, Itoh M, Fujii T
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] Effects of emotion and reward motivation on neural activity associated with episodic memory encoding : a PET study (2008)
  • Author(s): Shigemune Y, Abe N, Suzuki M, Ueno A, Mori E, Tashiro M, Itoh M, Fujii T
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] Recollection failure increases false recognition in patients with Alzheimer's disease (2008)
  • Author(s): Abe N, Fujii T, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Takagi M, Hiraoka K, Yamasaki H, Hirayama K, Choi H, Mori E
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] Roles of the medial frontal cortex and hippocampus in memory-guided future planning (2008)
  • Author(s): Okuda J, Watanabe M, Fujii T, Suzuki M, Abe N, Tsukada M
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] The neural network for temporal order memory retrieval : evidence from lesion and PET studies (2007)
  • Author(s): Suzuki M, Hashimoto R, Hirayama K, Abe N, Ueno A, Tashiro M, Mori E, Itoh M, Fujii T
  • Organizer: International Neuropsychological Society Mid-Year Meeting 2007
  • Place of Presentation: Bilbao, Spain
• [Presentation] A peculiar form of delusional misidentification : a neuropsychological case study providing a window on person identification (2007)
  • Author(s): Abe N, Ishii H, Fujii T, Ueno A, Lee EJ, Ishioka T, Mori E
  • Organizer: International Neuropsychological Society Mid-Year Meeting 2007
  • Place of Presentation: Bilbao, Spain
• [Presentation] Brain mechanisms underlying dissociative retrograde amnesia : an fMRI study (2007)
  • Author(s): Kikuchi H, Fujii T, Abe N, Suzuki M, Mugikura S, Takahashi S, Mori E
  • Organizer: International Neuropsychological Society Mid-Year Meeting 2007
  • Place of Presentation: Bilbao, Spain
• [Presentation] Distinct medial temporal lobe activations associated with the retrieval of different types of information attached with items : an fMRI study (2006)
  • Author(s): Fujii T, Suzuki M, Abe N, Mugikura S, Ueno A, Mori E, Takahashi S
  • Organizer: The 4^<th> International Conference on Memory
  • Place of Presentation: Sydney, Australia
• [Presentation] Neural basis of the retrieval of temporal order memory of experienced events : A PET study (2006)
  • Author(s): Suzuki M, Abe N, Ueno A, Tashiro M, Mori E, Itoh M, Fujii T
  • Organizer: The 4^<th> International Conference on Memory
  • Place of Presentation: Sydney, Australia
• [Presentation] Brain activities associated with false memory and deception : an fMRI investigation (2006)
  • Author(s): Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T
  • Organizer: The 4^<th> International Conference on Memory
  • Place of Presentation: Sydney, Australia
• [Presentation] Reactivation of medial temporal lobe and occipital lobe during retrieval of color information : a PET study (2006)
  • Author(s): Ueno A, Abe N, Suzuki M, Mori E, Tashiro M, Itoh M, Fujii T
  • Organizer: 12th Annual meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Florence, Italy
• [Presentation] Neural correlates of successful retrieval of 'person' as an information source of episodic memory : an event-related fMRI study (2006)
  • Author(s): Mugikura S, Abe N, Suzuki M, Ueno A, Higano S, Takahashi S, Fujii T
  • Organizer: 12th Annual meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Florence, Italy
• [Book] ヒトの海馬の機能イメ-ジング. 比較海馬学(渡辺茂, 岡市広成) (2008)
  • Author(s): 藤井俊勝, 鈴木麻希
  • Publisher: ナカニシヤ出版
• [Book] The basal forebrain and episodic memory. In : Huston JP(ed) : Handbook of Behavioral Neuroscience Handbook of Episodic Memory, Dere E, Easton A, Nadel L, Huston JP(eds). Elsevier (2008)
  • Author(s): Fujii T
  • Publisher: The Netherlands
• [Book] Handbook of Behavioral Neuroscience, Vol. 18, Handbook of Episodic Memory (2008)
  • Author(s): Fuiii T
  • Publisher: The basal forebrain and episodic memory
• [Book] ヒトの海馬の機能イメージングIn:『比較海馬学』渡辺茂、岡市広成編 (2008)
  • Author(s): 藤井俊勝、鈴木麻希
  • Publisher: ナカニシヤ出版
• [Book] 嘘とだましの心理学-戦略的なだましからあたたかい嘘まで-(嘘の脳内メカニズム-脳機能画像研究を中心に In : )(箱田裕司, 仁平義明編) (2006)
  • Author(s): 阿部修士, 藤井俊勝
  • Publisher: 有斐閣(東京)