Development of high sensitivity, high resolution animal PET system for molecular imaging research

• Project/Area Number: 18390338
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe City College of Technology
• Principal Investigator: YAMAMOTO Seiichi Kobe City College of Technology, 教授 (00290768)
• Co-Investigator(Kenkyū-buntansha): KUDO Hiroyuki 筑波大学, 情報工学部, 准教授 (60221933) ; SENDA Michio 先端医療振興財団, 先端医療研究所, 副所長 (00216558)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,500,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥3,300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2006: ¥4,200,000 (Direct Cost: ¥4,200,000)
• Keywords: PET / 高分解能 / 高感度 / 分子イメージング / DOI / GSO / 波形解析 / ポジトロン / 放射線検出器 / 核医学

Research Abstract

シンチレータのガンマ線の突き抜けによる性能劣化の問題点を解決した深さ方向の弁別可能な(depth-of-interaction(DOI)高分解能高感度動物PET装置の開発を行った。そのための"シンチレータ積層-波形解析方式"を用いた3層DOI検出器を開発した。PET用検出器の電子回路の開発も行った。さらに開発した検出器をリング状に配置した小型動物用PET装置を組み上げデータ収集と画像再構成を行った。

Research Products

• [Journal Article] A Dual Layer DOI GSO Block Detector for a Small Animal PET (2009)
  • Author(s): S. Yamamoto
  • Journal Title: Nucl. Instr. Meth.-A, vol. 598 Pages: 480-484
• [Journal Article] A dual layer DOI GSO block detector for a small animal PET (2009)
  • Author(s): Seiichi Yamamoto
  • Journal Title: Nuclear Instruments and Methods in Physics research A 598 Pages: 480-484
  • Peer Reviewed
• [Journal Article] Optimization of the integration time of pulse shape analysis for dual layer detector with different amount of Ce (2008)
  • Author(s): S. Yamamoto
  • Journal Title: Nucl. Instr. Meth.-A vol. 587 Pages: 319-323
• [Journal Article] Optimization of the integration time of pulse shape analysis for dual layer GSO detector with different amount of Ce (2008)
  • Author(s): Seiichi Yamamoto
  • Journal Title: Nuclear Instruments and Methods in Physics research A 587 Pages: 319-323
  • Peer Reviewed
• [Journal Article] Development of a tweezers-type coincidence imaging detector (2008)
  • Author(s): Seiichi Yamamoto, Yusuke Sakamoto, et al.
  • Journal Title: Annals of Nuclear Medicine 22 Pages: 387-393
  • NAID: 10021281368
  • Peer Reviewed
• [Journal Article] Optimization of the time of pulse shape analysis for dual-layer GSO detector with different amount of Ce (2008)
  • Author(s): Seiichi Yamamoto
  • Journal Title: Nuclear Instruments and Methods in Physics Research A 587 Pages: 319-323
  • Peer Reviewed
• [Journal Article] Possibility evaluation for the three to four layer DOI detector using GSOs (2007)
  • Author(s): Seiichi Yamamoto
  • Journal Title: Possibility evaluation for the three to four layer DOI detector using GSOs Vol.48, No.6 Pages: 164-164
• [Journal Article] A Dual Layer DOI GSO Block Detector for a Small Animal PET (2006)
  • Author(s): Seiichi Yamamoto
  • Journal Title: Conference Records of Nuclear Science Symposium(NSS) and Medical Imaging Conference (MIC) 2006(COROM)
• [Journal Article] Performance Comparison of Two DOI-GSO Block Detectors with Different Fabrication Methods (2006)
  • Author(s): Seiichi Yamamoto, et al.
  • Journal Title: Conference Records of Nuclear Science Symposium(NSS) and Medical Imaging Conference (MIC) 2006(COROM)
• [Presentation] Three layers GSO block detectors for small animal PET system (2008)
  • Author(s): Seiichi Yamamoto
  • Organizer: IEEE Medical Imaging Conference
  • Place of Presentation: Dresden, Germany
  • Year and Date: 2008-10-23
• [Presentation] Three layers GSO block detectors for small animal PET system (2008)
  • Author(s): S. Yamamoto
  • Organizer: IEEE Medical Imaging Conferenc
  • Place of Presentation: Dresden, Germany
• [Presentation] DOI-block detectors using LGSOs with differentdecay times (2008)
  • Author(s): S. Yamamoto, H. Ishibashi
  • Organizer: IEEE Medical Imaging Conference
  • Place of Presentation: Dresden, Germany
• [Presentation] Possibility evaluation for the three to four layer DOI detector using GSOs (2007)
  • Author(s): S. Yamamoto
  • Organizer: Journal of Nuclear Medicine(Proceedings of the SNM 54th Annual Meeting), vol. 48, no. 6, 164P
• [Presentation] Possibility evaluation for the three to four layer DOI detector using GSOs (2007)
  • Author(s): Seiichi Yamamoto
  • Organizer: IEEE Medical Imaging Conference
  • Place of Presentation: 米国、ホノルル
• [Presentation] Performance Comparison of Two DOI-GSO Block Detectors with Different Fabrication Methods (2006)
  • Author(s): S. Yamamoto, N. Shimura, H. Ishibashi
  • Organizer: 2006 Medical Imaging Conference
  • Place of Presentation: San Diego CA,USA
• [Presentation] A large field of view positron imager based on one-dimensional sharing block detectors (2006)
  • Author(s): S. Yamamoto, K. Matumoto and M. Senda
  • Organizer: Society of Nuclear Medicine annul meeting
  • Place of Presentation: San Diego,CA,USA
• [Presentation] Dual layer GSO block detectors for a small animal PET (2006)
  • Author(s): S. Yamamoto
  • Organizer: Society of Nuclear Medicine annul meeting
  • Place of Presentation: San Diego,CA,USA
• [Book] 非侵襲・可視化技術ハンドブック-ナノ・バイオ・医療から情報システムまで(小川誠二ほか監修) (2007)
  • Author(s): 山本誠一、他
  • Publisher: (株)エヌ・ディー・エス
• [Patent(Industrial Property Rights)]
  • Industrial Property Number: 平10-223427