| Project/Area Number |
18390501
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tsurumi University |
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Principal Investigator |
KOBAYASHI Kaoru Tsurumi University, School of Dental Medicine, Department of Oral Radiology, Professor (50139614)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Takumi Tsurumi University, School of Dental Medicine, The Second Department of Prosthetic Dentistry, Assistant (20267537)
HAMADA Yoshiki Tsurumi University, School of Dental Medicine, First Department of Oral and Maxillofacial Surgery, Lecturer (70247336)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,180,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2006: ¥13,100,000 (Direct Cost: ¥13,100,000)
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| Keywords | Diagnostic Radiology / Obstructive sleep apnea(OSA) / 閉塞性睡眠時無呼吸症候群 / 上気道 / 画像診断 / Computed Tomography / Polysomonography / 高次元画像 / Polysomnography / 無作為割付試験 |
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| Research Abstract |
Obstructive sleep apnea (OSA) is a disorder characterized by repetitive upper airway collapse during sleep. Identifying the exact location of the obstruction is important to obtain an effective treatment. For many years 2-dimensional (2D) cephalometric images have been used to look for anatomic differences between OSA patients and normal subjects (non-OSA), and researchers have reported significant craniofacial differences such as size and position of the mandible, posterior airway space enlargement, and in the size of the tongue and soft palate. While 2D imaging is valuable, the complex shape of the airway is not fully appreciated except with 3D images and nature of the obstruction in obstructive sleep apnea (OSA) patients. Ten OSA patients and 10 non-OSA control subjects were imaged using conebeam computed tomography to compare their upper airway structure.
This project have four phases of following steps : 1. The systems construction of the high-dimensional image data, 2. The decision of the clinical item, 3. Examination of the diagnosis accuracy by the randomized controlled trial, 4. The establishment of the diagnostic criteria.
The following conclusions were provided about the OSA patients :
(1) we demonstrate the utility of diagnosis of anatomy with the 3D airway imaging with CBCT in awake patients in the supine position ; (2) we show the characteristics of OSA airway that may contribute to distinguishing OSA cases from non-OSA cases.
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