Comprehensive analysis of Toll-like receptor-related genes in oral cancer patients and development of individual cancer immunotherapy
| Project/Area Number |
18390543
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Musashino University |
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Principal Investigator |
OKAMOTO Masato Musashino University, 薬学研究所, 客員教授 (10243718)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Hideo 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (30116131)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥17,220,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2006: ¥10,200,000 (Direct Cost: ¥10,200,000)
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| Keywords | 口腔癌 / 癌免疫療法 / TLR / BRM / 個別化治療 |
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| Research Abstract |
癌治療において免疫療法が注目されているが、どのような免疫療法剤をどのような患者にしようするべきか、その基準は未だ不明である。我々は口腔癌患者の免疫細胞の遺伝子を検索することにより、各種免疫療法剤の効果が見込める患者、見込めない患者の選択基準の確立に寄与するデータが得られた。さらに、これらのデータは、効果が見込めない患者における対処法の確立にも寄与すると考えられる。
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] mmunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala.2006
Author(s)
Ramos F, Takaishi Y, Kawazoe K, Osorio C, Duque C, Acuna R, Fujimoto Y, Sato M, Okamoto M, Oshikawa T, Ahmed SU
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Journal Title
Phytochemistry 67(11)
Pages: 1143-1150
Related Report
Peer Reviewed
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[Journal Article] Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling.2006
Author(s)
Okamoto M, Oshikawa T, Tano T, Ahmed SU, Kan S, Sasai A, Akashi S, Miyake K, Moriya Y, Ryoma Y, Saito M, Sato M
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Journal Title
J Immunother 29(1)
Pages: 78-86
Related Report
Peer Reviewed
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[Journal Article] Anti-tumor effect of OK-432-derived DNA: One of the active constituents of OK-432, a streptococcal immunotherapeutic agent.2006
Author(s)
Oshikawa T, Okamoto M, Tano T, Sasai A, Kan S, Moriya Y, Ryoma Y, Saito M, Akira S, Sato M
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Journal Title
J Immunother 29(2)
Pages: 143-150
Related Report
Peer Reviewed
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[Presentation] nduction of helper T-cell 1-dominant state by an immunotherapeutic agent OK-432, 5-fluorouracil and radiation via suppressor of cytokine signaling -1 and -3.2007
Author(s)
Oshikawa, T., Okamoto, M., Tsukada, J., Ahmed, S.U., Yazaki, Y
Organizer
98th Annual Meeting of American Association for Cancer Research
Place of Presentation
Los Angeles, CA
Related Report
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[Presentation] Induction of helper T-cell 1-dominant state by an immunotherapeutic agent OK-432, 5-fluorouracil and radiation: Involvement of suppressor of cytokine signaling -1 and -32006
Author(s)
Ahmed, S.U, Sasai, A., Sato, Kan, S., Sato, M
Organizer
97th Annual Meeting of American Association for Cancer Research
Place of Presentation
Washington, DC
Related Report
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