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Molecular mechanisms of conformational changes of proteins and neurodegeneration in neurodegenerative diseases.

Research Project

Project/Area Number 18300117
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

HASEGAWA Masato  Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 副参事研究員 (10251232)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥16,440,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2006: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsタウ / αシヌクレイン / TDP-43 / アルツハイマー / パーキンソン / リン酸化 / ユビキチン化 / 断片化 / 線維 / アミロイド / アミロイドβ / ユビキチン / 封入体 / FTLD / Aβ / アミロイド線維
Research Abstract

神経変性の共通の分子メカニズムを明らかにすることを目的として、患者脳に蓄積する蛋白質の解析、リコンビナント蛋白質を用いた解析を行った。その結果、同じ4リピートタウが蓄積するPSPとCBDにおいて、蓄積するタウの線維構造が異なっている可能性が示唆された。また、FTLD、ALSに蓄積するユビキチン陽性封入体の構成タンパク質としてリン酸化TDP-43を同定した。さらにαシヌクレインの部位特異抗体を用いて、αシヌクレインのモノマーから線維化への構造変化をとらえることに成功した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report

Research Products

(101 results)

All 2009 2008 2007 2006

All Journal Article Presentation Book Patent(Industrial Property Rights)

  • [Journal Article] TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.2009

    • Author(s)
      Davidson Y, Amin H, Kelley T, Shi J, Tian J, Kumaran R, Lashley T, Lees AJ, Duplessis D, Neary D, Snowden J, Akiyama H, Arai T, Hasegawa M, et al.
    • Journal Title

      Acta Neuropathol. [Epub ahead of print]

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of casein kinase-1 phosphorylation sites on TDP-43.2009

    • Author(s)
      Kametani F, Nonaka T, Suzuki T, Arai T, Dohmae N, Akiyama H, Hasegawa M.
    • Journal Title

      Biochem Biophys Res Commun. 382

      Pages: 405-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 pathology in familial British dementia.2009

    • Author(s)
      Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer PL.
    • Journal Title

      Acta Neuropathol. [Epub ahead of print]

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conversion of wild-type α-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.2009

    • Author(s)
      Yonetani M, Nonaka T, Masuda M, Inukai Y, Oikawa T, Hisanaga S, Hasegawa M.
    • Journal Title

      J Biol Chem 284

      Pages: 7940-50

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of α-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.2009

    • Author(s)
      Masuda M, Hasegawa M, Nonaka T, Oikawa T, Yonetani M, Yamaguchi Y, Kato K, Hisanaga S, Goedert M.
    • Journal Title

      FEBS Lett 583

      Pages: 787-91

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.2009

    • Author(s)
      Nonaka T, Arai T, Buratti E, Baralle FE, Akiyama H, Hasegawa M.
    • Journal Title

      FEBS Lett 583

      Pages: 394-400

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies2009

    • Author(s)
      Arai T Mackenzie IR, Hasegawa M, Nonaka T, Niizato K, Tsuchiya K, Iritani S, Onaya M, Akiyama H
    • Journal Title

      Acta Neuropathol. 117

      Pages: 125-36

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemp oral lobar degeneration and in other neurodegenerative diseases : a degenerative process distinct from normal ageing2009

    • Author(s)
      Davidson Y, et al
    • Journal Title

      Acta Neuropathol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 pathology in familial British dementia2009

    • Author(s)
      Schwab C, et al
    • Journal Title

      Acta Neuropathol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of casein kinase-1 phosphorylation sites on TDP-432009

    • Author(s)
      Kametani F, et al
    • Journal Title

      Biochem Biophys Res Commun 382

      Pages: 405-409

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conversion of wild-type α-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant2009

    • Author(s)
      Yonetani M, et al
    • Journal Title

      J Biol Chem 284

      Pages: 7940-7950

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of alpha-synuclein fibril assembly by small molecules : analysis using epitope-specific antibodies2009

    • Author(s)
      Masuda, M., et al
    • Journal Title

      FEBS Lett 583

      Pages: 787-791

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells2009

    • Author(s)
      Nonaka T, et al
    • Journal Title

      FEBS Lett 583

      Pages: 394-400

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies2009

    • Author(s)
      Arai T, et al
    • Journal Title

      Acta Neuropathol 117

      Pages: 125-136

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease2009

    • Author(s)
      Fujishiro H, et al
    • Journal Title

      Acta Neuropathol 117

      Pages: 151-158

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Colocalization of TDP-43 and Huntingtin in inclusions of Huntington's disease2009

    • Author(s)
      Schwab C, et al
    • Journal Title

      J Neurolpathol Exp Neurol 67

      Pages: 1159-1165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal phosphorylation of Ser409-410 of TDP-43 in FTLD-U and ALS2009

    • Author(s)
      Inukai Y, et al
    • Journal Title

      FEBS Lett 582

      Pages: 2899-2904

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis2009

    • Author(s)
      Hasegawa M, et al
    • Journal Title

      Ann Neurol 64

      Pages: 60-70

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease.2008

    • Author(s)
      Fujishiro H, Uchikado H, Arai T, Hasegawa M, Akiyama H, Yokota O, Tsuchiya K, Togo T, Iseki E.
    • Journal Title

      Acta Neuropathol. 117

      Pages: 151-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Colocalization of TDP-43 and Huntingtin in inclusions of Huntington's disease2008

    • Author(s)
      Schwab C, Arai T, Hasegawa M, Yu S McGeer PL
    • Journal Title

      J Neurolpathol Exp Neurol 67

      Pages: 1159-65

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.2008

    • Author(s)
      Inukai Y, Nonaka T, Arai T, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle FE, Akiyama H, Hisanaga SI, Hasegawa M,
    • Journal Title

      FEBS Lett 582

      Pages: 2289-2904

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.2008

    • Author(s)
      Hasegawa M, Arai T, Nonaka T, Kametani F, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle F, Morita M, Nakano I, Oda T, Tsuchiya K, Akiyama H
    • Journal Title

      Ann Neurol 64

      Pages: 60-70

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.2008

    • Author(s)
      Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H.
    • Journal Title

      Exp Neurol 210

      Pages: 409-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.2008

    • Author(s)
      Obi, K., *Akiyama, H., Kondo, H. Shimomura, Y., Hasegawa, M., et. al.
    • Journal Title

      Exp.Neurol

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated TDP-43 in Frontotemporal lobar degeneration and ALS.2008

    • Author(s)
      *Hasegawa, M., *Arai, T., Nonaka, T., Kametani, F., et. al.
    • Journal Title

      Ann.Neurol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43(TAR DNA-binding protein of 43kDa)とその意義.2008

    • Author(s)
      新井 哲明、長谷川 成人
    • Journal Title

      Clin.Neurosci. 26

      Pages: 301-302

    • Related Report
      2007 Annual Research Report
  • [Journal Article] タウパチーの生化学、分子生物学2008

    • Author(s)
      青柳 浩史、長谷川 成入
    • Journal Title

      Cogniton & Dementia 7

      Pages: 127-135

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.2007

    • Author(s)
      Ishii A, Nonaka T, Taniguchi S, Saito T, Arai T, Mann D, Iwatsubo T, Hisanaga SI, Goedert M, Hasegawa M
    • Journal Title

      FEBS Lett 581

      Pages: 4711-4717

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein.2007

    • Author(s)
      Sasakawa H, Sakata E, Yamaguchi Y, Masuda M, Mori T, Kurimoto E, Iguchi T, Hisanaga SI, Iwatsubo T, Hasegawa M, Kato K
    • Journal Title

      Biochem Biophys Res Commun 363

      Pages: 795-799

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibrillogenic nuclei composed of P301L mutant tau induce elongation of P301L tau, but not wild-type tau.2007

    • Author(s)
      Aoyagi H, Hasegawa M, Tamaoka A
    • Journal Title

      J Biol Chem 282

      Pages: 20309-20318

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2007

    • Author(s)
      Hasegawa M, Arai T, Akiyama H, Nonaka T, Mori H, Hashimoto T, Yamazaki M, Oyanagi K.
    • Journal Title

      Brain 130

      Pages: 1386-1394

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.2007

    • Author(s)
      Sato K, Zhu YS, Saito T, Yotsumoto K, Asada A, Hasegawa M, Hisanaga S.
    • Journal Title

      J Neurosci Res. 85

      Pages: 3071-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibrillogenic nuclei composed of P30IL mutant tau induce elongation of P30IL tau,but not wild-type tau.2007

    • Author(s)
      Aoyagi, H., *Hasegawa, M., & Tamaoka, A.
    • Journal Title

      J.Biol.Chem. 282

      Pages: 20309-20318

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2007

    • Author(s)
      Hasegawa, M., *Arai, T., Akiyama, H., Nonaka, T., et. al.
    • Journal Title

      Brain 130

      Pages: 1386-1394

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein:Implication for alpha-synucleinopathies.2007

    • Author(s)
      Ishii, A., Nonaka, T., Taniguchi S., Saito, T., Arai, T., Mann, D., Iwatsubo, T., Hisanaga, S., Goedert, M. & *Hasegawa, M.
    • Journal Title

      FEBS Lett. 581

      Pages: 4711-4717

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of alpha-synuclein.2007

    • Author(s)
      Sasakawa, H., Sakata, E., Yamaguchi, Y., Masuda, M., Mori, T., Kurimoto, E., Iguchi, T., Hisanaga, S., Iwatsubo, T., Hasegawa, M., & *Kato K
    • Journal Title

      Biochem.Biophys.Res.Commun. 363

      Pages: 795-799

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.2007

    • Author(s)
      Sato, K., Zhu, Y. S., Saito, T., Yotsumoto, K., Asada, A., Hasegawa, M. & *Hisanaga, S.
    • Journal Title

      J.Neuroscz.Res. 85

      Pages: 3071-3078

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] タウ、プログラニュリン、TDP-43と神経変性.2007

    • Author(s)
      長谷川 成人、新井 哲明
    • Journal Title

      実験医学 25

      Pages: 53-61

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ALSでみられるユビキチン化封入体の構成蛋白.2007

    • Author(s)
      長谷川 成人、新井 哲明
    • Journal Title

      Brain & Nerve 59

      Pages: 1171-1177

    • Related Report
      2007 Annual Research Report
  • [Journal Article] FTLDおよびALS出現するユビキチン陽性封入体の主要構成成分としてのTDP-43の同定.2007

    • Author(s)
      新井 哲明、秋山 治彦、長谷川 成人
    • Journal Title

      Dementia Japan 21

      Pages: 89-103

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ピック病の分子生物学.2007

    • Author(s)
      新井 哲明、長谷川 成人
    • Journal Title

      老年精神医学雑誌 18

      Pages: 605-615

    • Related Report
      2007 Annual Research Report
  • [Journal Article] シヌクレイノパチーの基礎研究における最近の進歩.2007

    • Author(s)
      野中 隆、増田 雅美、長谷川 成人
    • Journal Title

      Dementia Japan 21

      Pages: 8-14

    • Related Report
      2007 Annual Research Report
  • [Journal Article] タウとアルツハイマー病.2007

    • Author(s)
      笈川 貴行、長谷川 成人
    • Journal Title

      医学のあゆみ, 220

      Pages: 374-378

    • Related Report
      2007 Annual Research Report
  • [Journal Article] α-シヌクレイン.2007

    • Author(s)
      野中 隆、増田 雅美、長谷川 成人
    • Journal Title

      日本臨床 66

      Pages: 102-106

    • Related Report
      2007 Annual Research Report
  • [Journal Article] TDP-43と神経変性疾患.2007

    • Author(s)
      長谷川 成人、新井 哲明
    • Journal Title

      BIO CIinica 23

      Pages: 61-64

    • Related Report
      2007 Annual Research Report
  • [Journal Article] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.2006

    • Author(s)
      Arai T*, Hasegawa M*, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, Oda T
    • Journal Title

      Biochem Biophys Res Commun 351

      Pages: 602-611

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.2006

    • Author(s)
      Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min DS, Kim J, Paik SR, Chung KC
    • Journal Title

      J Biol Chem 281

      Pages: 33250-33257

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Small molecule inhibitors of alpha-synuclein filament assembly.2006

    • Author(s)
      Masuda M, Suzuki N, Taniguchi S, Oikawa T, Nonaka T, Iwatsubo T, Hisanaga SI, Goedert M, Hasegawa M
    • Journal Title

      Biochemistry 45

      Pages: 6085-6094

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006

    • Author(s)
      Masuda M, Dohmae N, Nonaka T, Oikawa T, Hisanaga S, Goedert M, Hasegawa M
    • Journal Title

      FEBS Lett 580

      Pages: 1775-1779

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological and biochemical studies on a case of Pick disease with severe white matter atrophy.2006

    • Author(s)
      Yamakawa K, Takanashi M, Watanabe M, Nakamura N, Kobayashi T, Hasegawa M, Mizuno Y, Tanaka S, Mori H.
    • Journal Title

      Neuropathology 26

      Pages: 586-591

    • NAID
      10019264634
    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biochemistry and molecular biology of tauopathies.2006

    • Author(s)
      Hasegawa M
    • Journal Title

      Neuropathology 26

      Pages: 484-490

    • NAID
      10019264205
    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes.2006

    • Author(s)
      Sakai K, Piao YS, Kikugawa K, Ohara S, Hasegawa M, Takano H, Fukase M, Nishizawa M, Kakita A, Takahashi H
    • Journal Title

      Acta Neuropathol 112

      Pages: 341-348

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006

    • Author(s)
      Wakabayashi K, Mori F, Hasegawa M, Kusumi T, Yoshimura I, Takahashi H, Kaneko S
    • Journal Title

      Neuropathology 26

      Pages: 66-71

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.2006

    • Author(s)
      Hasegawa, M., Arai, T., Akiyama, H., Nonaka, T., Mori, H., Hashimoto, T., Yamazaki, M., Oyanagi,K.
    • Journal Title

      Brain (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis2006

    • Author(s)
      Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchida, K., Yoshida, M., Hashizume,Y, Oda
    • Journal Title

      Biochem.Biophys.Res.Commun 351

      Pages: 602-611

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DyrklA phosphorylates alpha-synuclein and enhances intracellular inclusion formation.2006

    • Author(s)
      Kim, E.J., Sung, J.Y., Lee, H.J., Rhim, H., Hasegawa, M., Iwatsubo, T., Min, D.S., Kim.J., Paik, S.R., Chung,K.C.
    • Journal Title

      J Biol Chem 281

      Pages: 33250-33257

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Small molecule inhibitors of alpha-synuclein filament assembly.2006

    • Author(s)
      Masuda, M., Suzuki, N., Taniguchi, S., Oikawa, T., Nonaka, T., Iwatsubo, T., Hisanaga, S.I., Goedert, M., Hasegawa,M.
    • Journal Title

      biochemistry 45

      Pages: 6085-6094

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006

    • Author(s)
      Masuda, M., Dohmae, N., Nonaka, T., Oikawa, T., Hisanaga, S., Goedert, M., Hasegawa,M.
    • Journal Title

      FEBS Lett. 580

      Pages: 1775-1779

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes.2006

    • Author(s)
      Sakai, K., Piao, Y.S, Kikugawa, K., Ohara, S., Hasegawa, M., Takano, H., Fukase, M., Nishizawa, M., Kakita, A., Takahashi,H.
    • Journal Title

      Acta Neuropathol.(Berl) 112

      Pages: 341-348

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006

    • Author(s)
      Wakabayashi, K., Mori, F., Hasegawa, M., Kusumi, T., Yoshimura, I., Takahashi, H., Kaneko,S.
    • Journal Title

      Neuropathology 26

      Pages: 66-71

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Biochemistry and molecular biology of tauopathies.2006

    • Author(s)
      Hasegawa, M.
    • Journal Title

      Neuropathology 26

      Pages: 484-490

    • NAID
      10019264205
    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pathological and biochemical studies on a case of Pick disease with severe white matter atrophy.2006

    • Author(s)
      Yamakawa K, Takanashi M, Watabane M, Nakamura N, Kobayashi T, Hasegawa M, Mizuno Y, Tanaka S, Mori H
    • Journal Title

      Neuropathology 26

      Pages: 586-591

    • NAID
      10019264634
    • Related Report
      2006 Annual Research Report
  • [Presentation] ALS、FTLDにおけるリン酸化TDP-43の蓄積2008

    • Author(s)
      長谷川成人, 野中隆, 新井哲明, 犬飼有紀, 亀谷富由樹, 久永眞市, 秋山治彦
    • Organizer
      第81回日本生化学会大会, シンポジウム「神経変性疾患関連遺伝子探索と機能解析」
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] ALS、FTLDにおけるリン酸化TDP-43の蓄積2008

    • Author(s)
      長谷川成人, 他
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] TDP-43断片の発現による細胞内凝集体の形成2008

    • Author(s)
      野中隆, 他
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] FTLD、ALSに蓄積する異常TDP-43 の解析2008

    • Author(s)
      長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 吉田眞理, 橋詰良夫, Beach T, 森田光哉, 中野今治, 織田辰郎, 土谷邦秋, 秋山治彦
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] TDP-43の細胞内封入体モデルの作製2008

    • Author(s)
      野中隆, 新井哲明, 秋山治彦, 長谷川成人
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] FTLD、ALSに蓄積する異常TDP-43の解析2008

    • Author(s)
      長谷川成人, 他
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] TDP-43の細胞内封入体モデルの作成2008

    • Author(s)
      野中隆, 他
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] αシヌクレインの線維形成におけるA30P凝集核の効果2008

    • Author(s)
      米谷元邦, 犬飼有紀, 野中隆, 久永眞市, 長谷川成人
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] TDP-43におけるSer409/410の異常リン酸化2008

    • Author(s)
      犬飼有紀, 野中隆, 新井哲明, 吉田眞理,橋詰良夫, 秋山治彦, 久永眞市, 長谷川成人
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] TDP-43の蓄積を中心とした神経病理2008

    • Author(s)
      新井哲明, 他
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] TDP-43オーバービュー2008

    • Author(s)
      長谷川成人
    • Organizer
      厚生労働省「筋萎縮性側索硬化症の病態に基づく画期的治療法の開発」平成20年度ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Accumulation of phosphorylated TDP-43 in neurodegenerative disorders.2008

    • Author(s)
      Arai T, Hasegawa M, Nonaka T, Kametani F, Ikeda K, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle F, Morita M, Nakano I, Oda T, Tsuchiya K, Akiyama H
    • Organizer
      International Conference on Alzheimer's Disease 2008
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2008-07-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Intracellular aggregation of phosphorylated and ubiquitinated TDP-43 in SH-SY5Y cells.2008

    • Author(s)
      Nonaka T, Arai T, Akiyama H, Buratti E, Baralle F E, and Hasegawa M
    • Organizer
      International Conference on Alzheimer's Disease 2008
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2008-07-27
    • Related Report
      2008 Final Research Report
  • [Presentation] FTDにおけるTDP-43蓄積の意義2008

    • Author(s)
      長谷川成人, 新井哲明, 野中隆, 亀谷富由樹, 吉田眞理, 橋詰良夫, Thomas Beach, 森田光哉, 中野今治, 織田辰郎, 土谷邦秋, 秋山治彦
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] TDP-43凝集物に特異的に結合する抗体.2008

    • Author(s)
      長谷川 成人、新井 哲明、野中 隆、亀谷 富由樹、秋山 治彦
    • Organizer
      第7回研究交流フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2008-02-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)、前頭側頭葉変性症(FTLD)に蓄積するTDP-43の解析.2008

    • Author(s)
      野中 隆、長谷川 成人
    • Organizer
      第3回プロテオミクス・構造生物学講演会,
    • Place of Presentation
      岡崎
    • Year and Date
      2008-01-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に蓄積するユビキチン陽性封入体の構成タンパク質の同定.2007

    • Author(s)
      長谷川 成人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phosphorylated and ubiquitinated alpha-synuclein forms fibrillar inclusions in SH-SY5Y cells.2007

    • Author(s)
      Nonaka, T., Watanabe, S., Iwatsubo, T., Hasegawa, M.
    • Organizer
      The Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体構成蛋白の同定.2007

    • Author(s)
      長谷川 成人
    • Organizer
      首都大バイオカンファレンス2007
    • Place of Presentation
      東京
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] ALSにおけるTDP-43の蓄積の意義.2007

    • Author(s)
      長谷川 成人
    • Organizer
      ALSの画期的診断,治療法に関する研究班,平成19年度ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2007-09-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] TDP-43の基礎と病態.2007

    • Author(s)
      長谷川 成人
    • Organizer
      厚生労働科学研究費補助金難治性疾患克服研究事業, 神経変性疾患に関する調査研究班ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2007-08-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] FTLD,ALSにおけるTDP-43の蓄積.2007

    • Author(s)
      長谷川 成人, 新井 哲明, 野中 隆, 他
    • Organizer
      平成19年度文科省科学研究費補助金「特定領域研究」第5領域「病態脳」夏のワークショップ(班会議)
    • Place of Presentation
      札幌.
    • Year and Date
      2007-08-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体のプロテオミクス解析とTDP-43の同定2007

    • Author(s)
      長谷川成人, 新井哲明
    • Organizer
      日本ヒトプロテオーム機構第5回大会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-31
    • Related Report
      2008 Final Research Report
  • [Presentation] 前頭側頭葉変性症、筋萎縮性側索硬化症に出現するユビキチン陽性封入体のプロテオミクス解析とTDP-43の同定.2007

    • Author(s)
      長谷川 成人, 新井 哲明
    • Organizer
      日本ヒトプロテオーム機構第5回大会,
    • Place of Presentation
      東京
    • Year and Date
      2007-07-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] FTLD-UにおけるUBQ陽性封入体のプロテオミクス解析とTDP-43の同定.2007

    • Author(s)
      長谷川 成人
    • Organizer
      第48回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] タウ陰性ユビキチン陽性封入体を伴う前頭側頭葉変性症におけるプログラニュリンおよびTDP-43の免疫組織化学的検討.2007

    • Author(s)
      新井 哲明, 長谷川 成人, 他
    • Organizer
      第48回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] グアムPDC患者脳におけるTDP-43の蓄積2007

    • Author(s)
      長谷川成人, 新井哲明, 秋山治彦, 橋本智代, 山崎峰雄, 小柳清光
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] シヌクレイノパチーの基礎研究2006

    • Author(s)
      長谷川成人
    • Organizer
      第25 回日本認知症学会, シンポジウム3 「シヌクレイノパチーの臨床と基礎研究」
    • Place of Presentation
      広島
    • Year and Date
      2006-10-07
    • Related Report
      2008 Final Research Report
  • [Presentation] CK2 is the major enxyme in brain that generates PSer129 epitope of alpha-synuclein.2006

    • Author(s)
      Hasegawa M, Ishii A, Nonaka T, Saito T, Arai T, Hisanaga S, Iwatsubo T
    • Organizer
      The 6th Annual Meeting of International College of Geriatric Psychoneuropharmacology (ICGP)
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2006-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Proteasome inhibition by alpha-synuclein in living cells.2006

    • Author(s)
      Nonaka T, Hasegawa M
    • Organizer
      The 10th International Conference on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2006-07-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Small molecule inhibitors of alpha-synuclein filament assembly.2006

    • Author(s)
      Masuda M, Suzuki N, Taniguchi S, Oikawa T, Nonaka T, Iwatsubo T, Hisanaga S, Goedert M, Hasegawa M
    • Organizer
      The 10th International Conference on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2006-07-19
    • Related Report
      2008 Final Research Report
  • [Book] タウ:老年期認知症ナビゲーター(平井俊策監修)2006

    • Author(s)
      長谷川成人
    • Publisher
      東京 : メディカルレビュー社
    • Related Report
      2008 Final Research Report
  • [Book] 神経原線維変化: 老年期認知症ナビゲーター( 平井俊策監修)2006

    • Author(s)
      長谷川成人
    • Publisher
      東京 : メディカルレビュー社
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] TDP-43蓄積細胞モデル2008

    • Inventor(s)
      野中隆、新井哲明、秋山治彦、長谷川成人
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構
    • Industrial Property Number
      2008-101899
    • Filing Date
      2008-04-09
    • Application Year
      2008
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 遺伝子変異を用いた筋萎縮性側索硬化症の予測法2008

    • Inventor(s)
      糸川昌成、新井誠、長谷川成人、野中隆, 秋山治彦、新井哲明
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構
    • Industrial Property Number
      2008-095035
    • Filing Date
      2008-04-01
    • Application Year
      2008
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 遺伝子変異を用いた筋萎縮性側索硬化症の予測法2008

    • Inventor(s)
      糸川 昌成、長谷川 成人、 他
    • Industrial Property Rights Holder
      医学研究機構
    • Industrial Property Number
      2008-095035
    • Filing Date
      2008-04-01
    • Application Year
      2008
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] TDP-43凝集物に特異的に結合する抗体2007

    • Inventor(s)
      長谷川成人、新井哲明、野中隆、亀谷富由樹、秋山治彦
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構
    • Industrial Property Number
      2007-178583
    • Filing Date
      2007-07-06
    • Application Year
      2007
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] TDP-43凝集物に特異的に結合する抗体2007

    • Inventor(s)
      長谷川 成人、 他
    • Industrial Property Rights Holder
      医学研究機構
    • Industrial Property Number
      2007-178583
    • Filing Date
      2007-07-06
    • Application Year
      2007
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経変性疾患治療用物質のスクリーニング方法2006

    • Inventor(s)
      野中隆、増田雅美、長谷川成人
    • Industrial Property Rights Holder
      財団法人東京都医学研究機構
    • Industrial Property Number
      2006-030530
    • Filing Date
      2006-02-08
    • Application Year
      2006
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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