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CLINICAL AND BASIC STUDY ON THE PERSISTANT PAIN WITH ENDODONTIC DISEASES

Research Project

Project/Area Number 18390504
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SUNAKAWA Mitsuhiro  Tokyo Medical and Dental University, 歯学部附属病院, 准教授 (30179288)

Co-Investigator(Kenkyū-buntansha) SUDA Hideaki  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (00114760)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,920,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2006: ¥7,000,000 (Direct Cost: ¥7,000,000)
Keywords歯髄炎 / mustard oil / 中枢神経系 / p38MAPK / GFAP / NMDAR / 日本語版McGill疼痛質問表 / VAS法 / Mustard oil / 三叉神経脊髄路核 / 視床 / p 38MAPK / Musratd oil / 視床内側背側(MS)核 / 歯髄駆動ニューロン / NMDA型受容体 / MK-801 / 歯原性慢性疼痛
Research Abstract

歯髄疾患に伴う難治性疼痛の発症機構を解明する基礎的研究として, 歯髄を化学的に刺激した際の中枢神経系の早期応答(neuron活性, mRNAの発現状況)を解明する神経科学的研究を行い, neuronのみならずgliaも早期から活性化されていることを示した。歯髄疾患に伴う難治性疼痛の臨床的研究では, 患者の治療前の疼痛状態を客観的に測定する方法として日本語版McGill疼痛質問表とVAS法による解析の確立を試み, 各々のスコアが有意に高い値を示すことが判明した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (26 results)

All 2009 2008 2007 2006 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (17 results)

  • [Journal Article] ラット臼歯に誘発した根分岐部病変の初期発症過程における免疫機能分子およびToll-likeレセプターmRNA発現の亢進2009

    • Author(s)
      金子友厚, 興地隆史, 砂川光宏, 金子実弘, チョックチャナチャイサクンウライワン, 河村隼, 須田英明
    • Journal Title

      日歯保存誌 52(印刷中)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯髄のmustard oil刺激により誘発されたラット脳幹におけるp38MAPK及びGFAPのアップレギュレーション2008

    • Author(s)
      砂川光宏
    • Journal Title

      日本歯科保存学会雑誌 第51巻秋季特別号

      Pages: 31-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMDAR, GFAP and p38MAPK mRNA Up-regulation Following MO Tooth Pulp Stimulation.2008

    • Author(s)
      Sunakawa M.
    • Journal Title

      J. KACD 33(6)

      Pages: 719-719

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Properties of odontogenic chronic pain in patients with endodontic diseases.2007

    • Author(s)
      Sunakawa M.
    • Journal Title

      日本歯科保存学雑誌 第50巻秋季特別号

      Pages: 28-28

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯原性の慢性痛-特に歯内治療の観点から-2006

    • Author(s)
      砂川光宏
    • Journal Title

      Pain Clinic 26(8)

      Pages: 1066-1073

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MK-801 microinjection reduced the thalamic MD tooth-pulp driven neurons responses.2006

    • Author(s)
      Sunakawa M
    • Journal Title

      Journal of Dental Research 85・Special Issue

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Microinjection of MK-801, NMDA antagonist, reduces the thalamic MD tooth pulp-driven neurons' responses.2006

    • Author(s)
      Sunakawa M
    • Journal Title

      Journal of KACD 31.6

      Pages: 596-596

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NMDARs, p38MAPK and GEAP mRNA up-regulation following MO tooth pulp stimulation

    • Author(s)
      Sunakawa M., Kaneko T., Chokechana-chaisakulU., Kaneko M., Suda H.
    • Journal Title

      NMDARs,. Pain (Submitted)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A gene expression analysis of dental pulp and periodontal ligament of acutely traumatized root

    • Author(s)
      Kaneko T., Okiji T., Kaneko R., Sunakawa M., Kaneko M., Suda H.
    • Journal Title

      J.Endod. (Submitted)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] p38MAPK and GFAP are up-regulated by MO tooth pulp stimulation2008

    • Author(s)
      Sunakawa M
    • Organizer
      The 86^<th> Joint-Scientific Meeting Between KACD and JSCD
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯髄のmustard oil刺激により誘発されたラット脳幹におけるp38MAPKおよびGFAPのアップレギュレーション2008

    • Author(s)
      砂川光宏, 金子友厚, 金子実弘, 須田英明
    • Organizer
      第129回日本歯科保存学会
    • Place of Presentation
      富山
    • Year and Date
      2008-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯髄のmustard oil刺激により誘発されたラット脳幹におけるp38MAPK及びGFAPのアップレギュレーション2008

    • Author(s)
      砂川光宏
    • Organizer
      日本歯科保存学会2008年度秋季大会(第129回)
    • Place of Presentation
      富山、日本
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] p38MAPK and GFAPmRNAwere up-regulated by MO tooth pulp stimulation2008

    • Author(s)
      Sunakawa M., Kaneko T., Kaneko M., Suda H.
    • Organizer
      The 86^<th> IADR annual meeting
    • Place of Presentation
      Toronto、Canada
    • Year and Date
      2008-07-05
    • Related Report
      2008 Final Research Report
  • [Presentation] NMDAR, GFAP and p38MAPK mRNA Up-regulation Following MO Tooth Pulp Stimulation.2008

    • Author(s)
      Sunakawa M
    • Organizer
      The 10^<th> IADR annual meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] NMDARs, GFAP, and p38MAPK mRNA up-regulation followinh MO tooth pulp stimulation2008

    • Author(s)
      Sunakawa M., Kaneko T., Kaneko M., Kawamura J., Suda H.
    • Organizer
      The 10^<th> Joint-Scientific Meeting of JSCD and KACD
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯内治療に伴う慢性痛の臨床的解析2008

    • Author(s)
      砂川光宏, 須田英明
    • Organizer
      第21回日本歯科医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯内治療に伴う慢性痛の臨床的解析2008

    • Author(s)
      砂川光宏
    • Organizer
      第21回日本歯科医学会総会
    • Place of Presentation
      横浜, 日本
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯科保存領域の痛みとその臨床的対応について2007

    • Author(s)
      砂川光宏
    • Organizer
      平成19年度日本歯内療法学会認定医セミナー
    • Place of Presentation
      東京
    • Year and Date
      2007-11-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 歯科保存領域の痛みとその臨床的対応について2007

    • Author(s)
      砂川 光宏
    • Organizer
      平成19年度日本歯内療法学会認定医セミナー
    • Place of Presentation
      東京(日本)
    • Year and Date
      2007-11-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Properties of odontogenic chronic pain in patients with endodontic diseases2007

    • Author(s)
      Sunakawa M., Suda H
    • Organizer
      The 9^<th> Joint Scientific Meeting of JSCD and KACD
    • Place of Presentation
      Okayama. Japan
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Properties of odontogenic chronic pain in patients with endodontic diseases.2007

    • Author(s)
      Sunakawa M.
    • Organizer
      The 9th JSCD & KSCD Meeting
    • Place of Presentation
      Okayama(Japan)
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clinical countermeasures for pain associated with endodontic treatment2007

    • Author(s)
      Sunakawa M.
    • Organizer
      The 5^<th> Asian Dental Forum
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2007-10-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Properties of odontogenic chronic pain in patients with endodontic diseases2007

    • Author(s)
      Sunakawa M., Suda H
    • Organizer
      IFEA 7^<th> World Endodontic Congress
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2007-08-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Properties of odontogenic chronic pain in patients with endodontic diseases.2007

    • Author(s)
      Sunakawa M.
    • Organizer
      IFEA 7th World Endodontic Congress
    • Place of Presentation
      Vancouver(Canada)
    • Year and Date
      2007-08-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Microinjection of MK-801, NMDA receptor antagonist, reduces the thalamic MD tooth pulp driven neurons2006

    • Author(s)
      Sunakawa M., Kaneko M., Suda H.
    • Organizer
      The 8^<th> Joint Scientific Meeting of JSCD and KACD
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2006-11-24
    • Related Report
      2008 Final Research Report
  • [Presentation] MK-801 microijection reduced tha thalamic MD tooth pulp-driven neurons' responses2006

    • Author(s)
      Sunakawa M., Kaneko M., Suda H
    • Organizer
      The 84^<th> IADR Annual Meeting
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2006-06-08
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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