Why does the autoantibody against cytokine incease in patients with idiopathic pulmonary alveolar proteinosis?
| Project/Area Number |
18390240
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
NAKATA Koh Niigata University, Medical and Dental Hospital, professor (80207802)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Yoshikazu Niigata University, International Medical Center of Japan, 研究部長 (90240895)
NAKAGAKI Kazuhide Nippon Veterinary and Life Science University, 獣医学部, associate professor (90143635)
TAZAWA Ryushi Niigata University, Medical and Dental Hospital, Lecturer (70301041)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,940,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥12,000,000 (Direct Cost: ¥12,000,000)
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| Keywords | pulmonary alveolar proteinosis / granulocyte macrophage colony stimulating factor / alveolar macrophage / lung surfactant / bronchoalveolar lavage / autoantibody / cytokine / autoimmune disease / ケモカイン / 原発性肺胞蛋白症 / 免疫複合体 |
|---|
| Research Abstract |
Recent studies have revealed that neutrophils from PAP patients had reduced basal functions such as phagocytosis, cell-adhesion, H_2O_2 production, and microbial killing (Uchida, et. Al.. NEJM.2007). In contrast, we found that some subsets of peripheral blood T and B cells were activated or excessively matured compared to normal controls. In CD4^+ cells, the number of naive T cells was reduced and the effecter-memory/naive ratio was up-regulated. Interestingly, small amount of CD4^+ cells were proliferating ex vivo without any stimulation. In B cells, CD38^+ activated cells were increased in both naive and memory B cell subset, whereas the expression of CD19 was reduced compared to the controls. Cells expressing CD138, a plasma cell marker, were significantly increased. Importantly, GM-CSF autoantibody was detected in the culture supernatants of peripheral blood mononuclear cells after 2 days incubation without any stimulation. These results suggested that some subsets of T and B cells were driven to be matured/activated and possibly promoted to produce the autoantibody.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Anti-cytokine autoantibodies are ubiquitous in healthy individuals.2007
Author(s)
Watanabe M, Uchida K, Nakagaki K, Kanazawa H, Trapnell B. C., Hoshino Y, Kagamu H, Yoshizawa H, Keicho N, Goto H, and Nakata K.
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Journal Title
FEBS Letters 581(10)
Pages: 2017-2021
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Pulmonary Mycobacterium avium complex infection: Association with NRAMP 1 polymorphisms2007
Author(s)
Tanaka, G., Shojima, J., Matsushita, I., Nagai, H., Kurashima, A. Nakata, K., Toyota, E., Kobayashi, N,. Kudo, K., Keicho, N
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Journal Title
Eur Respir J 30
Pages: 90-96
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Expression of PU.1 and terminal differentiation of alveolar macrophages in newborn rats2007
Author(s)
Iwabuchi, H., Kawasaki, T., Yamamoto, T., Uchiyama, M., Nakata, K., Naito, M
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Journal Title
Cell Tissue Res 329(1)
Pages: 71-79
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis2007
Author(s)
Hoshino, Y., Hoshino, S., Gold, JA. Raju, B., Prabhakar, S., Pine, R., Rom, WN., Nakata, K., Weiden, M
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Journal Title
J Infect Dis 195(9)
Pages: 1303-1310
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Anti-cytokine autoantibodies are ubiquitous in healthy individuals2007
Author(s)
Watanabe, M., Uchida, K., Nakagaki, K., Kanazawa, H., Trapnell, B.C., Hoshino, Y., Kagamu, H., Yoshizawa, H., Keicho, N., Goto, H., Nakata, K
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Journal Title
FEBS Letters 581(10)
Pages: 2017-2021
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] A survey of tuberculosis prevalence in Hanoi, Vietnam2007
Author(s)
Horie, T., Lien, LT., Tuan, LA. Tuan, PL., Sakurada, S., Yanai, H., Keicho, N., Nakata, K
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Journal Title
Int J Tuberc Lung Dis 11(5)
Pages: 562-566
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Anti-cytokine autoantibodies are ubiquitous in healthy individuals.2007
Author(s)
. Watanabe M, Uchida K, Nakagaki K, Kanazawa H, Trapnell B. C., Hoshino Y, Kagamu H, Yoshizawa H, Keicho N, Goto H, and Nakata K.
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Journal Title
FEBS Letters 581(10)
Pages: 2017-2021
Related Report
Peer Reviewed
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[Book] 今日の診断基準2007
Author(s)
泉 信有, 中田 光
Total Pages
118
Publisher
南江堂
Description
「研究成果報告書概要(和文)」より
Related Report
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[Book] 内科学2006
Author(s)
中田 光, ほか 監修 金渾一郎, 北原光夫, 山口徹, 小俣正男
Total Pages
2994
Publisher
医学書院
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