Evaluation of bio-degradation of resin/tooth interface at nano-level

• Project/Area Number: 18390502
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SANO Hidehiko Hokkaido University, 大学院・歯学研究科, 教授 (90205998)
• Co-Investigator(Kenkyū-buntansha): INOUE Satoshi 北海道大学, 大学病院, 講師 (80184745) ; NODA Mamoru 北海道大学, 大学病院, 講師 (10301889) ; HASIMOTO Masanori 北海道医療大学, 講師 (00337164)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥15,880,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥1,680,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2007: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2006: ¥8,600,000 (Direct Cost: ¥8,600,000)
• Keywords: バイオデグラデーション / 接着耐久性 / 接着界面 / ナノテクノロジー / ナノテクノロジ / 歯質接着 / 重合 / 酵素

Research Abstract

生体内でレジン象牙質界面に引き起こされるバイオデグラデーション(生体劣化)を防ぐことは重要である。そのためには、(1) 接着界面にナノインタラクションゾーンを形成する、(2) 生体材料を用いて接着界面を再石灰化させる、(3) ナノテクノロジーを応用して、接着界面の重合率を向上させ界面の長期耐久性を向上させる、という3点が今後の重要な研究課題であることが判明した。

Research Products

• [Journal Article] Effect of a new thermal cyclingmethod on bond strength of two-stepself-etching adhesive systems (2007)
  • Author(s): Nakata T, Fujita M, Nagano F, Noda M, Sano H.
  • Journal Title: DentMater J. 26 Pages: 635-641
  • Peer Reviewed
• [Journal Article] Bonding characteristics ofnewly developed all-in-one adhesives (2007)
  • Author(s): Sidhu SK, Omata Y, Tanaka T, Koshiro K, Spreafico D, Semeraro S, Mezzanzanica D, Sano H
  • Journal Title: J Biomed Mater Res B Appl Biometer 80 Pages: 297-303
  • Peer Reviewed
• [Journal Article] Effect of different burgrinding on the bond strength ofself-etching adhesives (2006)
  • Author(s): Semeraro S, Mezzanzanica D, Spreafico D, Gagliani M, Re D, Tanaka T, Sidhu SK, Sano H
  • Journal Title: Oper Dent. 31,80 Pages: 317-323
  • Peer Reviewed
• [Presentation] Keynote address"Durability of Bonds" (2008)
  • Author(s): Sano H
  • Organizer: International Associationfor Dental Research
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-06
• [Presentation] Improved bond performance of dental adhesive system using nanotechnology (2008)
  • Author(s): Futami Nagano
  • Organizer: ISN T2008
  • Place of Presentation: 北海道大学、札幌
  • Year and Date: 2008-06-17
• [Presentation] Expansion of Nano-technology for dental adhesionusing colloidal platinum nanoparticles (2008)
  • Author(s): Hoshika S
  • Organizer: International Association for Dental Research
  • Place of Presentation: Miami, USA
  • Year and Date: 2008-04-04
• [Presentation] Symposia, Present Status and Future of Self-etching Systems (2008)
  • Author(s): Sano H
  • Organizer: International Symposium for Adhesive Dentistry 2008 in Kanazawa
  • Place of Presentation: Kanazawa
  • Year and Date: 2008-02-17
• [Presentation] Current Trends in Adhesive Dentistry Part I and II (2007)
  • Author(s): Sano H
  • Organizer: GBMD
  • Place of Presentation: Sao Paulo, Brazil
• [Book] Dental biomaterials Imaging(testing and modeling) (2008)
  • Author(s): Sano H
  • Publisher: Woodhead Publishing Limited