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Development of a new pulse oximeter for the dental pulp blood by using the absorbance difference between blue and violet LEDs

Research Project

Project/Area Number 18300168
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MIWA Zenzo  Tokyo Medical and Dental University, 歯学部附属病院, 講師 (30157705)

Co-Investigator(Kenkyū-buntansha) TAKAGI Yuzo  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (30124697)
IKAWA Motohide  東北大学, 病院歯科医療センター, 助教 (80176065)
MATSUURA Yuji  東北大学, 大学院・医工学研究科, 教授 (10241530)
TAKATANI Setsuo  東京医科歯科大学, 生体材料研究所, 教授 (40154786)
OHUCHI Katsuhiro  東京医科歯科大学, 生体材料研究所, 助教 (20322084)
Co-Investigator(Renkei-kenkyūsha) KAKINO Satoko  東京医科歯科大学, 歯学部附属病院, 医員 (30516307)
OHUCHI Katsuhiro  鈴鹿医療科学大学, 臨床工学科, 准教授 (20322084)
Research Collaborator KAKINO Satoko  東京医科歯科大学, 大学院・医歯学総合研究科, 大学院生
KIRIMOTO Akiko  東京医科歯科大学, 生体材料研究所, 研究員
YOHOYAMA Eriko  東北大学, 大学院・医工学研究科, 大学院生
OHTA Aoi  東北大学, 工学部, 学生
WATANABE Tomoki  東北大学, 工学部, 学生
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥12,360,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2006: ¥6,900,000 (Direct Cost: ¥6,900,000)
Keywords透過型光電脈波法 / 発光ダイオード / 歯髄血流測定 / 非侵襲的診断装置 / 酸素飽和度 / ヘマトクリット / 歯髄診断器
Research Abstract

電気歯髄診断法に変わって、歯の生死のみならず歯髄の健康状態をも診断できる非侵襲的で客観的な新しい透過型光電脈波法による診断装置を開発するために、抜去歯モデルおよび被験者の歯で光学的な基礎研究を行った。4波長の発光ダイオード(LED)を使用して測定した歯および歯髄血の透過光強度や歯髄脈波振幅の変化から、血液の定量測定や酸素飽和度測定などを予測でき患者の歯髄診断に応用できる可能性が示唆された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (40 results)

All 2009 2008 2007 2006 Other

All Journal Article (13 results) (of which Peer Reviewed: 7 results) Presentation (22 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Absolute transmitted light plethysmography for assessment of dental pulp vitality through quantification of pulp chamber hematocrit by a three-layer model2008

    • Author(s)
      Kakino S., Takagi Y., Takatani S.
    • Journal Title

      Journal of Biomedical. Optics 13(5), 054023

      Pages: 1-17

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 発光ダイオードを応用した新しい歯科臨床検査機器の開発2008

    • Author(s)
      三輪全三, 柿野聡子, 高木裕三
    • Journal Title

      日本歯科医学会雑誌 27

      Pages: 45-49

    • NAID

      10024176746

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Raman imaging of carious using a hollow optical fiber probe2008

    • Author(s)
      Yokoyama E., Kakino S., Matsuura Y.
    • Journal Title

      Applied Optics 47

      Pages: 4227-4230

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absolute transmitted light plethysmography for assessment of dental pulp vitality through quantification of pulp chamber hematocrit by a three-layer model.2008

    • Author(s)
      S. Kakino
    • Journal Title

      Journal of Biomedical Optics 13(5)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Raman imaging of carious lesions using a hollow optical fiberprobe2008

    • Author(s)
      Y. Matsuura
    • Journal Title

      Applied Optics 47

      Pages: 4227-4230

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 発光ダイオードを応用した新しい歯科臨床検査機器の開発2008

    • Author(s)
      三輪全三
    • Journal Title

      日本歯科医学会雑誌 27

      Pages: 45-49

    • NAID

      10024176746

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new multi-wavelength optical-plethysmograph for quantative determination of pulpal hemoglobin content and oxygen level using green and near-infrared LEDs2007

    • Author(s)
      Kakino S.
    • Journal Title

      Proceedings of SPIE2007(The Society of Photo-Optical Instrumentation Engineers.)Lasers in Dentistry XIII 642508

      Pages: 1-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new multi-wavelength optical-plethysmograph for quantitative determination of pulpal hemoglobin content and oxygen level using green and near-infrared LEDs.2007

    • Author(s)
      Satoko Kakino
    • Journal Title

      Proceedings of SPIE2007(The Society of Photo-Optical Instrumentation Engineers.) Lasers in Dentistry X III 6425

    • Related Report
      2006 Annual Research Report
  • [Journal Article] LED透過光を用いた歯髄血流の定量的診断2006

    • Author(s)
      柿野聡子
    • Journal Title

      第5回光・エレクトロニクス・情報通信と高齢化社会の医療・健康技術を考える会論文集-歯科医療における光エレクトロニクスの進展- 5

      Pages: 13-20

    • Related Report
      2008 Final Research Report
  • [Journal Article] 光学的非侵襲歯髄Viability診断法の開発-ヒト抜去上顎中切歯の透過光特性-.2006

    • Author(s)
      柿野 聡子
    • Journal Title

      第45回日本生体工学会 抄録集

      Pages: 595-595

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A new device for transmitted-light plethysmography of dental pulp applicable in a bright room.2006

    • Author(s)
      Zenzo Miwa
    • Journal Title

      The 5th Conference of Pediatric Dentistry Association of Asia Abstr.

      Pages: 78-78

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of light-transmission property of the human central incisors; Optacal non-invasive method for dental diagnosis.2006

    • Author(s)
      Satoko Kakino
    • Journal Title

      The 5th Conference of Pediatric Dentistry Association of Asia Abstr.

      Pages: 77-77

    • Related Report
      2006 Annual Research Report
  • [Journal Article] LED透過光を用いた歯髄血流の定量的診断.2006

    • Author(s)
      柿野 聡子
    • Journal Title

      第5回 光・エレクトロニクス・情報通信と高齢社会の医療・健康技術を考える研究会-歯科医療における光エレクトロニクスの進展- 5

      Pages: 13-20

    • Related Report
      2006 Annual Research Report
  • [Presentation] 透過型光電脈波法による小児期外傷歯の診断2009

    • Author(s)
      柿野聡子
    • Organizer
      第2回光・量子デバイス研究会
    • Place of Presentation
      和光市
    • Year and Date
      2009-02-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 透過型光電脈波法による小児期外傷歯の歯髄診断2009

    • Author(s)
      柿野聡子
    • Organizer
      第2回光・畳子デバイス研究会
    • Place of Presentation
      和光市
    • Year and Date
      2009-02-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Measurement of the trans-mitted-light through human upper incisors2009

    • Author(s)
      Ikawa M.
    • Organizer
      The 3rd International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      Sendai
    • Year and Date
      2009-01-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Measurement of the transmitted-light through human upper incisors.2009

    • Author(s)
      M. Ikawa.
    • Organizer
      3rd International Symposium for Interface Oral Health Science in Sendai
    • Place of Presentation
      仙台
    • Year and Date
      2009-01-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of the transimitted-light through the human teeth in vivo.2008

    • Author(s)
      M. Ikawa.
    • Organizer
      Japanese Association for Dental Research
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of the transmitted -light through the human teeth in vivo2008

    • Author(s)
      Ikawa M.
    • Organizer
      JADR
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Optical non- invasive recordings of pulpal blood flow in the traumatized teeth using transmitted-light plethysmography2008

    • Author(s)
      Kakino S., Miwa Z., Miyashin M., Takagi Y., Matsuura Y., Matoba K.
    • Organizer
      The 4th Sino-Japanese Conference on Stomatology
    • Place of Presentation
      Xi-an
    • Year and Date
      2008-09-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Optical non-invasive recordings of pulpal blood flow in the traumatized teeth using transmitted-1ight plethysmography.2008

    • Author(s)
      S. Kakino
    • Organizer
      第4回日中歯科医学大会
    • Place of Presentation
      西安
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of clinical transmitted-light plethysmography system for non- invasive pulpal diagnosis2008

    • Author(s)
      Kakino S., Miwa Z., Takagi Y., Matsuura Y., Kazunari M.
    • Organizer
      6th Association of Asia Pediatric Dentistry
    • Place of Presentation
      Kuala Lumpur
    • Year and Date
      2008-07-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of clinical transmitted-light plethysmography system for non-invasive pulpal diagnosis.2008

    • Author(s)
      S. Kakino
    • Organizer
      6th Association of Asia Pediatric Dentistry
    • Place of Presentation
      クアラルンプール
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯髄脈波検出光学系の基礎的検討2008

    • Author(s)
      太田葵、柿野聡子、三輪全三、高木裕三、松浦祐司
    • Organizer
      第28回レーザー学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-01-31
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 中空ファイバプローブを用いた初期う歯検出の試み(2008)2008

    • Author(s)
      横山江里子
    • Organizer
      第28回レーザー学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-01-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] Investigation of pulpal blood flow in replanted teeth by TLP2007

    • Author(s)
      Miwa Z., Kakino S., MotegiM., Ikawa M., TakagiY.
    • Organizer
      The 21th Congress of International Asociation of Pediatric Dentistry
    • Place of Presentation
      Hong Kong
    • Year and Date
      2007-06-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Investigation of pulpal blood flow in replanted teeth by TLP2007

    • Author(s)
      Zenzo Miwa
    • Organizer
      21th International Association of Pediatric Dentistry
    • Place of Presentation
      Hong Kong
    • Year and Date
      2007-06-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 透過型光電脈波法の歯髄診断への応用2007

    • Author(s)
      柿野聡子
    • Organizer
      レーザー学会東北・北海道支部講演会
    • Place of Presentation
      仙台
    • Year and Date
      2007-02-09
    • Related Report
      2008 Final Research Report
  • [Presentation] A new multi-wavelength optical plethysmo- graph for quantitative determination of pulpal hemoglobincontent and green oxygen level usingand near-infrared LEDs2007

    • Author(s)
      Kakino S., Miwa Z., Takagi Y., Kirimoto A., Ohuchi K., Takatani S.
    • Organizer
      Photonics West 2007, Biomedical Optics, Lasersin DentistryXIII
    • Place of Presentation
      California
    • Year and Date
      2007-01-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 透過型光脈波法を用いた歯髄血流測定2006

    • Author(s)
      柿野聡子
    • Organizer
      次世代バイオメディカルレーザ応用技術調査専門委員会
    • Place of Presentation
      東京
    • Year and Date
      2006-12-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯科医療における光エレクトロニクス2006

    • Author(s)
      三輪全三
    • Organizer
      第5回光・エレクトロニクス・情報通信と高齢社会の医療・健康技術を考える研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] LED透過光を用いた歯髄血流の定量的診断2006

    • Author(s)
      柿野聡子、三輪全三、高木裕三、桐本明子、大内克洋、高谷節雄
    • Organizer
      第5回光・エレクトロニクス・情報通信と高齢社会の医療・健康技術を考える研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] A new device for transmitted-light plethysmography of dental pulp applicable in a bright room2006

    • Author(s)
      Miwa Z., Kakino S., Kirimoto A., Takagi Y., Ohuchi K., Takatani S.
    • Organizer
      The 5th Conference of Pediatric DentistryAssociation of Asia
    • Place of Presentation
      Kaohsiung
    • Year and Date
      2006-06-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis oflight-transmission property of thhuman central incisors ; Optical non-invasive method for dental diagnosis2006

    • Author(s)
      Kakino S.,Miwa Z., Kirimoto A., Takagi Y., Ohuchi K, Takatani S.
    • Organizer
      The 5th Conference of Pediatric Dentistry Association of Asia
    • Place of Presentation
      Kaohsiung
    • Year and Date
      2006-06-23
    • Related Report
      2008 Final Research Report
  • [Presentation] 光学的非侵襲歯髄Viability診断方法の開発-ヒト抜去上顎中切歯の透過光特性-2006

    • Author(s)
      柿野聡子、三輪全三、高木裕三、姫野彰子、大内克洋、高谷節雄
    • Organizer
      第45回日本生体医工学会
    • Place of Presentation
      福岡
    • Year and Date
      2006-05-16
    • Related Report
      2008 Final Research Report
  • [Remarks] 三輪全三, 柿野聡子, 高木裕三, 桐本明子, 大内克洋, 高谷節雄簡便かつ非侵襲・定量診断が可能な歯髄脈波測定装置の開発. イノベーションジャパン2006. 東京. 2006年9月13-15日

    • Related Report
      2008 Final Research Report
  • [Remarks] 三輪全三、柿野聡子、高木裕三、桐本明子、大内克洋、高谷節雄. 歯髄の簡便かつ非襲侵・定量診断が可能な新しい透過光脈波測定装置. 産学官技術交流フェア2006. 東京2006年10月11-13日

    • Related Report
      2008 Final Research Report
  • [Remarks] 三輪全三、柿野聡子、高木裕三、桐本明子、大内克洋、高谷節雄.ライフサイエンスレポート(知財本部広報紙), 歯髄の簡便かつ非侵襲・定量診断が可能な新しい透過光脈波測定装置、10 : 70-73, 2006

    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 歯髄腔内血液測定方法、装置及び歯髄腔内血液測定用アダプタ2007

    • Inventor(s)
      三輪全三、柿野聡子、井川資英、高谷節雄、大内克洋、星英男、高木裕三、桐本明子(東京医科歯科大学)
    • Industrial Property Rights Holder
      国際出願PCT/JP
    • Patent Publication Number
      2007-167339
    • Filing Date
      2007-06-28
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許権2006

    • Inventor(s)
      三輪全三, 他
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2006-06-21
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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