Pathological and molecular biological analysis of nervous lesions caused by glioma-inducing retroviruses
| Project/Area Number |
18380179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OCHIAI Kenji (KENJI Ochiai) Hokkaido University, 大学院・獣医学研究科, 准教授 (80214162)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Kazuhiko 北海道大学, 大学院・獣医学研究科, 教授 (90250498)
ONO Etsuro 九州大学, 大学院・医学研究科, 教授 (00160903)
TOMIOKA Yukiko 北海道大学, 遺伝子病制御研究所, 助教 (50374674)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,670,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2006: ¥7,700,000 (Direct Cost: ¥7,700,000)
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| Keywords | ウイルス性腫瘍 / 神経系腫瘍 / トリ白血病ウイルス / 発癌 / レトロウイルス / トリ / グリオーマ / 中枢神経系腫瘍 / 発癌機構 / トランスジェニックニワトリ / トランスジェニックマウス |
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| Research Abstract |
In order to clarify the pathogenesis of nervous system disorders due to retrovirus infection, fowl glioma-inducing virus (FGV) belonging to avian leukosis viruses (ALVs), FGV-mutants, and another ALVs isolated from chickens affected with glioma or peripheral nerve tumors were examined by molecular biological analysis and their pathogenicity to nervous system was compared by experimental infections. The main results suggest that env gene may be not a major determinant for the induction of glioma. Also, one transgenic (Tg) chimera chicken (G(0)) carrying FGV-LTR obtained in this study is expected to be useful for analysis of the LTR function.
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Report
(6 results)
Research Products
(31 results)
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[Journal Article] Prevalence of fowl glioma-inducing virus in chickens of zoological gardens in Japan and nucleotide variation in the env gene2008
Author(s)
Hatai, H., Ochiai, K., Murakami, M., Imanishi, S., Tomioka, Y., Toyoda, T., Ohashi, K., Umemura, T.
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Journal Title
J. Vet. Med. Sci. 70(5)
Pages: 469-474
NAID
Related Report
Peer Reviewed
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[Journal Article] A recombinant avian leukosis virus associated with fowl glioma in layer chickens in Japan2008
Author(s)
Hatai, H., Ochiai, K., Nagakura, K., Imanishi, S., Ochi, A., Kozakura, R., Ono, M., Goryo, M., Ohashi, K., Umemura, T.
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Journal Title
Avian Pathol. 37(2)
Pages: 127-137
Related Report
Peer Reviewed
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[Presentation] Prevalence of fowl glioma in Japan and the causal avian leukosis viruses2007
Author(s)
Hatai, H., Ochiai, K., Ochi, A., Ohashi, K., Umemura, T.
Organizer
Combined 58th and 42nd annual meeting of the American college of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology
Place of Presentation
Savannah Inter-national Trade and Convention Center Savannah, Georgia, USA
Related Report
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