Molecular mechanisms for regulation of hematopoietic and leukemia stem cell population by nucleolar molecules
| Project/Area Number |
18390281
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kanazawa University |
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Principal Investigator |
HIRAO Atsushi Kanazawa University, がん研究所, 教授 (90343350)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,340,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
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| Keywords | 造血幹細胞 / 白血病 / 分化 / 核小体 / 細胞分化 |
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| Research Abstract |
正常造血幹細胞と白血病幹細胞の共通性を解明するアプローチとして、核小体に焦点を当てて研究を進めた。核小体分子Nucleosteminは、未分化な造血幹細胞に高い発現が認められた。Nucleosteminの発現をGFPによってモニターするレポーターシステムを構築し、造血系で解析したところ、正常造血および骨髄性白血病において、未分化細胞を濃縮することができた。これらの知見は、将来の白血病治療薬の標的となる分子の特定に寄与することが期待された。
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity2008
Author(s)
Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A.
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Journal Title
Stem Cells 12
Pages: 3237-46
Related Report
Peer Reviewed
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[Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool2007
Author(s)
Miyamoto K, Araki YK, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A.
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Journal Title
Cell Stem Cell 1
Pages: 101-112
Related Report
Peer Reviewed
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[Journal Article] Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals2007
Author(s)
Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N, Hara E.
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Journal Title
Proc Natl Acad Sci USA 104
Pages: 15034-9
Related Report
Peer Reviewed
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[Journal Article] Regulation of reactive oxygen species by atm is essential for proper response to DNA double-strand breaks in lymphocytes2007
Author(s)
Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A.
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Journal Title
J Immunol 178
Pages: 103-10
Related Report
Peer Reviewed
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[Journal Article] Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells2006
Author(s)
Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T.
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Journal Title
Nature Med. 12
Pages: 446-451
Related Report
Peer Reviewed
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[Presentation] 36th Congress of2008
Author(s)
HIrao A, Stemness in normal, malignant tissues
Organizer
the International Society of Oncology & BioMarkers
Place of Presentation
Tokyo
Year and Date
2008-10-07
Related Report
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