Molecular bases of hypoglycemc index diet which prevents metabolic syndrome

• Project/Area Number: 18300232
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: TAKEDA Eiji The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (00144973)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Hironori 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60314861) ; ARAI Hidekazu 静岡県立大学, 食品栄養科学部, 准教授 (60325256)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,400,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥1,800,000); Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2006: ¥9,600,000 (Direct Cost: ¥9,600,000)
• Keywords: メタボリック症候群 / グリセミック・インデックス / パラチノース / オレイン酸 / リノール酸 / キシリトール / 遺伝子発現 / 組み合わせ食 / めかぶ / 大麦 / デスアシルグレリン / 白血球遺伝子 / シュクロース / 糖毒性 / 脂肪毒性 / 脂肪組織炎症性反応

Research Abstract

1) 低グリセミック・インデックス(GI)食のメタボリック症候群予防効果に関するラットを用いた分子機構として、門脈内グルコース濃度上昇に応答する早期インスリン分泌能の解明、パラチノースとオレイン酸の組合せ食および長期キシリトールの糖質・脂質代謝改善効果、苦瓜の食後高血糖抑制機序、糖質調整流動食の長期投与による内臓脂肪蓄積予防、2) 低GI食のメタボリック症候群予防効果に関するヒトによる評価では、粘性食品の食後高血糖予防効果、糖質調整流動食のメタボリック症候群予防効果、大麦および糖質調整流動食Inslowのメタボリック症候群予防効果、3) メタボリック症候群の予防に関与するヒト末梢血白血球遺伝子としてpyxuvate dehydrogenase kinase, isozyme 4(PDK4)、calnitine palmitoyltransferase 1A(liver)(CPTIA)を同定した。

Research Products

• [Journal Article] Fermented ginseng improves the first-night effect in humans (2009)
  • Author(s): Kitaoka K, Uchida K, Okamoto N, Chikahisa S, Miyazaki T, Takeda E, Hiroyoshi Sei H
  • Journal Title: SLEEP 32 Pages: 413-421
  • Peer Reviewed
• [Journal Article] Does-dependent Effects of Barley Cooked with White Rice on postprandial Glucose and Desacyl Ghrelin Levels (2009)
  • Author(s): Sakuma M, Yamanaka-Okumura H, Naniwa N, Matsumoto D, Tsunematsu M, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: J Clin Biochem Nutr 44 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Improvement of glucose metabolism in patients with impaired glucose tolerance or diabetes by long-term administration of a palatinose-based liquid formula as a part of breakfast (2009)
  • Author(s): Sakuma M, Arai H, Mizuno A, Fukaya M, Matsuura M, Sasaki H, Yamanaka-Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E
  • Journal Title: J Clin Biochem Nutr 44 Pages: 151-159
  • NAID: 130004466575
  • Peer Reviewed
• [Journal Article] Docs-dependent Effccts of Barley Cooked with White Rice on postprandial Glucose and Desacyl Ghrelin Levels. (2009)
  • Author(s): Sakuma M, et al
  • Journal Title: J Clin Binochem Nutr 44 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice (2008)
  • Author(s): Sei H, Oishi K, Chikahisa S, Kitaoka K, Takeda E, Ishida N
  • Journal Title: Endocrinology 149 Pages: 3576-3580
  • Peer Reviewed
• [Journal Article] Natto and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses (2008)
  • Author(s): Taniguchi A, Yamanaka-Okumura H, Nishida Y, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: Asia Pacific J Clin Nutr 17 Pages: 663-668
  • Peer Reviewed
• [Journal Article] Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats (2008)
  • Author(s): Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: J Med Invest 55(3-4) Pages: 183-95
  • NAID: 130004465140
  • Peer Reviewed
• [Journal Article] Palalinose and olcic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats. (2008)
  • Author(s): Sato K, et al
  • Journal Title: J Med Invest 55 Pages: 183-195
  • Peer Reviewed
• [Journal Article] Natto and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses. (2008)
  • Author(s): Taniguchi A, et al
  • Journal Title: Asia Pacific J Clin Nutr 17 Pages: 663-668
  • Peer Reviewed
• [Journal Article] Effects of palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men (2007)
  • Author(s): Arai H, Mizuno A, Sakuma M, Fukaya M, Matsuo K, Muto K, Sasaki H, Matsuura M, Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E
  • Journal Title: Metabolism Clinical and Experimental 56 Pages: 15-121
  • Peer Reviewed
• [Journal Article] Phosphate Restriction in Diet Therapy, Nutrition and Kidney Disease (2007)
  • Author(s): Takeda E, Yamamoto H, Nishida Y, Sato T, Sawada N, Taketani Y
  • Journal Title: A New Era. Contrib Nephrol. Basel, Karger Vol 155 Pages: 113-124
  • Peer Reviewed
• [Journal Article] Early-phase insulin secretion is disturbed in obese subjects with glucose intolerance (2007)
  • Author(s): Mizuno A, Arai H, Fukaya M, Sato M, Yamanaka-Okumura H, Takeda E, Doi T
  • Journal Title: Metabolism Clinical and Experimental 56 Pages: 856-862
  • Peer Reviewed
• [Journal Article] The Anti-Obesity Effect of the Palatinose-Based Formula Inslow is Likely due to an Increase in the Hepatic PPAR α and Adipocyte PPAR γ・Gene Expressions (2007)
  • Author(s): Matsuo K, Arai H, Muto K, Fukaya M, Sato T, Mizuno A, Sakuma M, Yamanaka-Okumura H, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E
  • Journal Title: J Clin Biochem Nutr 40 Pages: 234-241
  • Peer Reviewed
• [Journal Article] Gene Expression in Low Glycemic IndexDiet-Impact on Metabolic Control, Tai ES, Gillies PJ (eds) (2007)
  • Author(s): Takeda E, Arai H, Muto K, Matsuo K, Sakuma M, Fukaya M, Yamanaka-Okumura H, Yamamoto H, Taketani Y
  • Journal Title: Nutrigenomics- Opportunities in Asia. Forum Nutr Basel, Karger 160 Pages: 127-139
  • Peer Reviewed
• [Journal Article] Mechanism of rapid-phase insulin response to elevation of portal glucose concentration (2007)
  • Author(s): Fukaya M, Mizuno A, Arai H, Muto K, Uebanso T, Matsuo K, Yamamoto H, Taketani Y, Doi T, Takeda E
  • Journal Title: Am J Physiol Endocrinol Metab 293
  • Peer Reviewed
• [Journal Article] Dietary Palatinose and Oleic Acid Ameliorate Disorders of Glucose and Lipid Metabolism in Zucker Fatty Rats (2007)
  • Author(s): Sato K, Arai H, Mizuno A, Fukaya M, Sato T, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E
  • Journal Title: J Nutr 137 Pages: 1908-1915
  • Peer Reviewed
• [Journal Article] Water extract of Cordyceps sinensis(WECS)inhibits the RANKL-induced osteoclast differentiation (2007)
  • Author(s): Mizuha Y, Yamamoto H, Sato T, Tsuji M, Masuda M, Uchida H, Sakai K, Taketani Y, Yasutomo K, Sasaki H, Takeda E
  • Journal Title: BioFactors 30 Pages: 105-116
  • Peer Reviewed
• [Journal Article] Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats (2007)
  • Author(s): Uebanso T, Arai H, Taketani Y, Fukaya M, Yamamoto H, Mizuno A, Uryu K, Hada T, Takeda E
  • Journal Title: J Nutr Sci Vitamino 1.53 Pages: 482-488
  • NAID: 110006531867
  • Peer Reviewed
• [Journal Article] Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men (2007)
  • Author(s): Arai H, Mizuno A, Sakuma M, M Fukaya M, Matsuo K, Muto K, Sasaki H, Matsuura H, Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E
  • Journal Title: Metabolism 56 Pages: 115-121
  • Peer Reviewed
• [Journal Article] Early-phase insulin secretion is disturbed in obese subjects with glucose intolerance (2007)
  • Author(s): Mizuno A
  • Journal Title: Metabolism 56 Pages: 856-862
  • Peer Reviewed
• [Journal Article] The anti-obesity effect of the palatinose-based formula Inslow is likely due to an imcrease in the hepatic PPAR-α and adipocyte PPAR-γgene expressions (2007)
  • Author(s): Matsuo K
  • Journal Title: J Clin Biochem Nutr 40 Pages: 234-241
  • Peer Reviewed
• [Journal Article] Nutritional treatment of a patient with hepatic cirrhosis with the novel low glycemic index liquid food(Inslow) (2007)
  • Author(s): Matsumoto D
  • Journal Title: J Med Invest 54 Pages: 375-380
  • Peer Reviewed
• [Journal Article] Mechanism of rapid-phase insulin response to elevation of portal glucodse concentration (2007)
  • Author(s): Fukaya M
  • Journal Title: Am J Physiol Endocrinol Metab 293
  • Peer Reviewed
• [Journal Article] A combination of dietary palatinose and oleic acid ameliorates disorders of glucose and lipid metabolism in Zucker Fatty rats (2007)
  • Author(s): Sato K
  • Journal Title: J Nutr 139 Pages: 1908-1915
  • Peer Reviewed
• [Journal Article] Nutrigenomics-Opportunities (2007)
  • Author(s): Takeda E
  • Journal Title: Asia.Forum Nutr, Karger,Basel Pages: 127-139
• [Journal Article] Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second meal effect in healthy men. (2007)
  • Author(s): Arai Hidekazu
  • Journal Title: Metabolism 56 Pages: 115-121
• [Journal Article] Effect of late evening snack with rice ball on energy metabolism in liver cirrhosis (2006)
  • Author(s): Yamanaka-Okumura H, Nakamura T, Takeuchi H, Miyake H, Katayama T, Arai H, Taketani Y, Fujii M, Shimada H, Takeda E
  • Journal Title: European Journal of Clinical Nutrition 60 Pages: 1067-1072
  • Peer Reviewed
• [Journal Article] Acute sffect of oral phosphate loading on serum fibroblast groeth factor 23 levels in healthy men (2006)
  • Author(s): Nishida Y, Taketani Y, Yamanaka-Okumura H, Imamura F, Tanigichi A, Sato T, Shuto E, Nashiki K, Arai H, Yamamoto H, Takeda E
  • Journal Title: Kidney International 70 Pages: 2141-2147
  • Peer Reviewed
• [Journal Article] Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate contransporter gene (2006)
  • Author(s): Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E
  • Journal Title: Biochim Biophys Acta 1732 Pages: 43-52
  • Peer Reviewed
• [Journal Article] Immobilization decreases duodenal calcium absorption through a 1, 25-dihydroxyvitamin D-dependent pathway (2006)
  • Author(s): Sato T, Yamamoto H, Sawada N, Nashiki K, Tsuji M, Nikawa T, Arai H, Morita K, Taketani Y, Takeda E
  • Journal Title: J Bone Miner Metab 24 Pages: 291-299
  • Peer Reviewed
• [Journal Article] Effect of late evening snack with rice ball on energy metabolism in liver cirrhosis. (2006)
  • Author(s): Yamanaka-Okumura Hisami
  • Journal Title: Eur J Clin Nutr 60 Pages: 1067-1072
• [Journal Article] Restraint stress alters the duodenal expression of genes important for lipid metabolism in rat. (2006)
  • Author(s): Sato Tadatoshi
  • Journal Title: Toxicology 227 Pages: 248-261
• [Journal Article] Estimation of the total daily energy expenditure and its components by monitoring the heart rate in Japanese endurance athletes. (2006)
  • Author(s): Motonaga Keiko
  • Journal Title: J Nutr Sci Vitaminol 52 Pages: 360-367
• [Journal Article] Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. (2006)
  • Author(s): Nishida Yuka
  • Journal Title: Kidney Int 70 Pages: 2141-2147
• [Journal Article] A novel function of phosphate-mediated intracellular signal transduction pathways. (2006)
  • Author(s): Takeda Eiji
  • Journal Title: Adv Enzyme Regul. 46 Pages: 154-161
• [Journal Article] Acute effect of elevation of serum phosphorus on endothelial function with reference to oxidative stress and NO production
  • Author(s): Shuto E, Taketani Y, Tanaka R, Harada N, Isshiki M, Sato M, Nashiki K, Amo K, Yamamoto H, Higashi Y, Nakaya Y, Takeda E
  • Journal Title: J Amer Soo Nephrol (in press)
  • Peer Reviewed
• [Presentation] 長期キシリトール投与による糖質・脂質代謝改善効果 (2008)
  • Author(s): 阿望 幾久子
  • Organizer: 第11回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-01-12
• [Presentation] Effects of long-term intake of xylitol on visceral fat accumulation in rats fed high-fat diet (2008)
  • Author(s): Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E
  • Organizer: American Diabetes Association's 68th Scientific Sessions
  • Place of Presentation: San Francisco, USA
• [Presentation] Effects of long-term intake of xylitol on visceral fat accumulation in rats fed high-fat diet. (2008)
  • Author(s): Amo K, et al
  • Organizer: 第68回米国糖尿病学会
  • Place of Presentation: サンフランシスコ
• [Presentation] Combination of food and nutrients for metabolic syndrome (2007)
  • Author(s): Takeda E
  • Organizer: International Conference on Food Factors for Health Promotzon -IcoFF2007-
  • Place of Presentation: 京都
  • Year and Date: 2007-11-30
• [Presentation] 食後高血糖抑制効果を有する麦の配合割合の検討 (2007)
  • Author(s): 佐久間 理英
  • Organizer: 第61回日本栄養・食糧学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-20
• [Book] 食品技術総合事典・食品の機能性の評価手法 ・ヒト試験による機能性評価 (2008)
  • Author(s): 武田英二, 奥村仙示
  • Publisher: 朝倉書店
• [Book] Nutrigenomics-Opportunities in Asia.Forum Nutr (2007)
  • Author(s): Takeda E
  • Publisher: Karger, Base1
• [Book] 機能性食品の事典 (2007)
  • Author(s): 武田 英二
  • Publisher: 朝倉書店
• [Book] Nutrition and Kidney Diseases : A New Era, Contrib Nephrol. (Basel, Suzuki H, Kimmel PL (eds), Karger, vol 155) (2007)
  • Author(s): Takeda Eiji
  • Total Pages: 12
  • Publisher: Phosphate restriction in diet therapy.
• [Book] メタボリックシンドローム、栄養評価と治療
  • Author(s): 武田英二、阿望幾久子、上番増喬
  • Publisher: メディカルレビュー社
• [Patent(Industrial Property Rights)] GABA作動性ニューロン賦活剤 (2007)
  • Inventor(s): 武田英二、寺尾純二、勢井宏義、柳原啓之、北岡和義、宮崎寿次、北島智恵子
  • Industrial Property Number: 2007-164115
  • Filing Date: 2007-06-21
• [Patent(Industrial Property Rights)] 抗不安抗うつ剤 (2007)
  • Inventor(s): 武田英二、寺尾純二、勢井宏義、柳原啓之、北岡和義、宮崎寿次、北島智恵子
  • Industrial Property Number: 2007-164183
  • Filing Date: 2007-06-21
• [Patent(Industrial Property Rights)] 抗不安抗うつ剤 (2007)
  • Inventor(s): 武田英二、寺尾純二、勢井宏義、柳原啓之、北岡和義、宮崎寿次、北島智恵子
  • Industrial Property Number: 2007-164034
  • Filing Date: 2007-06-21
• [Patent(Industrial Property Rights)] 血中デスアシルグレリン濃度による血糖値・血中インスリン濃度の予測方法 (2007)
  • Inventor(s): 武田英二、奥村仙示、佐久間理英
  • Industrial Property Number: 2007-248241
  • Filing Date: 2007-09-25
• [Patent(Industrial Property Rights)] 血中デスアシルグレリン濃度による血糖値・血中インスリン濃度の予測方法 (2007)
  • Inventor(s): 武田 英二、奥村 仙示、佐久間 理英
  • Industrial Property Rights Holder: 徳島大学
  • Industrial Property Number: 2007-248241
  • Filing Date: 2007-09-25