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Improvement and Systematization of the Exploitation of Information for Nutrigenomics Analyses of Food Function

Research Project

Project/Area Number 18380077
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

KATO Hisanori  The University of Tokyo, 大学院・農学生命科学研究科, 准教授 (40211164)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,320,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
KeywordsDNAマイクロアレイ / カロリー制限 / タンパク質栄養 / データベース / ニュートリゲノミクス / トランスクリプトミクス / プロテオミクス / 高脂肪食 / 食品機能 / タシパク質栄養 / 皮膚 / アミノ酸 / トランスクリプトーム / プロテオーム / カルニチン / 食の安全性
Research Abstract

様々なタンパク質栄養条件に応答した肝臓や皮膚での遺伝子発現の網羅的応答を幅広く明らかにした。それらのデータを有効に解析するためのバイオインフォマティクス手法を高度活用し、栄養研究における情報の有効利用を推進した。また、高脂肪食摂食や運動、抗肥満食品因子、マイルドなカロリー制限等に対する網羅的遺伝子発現やタンパク質量の応答に関する情報を蓄積した。従来から構築して維持しているニュートリゲノミクスデータベースを大幅に改良し、世界のニュートリゲノミクス研究を格段に発展させる礎を築いた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (37 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (15 results) (of which Peer Reviewed: 10 results) Presentation (16 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Effect of fasting on the peripheral circadian gene expression in rats2010

    • Author(s)
      Dong, Y., Wu, T., Ni, Y. H., Kato, H., Fu, Z. W.
    • Journal Title

      Biol. Rhythm Res. 41

      Pages: 41-47

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of circadian gene expression in the kidney by light and food cues in rats2010

    • Author(s)
      Wu, T., Ni, Y., Dong, Y, Kato, H., Fu, Z. W.
    • Journal Title

      Am. J. Physiol. Regul. Integr. Comp. Physiol. 298

      Pages: 635-641

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of mild restriction of food intake on gene expression profile in the liver of young rats : reference data for in vivo nutrigenomics study2010

    • Author(s)
      Saito, K., Ohta, Y., Sami, M., Kanda, T., Kato, H.
    • Journal Title

      Brit. J. Nutr. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genes related to the ubiquitin-proteasome system are up-regulated in the brown adipose tissue of 24 h-fasted rats2008

    • Author(s)
      Nakai, N., Hashida, H., Kadota, K., Minami, M., Shimizu, K., Matsumoto, I., Kato H., Abe, K.
    • Journal Title

      Biosci. Biotechnol. Biochem 72

      Pages: 139-148

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Opposite effects of PU.1 on mast cell stimulation2008

    • Author(s)
      Niwa, Y, Nishiyama, C., Nakano, N., Kamei, A., Kato, H., Kanada, S., Ikeda, S., Ogawa, H., Okumura, K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 375

      Pages: 95-100

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light and food signals cooperate to entrain the rat pineal circadian system.2008

    • Author(s)
      Wu, T., Jin, Y. X., Kato, H., Fu, Z. W
    • Journal Title

      J. Neurosci. Res. 86

      Pages: 3246-3255

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nutrigenomics : the cutting edge and Asian perspectives.2008

    • Author(s)
      Kato, H.
    • Journal Title

      Asia Pac. J. Clin. Nutr. 17 (S1)

      Pages: 12-15

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effects of light cues on re-entrainment of the food-dominated peripheral clocks in mammals.2008

    • Author(s)
      Wu, T., Jin, Y. X., Ni, Y.H., Zhang, D. P., Kato, H. Fu, Z. W.
    • Journal Title

      Gene 419

      Pages: 27-34

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opposite effects of PU. 1 on mast cell stimulation.2008

    • Author(s)
      Niwa, Y., Nishiyama, C., Nakano, N., Kamei, A., Kato, H., 他
    • Journal Title

      Biochelii. Biophys. Res. Commum 357

      Pages: 95-100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light and food signals cooperate to entrain the rat pineal circadian system.2008

    • Author(s)
      Wu, T., J in, Y. X., Kato, H. and Fu, Z. W.
    • Journal Title

      J. Neurosci. Res. 86

      Pages: 3246-3255

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genes related to the ubiquitin-proteasome system are up-regulated in the brown adipose tissue of 24 h-fasted rats2008

    • Author(s)
      Nakai, Y.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry 72

      Pages: 139-148

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutrigenomics:the cutting edge and Asian perspectives2008

    • Author(s)
      Kato, H.
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition 17

      Pages: 12-15

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ニユートリゲノミクスの新潮流-テーラーメード栄養を身近なものに2007

    • Author(s)
      加藤久典, 小林進, 勝谷友宏, 三谷康正
    • Journal Title

      バイオサイエンスとインダストリー 65

      Pages: 19-23

    • Related Report
      2008 Final Research Report
  • [Journal Article] Safety evalution of hypoallergenic wheat flour using a DNA microarray.2006

    • Author(s)
      Narasaka, S., Endo, Y., Fu, ZW., Moriyama, M., Arai, S., Abe, K., Kato, H.
    • Journal Title

      Biosci. Biotechnol. Biochem. 70

      Pages: 1464-1470

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gene expression analysis of the anti-obesity effect by apple polyphenols in rats fed a high fat diet or a normal diet.2006

    • Author(s)
      Ohta, Y., Sami, M., Kanda, T., Saito, K., Osada, K., Kato, H.
    • Journal Title

      J. Oleo Sci. 55

      Pages: 305-314

    • NAID

      130000055561

    • Related Report
      2006 Annual Research Report
  • [Presentation] Functional study of an amino acid response element of the phosphoenolpyruvate carboxykinase 2 (PEPCK2) gene2009

    • Author(s)
      石井駿介
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2009-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Data storage and comparative analysis of gene expression profiles for promotion of nutrigenomics study2009

    • Author(s)
      Kenji Saito
    • Organizer
      19th International Congress of Nutrition
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-10-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of lysine on lipid metabolism : A nutrigenomics study2009

    • Author(s)
      Aya okumura
    • Organizer
      19th International Congress of Nutrition
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-10-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Phosphoenolpyruvate carbosykinase2(PEPCK1)遺伝子におけるアミノ酸応答配列の機能解析2009

    • Author(s)
      石井駿介、小野絢香、斉藤憲司、加藤久典
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 卵殻膜摂食が肝機能と皮膚機能に及ぼす影響のトランスクリプトーム解析2009

    • Author(s)
      斉藤憲司、山根拓実、大石祐一、長谷部由紀夫、加藤久典
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 鉄欠乏食がラット肝臓遺伝子発現プロファイルに及ぼす影響2009

    • Author(s)
      亀井飛鳥、渡部由貴、根元智子、上原万理子、加藤久典、中井雄治、阿部啓子
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] PEPCK2遺伝子のアミノ酸応答配列近傍領域の機能解析2008

    • Author(s)
      石井駿介、加藤久典
    • Organizer
      第2回日本アミノ酸学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] タンパク質栄養悪化がラット皮膚遺伝子発現プロファイルに及ぼす影響の解析2008

    • Author(s)
      亀井飛鳥、中井雄治、加藤久典
    • Organizer
      第2回日本アミノ酸学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] リジンによる脂質代謝制御機構の解析2008

    • Author(s)
      奥村亜也、平林由理、趙治嘉、村上仁志、小林久峰、藤條武司、加藤久典
    • Organizer
      第2回日本アミノ酸学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] タンパク質栄養悪化がラット皮膚遺伝子発現プロフアイルに及ぼす影響の解析2008

    • Author(s)
      亀井飛鳥
    • Organizer
      2008年度日本農芸化学会大会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] タンパク質栄養の悪化がラット皮膚遺伝子発現プロファイルに及ぼす影響の解析2008

    • Author(s)
      亀井 飛鳥
    • Organizer
      2008年度日本農芸化学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 各分枝鎖アミノ酸単欠乏がHepG2細胞の遺伝子発現プロファイルに及ぼす影響2007

    • Author(s)
      小野 絢香
    • Organizer
      2007年度日本アミノ酸学会年次大会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of supplemental amino acids on geneexpression of conagen-related genes in healthy rat skin2007

    • Author(s)
      Kamei, A.
    • Organizer
      Asian Congress of Nutrition
    • Place of Presentation
      台湾
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 摂食量・体重の差異がラット遺伝子発現に及ぼす影響の網羅的解析2007

    • Author(s)
      斉藤憲司
    • Organizer
      第61回日本栄養・食糧学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2007-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 各種アミノ酸摂取がラット皮膚遺伝子発現に及ぼす影響の解析2007

    • Author(s)
      亀井飛鳥
    • Organizer
      2007年度日本農芸化学会大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] タンパク質栄養悪化の影響のプロテオーム解析2007

    • Author(s)
      加藤裕美
    • Organizer
      2007年度日本農芸化学会大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2008 Final Research Report
  • [Book] Genomics applied to nutrients and functional foods in Japan : State of the art In : Genomics, proteomics, and metabolomics in nutraceuticals and functional foods. Bagchi, D., Lau, F.C. and Bagchi, M (eds)2010

    • Author(s)
      Abe, K., Kato, H., Yasuoka, A., Nakai, Y.
    • Publisher
      Wiley-Blackwell
    • Related Report
      2008 Final Research Report
  • [Book] ニユートリゲノミクスのアレイ解析「遺伝子医学MOOK (10)、DNAチップ/マイクロアレイ 臨床応用の実際」(油谷浩幸編)2008

    • Author(s)
      加藤久典, 阿部啓子
    • Publisher
      メデイカルドゥ
    • Related Report
      2008 Final Research Report
  • [Book] 第5章 アミノ酸機能のニユートリゲノミクス解析「アミノ酸の機能特性-ライフサイエンスにおける新しい波-」(日本栄養・食糧学会監修)2007

    • Author(s)
      加藤久典
    • Publisher
      建吊社
    • Related Report
      2008 Final Research Report
  • [Remarks] ニユートリゲノミクスデータベース:

    • URL

      http://133.11.220.243/nutdb.html

    • Related Report
      2008 Final Research Report
  • [Remarks] Kgee Overviewer (β版):

    • URL

      http://133.11.220.243/cgi-bin/gomi/kegg/kegg_viewer2.cgi

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://133.11.220.243/nutdb.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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