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Proteomic analysis of the invading mechanism of Neospora caninum and development of novel preventive and treatment methods

Research Project

Project/Area Number 18380180
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

XUAN Xuenan  Obihiro University of Agriculture and Veterinary Medicine, 原虫病研究センター, 教授 (10292096)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Naoaki  帯広畜産大学, 原虫病研究センター, 准教授 (80301802)
SUGIMOTO Chihiro  北海道大学, 人獣共通感染症リサーチセンター, 教授 (90231373)
TAKASHIMA Yasuhiro  岐阜大学, 応用生物科学部, 准教授 (20333552)
Co-Investigator(Renkei-kenkyūsha) YOKOYAMA Naoaki  帯広畜産大学, 原虫病研究センター, 准教授 (80301802)
SUGIMOTO Chihiro  北海道大学, 人獣共通感染症リサーチセンタ, 教授 (90231373)
TAKASHIMA Yasuhiro  岐阜大学, 応用生物科学部, 准教授 (20333552)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,540,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Keywordsネオスポラ / トキソプラズマ / プロテオミックス / ワクチン / 治療薬 / MALDI-TOF-MS / 抗原 / 酵素 / Neospora caninum / Toxoplasma gondii / 感染機構 / プロテオーム / 薬剤標的分子 / 組換えワクチン / 抗原虫薬 / 治療 / 予防 / 抗原タンパク質
Research Abstract

The aims of this study were to widen our view on the global expression of protein profile of Neospora caninum parasite and to discover vaccine and drug target molecules for control of neosporosis. Approximately 600 protein spots were detected on 2-DE, and 60 proteins were identified by MALDI-TOF-MS analysis. Some of the identified proteins were predicted to be involved in the invasion of the parasite into the host cells and in parasite metabolism. Therefore, some of these proteins could be potential vaccine candidates and drug targets.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (58 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (41 results) (of which Peer Reviewed: 38 results) Presentation (14 results) Remarks (3 results)

  • [Journal Article] Characterization of a novel thrombospondin-related protein in Toxoplasma gondii2010

    • Author(s)
      Kawase, O., Nishikawa, Y., Bannai, H., Matsuo, T., Xuan, X.
    • Journal Title

      Parasitol. Int. 59

      Pages: 211-216

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neospora caninum : application of apical membrane antigen 1 encapsulated in the oligomannose-coated liposomes for reduction of offspring mortality from infection in BALB/c mice2010

    • Author(s)
      Zhang, H., Nishikawa, Y., Yamagishi, J., Zhou, J., Kojima, N., Yokoyama, N., Xuan, X.
    • Journal Title

      Exp. Parasitol. 125

      Pages: 130-136

    • NAID

      120006390516

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterizaion of a leucine aminopeptidase from Toxoplasma gondii2010

    • Author(s)
      Jia, H., Nishikawa, Y., Luo, Y., Yamagishi, J., Sugimoto, C., Xuan, X.
    • Journal Title

      Mol. Biochem. Parasitol. 170

      Pages: 1-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neospora caninum : application of apical membrane antigen 1 encapsulated in the oligomannose-coated liposomes for reduction of offspring mortality from infection in BALB/c mice.2010

    • Author(s)
      Zhang, et al.
    • Journal Title

      Exp.Parasitol. 125

      Pages: 130-136

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterizaion of a leucine aminopeptidase from Toxoplasma gondii.2010

    • Author(s)
      Jia, et al.
    • Journal Title

      Mol.Biochem.Parasitol. 170

      Pages: 1-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a novel thrombospondin-related protein in Toxoplasma gondii.2010

    • Author(s)
      Kawase, et al.
    • Journal Title

      Parasitol.Int. 59

      Pages: 211-216

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overproduction of the pro-apoptotic molecule, programmed cell death 5, in Toxoplasma gondii leads to increased apoptosis of host macrophages2009

    • Author(s)
      Bannai, H., Nishikawa, Y., Ibrahim, H., Yamada, K., Kawase, O., Watanabe, J., Sugimoto, C., Xuan, X.
    • Journal Title

      J. Vet. Med. Sci. 71

      Pages: 1183-1189

    • NAID

      130000134476

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii cyclophilin 18-mediated production of nitric oxide induces bradyzoite conversion in a CCR5-dependent manner2009

    • Author(s)
      Ibrahim, H. M., Bannai, H., Xuan, X., Nishikawa, Y.
    • Journal Title

      Infect. Immun. 77

      Pages: 3686-3695

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a transferring antibody against Neospora caninum infection in a murine model2009

    • Author(s)
      Nishikawa, Y., Zhang, H., Huang, P., Zhang, G., Xuan, X.
    • Journal Title

      Vet. Parasitol. 160

      Pages: 60-65

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunization with oligomannose-coated liposome-entrapped dense granule protein 7 protects dams and offspring from Neospora caninum infection in mice2009

    • Author(s)
      Nishikawa, Y., Zhang, H., Ikehara, Y., Kojima, N., Xuan, X., Yokoyama, N.
    • Journal Title

      Clin Vaccine Immunol. 16

      Pages: 792-797

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a transferring antibody against Neospora caninum infection in a murine model.2009

    • Author(s)
      Nishikawa, et al.
    • Journal Title

      Vet.Parasitol. 160

      Pages: 60-65

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunization with oligomannose-coated liposome-entrapped dense granule protein 7 protects dams and offspring from Neospora caninum infection in mice.2009

    • Author(s)
      Nishikawa, et al.
    • Journal Title

      Clin Vaccine Immunol. 16

      Pages: 792-797

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a transferring antibody against Neospora caninum infection in a murine model2009

    • Author(s)
      Nishikawa, Y., Zhang, H., Huang, P., Zhang, G., Xuan, X.
    • Journal Title

      Vet.Parasitol. 160

      Pages: 60-65

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The influence of the regulation of Toxoplasma gondii TgMIC2 transgene on host cell infection2008

    • Author(s)
      Buates, S., Xuan, X., Igarashi, M., Sugimoto, C., Inoue, N.
    • Journal Title

      J. Protozool. Res. 18

      Pages: 79-95

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Programmed Cell Death 5 from Toxoplasma gondii A secreted molecule that exerts a pro-apoptotic effect on host cells2008

    • Author(s)
      Bannai, H., Nishikawa, Y., Matsuo, T., Kawase, O., Watanabe, J., Sugimoto, C., Xuan, X.
    • Journal Title

      Mol. Biochem. Parasitol. 159

      Pages: 112-120

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein2008

    • Author(s)
      Nishikawa, Y., Zhang, H., Ibrahim, H. M., Ui, F., Ogiso, A., Xuan, X.
    • Journal Title

      Parasitol. Int. 57

      Pages: 219-222

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of the initial site of Toxoplasma gondii reactivation in brain tissue2008

    • Author(s)
      Takashima, Y., Suzuki, K., Xuan, X., Nishikawa, Y., Unno, A., Kitoh, K.
    • Journal Title

      Int. J. Parasitol. 38

      Pages: 601-607

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Programmed Cell Death 5 from Toxoplasma gondii : A secreted molecule that exerts apro-apoptotic effect on host cells2008

    • Author(s)
      Bannai, et.al.
    • Journal Title

      Mol. Biochem. Parasitol 159

      Pages: 112-120

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein2008

    • Author(s)
      Nishikawa, et.al.
    • Journal Title

      Parasitol. Int 57

      Pages: 219-222

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serological survey of Neospora caninum infection among dogs in Japan through species-specific ELISA2008

    • Author(s)
      Kubota, et.al.
    • Journal Title

      J. Vet. Med. Sci 70

      Pages: 869-872

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii : Detection of MIC10 antigen in sera of experimentally infected mice2008

    • Author(s)
      Dautu, et.al.
    • Journal Title

      Exp. Parasitol 118

      Pages: 362-371

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of the initial site of Toxoplasma gondii reactivation in brain tissue2008

    • Author(s)
      Takashima, et.al.
    • Journal Title

      Int. J. Parasitol 38

      Pages: 601-607

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A heterologous prime-boost vaccination regime using DNA and a vaccinia virus, both expressing GRA4, induced protective immunity against Toxoplasma gondii infection in mice2007

    • Author(s)
      Zhang, G., Huong, T., Battur, J., Zhou, J., Zhang, H., Liao, M., Kawase, O., Lee, E. G., Dautu, G., Igarashi, M., Nishikawa, Y., Xuan, X.
    • Journal Title

      Parasitology 134

      Pages: 1339-1346

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of calcium-dependent secretion in Toxoplasma gondii2007

    • Author(s)
      Kawase, O., Nishikawa, Y., Zhang, H., Zhang, G., Bannai, H., Jin, S., Lee, E. G., Xuan, X.
    • Journal Title

      Proteomics 7

      Pages: 3718-3725

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii infection induces apoptosis in noninfected macrophages : role of nitric oxide and other soluble factors2007

    • Author(s)
      Nishikawa, Y., Kawase, O., Vielemeyer, O., Suzuki, H., Joiner, K. A., Xuan, X., Nagasawa, H.
    • Journal Title

      Parasite Immunol. 29

      Pages: 375-385

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of ribosomal phosphoprotein P0 of Neospora caninim as a potential common vaccine candidate for the control of both neosporosis and toxoplasmosis2007

    • Author(s)
      Zhang, H., Lee, E. G., Liao, M., Comaore, M., Zhang, G., Kawase, O., Fujisaki, K., Sugimoto, C., Nishikawa, Y., Xuan, X.
    • Journal Title

      Mol. Biochem. Parasitol. 153

      Pages: 141-148

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and anti-NcAMA1 antibody inhibit host cell invasion by both parasites2007

    • Author(s)
      Zhang, H., Compaore, M., Lee, E. G., Liao, M., Zhang, G., Sugimoto, C., Nishikawa, Y, Xuan, X.
    • Journal Title

      Mol. Biochem. Paarasitol. 151

      Pages: 205-212

    • NAID

      120006390242

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of calcium-dependent secretion in Toxoplasma gondii2007

    • Author(s)
      Kawase, O., Nishikawa, Y., Zhang, H., Zhang, G., Bannai, H., Jin, S., Lee, E.G., Xuan, X.
    • Journal Title

      Proteomics 7

      Pages: 3718-3725

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Identification of ribosomal phosphoprotein P0 of Neospora caninim as a potential common vaccine candidate for the control of both neosporosis and toxoplasmosis2007

    • Author(s)
      Zhang, H., Lee, E.G., Liao, M., Comaore, M., Zhang, G., Kawase, O., Fujisaki, K., Sugimoto, C., Nishikawa, Y., Xuan, X.
    • Journal Title

      Mol. Biochem. Parasitol 153

      Pages: 141-148

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and anti-NcAMA1 antibody inhibit host cell invasion by both parasites2007

    • Author(s)
      Zhang, H., Compaore, M., Lee, E.G., Liao, M., Zhang, G., Sugimoto, C., Nishikawa, Y, Xuan, X.
    • Journal Title

      Mol. Biochem. Paarasitol. 151

      Pages: 205-212

    • NAID

      120006390242

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Identification of ribosomal phosphoprotein P0 of Neospora caninim as a potential common vaccine candidate for the control of both neosporosis and toxoplasmosis.2007

    • Author(s)
      Zhang, et. al.
    • Journal Title

      Mol. Biochem. Parasitol. 153

      Pages: 141-148

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and anti-NcAMA1 antibody inhibit host cell invasion by both parasites.2007

    • Author(s)
      Zhang, et. al.
    • Journal Title

      Mol. Biochem. Paarasitol. 151

      Pages: 205-212

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of calcium-dependent secretion in Toxoplasma gondii.2007

    • Author(s)
      Kawase, et. al.
    • Journal Title

      Proteomics 7

      Pages: 3718-3725

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii2006

    • Author(s)
      Khan, A., Bohme, U., Kelly, K. A., Adlem, E., Brooks, K., Simmonds, M., Mungall, K., Quail, M. A., Arrowsmith, C., Chillingworth, T., Churcher, C., Harris, D., Collins, M., Fosker, N., Fraser, A., Hance, Z., Jagels, K., Moule, S., Murphy, L., O'Neil, S., Rajandream, A., Saunders, D., Seeger, K., Whitehead, S., Mayr, T., Xuan, X., Watanabe, J., Suzuki, Y., Wakaguri, H., Sugano, S., Sugimoto, C., Paulsen, I., Mackey, A. J., Roos, D. S., Hall, N., Berriman, M., Barrell, B., Sibley, L. D., Ajioka, J. W.
    • Journal Title

      Genome Res. 16

      Pages: 1119-1125

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a protein disulfide isomerase of Neospora caninum in excretory-secretory products and its IgA binding and enzymatic activities2006

    • Author(s)
      Laio, M., Ma, L., Bannai, H., Lee, E. G., Zhang, H., Xuan, X., Fujisaki, K.
    • Journal Title

      Vet. Parasitol. 139

      Pages: 47-56

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii2006

    • Author(s)
      Khan, A., Bohme, U., Kelly, K. A., Adlem, E., Brooks, K., Simmonds, M., Mungall, K., Quail, M. A., Arrowsmith, C., Chillingworth, T., Churcher, C., Harris, D., Collins, M., Fosker, N., Fraser, A., Hance, Z., Jagels, K., Moule, S., Murphy, L., O'Neil, S., Rajandream, A., Saunders, D., Seeger, K., Whitehead, S., Mayr, T., Xuan, X., Watanabe, J., Suzuki, Y., Wakaguri, H., Sugano, S., Sugimoto, C., Paulsen,I., Mackey, A. J., Roos, D. S., Hall, N., Berriman, M., Barrell, B., Sibley, L. D., Ajioka, J. W.
    • Journal Title

      Genome Res. 16

      Pages: 1119-1125

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii.2006

    • Author(s)
      Khan, et al.
    • Journal Title

      Genome Res. 16・9

      Pages: 1119-1125

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic characterization of GRA6 genes from Toxoplasma gondii from pigs in Okinawa, Japan.2006

    • Author(s)
      Zakimi, et al.
    • Journal Title

      J. Vet. Med. Sci. 68・10

      Pages: 1105-1107

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a protein disulfide isomerase of Neospora caninum in excretory-secretory products and its IgA binding and enzymatic activities.2006

    • Author(s)
      Liao, et al.
    • Journal Title

      Vet. Parasitol. 139・1

      Pages: 47-56

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High-resolution characterization of Toxoplasma gondii transcriptome with a massive parallel sequencing method

    • Author(s)
      Yamagishi, J., Wakaguri, H., Ueno, A., Goo, Y. K., Tolba, M., Igarashi, M., Nishikawa, Y., Sugimoto, C., Suzuki, Y., Watanabe, J., Xuan, X.
    • Journal Title

      DNA Res. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of CD122(+) cells in resistance against Neospora caninum infection in a murine model

    • Author(s)
      Nishikawa, Y., Zhang, H., Ibrahim, H. M., Yamada, K., Nagasawa, H., Xuan, X.
    • Journal Title

      J. Vet. Med. Sci. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] トキソプラズマの比較トランスクリプトーム解析-ステージ変換機構の解明に向けて-2010

    • Author(s)
      山岸潤也, 渡辺純一, 上野晃生, 五十嵐慎, 若栗浩幸, 鈴木譲, 玄学南
    • Organizer
      第79回日本寄生虫学会
    • Place of Presentation
      旭川市
    • Year and Date
      2010-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] ネオスポラ特異的移行抗体は原虫感染の防御に関与しない2010

    • Author(s)
      西川義文, 張厚双, 賈洪林, 張国宏, 玄学南
    • Organizer
      第149回日本獣医学会
    • Place of Presentation
      武蔵野市
    • Year and Date
      2010-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 次世代型シーケンサーを用いたトキソプラズマトランスクリプトームの詳細解析2009

    • Author(s)
      山岸潤也, 渡辺純一, 上野晃生, 五十嵐慎, 若栗浩幸, 鈴木譲, 菅野純夫, 玄学南
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      鳥取市
    • Year and Date
      2009-09-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Apical membrane antigen-1 (NcAMA-1) によるネオスポラ垂直感染に対する防御効果2009

    • Author(s)
      西川義文, 張厚双, 池原譲, 小島直也, 横山直明, 玄学南
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      鳥取市
    • Year and Date
      2009-09-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Apical membrane antigen-1(NcAMA1)によるネオスポラ垂直感染に対する防御効果2009

    • Author(s)
      西川義文, ら
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      鳥取大学
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] オリゴ糖リポソームを用いたネオスポラ垂直感染に対するワクチン開発2009

    • Author(s)
      西川義文, 張厚双, 池原譲, 小島直也, 玄学南, 横山直明
    • Organizer
      第147回日本獣医学会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2009-04-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Construction of recombinant Neospora caninum expressing TgSAG1 and evaluation of its protective effects against Toxoplasma gondii infection in mice2008

    • Author(s)
      Xuan, X., Zhang, G., Zhang, H., Nishikawa, Y.
    • Organizer
      7^<th> Louis Pasteur Conference
    • Place of Presentation
      Paris, France
    • Year and Date
      2008-11-12
    • Related Report
      2009 Final Research Report
  • [Presentation] ネオスポラ感染抵抗性におけるNK細胞とNKT細胞の役割2008

    • Author(s)
      西川義文, 張厚双, 玄学南
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-25
    • Related Report
      2009 Final Research Report
  • [Presentation] ネオスポラ感染抵抗性におけるNK細胞とNKT細胞の役割2008

    • Author(s)
      西川義文, ら
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎大学
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] トキソプラズマ原虫におけるカルシウム依存的分泌タンパク質の網羅的同定および動態解析2008

    • Author(s)
      川瀬摂, 西川義文, 神繁樹, 李應具, 玄学南
    • Organizer
      第145回日本獣医学会
    • Place of Presentation
      相模原市
    • Year and Date
      2008-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] ネオスポラ感染牛における流産関連分子の検出2008

    • Author(s)
      西川義文, 黄鵬龍, 寥敏, 張厚双, 李應具, 玄学南
    • Organizer
      第145回日本獣医学会
    • Place of Presentation
      相模原市
    • Year and Date
      2008-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 種特異的ELISAによる全国の犬の抗 Neospora caninum 抗体保有状況調査2007

    • Author(s)
      久保田直樹, 坂田義美, 宮崎直美, 玄学南, 猪熊壽
    • Organizer
      第144回日本獣医学会
    • Place of Presentation
      江別市
    • Year and Date
      2007-09-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Toxoplasma gondii の全身伝搬における血中 free tachyzoite と抹消血細胞感染感染 tachyzoite の関与2007

    • Author(s)
      海野明宏, 玄学南, 西川義文, 鈴木和彦, 鬼頭克也, 高島康弘
    • Organizer
      第144回日本獣医学会
    • Place of Presentation
      江別市
    • Year and Date
      2007-09-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Babesia gibsoni のTRAP抗原を発現する組換え Toxoplasma gondii の作製とその免疫原性の解析2006

    • Author(s)
      熊谷明子, 西川義文, 周金林, 張国宏, 賈洪林, 中村千夏, 玄学南
    • Organizer
      第142回日本獣医学会
    • Place of Presentation
      山口市
    • Year and Date
      2006-09-23
    • Related Report
      2009 Final Research Report
  • [Remarks] 研究室のホームページ, にて関連研究活動・業績等を発信している

    • URL

      http://www.obihiro.ac.jp/~geneticbiochem/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.obihiro.ac.jp/~geneticbiochem/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.obihiro.ac.jp/~geneticbiochem/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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