| Budget Amount *help |
¥16,670,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2006: ¥7,700,000 (Direct Cost: ¥7,700,000)
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| Research Abstract |
In order to clarify the pathogenesis of nervous system disorders due to retrovirus infection, fowl glioma-inducing virus (FGV) belonging to avian leukosis viruses (ALVs), FGV-mutants, and another ALVs isolated from chickens affected with glioma or peripheral nerve tumors were examined by molecular biological analysis and their pathogenicity to nervous system was compared by experimental infections. The main results suggest that env gene may be not a major determinant for the induction of glioma. Also, one transgenic (Tg) chimera chicken (G(0)) carrying FGV-LTR obtained in this study is expected to be useful for analysis of the LTR function.
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