Standard Methods and Nutritional biochemistry for Production ofRadical-free Healthy Meats

• Project/Area Number: 18380157
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Tohoku University
• Principal Investigator: TOYOMIZU Masaaki Tohoku University, 大学院・農学研究科, 教授 (80180199)
• Co-Investigator(Kenkyū-buntansha): MIYAZAWA Teruo 東北大学, 大学院・農学研究科, 教授 (20157639)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥12,760,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥1,860,000); Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
• Keywords: 活性酵素 / ミトコンドリア / ブロイラ- / 暑熱 / プロトンリ-ク / 栄養制御 / 脱共役タンパク質 / UCP / 活性酸素 / ブロイラー / プロトンリーク / 脱共役たんぱく質 / フロンティア環境 / 肉用鶏ブロイラー / 暑熱ストレス / 膜電位

Research Abstract

家畜・家禽は、外部刺激によるストレス条件下では生体構成成分の過酸化が生じ、生産性が低下する。本研究では、暑熱ストレス時においても「ラジカルフリーの健康肉」を設計するため栄養制御による飼養技術基盤を構築した。すなわち、暑熱ストレス下では02・-産生の増加が、脱共役タンパク質低下ならびに基質酸化の上昇→膜電位の上昇→02・-産生増大との「カスケード」が存在するが、オリ-ブ油の給与によりこの流れを負に制御することに成功した。

Research Products

• [Journal Article] Olive oil-supplemented diet alleviates acute heat stress-induced mitochondrial ROS production in chicken skeletal muscle (2009)
  • Author(s): Mujahid A., Y.Akiba and M. Toyomizu
  • Journal Title: American Journal of Physiology (in press)
  • Peer Reviewed
• [Journal Article] Progressive Changes in thephysiological responses of heat-stressed broiler chickens (2009)
  • Author(s): Mujahid A., Y.Akiba, M.Toyomizu
  • Journal Title: J.Poult.Sci 46 Pages: 163-167
  • Peer Reviewed
• [Journal Article] Progressive changes in the physiological responses of heat-stressed broiler chickens (2009)
  • Author(s): Ahmad M., Akiba Y., Toyomizu M.
  • Journal Title: J. Poul t. Sci. 46 Pages: 163-167
  • NAID: 10024799619
  • Peer Reviewed
• [Journal Article] Tocotrienol Contents in Hen Eggs : its Fortification by Supplementing Rice Bran Scum Oil into Feeds (2008)
  • Author(s): Phumon SOOKWONG, Kiyotaka NAKAGAWA Shin-ichi NAKAJIMA, Yoshikazu AMANO, Masaaki TOYOMIZU, and Teruo MIYAZAWA
  • Journal Title: Biosci. Biotechnol. Biochem 72(11) Pages: 3044-3047
  • Peer Reviewed
• [Journal Article] Sequential changes in superoxide production, anion carriers and substrate oxidation in skeletal muscle mitochondria of heat-stressed chickens (2007)
  • Author(s): Mujahid A., Y.Akiba, Warden CH, M.Toyomizu
  • Journal Title: FEBS Letters 581 Pages: 3461-3467
  • Peer Reviewed
• [Journal Article] Mitochondrial Oxidative Damage in Chicken Skeletal Muscle Induced by Acute Heat Stress (2007)
  • Author(s): MUJAHID A., N.R.Pumford, W.Bottje, K.Nakagawa, T.Miyazawa, Y.Akiba, M.Toyomizu
  • Journal Title: J.Poult.Sci 44(4) Pages: 439-445
  • NAID: 10019768438
  • Peer Reviewed
• [Journal Article] Acute heat stress induces oxidative stress and decreases adaptation in young white leghorn cockerels bydownregulation of avian uncoupling protein (2007)
  • Author(s): Mujahid A, K.Sato, Y.Akiba, M.Toyomizu
  • Journal Title: Poult sci 86 Pages: 364-371
  • Peer Reviewed
• [Journal Article] Sequential changes in superoxide production, anion carriers and substrate oxidation in skeletal muscle mitochondria of heat-stressed chickens. (2007)
  • Author(s): Mujahid A, Akiba Y, Warden C H, Toyomizu M.
  • Journal Title: FEBS Letters 581 Pages: 3461-3467
  • Peer Reviewed
• [Journal Article] Acute heat stress induces oxidative stress and decreases adaptation in young white leghorn cockerels by downregulation of avian uncoupling protein. (2007)
  • Author(s): Mujahid A.
  • Journal Title: Poult Sci. 86 Pages: 364-371
• [Journal Article] Mitochondrial Oxidative Damage in Chicken Skeletal Muscle Induced by Acute Heat Stress. (2007)
  • Author(s): Mujahid A.
  • Journal Title: J Poult Sci. (In press)
• [Journal Article] Acute heat stress stimulatesmitochondrial superoxide production in broiler skeletal muscle, possibly via down- regulation of uncoupling protein content (2006)
  • Author(s): Mujahid A., K.Sato, Y.Akiba, M.Toyomizu
  • Journal Title: Poult Sci 85 Pages: 1259-1265
  • Peer Reviewed
• [Journal Article] Acute heat stress stimulates mitochondrial superoxide production in broiler skeletal muscle, possibly via down-regulation of uncoupling protein content. (2006)
  • Author(s): Mujahid, A.
  • Journal Title: Poult Sci. 85 Pages: 1259-1265