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Efficient utilization of multiple decision processes in the research and development

Research Project

Project/Area Number 18300096
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research InstitutionMeisei University

Principal Investigator

HIROTSU Chihiro  Meisei University, 理工学部, 教授 (60016730)

Co-Investigator(Kenkyū-buntansha) SUZUKI Kazuyuki  電気通信大学, 電気通信学部, 教授 (00130071)
SEO Takashi  東京理科大学, 理学部, 准教授 (00266909)
USHIJIMA Masartu  , 癌研・ゲノムセンター, 研究員 (60328565)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥15,220,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywords牛の月例判別 / ゲノム解析 / 誤発見率 / 国際共同治験 / 多変量多重比較法 / 大規模分割表,適応型計画 / 比較臨床試験 / 非劣性・優越性統合解析 / 用量・反応パターン解析 / 新薬開発臨床試験 / 多変量経時測定データ / 多変量欠測値データ / 副作用自発報告時系列 / 分割表の行の多重比較 / 用量反応パターン推測 / False Discovery Rate / SNPデータによる遺伝子間相互作用解析 / 大規模分割表 / 適応型計画 / 国際共同臨床試験計画 / 寿命分布の推測 / 適応型臨床試験計画 / 複合信頼区間方式 / 多変量Tukey法 / 同等性検証 / 米国産牛月例判別 / 多重決定方式 / 用量反応解析 / 臨床試験
Research Abstract

We developed a total research on the efficient utilization of multiple decision processes including the estimation of the month age of the American cattle, a unifying approach of non-inferiority, equivalence and superiority tests in a comparative clinical trial, clustering rows of a two-way contingency table and a new approach to estimating the dose response pattern. In particular the clustering rows of a contingency table made a progress in the multiple comparison procedures in the analysis of a two-way interaction and led to a new theme of detecting a signal of a prominent combination in the large two-way table of drugs and adverse events. Further the research on the multivariate multiple comparison procedures, the control of the false discovery rate in the analysis of the micro-array data and the reliability analysis based on the post market data have been developed by the collaborative researchers.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (61 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (29 results) (of which Peer Reviewed: 20 results) Presentation (26 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Testing Equality of Mean Vect ors in Two Sample Problem with Missi ng Data2010

    • Author(s)
      Nobumichi Shutoh, Makiko Kusumi, Wata ru Morinaga, Shunichi Yamada, Takashi Seo
    • Journal Title

      Communications in Statistic s-Simulation and Computation Vol.39

      Pages: 487-500

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Testing Equality of Mean Vectors in Two Sample Problem with Missing Data2010

    • Author(s)
      Nobumichi Shutoh, Makiko Kusumi, Wataru Morinaga, Shunichi Yamada, Takashi Seo
    • Journal Title

      COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION 39

      Pages: 487-500

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clustering Rows and /or Columns of a Two-way Contingency Table and a Related Distribution Th eory2009

    • Author(s)
      Chihiro Hirotsu
    • Journal Title

      Computational Statistics and D ata Analysis Vol.53

      Pages: 4508-4515

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clustering rows and/or columns of a two-way contingency table and a related distribution theory2009

    • Author(s)
      Chihiro Hirotsu
    • Journal Title

      Computational Statistics and Data Analysis 53

      Pages: 4508-4515

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Testing equality of two mean vectors and simultaneous confidence intervals in repeated measures with missing data2009

    • Author(s)
      Kazuyuki Koizumi, Takashi Seo
    • Journal Title

      Journal of the Japanese Society of Computational Statistics 22

      Pages: 33-41

    • NAID

      110007502777

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATP Citrate Lyase: Activation and Therapeutic I mplications in Non-Small Cell Lung Cancer2008

    • Author(s)
      Masaru Ushijima, et al.
    • Journal Title

      Cancer Research Vol.68

      Pages: 8547-8554

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 信頼性・安全性確保への提言-全体マップ2008

    • Author(s)
      鈴木和幸
    • Journal Title

      品質 38

      Pages: 405-412

    • NAID

      110006976961

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 信頼性・安全性の確保への提言一全体マップ2008

    • Author(s)
      鈴木和幸
    • Journal Title

      品質 38

      Pages: 405-412

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inference on biological mechanisms using an integrated phenotype prediction model.2008

    • Author(s)
      Masaru Ushijima, et al.
    • Journal Title

      Hiroshima Journal of Medical Sciences 57

      Pages: 7-15

    • NAID

      120005323916

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATP Citrate Lyase : Activation and Therapeutic Implications in Non-Small CeH Lung Cancer2008

    • Author(s)
      Masaru Ushijima, et al.
    • Journal Title

      Cancer Research 68

      Pages: 8547-8554

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Unifying Approac h to Non-inferiority、Equivalence and Superiority Tests2007

    • Author(s)
      Chihiro Hirotsu
    • Journal Title

      Pharmaceutical、Statistics Vol.6

      Pages: 193-203

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Warranty Data with Covariate2007

    • Author(s)
      Kazuyuki Suzuki, et al.
    • Journal Title

      Journal of Risk and Reliability Vol.221

      Pages: 249-255

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A unifying approach to non-inferiority 、equivalence and superiority tests2007

    • Author(s)
      Chihiro Hirotsu
    • Journal Title

      Pharmaceutical Statistics 6

      Pages: 193-203

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A unifying approach to non-inferiority, equivalence and superiority tests2007

    • Author(s)
      Chihiro Hirotsu
    • Journal Title

      Pharmaceutical Statistics 6

      Pages: 193-203

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of warranty data with covariates2007

    • Author(s)
      Kazuyuki Suzuki, et. al.(Karim, M.R.)
    • Journal Title

      Journal of Risk and Reliability 221

      Pages: 249-255

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Strength, Fracture Cause, and Fracture Location Data on the Reliability Analysis of Ceramics2007

    • Author(s)
      Kazuyuki Suzuki, et. al.(Matsuo, Y.)
    • Journal Title

      Key Engineering Materials 352

      Pages: 17-20

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アンケート調査に基づく顧客潜在ニーズの抽出2007

    • Author(s)
      鈴木 和幸, 他(坂田 理彦)
    • Journal Title

      品質 35

      Pages: 68-79

    • NAID

      130007854199

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common Peak Approach Using Mass Spectrometry Data Sets for Predictinfg the Effects of Anticancer Drugs on Breast Cancer2007

    • Author(s)
      Masaru Ushijima, et. al.(ushijima, M.)
    • Journal Title

      Cancer Informatics 3

      Pages: 285-293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous confidence intervals for all contrasts of the means in repeated measures with missing observations2006

    • Author(s)
      Koizumi, K. and Seo, T.
    • Journal Title

      SUT Journal of Mathematics 42

      Pages: 133-144

    • NAID

      120006398042

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 臨床情報とOMICS情報のバイオインフォマティクス的アプローチ2006

    • Author(s)
      牛嶋 大、宮田 敏、松浦正明
    • Journal Title

      生体医工学 44

      Pages: 390-396

    • NAID

      110005716757

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 非劣性,同等性,優越性検証のための多重決定方式による統合的接近法2006

    • Author(s)
      広津千尋
    • Journal Title

      日本統計学会誌 36・1

      Pages: 37-44

    • NAID

      110004851274

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A unifying approach to non-inferiority, equivalence and superiority tests via multiple decision processes2006

    • Author(s)
      Hirotsu, C.
    • Journal Title

      Proceedings in computational Statistics

      Pages: 1001-1006

    • NAID

      110004851274

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Estimation the dose response patterns in a phase 2 clinical trial2006

    • Author(s)
      Hirotsu, C., Yamamoto, S.
    • Journal Title

      Proceedings in International Biometric Conference

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Optimality of Monotone Procedure in Preventive Maintenance Using Non-independent Monitoring Information2006

    • Author(s)
      Jin, L., Suzuki, K.
    • Journal Title

      Journal of Reliability Engineering Association of Japan 28

      Pages: 381-393

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 作業の階層構造に基づくヒューマンエラーの相対リスク評価手法2006

    • Author(s)
      宮地由芽子, 柴田徹, 井上貴文, 鈴木和幸
    • Journal Title

      日本信頼性学会誌 28

      Pages: 521-533

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Optimality of κ-out-of-η Systems for Condition Monitoring Maintenance Using Dependent Information2006

    • Author(s)
      Jin, L., Horikoshi, Y., Suzuki, K.
    • Journal Title

      Proceedings of the 2006 Asian International Workshop on Advanced Reliability Modeling

      Pages: 132-141

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 多変量Tukey-Kramer型多重比較法とその保守性2006

    • Author(s)
      瀬尾隆, 西山貴弘
    • Journal Title

      日本統計学会誌 36・1

      Pages: 79-144

    • NAID

      110004851277

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Simultaneous confidence intervals for all contrasts of the means in repeated measures with missing observations2006

    • Author(s)
      Koizumi, K., Seo, T.
    • Journal Title

      SUT Journal of Mathematics 42/1

      Pages: 133-144

    • NAID

      120006398042

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 臨床情報とOMICS情報のバイオインフォティクス的アプローチ2006

    • Author(s)
      牛嶋大, 宮田敏, 松浦正明
    • Journal Title

      生体医工学 44・3

      Pages: 390-396

    • Related Report
      2006 Annual Research Report
  • [Presentation] A new method for detecting epistasis from genome-wide SNP data2010

    • Author(s)
      牛嶋大
    • Organizer
      第8回日米癌学会合同シンポジウム
    • Place of Presentation
      ハワイ島(Hilton Waikoloa Village)
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分割表の行のクラスタリング-医薬品副作用自発報告データへの応用-2009

    • Author(s)
      広津千尋
    • Organizer
      第8回統計関連学会連合大会
    • Place of Presentation
      同志社大学、京都
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1標本問題における2-Step単調欠測データの下での平均ベクトルの検定統計量について2009

    • Author(s)
      山崎彰子, 瀬尾隆
    • Organizer
      第8回統計関連学会連合大会
    • Place of Presentation
      同志社大学、京都
    • Year and Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成長曲線モデルにおけるプロファイル分析2009

    • Author(s)
      櫻井智子, 瀬尾隆, 藤越康祝
    • Organizer
      第8回統計関連学会連合大会
    • Place of Presentation
      同志社大学、京都
    • Year and Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Row-wise multiple comparison approach to the analysis of two-way interaction with particular interest in the ordered rows and/or columns2009

    • Author(s)
      広津千尋
    • Organizer
      Vienna Biometric Society
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Statistical Issues in Pharmaceutical Industry2009

    • Author(s)
      広津千尋
    • Organizer
      5^<th> International Symposium on Business and Industrial Statistics
    • Place of Presentation
      Stellenbosh, South Africa
    • Year and Date
      2009-08-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pharmaceutical Statistics in Industry2009

    • Author(s)
      広津千尋
    • Organizer
      The 57^<th> Session of the International Statistical Institute
    • Place of Presentation
      Durban, South Africa
    • Year and Date
      2009-08-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Row-wise multiple comparisons approach to the analysis of interaction effects with various applications2009

    • Author(s)
      広津千尋
    • Organizer
      Basel Biometric Society
    • Place of Presentation
      Basel, Switzerland
    • Year and Date
      2009-08-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] A simple method for detecting epistasis in genome-wide association studies2009

    • Author(s)
      牛嶋 大
    • Organizer
      6th International Conference on Multiple Comparison Procedures (MCP 2009)
    • Place of Presentation
      東京理科大学
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clustering rows of a two-way contingency table with an application to the spontaneous reporting data of the adverse events2009

    • Author(s)
      Chihiro Hirotsu, et al.
    • Organizer
      6th International Conference on Multiple Comparison Procedures (MCP2009)
    • Place of Presentation
      東京理科大学
    • Year and Date
      2009-03-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pharmaceutical Statistics in Industry2009

    • Author(s)
      Chihiro Hirotsu
    • Organizer
      The 57th Sess ion of the International Statistical Institute
    • Place of Presentation
      Durban、South Africa
    • Related Report
      2009 Final Research Report
  • [Presentation] Statistical Issues in Pharmaceutical Industry2009

    • Author(s)
      Chihiro Hirotsu
    • Organizer
      5th International Symposium on Business and Industrial Statistics
    • Place of Presentation
      Stellenbo sh、South Africa
    • Related Report
      2009 Final Research Report
  • [Presentation] ゲノムワイドSNPデータを用いた遺伝子間相互作用の探索2009

    • Author(s)
      牛嶋大
    • Organizer
      第8回統計関連学会連合大会
    • Place of Presentation
      同志社大学、京都
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Asymptotic Properties of Test Statistics for Equality of Mean Vectors with Missing Observations2008

    • Author(s)
      瀬尾 隆, 他
    • Organizer
      日本計算機統計学会
    • Place of Presentation
      先端医療振興財団・臨床研究情報センター
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 分割表の行のクラスタリングと関連する分布論2008

    • Author(s)
      広津千尋
    • Organizer
      2008年度統計関連学会連合大会
    • Place of Presentation
      慶応義塾大学
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clustering rows of a two-way contingency table with related distribution theory2008

    • Author(s)
      Chihiro Hirotsu
    • Organizer
      Computational Statistics(COMPSTAT) 2008
    • Place of Presentation
      University of Porto、 Portugal
    • Year and Date
      2008-08-26
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Clustering rows of a two-way contingency table with related distribution theory2008

    • Author(s)
      Chihiro Hirotsu
    • Organizer
      Computational Statistics 2008
    • Place of Presentation
      University of Porto, Portugal
    • Year and Date
      2008-08-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Estimation of Lifetime Distribution Using Warranty Data Consisting only of Failure Information2008

    • Author(s)
      Kazuyuki Suzuki, 他
    • Organizer
      International Conference on Accelerated Life Testing in Reliability and Quality Control
    • Place of Presentation
      Bordeaux France
    • Year and Date
      2008-06-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] ゲノムデータ解析におけるFDR2008

    • Author(s)
      牛嶋 大
    • Organizer
      日本計量生物学会年会
    • Place of Presentation
      筑波大学
    • Year and Date
      2008-06-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 管理要因に着目したヒューマンエラー解析とその組織要因の検討2008

    • Author(s)
      鈴木和幸, 他
    • Organizer
      日本品質管理学会第86回研究発表会
    • Place of Presentation
      日本科学技術連盟
    • Year and Date
      2008-05-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 欠測値をもつ2標本問題に対する平均ベクトル間の同等性検定と同時信頼区間.2008

    • Author(s)
      瀬尾 隆, 他
    • Organizer
      日本計算機統計学会
    • Place of Presentation
      秋田市文化会館
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Estimation of Lifetime Distribution Using Warr anty Data Consisting only of Failure Information2008

    • Author(s)
      Kazuyuki Suzuki, et al
    • Organizer
      International Conferenc e on Accelerated Life Testing in Reli ability and Quality Control
    • Place of Presentation
      Bordeau x France
    • Related Report
      2009 Final Research Report
  • [Presentation] 分割表における行のScheffe型多重比較法の応用について2007

    • Author(s)
      広津 千尋
    • Organizer
      2007年度統計関連学会連合大会
    • Place of Presentation
      神戸大学
    • Year and Date
      2007-09-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Key Concept of Reliability Improvement for New Product Development by Integrating Reliability Engineering and TQM2007

    • Author(s)
      Kazuyuki Suzuki
    • Organizer
      Intemational Conference on Reliability Maintainability and Safety
    • Place of Presentation
      China
    • Year and Date
      2007-08-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] A uniying approach to non-ingeriority,equivalence and superiority tests2007

    • Author(s)
      Chihiro Hirotsu
    • Organizer
      5th International Confbrence on Multiple Comarison Procedures(MCP2007)
    • Place of Presentation
      Medical University of Vienna
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] On the Conservative Simultaneous Confidence Procedures for Multiple Comparisons among Mean Vectors2007

    • Author(s)
      Takashi Seo, et al
    • Organizer
      15th InternationalConference of the Forum for Interdisciplinary Mathem atics on Interdisciplinary Mathematical & Statistical Techniques
    • Place of Presentation
      Shanghai, China
    • Related Report
      2009 Final Research Report
  • [Book] 信頼性七つ道具2008

    • Author(s)
      鈴木和幸, 他
    • Total Pages
      203
    • Publisher
      日科技連出版
    • Related Report
      2009 Final Research Report
  • [Book] (2008) : 信頼性七つ道具2008

    • Author(s)
      鈴木和幸(編著)
    • Total Pages
      203
    • Publisher
      日科技連出版
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.hino.meisei-u.ac.jp/phys/hiro

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.hino.meisei-u.ac.jp/phys/hirotsu/hh_hirotsu.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.hino.meisei-u.ac.jp/phys/hirotsu/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.hino.meisei-u.ac.jp/phys/hirotsu/

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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