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The study of stress processing in human brains and onset of stress related-diseases.

Research Project

Project/Area Number 18300226
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionJikei University School of Medicine

Principal Investigator

HIROKO Toshima  Jikei University School of Medicine, 医学部, 講師 (70328342)

Co-Investigator(Kenkyū-buntansha) ENDO Yoichi  東京慈恵会医科大学, 医学部, 講師 (20158786)
KIMURA Naofumi  東京慈恵会医科大学, 医学部, 教授 (80138742)
OBATA Toru  東京慈恵会医科大学, 医学部, 准教授 (80119776)
ETO Ken  東京慈恵会医科大学, 医学部, 助教 (00287210)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥9,730,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2006: ¥5,700,000 (Direct Cost: ¥5,700,000)
Keywordsストレスマネジメント / 近赤外光脳機能イメージング / 事象関連電位 / 血小板凝集能 / 自律神経機能 / ストレス / 心拍変動 / 耐性 / 全血流動性 / ノルアドレナリン / アドレナリン / 近赤外線トポグラフィー / 心電図RR間隔周波数解析 / ACTH
Research Abstract

(1) ヒトは、大きく分けてストレスが身体反応を起こしやすいタイプと、そうでないタイプに分けられる。前者では、ストレス負荷に対して脳血流が急激に増加する、脳波の伝達が速くなる、心電図所見で交感神経優位になっているなど、過剰な反応が確認された。(2) また、ヒトにストレスが加わると、血小板が活性化され、血栓を作りやすくなることがわかった。つまり、ストレス耐性の低いヒトでは、ストレス負荷で、血栓性疾患を起こしやすいことがわかった。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (27 results)

All 2009 2008 2007 2006

All Journal Article (12 results) (of which Peer Reviewed: 5 results) Presentation (15 results)

  • [Journal Article] Spontaneous platelet aggregation in normal subject assessed a laser light scattering method: An attempt at standardization2008

    • Author(s)
      Toshima H, et.al.(10)
    • Journal Title

      Platelets 19

      Pages: 293-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] アンケートに見る血小板凝集能検査法の現状-血小板凝集能検査の標準化にむけて-2008

    • Author(s)
      佐藤金夫、豊島裕子
    • Journal Title

      日本検査血液学会雑誌 9

      Pages: 167-776

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous platelet aggregation in normal subject assessed alaser light scattering method : An attempt at standardization2008

    • Author(s)
      Toshima H, et al
    • Journal Title

      Platelets 19

      Pages: 293-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アンケートに見る血小板凝集能検査測定法の現状一血小板凝集能検査の標準化に向けて-2008

    • Author(s)
      佐藤金夫, 豊島裕子, 他
    • Journal Title

      日本検査血液学会雑誌 9

      Pages: 167-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous platelet aggregation in normal subject assessed a laser light scattering method: An attempt at standardization2008

    • Author(s)
      Toshima H, et. al.
    • Journal Title

      Platelets (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生活リズムとストレス2007

    • Author(s)
      豊島裕子
    • Journal Title

      出向と肥満の関係・肥満と糖尿病 6

      Pages: 801-3

    • Related Report
      2008 Final Research Report
  • [Journal Article] 生活リズムとストレス。出向と肥満の関係。2007

    • Author(s)
      豊島 裕子
    • Journal Title

      肥満と糖尿病 6

      Pages: 801-803

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Whole-body vibration induces continuous excitation of vasomotor nerve, after the viblation loading2006

    • Author(s)
      豊島裕子
    • Journal Title

      日本衛生学雑誌 61(2)

      Pages: 249-249

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Arithmetic stress facilitates spontaneous platelet aggregation in healthy youth2006

    • Author(s)
      Toshima H, Obata T, et al.
    • Journal Title

      The Journal of Physiological Sciences 56(Suppl)

      Pages: 235-235

    • NAID

      130007038854

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 関節リウマチ患者の心理・正確の分析2006

    • Author(s)
      豊島裕子, 上里雅史
    • Journal Title

      日本内科学会雑誌 95(Suppl)

      Pages: 165-165

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 全身振動負荷に対する血管運動神経の2峰性反応2006

    • Author(s)
      豊島裕子, 遠藤陽一
    • Journal Title

      臨床神経 46(12)

      Pages: 1167-1167

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 脳卒中慢性期の内分泌機能障害2006

    • Author(s)
      豊島裕子, 本田英比古
    • Journal Title

      自律神経 43(2)

      Pages: 162-162

    • Related Report
      2006 Annual Research Report
  • [Presentation] New event-related potential (ERP) induced by loading of auditory and visual stimuli2009

    • Author(s)
      Toshima H
    • Organizer
      The 36^<th> Congress of International Union of Physiological Scientifices
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 聴覚・視覚二重刺激による事象関連電位の誘発-特徴的波形と個体差-2009

    • Author(s)
      豊島裕子
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 喫煙後の血栓形成性亢進2009

    • Author(s)
      豊島裕子
    • Organizer
      第106回日本内科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Influence of smoking on human Autonomic nervous system2009

    • Author(s)
      Toshima H
    • Organizer
      The 6^<th> Congress of the International Sciety for Autonomic Neuroscience
    • Place of Presentation
      Sydney
    • Related Report
      2008 Final Research Report
  • [Presentation] 心拍変動によるストレス反応評価-情動表出によるストレス反応評価-2008

    • Author(s)
      豊島裕子
    • Organizer
      第61回日本自律神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 心拍変動によるストレス反応評価-情動表出と主観的体験の測定-2008

    • Author(s)
      豊島 裕子, 他
    • Organizer
      第61回日本自律神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 心拍変動によるストレス反応評価2008

    • Author(s)
      豊島裕子
    • Organizer
      第105回日本内科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-13
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Evaluation of stress response in each individual using the heart rate power spectrem2008

    • Author(s)
      Toshima H
    • Organizer
      The 85th Annual Meeting of the Physiological society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Evaluation of stress response in each individual using the heart rate power spectrum.2008

    • Author(s)
      Toshima H
    • Organizer
      The 85th Annual Meeting of the Physiological society of Japan.
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Stress of a surgeon-Adverse effect of conducting surgeries on the surgeon's health2007

    • Author(s)
      Toshima H
    • Organizer
      The 5^<th> congress of the International Society for Autonomic Neuroscience
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-10-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 暗算負荷による血小板凝集能更新-経度血栓傾向診断のためのin vivo惹起-2007

    • Author(s)
      豊島裕子
    • Organizer
      第104回日本内科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 暗算負荷による血小板凝集能充進-軽度血栓傾向診断のためのin vivo惹起-2007

    • Author(s)
      豊島 裕子, 他
    • Organizer
      第104回日本内科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Brain imaging in Karuta players by near-infrared optical topo -graphy and event -related potential2007

    • Author(s)
      Toshima H
    • Organizer
      The 84^<th> annual Meeting of the physiological society of Japan
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 暗算負荷による血小板凝集能亢進2006

    • Author(s)
      豊島裕子
    • Organizer
      第7回日本検査血液学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-23
    • Related Report
      2008 Final Research Report
  • [Presentation] ストレス負荷による血小板α2A-adrenergic receptorの活性化2006

    • Author(s)
      豊島裕子
    • Organizer
      第59回日本自律神経学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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