Roles of the defense mechanisms against oxidative damage in nucleic acids for maintenance of brain cells

• Project/Area Number: 18300124
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kyushu University
• Principal Investigator: NAKABEPPU Yusaku Kyushu University, Medical Institute of Bioregulation, Professor (30180350)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥2,160,000); Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2006: ¥7,800,000 (Direct Cost: ¥7,800,000)
• Keywords: Reactive oxygen species / 8-oxoguanine / MTH1 / OGG1 / MUTYH / dopamine neuron / striatal medium spiny neuron / hippocampal neurogenesis / DNA酸化損傷 / 酸化ヌクレオチド損傷 / 遣伝子改変マウス / 細胞死 / 神経変性 / 神経新生 / ミトコンドリア / 核 / 酸化ストレス / パーキンソン病 / ハンチントン舞踏病 / ミトコンドリアゲノム / 核ゲノム

Research Abstract

The head investigator, Dr. Nakabeppu had shown that oxidation or deamination of bases or nucleotides by reactive oxygen species causes cellular dysfunction through accumulation of such aberrant bases or nucleotides within cells. In this project, we explored molecular pathways causing neuronal cell death or neuronal dysfunction under oxidative stress, by examining Mth1-, Ogg1-, Mutyh,- and Itpa -null mice and cell lines derived from these mutant mice, in comparison to wild-type mice and cell lines. Furthermore, functional analyses of fosB gene coding subunits of AP-1 transcription factor and its downstream target, galectin-1 were performed, in order to explore the regulatory mechanisms for the neurogenesis in hippocampal dentate gyrus under oxidative stress, as well as for the response to oxidative stress in brain. We have achieved the following results for 2 years.
[1] We have demonstrated that oxidation of nucleic acids is one of causes for the neuronal dysfunction of dopamine neurons, using a model mice for Parkinsonism.
[2] We showed that oxidative damage in nucleic acids plays a major role for degeneration of medium spiny neurons in the striatum caused by mitochondrial toxin, 3-nitropropionic acid.
[3] We elucidated the molecular pathways for cell death caused by accumulation of oxidized bases in either nuclear or mitochondrial genomes.
[4] We elucidated the molecular pathway for cell death caused by oxidation of mitochondrial nucleotide pool and the defense mechanism against it.
[5] We explored the sanitizing mechanism for deaminated purine nucleoside triphosphates generated by oxidative deamination.
[6] We have shown that fosB gene is involved in the regulation of neurogenesis in the hippocampal dentate gyrus under oxidative stress.
[7] We demonstrated that galectin-1 promotes neurogenesis in the hippocampal dentate gyrus.

Research Products

• [Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death (2008)
  • Author(s): Ichikawa J., et. al.
  • Journal Title: DNA Repair 7 Pages: 418-30
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2008)
  • Author(s): Oka S., et. al.
  • Journal Title: EMBO J 27 Pages: 421-432
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exnosure to sodium nitroprusside induces cell death (2008)
  • Author(s): Ichikawa, J., et. al.
  • Journal Title: DNA Repair 7(3) Pages: 418-430
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2008)
  • Author(s): Oka, S., et. al.
  • Journal Title: EMBO J 27(2) Pages: 421-432
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death. (2008)
  • Author(s): Ichikawa J., et. al.
  • Journal Title: DNA Repair 7(3) Pages: 418-30
  • Peer Reviewed
• [Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. (2008)
  • Author(s): Oka S., et. al.
  • Journal Title: EMBO J. 27(2) Pages: 421-432
  • Peer Reviewed
• [Journal Article] Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor,Elongin A (2007)
  • Author(s): Miyata K., et. al.
  • Journal Title: Cell Death Differ 14 Pages: 716-726
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Oxidative damage in nucleic acids and Parkinson's disease (2007)
  • Author(s): Nakabeppu Y., et. al.
  • Journal Title: J.Neurosci.Res 85 Pages: 919-934
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis (2007)
  • Author(s): Tsuzuki T., et. al.
  • Journal Title: Cancer Sci 98 Pages: 465-740
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS (2007)
  • Author(s): Kuraoka I., et. al.
  • Journal Title: DNA Repair 6 Pages: 841-851
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hyertension (2007)
  • Author(s): Ohtsubo T., et. al.
  • Journal Title: DNA Repair 6 Pages: 760-769
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis (2007)
  • Author(s): Sakamoto K., et. al.
  • Journal Title: Cancer Res 67 Pages: 6599-6604
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer (2007)
  • Author(s): Kunisada M., et. al.
  • Journal Title: J.Invest.Decmatol 127 Pages: 2865-2871
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination (2007)
  • Author(s): Guikema J. E., et. al.
  • Journal Title: 」.Exp.Med 204 Pages: 3017-26
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A (2007)
  • Author(s): Miyata, Y, et. al.
  • Journal Title: Cell Death Differ 14(4) Pages: 716-726
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease (2007)
  • Author(s): Nakabeppu, Y, et. al.
  • Journal Title: J Neurosci Res 85(5) Pages: 919-934
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis (2007)
  • Author(s): Tsuzuki, T., et. al.
  • Journal Title: Cancer Sci 98(4) Pages: 465-470
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS (2007)
  • Author(s): Kuraoka, I., et. al.
  • Journal Title: DNA Repair 6(6) Pages: 841-851
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Accumulation of 8-oxo-deoxyguanosine in Cardiovascular Tissues with the Development of Hypertension (2007)
  • Author(s): Ohtsubo, T., et. al.
  • Journal Title: DNA Repair 6(6) Pages: 760-769
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis (2007)
  • Author(s): Sakamoto, K., et. al.
  • Journal Title: Cancer Res 67(14) Pages: 6599-6604
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Narrow-Band UVB Induces More Carcinogenic Skin Tumors than Broad-Band UVB through the Formation of Cvclobutane Pyrimidine Dimer (2007)
  • Author(s): Kunisada, M., et. al.
  • Journal Title: J Invest Dermatol 127(12) Pages: 2865-2871
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] APE1 and APE2 Dependent DNA Breaks in Immunelobulin Class Switch Recombination (2007)
  • Author(s): Guikema, J.E.J., et. al.
  • Journal Title: J Exp Med 204(12) Pages: 3017-3026
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative damage in nucleic acids and Parkinson's disease. (2007)
  • Author(s): Nakabeppu Y., et. al.
  • Journal Title: J Neurosci Res. 85(5) Pages: 919-934
  • Peer Reviewed
• [Journal Article] Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor,Elongin A. (2007)
  • Author(s): Miyata K., et. al.
  • Journal Title: Cell Death Differ 14(4) Pages: 716-726
  • Peer Reviewed
• [Journal Article] Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension. (2007)
  • Author(s): Ohtsubo T., et. al.
  • Journal Title: DNA Repair 6(6) Pages: 760-769
  • Peer Reviewed
• [Journal Article] RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. (2007)
  • Author(s): Kuraoka I., et. al.
  • Journal Title: DNA Repair 6(6) Pages: 841-851
  • Peer Reviewed
• [Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis. (2007)
  • Author(s): Tsuzuki T., et. al.
  • Journal Title: Cancer Sci. 98(4) Pages: 465-740
  • Peer Reviewed
• [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. (2007)
  • Author(s): Sakamoto K., et. al.
  • Journal Title: Cancer Res. 67(14) Pages: 6599-6604
  • Peer Reviewed
• [Journal Article] Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer. (2007)
  • Author(s): Kunisada M., et. al.
  • Journal Title: J Invest Dermatol. 127(12) Pages: 2865-2871
  • Peer Reviewed
• [Journal Article] APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. (2007)
  • Author(s): Guikema J.E., et. al.
  • Journal Title: J Exp Med. 204(12) Pages: 3017-26
  • Peer Reviewed
• [Journal Article] RNA Polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor FTIIS. (2007)
  • Author(s): Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Seah, J., Kwei, M., Ikegami, T., Handa, H., Nakabeppu, Y., Tanaka, K
  • Journal Title: DNA Repair (印刷中)
• [Journal Article] Accumulation of 8-oxo-deoxyguanosine in Cardiovascular Tissues with the Development of Hypertension. (2007)
  • Author(s): Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M., Nakabeppu, Y.
  • Journal Title: DNA Repair (印刷中)
• [Journal Article] Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis. (2007)
  • Author(s): Tsuzuki, T., Nakatsu, Y., Nakabeppu, Y.
  • Journal Title: Cancer Sci (印刷中)
• [Journal Article] Oxidative Damage in Nucleit Acids and Parkinson's Disease. (2007)
  • Author(s): Nakabeppu, Y., Tsuchimoto, D., Yamaguchi, H., Sakumi, K.
  • Journal Title: J. Neurosci, Res. 85・5 Pages: 919-934
• [Journal Article] Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A. (2007)
  • Author(s): Miyata, K., Yasukawa, T., Fukuda, M., Takeuchi, T., Yamazaki, K., Sakumi, K., Tamamori-Adachi, M., Ohnishi, Y., Ohtsuki, Y., Nakabeppu, Y., Kitajima, S., Onishi, S., Aso, T.
  • Journal Title: Cell Death Differ. 14・4 Pages: 716-726
• [Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids (2006)
  • Author(s): Nakabeppu Y., et. al.
  • Journal Title: Biol Chem 387 Pages: 373-379
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neonatal ventral hippocampal lesions produce an elevation of ΔFosB-like protein(s) in the rodent neocortex (2006)
  • Author(s): Powell KJ., et. al.
  • Journal Title: Neuropsychopharmacology 31 Pages: 700-711
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] MTHl,an oxidized purine nucleoside triphosphatase,protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methy1-4-pheny1-1,2,3,6-tetrahdropyridine (2006)
  • Author(s): Yamaguchi H., et. al.
  • Journal Title: Cell Death Differ 13 Pages: 551-563
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the prefbmed regions for recombination and single nucleotide polymorphism in the human genome (2006)
  • Author(s): Ohno M., et. al.
  • Journal Title: Genome Res 16 Pages: 567-575
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association:the Hisayama Study (2006)
  • Author(s): Arima H., et. al.
  • Journal Title: Eur.J.Cancer Prev 15 Pages: 196-201
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] MTH1,an oxidized purine nucleoside triphosphatase,prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides (2006)
  • Author(s): Nakabeppu Y., et. al.
  • Journal Title: DNA Repair 5 Pages: 761-772
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Up-regulation of hMUTYH,a DNA repair enzyme,in the mitochondria of substantia nigra in Parkinson's disease (2006)
  • Author(s): Arai T., et. al.
  • Journal Title: Acta Neuropathol 112 Pages: 139-145
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an altemativc exon 2C of human MTH1 gene confbrs an amino temlinal extension that fhnctions as a mitochondrial targeting signal (2006)
  • Author(s): Sakai Y., et. al.
  • Journal Title: J.Mol.Med 84 Pages: 660-670
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis (2006)
  • Author(s): Akatsuka S., et. al.
  • Journal Title: Am.」.Pathol 169 Pages: 1328-1342
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesls therapy (2006)
  • Author(s): Thijssen V. L., et. al.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A 103 Pages: 15975-15980
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice (2006)
  • Author(s): Arima T., et. al.
  • Journal Title: Genomics 88 Pages: 650-658
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Stmcture by the Human MTH1 Protein (2006)
  • Author(s): Kamiya H., et. al.
  • Journal Title: 」.Biochem 140 Pages: 843-849
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides,8-oxo-dGMP and 2-oxo-dATP (2006)
  • Author(s): Nakmmura T., et. al.
  • Journal Title: Acta Crystallograph.Sect.F.Struct.Biol.Cryst.Commun 62 Pages: 1283-1285
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 活性酸素によるゲノムの酸化とヒトゲノムの多様性 (2006)
  • Author(s): 中別府 雄作, 他
  • Journal Title: 実験医学 24 Pages: 756-1753
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 脳神経変性疾患と酸化ストレス (2006)
  • Author(s): 中別府 雄作, 他
  • Journal Title: 分子細胞治療 5 Pages: 35-43
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 活性酸素と生命機能の制御 (2006)
  • Author(s): 中別府 雄作, 他
  • Journal Title: BIO Clinica 5 Pages: 35-43
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 酸化ストレスとミトコンドリア (2006)
  • Author(s): 中別府 雄作, 他
  • Journal Title: Clinical Neuroscience 21 Pages: 79-83
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids. (2006)
  • Author(s): Nakabeppu, Y., et. al.
  • Journal Title: Biol Chem 387(4) Pages: 373-379
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neonatal Ventral Hippocampal Lesions Produce an Elevation of DFosB-like Protein(s) In the Rodent Neocortex. (2006)
  • Author(s): Powell, K. J., et. al.
  • Journal Title: Neuropsychopharmacology 31(4) Pages: 700-711
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6- tetrahydronvridine. (2006)
  • Author(s): Yamaguchi, H., et. al.
  • Journal Title: Cell Death Differ 13(4) Pages: 551-563
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome. (2006)
  • Author(s): Ohno, M., et. al.
  • Journal Title: Genome Res 16(5) Pages: 567-575
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association : the Hisayama Study. (2006)
  • Author(s): Arima, H., et. al.
  • Journal Title: Eur J Cancer Prev 15(3) Pages: 196-201
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides. (2006)
  • Author(s): Nakabeppu, Y., et. al.
  • Journal Title: DNA Repair 5(7) Pages: 761-772
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease. (2006)
  • Author(s): Arai, T., et. al.
  • Journal Title: Acta Neuropathol 112(2) Pages: 139-145
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal. (2006)
  • Author(s): Sakai, Y, et. al.
  • Journal Title: J Mol Med 84(8) Pages: 660-670
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. (2006)
  • Author(s): Akatsuka, S., et. al.
  • Journal Title: Am J Pathol 169(4) Pages: 1328-1342
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. (2006)
  • Author(s): Thijssen, V.L, et. al.
  • Journal Title: Proc Natl Acad Sci U S A 103(43) Pages: 15975-15980
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. (2006)
  • Author(s): Arima,T., et. al.
  • Journal Title: Genomics 88(5) Pages: 650-658
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein. (2006)
  • Author(s): Kamiya, H., et. al.
  • Journal Title: J Biochem 140(6) Pages: 843-849
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP. (2006)
  • Author(s): Nakamura, T., et. al.
  • Journal Title: Acta Crystallograph Sect F Struct Biol Cryst Commun 62-Pt 12 Pages: 1283-1285
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidation of genome by reactive oxygen species and diversity of human genome (2006)
  • Author(s): Nakabeppu, Y., et. al.
  • Journal Title: Jikken Igaku 24(1) Pages: 756-1753
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neurodgenerative diseases and oxidative stress (2006)
  • Author(s): Nakabeppu., Y., et. al.
  • Journal Title: Bunnshi Saibou Chiryou 5(6) Pages: 35-43
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reactive oxigen species and regulation of biological function (2006)
  • Author(s): Nakabeppu, Y
  • Journal Title: BIO Clinina 21(12) Pages: 79-83
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative stress and mirochondria (2006)
  • Author(s): Nakabeppu, Y
  • Journal Title: Clinical Neuroscience 24(6) Pages: 639-642
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recognition of Nucleotide Analogs containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein. (2006)
  • Author(s): Kamiya, H., Cadena-Amaro, C., Dugue, L., Yakushiji, H., Minakawa, N., Matsuda, A., Pochet, S., Nakabeppu, Y., Harashima, H.
  • Journal Title: J. Biochem. 140・6 Pages: 843-849
• [Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP. (2006)
  • Author(s): Nakamura, T., Kitaguchi, Y., Miyazawa, M., Kamiya, H., Toma, S., Ikemizu, S., Shirakawa, M., Nakabeppu, Y., Yamagata, Y.
  • Journal Title: Acta Crystallograph, Sect. F. Struct. Biol. Cryst. Commun. 62・12 Pages: 1283-1285
• [Journal Article] The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. (2006)
  • Author(s): Arima, T., Yamasaki, K., John.R.M., Kato, K., Sakumi, K., Nakabeppu, Y., Wake, N., Kono, T.
  • Journal Title: Genomics 88・5 Pages: 650-658
• [Journal Article] Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. (2006)
  • Author(s): Thijssen, V.L., Postel, r。, Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum.L G., Bakkers, J., Mayo, K H., Poirier, F., Brifficen, A.W.
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. 103・43 Pages: 15975-15980
• [Journal Article] Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. (2006)
  • Author(s): Akatsuka, S., Aung, T.T., Dutta, K.K., Jinag.L., Lee, W.H., Liu, Y.T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., Naito, Y., Yoshikawa, T., Kasai, H., Tominaga, Y., Sakumi, K., Nakabeppu, Y., Kawai, Y., Uchida, K., Yamasaki, A., Tsuruyama, T., Yamada, Y., Toyokuni, S.
  • Journal Title: Am. J. Pathol. 169・4 Pages: 1328-1342
• [Journal Article] Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease. (2006)
  • Author(s): Arai, T., Fukae, J., Hatano, T., Kubo, S., Ohtsubo, T., Nakabeppu, Y., Mori, H., Mizuno, Y., Hattori, N.
  • Journal Title: Acta Neuropathol. 112・2 Pages: 139-145
• [Journal Article] The GT to GC single nucleotide polymorphism at the beginning of an altemative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal. (2006)
  • Author(s): Sakai, Y., Oda, H., Yoshimura, D., Furuichi, M., Kang, D., Iwai, S., Hara, T., Nakabeppu, Y.
  • Journal Title: J. Mol. Med. 84・8 Pages: 660-670
• [Journal Article] MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides. (2006)
  • Author(s): Nakabeppu, Y., Kajitani, K., Sakamoto, K., Yamaguchi, H., Tsuchimoto, D.
  • Journal Title: DNA Repair 5・7 Pages: 761-772
• [Journal Article] Angiotensin I-converting enzyme gene polyorphism modifies the smoking-cancer association : the Hisayama Study. (2006)
  • Author(s): Arima, H., Kiyohara, Y., Tanizaki, Y., Nakabeppu, Y., Kubo, M., Kato, I., Sueishi, K., Tsuneyoshi, M., Fujishima, M., Iida, M.
  • Journal Title: Eur. J. Cancer Prev. 15・3 Pages: 196-201
• [Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome. (2006)
  • Author(s): Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., Nakabeppu, Y.
  • Journal Title: Genome Res. 16・5 Pages: 567-575
• [Journal Article] Neonatal Ventral Hippocampal Lesions Produce an Elevation of ΔFosB-like Protein(s) In the Rodent Neocortex. (2006)
  • Author(s): Powell, K.J., Binder, T.L., Hori, S., Nakabeppu, Y., R., D., Weinberger, Lipska, B.K., Robertson, G.S.
  • Journal Title: Neuropsychopharmacology 31・4 Pages: 700-711
• [Journal Article] MTH1, an oxidized purine nucleoside triphospghatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydrophridine. (2006)
  • Author(s): Yamaguchi, H., Kajitani, K., Dan, Y., Furuichi, M., Ohno, M., Sakumi, K., Kang, D., Nakabeppu.Y.
  • Journal Title: Cell Death Differ. 13・4 Pages: 551-563
• [Journal Article] Mutagenesis and carcinogenesis carsed by the oxidation of nucleic acids. (2006)
  • Author(s): Nakabeppu, Y., Sakumi, K., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T., Nakatsu, Y.
  • Journal Title: Biol. Chem. 387・4 Pages: 373-379
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2008)
  • Author(s): Oka S., et. al.
  • Organizer: The Joint Symposium of the 3rd Intemational Symposium of Institutes Network and Hot Spring Harbor-Global COE Symposium
  • Place of Presentation: 別府
  • Year and Date: 2008-02-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2008)
  • Author(s): Oka, S., et. al.
  • Organizer: The Joint Symposium of the 3rd International Symposium of Institutes Network and Hot Spring Harbor?Global COE Symposium, Young Investigator Forum
  • Place of Presentation: Beppu
  • Year and Date: 2008-02-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. (2008)
  • Author(s): Oka S., et. al.
  • Organizer: The Joint Symposium of the 3^<rd> Intenational Symposium of Institutes Network and Hot Spring Harbor-Global COE Symposium
  • Place of Presentation: 別府
  • Year and Date: 2008-02-01
• [Presentation] Oxidative stress-induced intestinal tumorigenesis in mice with a targeted disruption of the Mutyh gene (2007)
  • Author(s): 中津 可道, 他
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Nitric oxide induces cell death through oxidation of mitochondrial deoxynucleotide pools (2007)
  • Author(s): Ichikawa J., et. al.
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Oxidative stress-induced intestinal tumorigenesis in mice with a targeted disruption of the Mutyh gene. (2007)
  • Author(s): 中津 可道, ら
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Nitric oxide induces cell death through oxidation of mitochondrial deoxynucleotide pools. (2007)
  • Author(s): Ichikawa J, et. al.
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] ゲノムに蓄積した8-オキソグアニンは染色体組換えを誘発する (2007)
  • Author(s): 大野 みずき, 他
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ITP結合タンパク質ITPBPIの生化学的特性の解析 (2007)
  • Author(s): 野中 麻里, 他
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 哺乳動物細胞における2-OH-ATPの生物学的影響 (2007)
  • Author(s): 太田 詠子, 他
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ゲノムに蓄積した8-オキソグアニンは染色体組換えを誘発する。 (2007)
  • Author(s): 大野 みずき, ら
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] ITP結合タンパク質ITPBP1の生化学的特性の解析 (2007)
  • Author(s): 野中 麻里, ら
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] ITPA-deficient mouse embryonic fibroblasts exhibit chromosomal aberrations (2007)
  • Author(s): Abolhassani N., et. al.
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ITPA-deficient mouse embryonic fibroblasts exhibit chromosomal aberrations. (2007)
  • Author(s): Abolhassani N, et. al.
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] 核とミトコンドリアゲノムに蓄積した8-オキソグアニンは異なる2つの経路による細胞死を誘導する (2007)
  • Author(s): 岡素 雅子, 他
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Oxidative damage to nuclear and mitochondrial DNAs initiates two distinct pathways of cell death (2007)
  • Author(s): Oka, S., et. al.
  • Organizer: BMB2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ITPA-deficient mouse embryonic fibroblasts exhibit chromosomal aberrations (2007)
  • Author(s): Abolhassani, N., et. al.
  • Organizer: BMB2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 8-Oxoguanine accumulated in genome induces chromosomal rercombination (2007)
  • Author(s): Ohno, M., et. al.
  • Organizer: BMB2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Analysis of biochemical properties of ITP- binding proteinITBP 1 (2007)
  • Author(s): Nonaka, M., et. al.
  • Organizer: BMB2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Biological effects of 2-OH-ATP in mammalian cells (2007)
  • Author(s): Ohno, E., et. al.
  • Organizer: BMB2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced intestinal tumorigenesis in mice with a targeted disruption of the Mutyh gene (2007)
  • Author(s): Nkatsu, Y., et. al.
  • Organizer: BMB2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Nitric oxide induces cell death through oxidation of mitochondrial deoxynucleotide pools (2007)
  • Author(s): Ichikawa, J., et. al.
  • Organizer: BMB2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice (2007)
  • Author(s): Tsuzuki T., et. al.
  • Organizer: 第1回アジア環境変異原学会・日本環境変異学会第36回大会
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice. (2007)
  • Author(s): Tsuzuki T, et. al.
  • Organizer: 日本環境変異学会・第36回大会
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] Mutyh遺伝子欠損マウスにおける酸化ストレス誘発消化管腫瘍の解析 (2007)
  • Author(s): 續 輝久, 他
  • Organizer: 日本放射線影響学会・第50回大会
  • Place of Presentation: 千葉
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Msh2欠損マウスにおける酸化ストレス誘発消化管発癌 (2007)
  • Author(s): 朴 晶淑, 他
  • Organizer: 日本放射線影響学会・第50回大会
  • Place of Presentation: 千葉
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Analysis of oxidative stress-induced tumors in the small intestine of Mutyh-deficient mice (2007)
  • Author(s): Tsuzuki, T., et. al.
  • Organizer: The 50th Annual Meeting of The Japan Radiation Research Society
  • Place of Presentation: Chiba
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Msh2 -deficient mice (2007)
  • Author(s): Piao, J., et. al.
  • Organizer: The 50th Annual Meeting of The Japan Radiation Research Society
  • Place of Presentation: Chiba
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyhsh-deficient mice (2007)
  • Author(s): Tsuzuki, T., et. al.
  • Organizer: 1st Asian Conference on Environmental Mutagens & 36th Annual Meeting of The Japanese Emvironmental Mutagen Society
  • Place of Presentation: Kitakyushu
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ΔFosB promotes neurogenesis in the dentate gyrus of mouse hippocampus after brain damage caused by excitotoxicity (2007)
  • Author(s): Yhtsudo N., et. al.
  • Organizer: The 37th annual meeting of the Society fbr Neuroscience
  • Place of Presentation: San Diego,CA,USA
  • Year and Date: 2007-11-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ΔFosB promotes neurogenesis in the dentate gyms of mouse hippocampus after brain damage caused by excitotoxicity (2007)
  • Author(s): Yutsudo, N., et. al.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, LA, USA
  • Year and Date: 2007-11-06
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ΔFosB promotes neurogenesis in the dentate gyrus of mouse hippocampus after brain damage caused by excitotoxicity (2007)
  • Author(s): Yutsudo N, et. al.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-06
• [Presentation] Disruption of Defbnce Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polyphenols (2007)
  • Author(s): Nakabeppu Y., et. al.
  • Organizer: 3rd International Confbrence on Polyphenol and Health
  • Place of Presentation: Kyoto
  • Year and Date: 2007-10-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Disruption of Defense Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polynhenols (2007)
  • Author(s): Nakabeppu, Y
  • Organizer: 3rd International Conference on Polyphenol and Health
  • Place of Presentation: Kyoto
  • Year and Date: 2007-10-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Disruption of Defence Mechanisms Against Oxidative Damage in Nucleic Acids and the Affect of Polyphenols. (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Organizer: 3^<td> International Conference on Polyphenol and Health
  • Place of Presentation: Kyoto
  • Year and Date: 2007-10-25
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2007)
  • Author(s): Oka S., et. al.
  • Organizer: Nordic Region Workshop on Mitocondrial Biogenesis and Disease(Scandmit07)
  • Place of Presentation: Murikka,Finland
  • Year and Date: 2007-10-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2007)
  • Author(s): Oka, S., et. al.
  • Organizer: Nordic Region Workshop on Mitocondrial Biogenesis and Disease
  • Place of Presentation: Murikka, Finland
  • Year and Date: 2007-10-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Defbnses against damage in nucleotide pools and the suppression of carcinogenesis,neurodegeneration and heart failure (2007)
  • Author(s): Nakabeppu Y., et. al.
  • Organizer: 38th Annual Meeting of the Environmental Mutagcn Society
  • Place of Presentation: Atlanta,GA,USA
  • Year and Date: 2007-10-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2007)
  • Author(s): Oka S., et. al.
  • Organizer: Japan-Finland Joint Meeting on Mitochondria(」-Fin Mit)
  • Place of Presentation: Tampere,Finland
  • Year and Date: 2007-10-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2007)
  • Author(s): Oka, S., et. al.
  • Organizer: Japan-Finland Joint Meeting on Mitochondria
  • Place of Presentation: Tampere, Finland
  • Year and Date: 2007-10-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Defenses against damage in nucleotide pools and the suppression of carcinogenesis,neurodegeneration and heart failure. (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Organizer: 38^<th> Annual Meeting of the Environmental Mutagen Society
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2007-10-22
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice (2007)
  • Author(s): Tsuzuki T., et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of various DNA reair-deficient mice (2007)
  • Author(s): Piao J., et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice (2007)
  • Author(s): Tsuzuki, T., et. al.
  • Organizer: The 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of various DNA repair-deficient mice (2007)
  • Author(s): Piao J, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] 8-オキソグアニンのゲノム蓄積は染色体組換えを促進する (2007)
  • Author(s): 大野 みずき, 他
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MMutyh遺伝子欠損マウスに生じた酸化ストレス誘発腫瘍における癌関連遺伝子の突然変異解析 (2007)
  • Author(s): 中津 可道, 他
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genomic accumulation of an oxidized base, 8-oxoguanine promotes homologous recombination (2007)
  • Author(s): Ohno, M., et. al.
  • Organizer: The 79th Annual Meeting of the Genetic Society of Japan
  • Place of Presentation: Okayama
  • Year and Date: 2007-09-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mutation analysis of cancer-related genes in oxidative stress-induced tumors occured in Mutyh-deficient mice (2007)
  • Author(s): Nakatsu, Y., et. al.
  • Organizer: The 79th Annual Meeting of the Genetic Society of Japan
  • Place of Presentation: Okayama
  • Year and Date: 2007-09-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 8-オキソグアニンのゲノム蓄積は染色体組換えを促進する。 (2007)
  • Author(s): 大野 みずき, ら
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-20
• [Presentation] Mutyh遺伝子欠損マウスに生じた酸化ストレス誘発腫瘍における癌関連遺伝子の突然変異解析 (2007)
  • Author(s): 中津 可道, ら
  • Organizer: 第79回日本遺伝学会大会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-20
• [Presentation] Galectin-1 promotes neurogenesls in the dentate gyms of mouse hippocampus after brain damae caused by excitotoxicity (2007)
  • Author(s): Kajitani K., et. al.
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会 合同学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ΔFosB promotes neurogenesls in the dentate gyms of mouse hippocampus after brain damae caused by excitotoxicity (2007)
  • Author(s): Yutsudo N., et. al.
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会 合同学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ΔFosB promotes neurogenesis in the dentate gyrus of mouse hlppocampus after brain damage caused by excitotoxicity (2007)
  • Author(s): Yutsudo N, et. al.
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会 合同学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] Galectin-1 promotes neurogenesis in the dentate gyros of mouse hippocampus after brain damage caused by excitotoxicity (2007)
  • Author(s): Kajitani K, et. al.
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会 合同学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] Oxidative damage in nucleic acids in Huntington's disease model (2007)
  • Author(s): Sheng Z., et. al.
  • Organizer: 第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会 合同学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Oxidative damage in nucleic acids in Huntington's disease model (2007)
  • Author(s): Sheng, Z., et. al.
  • Organizer: Neuro2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-09-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Galectin-1 promotes neurogenesis in the dentate gyrus of mouse hippocampus after brain damage caused by excitotoxicity (2007)
  • Author(s): Kajitani, K., et. al.
  • Organizer: Neuro2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-09-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ΔFosB promotes neurogenesis in the dentate gyms of mouse hippocampus after brain damage caused by excitotoxicity (2007)
  • Author(s): Yutsudo, N., et. al.
  • Organizer: Neuro2007
  • Place of Presentation: Yokohama
  • Year and Date: 2007-09-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Analyses of ITPA-deficient mouse and embryonic fibroblasts (2007)
  • Author(s): Abolhassani, N., et. al.
  • Organizer: The 19th annual meeting on Mouse Molecular Genetics
  • Place of Presentation: Cambridge, UK
  • Year and Date: 2007-09-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 8-オキソグアニンのゲノム蓄積は相同染色体組換えを促進し遺伝的多様性を生み出す原動力となる (2007)
  • Author(s): 大野 みずき, 他
  • Organizer: 第9回日本進化学会京都大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 8-オキソグアニンのゲノム蓄積は相同染色体組換えを促進し遺伝的多様性を生み出す原動力となる。 (2007)
  • Author(s): 大野 みずき, ら
  • Organizer: 第9回日本進化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-01
• [Presentation] Oxidativestress-inducedintestinaltumorigenesisinmicewithatargeted (2007)
  • Author(s): Tsuzuki T., et. al.
  • Organizer: The 13th International Congress of Radiation Research
  • Place of Presentation: San Francisco,CA,USA
  • Year and Date: 2007-07-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genomic accumulation of 8-oxoguanine promotes homologous rercombination, and thus driving genomic diversity (2007)
  • Author(s): Ohno, M., et. al.
  • Organizer: Society of Evolutionary Studies, Japan, The 9th Annual Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2007-07-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced intestinal tumorigenesis in mice with a targeted disruption of the Mutyh gene (2007)
  • Author(s): Tsuzuki T, et. al.
  • Organizer: The 13^<th> International Congress of Radiation Research
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2007-07-10
• [Presentation] Mice that express only DFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity (2007)
  • Author(s): Nakabeppu, Y., et. al.
  • Organizer: The 30th Annual Meeting of the Canadian College of Neuropsychopharmacology
  • Place of Presentation: Banff, Alberta, Canada
  • Year and Date: 2007-06-17
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mice that express only ΔFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity (2007)
  • Author(s): Nakabeppu Y., et. al.
  • Organizer: 30th Annual Meeting of the Canadian College of Neurpsychoharmacology(CCNP)
  • Place of Presentation: Banff,Alberm,Canada
  • Year and Date: 2007-06-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mice that express only ΔFosB display a hyperactive phenotype accompanied by increased neurogenesis and resistance to excitotoxicity (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Organizer: 30^<th> Annual Meeting of the Canadian College of Neuropsychopharmacology(CCNP)
  • Place of Presentation: Banff, Alberta, Canada
  • Year and Date: 2007-06-10
• [Presentation] Cell death caused by 8-oxoguanine (2007)
  • Author(s): Nakabeppu Y.
  • Organizer: 3rd Japan-US DNA Repair Meeting
  • Place of Presentation: Akiu,Sendai
  • Year and Date: 2007-05-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cell death caused by 8-oxoguanine (2007)
  • Author(s): Nakabeppu, Y
  • Organizer: 3rd Japan-US DNA Repair Meeting, Akiu
  • Place of Presentation: Sendai
  • Year and Date: 2007-05-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Cell death caused by 8-oxoguanine (2007)
  • Author(s): Nakabeppu Y
  • Organizer: 3^<rd> Japan-US DNA Repair Meeting
  • Place of Presentation: Akiu, Sendai
  • Year and Date: 2007-05-08
• [Presentation] Mutyh mediates two distinct cell death pathways by monitoring buildup of 8-oxoguanine in nuclear and mitochondrial genomes (2007)
  • Author(s): Oka S., et. al.
  • Organizer: 4th Meeting of Asian Society for Mitochondrial Research and Medicine
  • Place of Presentation: Seoul.Korea
  • Year and Date: 2007-02-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MUTYH mediates two distinct cell death pathways by monitoring buildup of 8-oxoguanine in nuclear and mitochondrial genomes (2007)
  • Author(s): Oka, S., et. al.
  • Organizer: 4th Meeting of Asian Society for Mitochondrial Research and Medicine
  • Place of Presentation: Seoul. Korea
  • Year and Date: 2007-02-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] AP Endonuclease Makes DNA Breaks in Switch Regions During Immunoglobulin Class Switch Recombination (2007)
  • Author(s): Schrader C. E., et. al.
  • Organizer: Keystone Symposia on Biology of B Cells in Health and Disease
  • Place of Presentation: Banff,Alberta
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ITPA-deficient mouse emblyonic fibroblasts exhibit chromosomal aberrations (2007)
  • Author(s): Abolhassani N., et. al.
  • Organizer: The 19th annual meeting on Mouse Molecular Genetics
  • Place of Presentation: Cambridge,UK
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] AP Endonuclease Makes DNA Breaks in Switch Regions During Immunoglobulin Class Switch Recombination (2007)
  • Author(s): Schrader, C.E., et. al.
  • Organizer: Keystone Symposia on Biology of B Cells in Health and Disease, Banff
  • Place of Presentation: Alberta Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochandrial DNAs. (2007)
  • Author(s): Oka S, et. al.
  • Organizer: Nordic Region Workshop on Mitochondria(Scandomit O7)
  • Place of Presentation: Murikka, Finland
• [Presentation] 核酸の酸化による生体障害とその防御機構-発がんから神経変性まで- (2006)
  • Author(s): 中別府 雄作
  • Organizer: 第17回中国四国生体ラジカル研究会
  • Place of Presentation: 岡山
  • Year and Date: 2006-07-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Defenses against Oxidative Damage in Nucleic Acids and the Suppression of Carcinogenesis and Neurodegeneration (2006)
  • Author(s): Nakabeppu, Y
  • Organizer: The 17th Chugoku & Shikoku Forum on Bioradicals
  • Place of Presentation: Okayama
  • Year and Date: 2006-07-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ITPase is a quality controller of the ATP pool (2006)
  • Author(s): Nakabeppu Y.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress, Satellite Symposium on Frontiers in Redox Sciences
  • Place of Presentation: 京都
  • Year and Date: 2006-06-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ITPase is a quality controller of the ATP pool (2006)
  • Author(s): Nakabeppu, Y
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress, Satellite Symposium on Frontiers in Redox Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2006-06-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] APC遺伝子変異陰性の家族性大腸腺腫症患者におけるMUTYH遺伝子変異の解析 (2006)
  • Author(s): 藤澤 律子, 他
  • Organizer: 第92回日本消化器病学会総会
  • Place of Presentation: 北九州
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヒトゲノムの多様性と8-オキソグアニン (2006)
  • Author(s): 大野 みずき, 他
  • Organizer: 第7回日本がん分子疫学研究会・第29回日本がん疫学研究会合同学術集会
  • Place of Presentation: 広島
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mutation analysis of tumor-associated genes in oxidative stress-induced tumors in the small intestine of Mutyh-deficient mice (2006)
  • Author(s): Isod, T., et. al.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Homozygous deletion of mouse Elongin A results in embryonic lethality due to excessive apoptosis (2006)
  • Author(s): Aso, T., et. al.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Some flavonoids prevent cis-and trans-effect of expanded ctg repeats in a stable pc12 cell transformants (2006)
  • Author(s): Furuya H., et. al.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 活性酸素による核酸の化学修飾と様々な生命現象 (2006)
  • Author(s): 中別府 雄作
  • Organizer: 変異機構研究会・第19回夏の学校
  • Place of Presentation: 瀬戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 転写因子Nrf2はカイニン酸誘発興奮毒性への脳応答を制御する (2006)
  • Author(s): 段由 規彦, 他
  • Organizer: 第29回日本神経科会大会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] プリンヌクレオシド三リン酸分解酵素MTH1は,海馬ミクログリアにおいて神経興奮毒性にともなう核酸の酸化損傷の蓄積を抑制する (2006)
  • Author(s): 梶谷 康介, 他
  • Organizer: 第29回日本神経科会大会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 8-オキソグアニンはゲノム進化の原動力か (2006)
  • Author(s): 大野 みずき, 他
  • Organizer: 第8回日本進化学会東京大会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヌクレオチドプール浄化機構の生物学的意義 (2006)
  • Author(s): 中別府 雄作
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 札幌
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 8-オキソグアニンとヒトゲノムの多様性 (2006)
  • Author(s): 中別府 雄作
  • Organizer: 日本遺伝学会第78回大会
  • Place of Presentation: つくば
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウス染色体における酸化的DNA損傷の分布 (2006)
  • Author(s): 赤塚 慎也, 他
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mutyh遺伝子欠損マウスにおける酸化ストレス誘発小腸腫瘍の解析 (2006)
  • Author(s): 磯田 拓郎, 他
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Increased expression of ΔFosB causes hyperlocomotor activity and fbarless behavior,and to which FosB efficiently counteracts and also attenuates ΔFosB-independent exploratory behavior (2006)
  • Author(s): OhnishiY N., et. al.
  • Organizer: The 36th annual meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta GA,USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] FosB and ΔFosB detemine susceptibility to excitotoxlcity induced by kainate (2006)
  • Author(s): Ohnishi Y. H., et. al.
  • Organizer: The 36th annual meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta GA,USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MTH1は,一酸化窒素に起因する酸化ストレスが誘発する細胞死を,ミトコンドリアゲノムへの酸化ヌクレオチドの取り込みを抑制する事で効率良く抑制する (2006)
  • Author(s): 市川 淳二, 他
  • Organizer: 第6回日本ミトコンドリア学会年会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 核とミトコンドリアゲノムに蓄積した酸化障害は異なる2つの経路により細胞死を誘導する (2006)
  • Author(s): 岡素 雅子, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 8-オキソグアニンの蓄積と姉妹染色分体の早期分離 (2006)
  • Author(s): 大野 みずき, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ITPase欠損と心臓の異常 (2006)
  • Author(s): 作見 邦彦, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 哺乳動物細胞における2-oH-ATPおよび8-oxo-GTPの生物学的影響 (2006)
  • Author(s): 太田 詠子, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 転写因子Nrf2はカイニン酸誘発興奮毒性への脳応答を制御する (2006)
  • Author(s): 段由 規彦, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ITP結合タンパク質ITPBP1の生化学的特性 (2006)
  • Author(s): 野中 麻里, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ATP固定化樹脂を用いた損傷ヌクレオチド結合タンパク質の探索 (2006)
  • Author(s): 土本 大介, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Analysis of oxidative stress-induced tumors in the small intestines of Mutyh-deficient mice (2006)
  • Author(s): Isoda T., et. al.
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] DNA修復遺伝子欠損マウスにおける酸化ストレス誘発消化管発癌 (2006)
  • Author(s): 朴 晶淑, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genomic and functional analyses of MUTYH in APC-negative Japanese patients with adenomatous polyposis (2006)
  • Author(s): Yanaru-Fujusawa R., et. al.
  • Organizer: The 92nd Annual Meeting of the Japanese Society of Gastroenterology
  • Place of Presentation: Kitakyushu
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Diversity of human genome and 8-oxoguanine (2006)
  • Author(s): Ohno M., et. al.
  • Organizer: oint Meeting of the 8th Annual Meeting of Japanese Society of Cancer Molecular Epidemiology and the 29th Annual Meeting of Japanese Society of Cancer Epidemiology
  • Place of Presentation: Hiroshima
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mutation analysis of tumor-associated genes in oxidative stress-induced tumors in the small intestine of Mutyh- deficient mice (2006)
  • Author(s): Isod, T., et. al.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Distribution of oxidative DNA lesions across the entire genome (2006)
  • Author(s): Akatsuka, S., et. al.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biologyand 11 th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Homozygous deletion of mouse Elongin A results in embryonic lethality due to excessive apoptosis (2006)
  • Author(s): Aso, T., et. al.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Some flavonoids prevent cis- and trans- effect of expanded ctg repeats in a stable pc12 cell transformants (2006)
  • Author(s): Furuya, H., et. al.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology, and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Biological responses to chemical modification of nucleic acids caused by reactive oxigen snecies (2006)
  • Author(s): Nakabeppu, Y
  • Organizer: The 19th Summer School of Mutagenesis
  • Place of Presentation: Seto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Transcription factor, NRF2 regulates brain response to kainate-induced excitotoxicity (2006)
  • Author(s): Dan, Y., et. al.
  • Organizer: The 29th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate- induced excitotoxicity (2006)
  • Author(s): Kajitani, K., et. al.
  • Organizer: The 29th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Does 8-oxoguanine drive genome evolution ? (2006)
  • Author(s): Ohno, M, et. al.
  • Organizer: Society of Evolutionary Studies, Japan, The 8th Annual Meeting
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Biological significance of mechanisms sanitizing nucleotide pools (2006)
  • Author(s): Nakabeppu, Y
  • Organizer: Biological significance of mechanisms sanitizing nucleotide pools
  • Place of Presentation: Sapporo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effects of 8-oxoguanine on human genome (2006)
  • Author(s): Ohno, M., et. al.
  • Organizer: The 78th Annual Meeting of the Genetic Society of Japan
  • Place of Presentation: Tsukuba
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Distribution of oxidative DNA damage on mouse chromosomes (2006)
  • Author(s): Akatsuka, S., et. al.
  • Organizer: The 65th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Analyses of oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice (2006)
  • Author(s): Isjoda, T., et. al.
  • Organizer: The 65th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Increased expression of ΔFosB causes hyperlocomotor activity and fearless behavior, and to which FosB efficiently counteracts and also attenuates ΔFosB- independent exploratory behavior (2006)
  • Author(s): Ohnishi, Y.N., et. al.
  • Organizer: The 36th annual meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta GA, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] FosB and determine susceptibility to excitotoxicity induced by kainate (2006)
  • Author(s): Ohnishi, Y.H., et. al.
  • Organizer: The 36th annual meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta GA, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] MTH1 efficiently suppresses NO-induced cell death by avoiding incorporation of oxidized nucleotides to mitochondrial genome (2006)
  • Author(s): Ichikawa, J., et. al.
  • Organizer: The 6th Annual Cnference of the Japanese Society of Mitochondrial Research and Medicine
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs (2006)
  • Author(s): Oka, S., et. al.
  • Organizer: The Molecular Biology Society of Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Premature separation of sister chromatids caused by accumulation of 8-oxoguanine (2006)
  • Author(s): Ohno, M., et. al.
  • Organizer: The Molecular Biology Society of Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Heart failure caused by ITPase deficiency (2006)
  • Author(s): Sakumi, K., et. al.
  • Organizer: The Molecular Biology Society of Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Biological effects of 2-OH-ATP and 8-oxo-GTP in mammalian cells (2006)
  • Author(s): Ohta, E., et. al.
  • Organizer: The Molecular Biology Society of Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Transcription factor, NRF2 regulates brain response to kainate-induced excitotoxicity (2006)
  • Author(s): Dan, Y., et. al.
  • Organizer: The Molecular Biology Society of Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Biochemical properties of ITP-binding protein, ITBP1 (2006)
  • Author(s): Nonaka, , M., et. al.
  • Organizer: The Molecular Biology Society of Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Screening of damaged nucleotide- binding proteins using an ATP-immobilized bead (2006)
  • Author(s): Tsuchimoto, D., et. al.
  • Organizer: The Molecular Biology Society of Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Analysis of oxidative stress-induced tumors in the small intestines of Mutyh-deficient mice (2006)
  • Author(s): Isoda, T., et. al.
  • Organizer: The Molecular Biology Society of Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of various DNA repair-deficient mice (2006)
  • Author(s): Piao, J., et. al.
  • Organizer: The Molecular Biology Society o Japan 2006 Forum
  • Place of Presentation: Nagoya
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Diversity of human genome and 8-oxoguanine
  • Author(s): Nakabeppu, Y
  • Organizer: The 78th Annual Meeting of the Genetic Society of Japan
  • Place of Presentation: Tsukuba
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced intestinal tumorigenesis in mice with a targeted disruption of the Mutyh gene
  • Author(s): Tsuzuki, T., et. al.
  • Organizer: The 13th International Congress of Radiation Research
  • Place of Presentation: San Francisco CA. USA.
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Oxidative stress-induced tumorigenesis in the small intestine of various DNA repair-deficient mice
  • Author(s): Piao, J., et. al.
  • Organizer: The 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Defenses against damage in nucleotide pools and the suppression of carcinogenesis, neurodegeneration and heart failure
  • Author(s): Y., Nakabeppu
  • Organizer: 38th Annual Meeting of the Environmental Mutagen Society
  • Place of Presentation: Atlanta, GA, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 遺伝子変異の機構図説分子病態学4版(一瀬白帝, 鈴木宏治編集) (2008)
  • Author(s): 中別府 雄作
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 遺伝子変異の機構 図説 分子病態学 4版(一瀬 白帝, 鈴木 宏治 編集) (2008)
  • Author(s): 中別 府雄作
  • Publisher: 中外医学社
• [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides.In Evans, MD.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Publisher: Springer,Austin,TX
  • Description: 「研究成果報告書概要(和文)」より
• [Book] DNA Replication and Transcription: In Meyrers RA(eds), Genomics and Genetics: From Molecular Details to Analysis and Techniques (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Publisher: Wiley-VCH Verlag GmbH and Co.,Weinheim,Germany
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides. In Evans, M.D.and Cooke, M.S.(eds), Oxidative Damage to Nucleic Acids. (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Publisher: Springer,Austin,TX
• [Book] DNA Replication and Transcription:In Meyrers RA(eds), Genomics and Genetics:From Molecular Details to Analysis and Techniques. (2007)
  • Author(s): Nakabeppu Y, et. al.
  • Publisher: Wiley-VCH Verlag GmbH and Co., Weinheim, Germany
• [Book] Prevention of the mutagenecity and cytotoxicity of oxidized purine nucleotides, In Oxidative Damage to Nucleic Acids (2007)
  • Author(s): Nakabeppu, Y., Behmanesh, M., Yamaguchi, H., Yoshimura, D., Sakumi, K
  • Total Pages: 14
  • Publisher: Landes Bioscience/Eurekah, Georgetown, TX USA
• [Book] DNA Replication and Transcripton. In : Meyers RA, editor. Genomics and Genetics : From Molecular Details to Analysis and Techniques. (2007)
  • Author(s): Nakabeppy Y, Maki H, Sekiguchi. M
  • Total Pages: 27
  • Publisher: Wiley-VCH Verlag GmbH ＆ Co., Weinheim, Germany
• [Remarks]
  • URL: http://www.bioreg.kyushu-u.ac.jp/nfg/index.html