Signaling mechanisms involved in novel synaptic plasticity in excitatory inputs in the cerebellum

• Project/Area Number: 18500290
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: The University of Tokyo
• Principal Investigator: KAKIZAWA Sho The University of Tokyo, Graduate School of Medicine, Assistant Professor (40291059)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥4,080,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: cerebellum / synapse / plasticity / calcium / 薬理学 / シグナル伝達 / 神経科学 / 生理学 / 脳・神経 / 一酸化窒素

Research Abstract

In 2006, we revealed that long-term potentiation (LTP) of parallel fiber(PF) -Purkinje cell synapse in the cerebellum was dependent on increase in calcium level in Purkinje cells. Because the LTP had been previously indicated to be dependent on nitric oxide (NO) signals, the LTP was revealed to be dependent on both Ca^<2+> and NO signals. These results also suggest possible interaction between Ca^<2+> and NO signals.
Thus, in 2007, we examined this hypothesis. Application of NO donor evoked increase in Ca^<2+> levels in Purkinje cells in the acute cerebellar slices. Burst stimulation of PF also induced elevation of intracellular Ca^<2+> levels. The PF-induced Ca^<2+> elevation was relatively slow and completely blocked by L-NAME, an antagonist of NO synthetase. These results strongly indicate that NO-dependent increase in Ca^<2+> in Purkinje cells is evoked in physiological condition. Furthermore, involvement of soluble guanylyl cyclase (sGC) was examined. However, bath application of sGC inhibitor, ODQ, had no effect on the NO-dependent Ca^<2+> increase in Purkinje cells.

Research Products

• [Journal Article] Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions (Review). (2008)
  • Author(s): Kakizawa, S., Moriguchi, S., Ikeda, A., Iino, M. & Takeshima, H.
  • Journal Title: Cerebellum (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions(Review) (2008)
  • Author(s): Kakizawa, S., Moriguchi, S., Ikeda, A. Iino, M. & Takeshima, H.
  • Journal Title: Cerebellum (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions(Review). (2008)
  • Author(s): Kakizawa, S., Moriguchi, S., Ikeda, A., Iino, M. & Takeshima, H.
  • Journal Title: Cerebellum in press(in press)
  • Peer Reviewed
• [Journal Article] Postsynaptic GABAB Receptor Signaling Enhances LTD in Cerebellar Purkinje Cells. (2007)
  • Author(s): Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M., Ogura, A., Iino, M. & Kano, M.
  • Journal Title: Journal of Physiology (London) 585 Pages: 549-563
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Regulation of Long-Term Depression and Climbing Fiber Territory by GluRδ2 at Parallel Fiber Synapses through its Carboxyl Terminal Domain in Cerebellar Purkinje Cells. (2007)
  • Author(s): Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K, Watanabe, M., Iino, M. & Mishina, M.
  • Journal Title: Journal of Neuroscience 27 Pages: 12096-12108
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. (2007)
  • Author(s): Ikeda, A., Miyazaki, T., Kakizawa, S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, S., Yamamoto, T., Yamazaki, T., Iino, M., Tsujimoto, G., Watanabe, M. & Takeshima, H.
  • Journal Title: Biochemical and Biophysical Research Communications 363 Pages: 835-839
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. (2007)
  • Author(s): Kina, S., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa, S., Hashimoto, K, Ohsugi, M., Kiyama, Y., Horai, R., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T. & Yamamoto, T.
  • Journal Title: European Journal of Neuroscience 26 Pages: 2269-2278
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells. (2007)
  • Author(s): Fujiwara, A., Kakizawa, S. & Iino, M.
  • Journal Title: Neuropharmacology 52 Pages: 1663-1670
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. (2007)
  • Author(s): Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M, Sakagami, H., Ikeda A., Kondo, K, Kano, M., Watanabe, M., Iino, M. & Takeshima, H.
  • Journal Title: EMBO Journal 26 Pages: 1924-1933
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Postsynaptic GABAB Receptor Signaling Enhances LTD in Cerebellar Purkinje Cells (2007)
  • Author(s): Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M., Ogura, A., Iino, M. & Kano, M.
  • Journal Title: Journal of Physiology 585 Pages: 549-563
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of Long-Term Depression and Climbing Fiber Territory by GluRδ2 at Parallel Fiber Synapses through its Carboxyl Terminal Domain in Cerebellar Purkinje Cells (2007)
  • Author(s): Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M. & Mishina, M.
  • Journal Title: Journal of Neuroscience 27 Pages: 12096-12108
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins (2007)
  • Author(s): Ikeda, A., Miyazaki, T., Kakizawa. S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, S., Yamamoto, T., Yamazaki, T., lino, M., Tsujimoto, G., Watanabe, M. & Takeshima, H.
  • Journal Title: Biochemical and Biophysical Research Communications 363 Pages: 835-839
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression (2007)
  • Author(s): Kina, S., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa. S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, R., Kakuta, S., Iwakura, Y., lino, M., Kano, M., Manabe, T. & Yamamoto, T.
  • Journal Title: European Journal of Neuroscience 26 Pages: 2269-2278
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells (2007)
  • Author(s): Fujiwara, A., Kakizawa. S. & Iino, M.
  • Journal Title: Neuropharmacology 52 Pages: 1663-1670
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity (2007)
  • Author(s): Kakizawa. S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, K., Kano, M., Watanabe, M., lino, M. & Takeshima, H.
  • Journal Title: EMBO Journal 26 Pages: 1924-1933
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neurotrophic Factors (2007)
  • Author(s): Kakizawa. S.
  • Journal Title: In Hormone Handbook(Ed. Urano, A., Nanko-do Press) Pages: 497-589
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Postsynaptic GABAB Receptor Signaling Enhances LTD in Cerebellar Purkinje Cells. (2007)
  • Author(s): Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M., Ogura, A., Iino, M.& Kano, M.
  • Journal Title: Journal of Physiology(London) 585 Pages: 549-563
  • Peer Reviewed
• [Journal Article] Regulation of Long-Term Depression and Climbing Fiber Territory by GluRδ2 at Parallel Fiber Synapses through its Carboxyl Terminal Domain in Cerebellar Purkinje Cells. (2007)
  • Author(s): Uemura, T., Yama, M., Sakimura, K., Watanabe, M., Ihlo, M.&Mishina, M.
  • Journal Title: Journal of Neuroscience 27 Pages: 12096-12108
  • Peer Reviewed
• [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. (2007)
  • Author(s): Ikeda, A., Miyazaki, T., Kakizawa. S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, S., Yamamoto, T., Yamazaki, T., Iino, M., Tsujimoto, G., Watanabe, M & Takeshima, H.
  • Journal Title: Biochemical and Biophysical Research Communications 363 Pages: 835-839
  • Peer Reviewed
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. (2007)
  • Author(s): Kina, S., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa. S., Hashimnoto, K, Ohsugi, M., Kiyama, Y., Horai, R., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T. & Yamamoto, T.
  • Journal Title: European Journal of Neuroscience 26 Pages: 2269-2278
  • Peer Reviewed
• [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells. (2007)
  • Author(s): Fujiwara, A., Kakizawa. S. & Iino, M.
  • Journal Title: Neuropharmacology 52 Pages: 1663-1670
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. (2007)
  • Author(s): Kakizawa, S., Kishimoto, Y., Hashimoto, K, Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, K., Kano, M., Watanabe, M., Iino, M.& Takeshima, H.
  • Journal Title: EMBO Journal 26 Pages: 1924-1933
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. (2007)
  • Author(s): Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo K, Kano M, Watanabe M, Iino M, Takeshima H
  • Journal Title: EMBO Journal 26・7 Pages: 1924-1933
• [Journal Article] Induction of cerebellar long-term depression requires activation of calcineurin in Purkinje cells. (2007)
  • Author(s): Fujiwara A, Kakizawa S, Iino M
  • Journal Title: Neuropharmacology (In press)
• [Journal Article] Postsynaptic inositol 1.4.5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF. (2006)
  • Author(s): Furutani, K., Okubo, Y., Kakizawa, S. & Iino, M.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 103 Pages: 8528-8533
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Postsynaptic inositol 1. 4. 5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF (2006)
  • Author(s): Furutani, K., Okubo, Y., Kakizawa, S. & Iino, M.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 103 Pages: 8528-8533
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Postsynaptic inositol 1.4.5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF. (2006)
  • Author(s): Furutani K, Okubo Y, Kakizawa S, Iino M
  • Journal Title: Proc. Natl. Aca. Sci. 103・22 Pages: 8528-8533
• [Presentation] 哺乳類小脳回路網の活動依存的な発達・維持機構 (2008)
  • Author(s): 柿澤 昌
  • Organizer: 第113回日本解剖学会総会・全国学術集会シンポジウム「脳の比較解剖学:小脳の進化」(オーガナイザー:工藤 基、山本 直之)
  • Place of Presentation: 大分
  • Year and Date: 2008-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Activity dependent development and maintenance of neuronal circuit in mammalian cerebellum (2008)
  • Author(s): Kakizawa. S.
  • Organizer: The 133th Annual Meeting of Japan Association of Anatomists(Symposium)
  • Place of Presentation: Oita.
  • Year and Date: 2008-03-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 哺乳類小脳回路網の活動依存的な発達・維持機構 (2008)
  • Author(s): 柿澤 昌
  • Organizer: 第113回日本解剖学会総会・全国学術集会シンポジウム 「脳の比較解剖学:小脳の進化」(オーガナイザー:工藤 基、山本 直之)
  • Place of Presentation: 大分
  • Year and Date: 2008-03-28
• [Presentation] 代謝型GABA受容体・代謝型グルタミン酸受容体クロストークによる小脳プルキンエ細胞LTDの増強 (2008)
  • Author(s): 上窪 裕二、田端 俊英、柿澤 昌、川上 大輔、渡辺 雅彦、小倉 明彦、飯野 正光、狩野 方伸.
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Maintenance of presynaptic function by postsynaptic IP3 signaling via BDNF. (2008)
  • Author(s): Kakizawa, S., Furutani, K., Okubo, Y. & Iino, M.
  • Organizer: Symposium in the 85th Annual Meeting of the Physiological Society of Japan "Modulation of synaptic transmission by diffusible factors" (Organizers: Kano, M. & Kakizawa, S.)
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Enhancement of cerebellar LTD by crosstalk between metabotrophic GABA receptor and metabotrophic glutamate receptors (2008)
  • Author(s): Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M., Ogura, A., lino, M. & Kano, M.
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo.
  • Year and Date: 2008-03-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Maintenance of presynaptic function by postsynaptic IP3 signaling via BDNF (2008)
  • Author(s): Kakizawa. S., Furutani, K., Okubo, Y. & lino, M.
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan(Symposium)
  • Place of Presentation: Tokyo.
  • Year and Date: 2008-03-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 代謝型GABA受容体-代謝型グルタミン酸受容体クロストークによる小脳プルキンエ細胞LTDの増強 (2008)
  • Author(s): 上窪 裕二、田端 俊英、柿澤 昌、川上 大輔、渡辺 雅彦、小倉 明彦、飯野 正光、狩野 方伸.
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] Maintenance of presynaptic function by postsynaptic IP3 signaling via BDNF. (2008)
  • Author(s): Kakizawa. S., Furutani, K., Okubo, Y.& Iino, M.
  • Organizer: Symposium in the 85th Annual Meeting of the Physiological Society of Japan "Modulation of synaptic transmission by diffusible factors"(Organizers: Kano, M.& Kakizawa, S.)
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] 小脳プルキンエ細胞においてグルタミン酸受容体δ2のC末端細胞質内ドメインは小脳LTDと登上線維の支配領域の調節に必要不可欠である (2008)
  • Author(s): 植村 健、柿澤 昌、山崎 美和子、崎村 建司、渡辺 雅彦、飯野 正光、三品 昌美.
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Essential role of carboxyl terminal of GluR62 in induction of cerebellar LTD and regulation of climbing fiber territory (2008)
  • Author(s): Uemura, T., Kakizawa. S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M. & Mishina M.
  • Organizer: The 81th Annual Meeting of the Japanese Pharmacological Society
  • Place of Presentation: Tokyo.
  • Year and Date: 2008-03-17
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of climbing fiber territory by the carboxyl terminal of GluRδ2 at parallel fiber synapses in cerebellar Purkinje cell. (2007)
  • Author(s): Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M. & Misnina, M.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of climbing fiber territory by the carboxyl terminal of GluRδ2 at parallel fiber synapses in cerebellar Purkinje cell (2007)
  • Author(s): Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M. & Mishina, M.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2007-11-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of climbing fiber territory by the carboxyl terminal of GluR δ2 at parallel fiber synapses in cerebellar Purkinje cell. (2007)
  • Author(s): Uemura, T., Kakizawa. S., Yamasaki, M., Sakimura, K, Watanabe, M., Iino, M.& Mishina, M.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-07
• [Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for cerebellar long-term depression. (2007)
  • Author(s): Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, K., Kano, M., Watanabe, M., Iino, M. & Takeshima, H.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for cerebellar long-term depression (2007)
  • Author(s): Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, K., Kano, M., Watanabe, M., Iino, M. & Takeshima, H.
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2007-11-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] GABABR-mGluR1シグナル・クロストークによる小脳LTDの増強 (2007)
  • Author(s): 上窪 裕二、田端 俊英、柿澤 昌、川上 大輔、渡辺 雅彦、飯野 正光、狩野 方伸.
  • Organizer: 第117回目本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] C57BL/6系統由来のES細胞を用いたグルタミン酸受容体δ2の細胞質内領域C末端ドメイン欠損マウスの樹立 (2007)
  • Author(s): 植村 健、柿澤 昌、山崎 美和子、崎村 建司、渡辺 雅彦、飯野 正光、三品 昌美
  • Organizer: 第117回日本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Enhancement of cerebellar LTD by crosstalk between GABAB receptor and mGluR1 signaling (2007)
  • Author(s): Kamikubo, Y., Tabata, T., Kakizawa. S., Kawakami, D., Watanabe, M., Iino, M. & Kano, M.
  • Organizer: The 117th Kanto-Branch Meeting of the Japanese Pharmacological Society
  • Place of Presentation: Tokyo.
  • Year and Date: 2007-10-06
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Establishment of C57/BL6 mouse line deficient in carboxyl terminal of GluRδ2 (2007)
  • Author(s): Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., lino, M. & Mishina, M.
  • Organizer: The 117th Kanto-Branch Meeting of the Japanese Pharmacological Society
  • Place of Presentation: Tokyo.
  • Year and Date: 2007-10-06
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] GABABR-mGluR1シグナル・クロストークによる小脳LTDの増強 (2007)
  • Author(s): 上窪 裕二、田端 俊英、柿澤 昌、川上 大輔、渡辺 雅彦、飯野 正光、狩野 方伸.
  • Organizer: 第117回日本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-06
• [Presentation] GluRδ2 regulates long-term depression through its carboxyl terminal domain in cerebellar Purkinje cells. (2007)
  • Author(s): Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M. & Mishina, M.
  • Organizer: The 2nd MCCS-Asia Symposium(Neuro2007 Satellite Symposium)
  • Place of Presentation: Yokohama
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] GluRδ2 regulates long-term depression through its carboxyl terminal domain in cerebellar Purkinje cells (2007)
  • Author(s): Uemura, T., Kakizawa, S., Yamasaki, M., Sakimura, K., Watanabe, M., Iino, M. & Mishina, M.
  • Organizer: The 2nd MCCS-Asia Symposium
  • Place of Presentation: Yokohama.
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Activity-Dependent Maintenance of Synaptic Function Mediated by Glutamate Receptors (2007)
  • Author(s): Kakizawa S.
  • Organizer: RIKEN-Brain Science Institute Cerebellar Colloquim
  • Place of Presentation: Wako
  • Year and Date: 2007-08-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Activity-dependent maintenance of synaptic function mediated by glutamate receptors (2007)
  • Author(s): Kakizawa. S.
  • Organizer: RIKEN-Brain Science Institute Cerebellar Colloquium(Invited Speaker)
  • Place of Presentation: Wako.
  • Year and Date: 2007-08-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Activity-Dependent Maintenance of Synaptic Function Mediated by Glutamate Receptors (2007)
  • Author(s): Kakizawa S.
  • Organizer: RIKEN-Brain Science Institute Cerebellar Colloquium
  • Place of Presentation: Wako
  • Year and Date: 2007-08-31
• [Presentation] ジャンクトフィリンを介するイオンチャンネル間の機能的共役は小脳シナプス可塑性に必須である (2007)
  • Author(s): 柿澤 昌、岸本 泰司、斉藤 真也、橋本 浩一、宮崎 太輔、古谷 和春、西 美幸、阪上 洋行、近藤 尚武、狩野 方伸、渡辺 雅彦、飯野 正光、竹島 浩
  • Organizer: 第80回日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Junctophilin-mediated functional crosstalk between ionic channels are essential for cerebellar long-term depression (2007)
  • Author(s): Kakizawa. S., Kishimoto, Y., Saitou, S., Hashimoto, K., Miyazaki, T., Furutani, K., Nishi, M., Sakagami, H., Kondo, K., Kano, M., Watanabe, M., Iino, M. & Takeshima, H.
  • Organizer: The 80th Annual Meeting of the Japanese Pharmacological Society
  • Place of Presentation: Nagoya.
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 活動依存的な小脳興奮性シナプスの機能維持とグルタミン酸受容体の関与 (2006)
  • Author(s): 柿澤 昌
  • Organizer: 生理学研究所研究会「シナプス形成と可塑性機構獲得の統合的理解へ向けた学際的アプローチ」(セクションオーガナイザー渡部文子)
  • Place of Presentation: 岡崎
  • Year and Date: 2006-11-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvement of glutamate receptors in activity-dependent functional maintenance of excitatory synapses in the cerebellum (2006)
  • Author(s): Kakizawa, S.
  • Organizer: NIPS Conference "Integrative Approach for Synaptic Development and Plasticity"(Invited Speaker)
  • Place of Presentation: Okazaki.
  • Year and Date: 2006-11-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Visualization and manipulation of the signaling systems in the CNS using Sindbis viral vectors (2006)
  • Author(s): Kakizawa, S.
  • Organizer: Symposium in the 29th Annual Meeting of the Japan Neuroscience Society "Spatiotemporally Controlled Expression of Exogenous Genes in Brain: Reoent Progress in Virus Vectors"(Organizrs: YUzaki, M. & Hirai, K.)
  • Place of Presentation: Kyoto
  • Year and Date: 2006-07-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Visualization and manipulation of the signaling systems in the CNS using Sindbis viral vectors (2006)
  • Author(s): Kakizawa, S.
  • Organizer: The 29th Annual Meeting of the Japan Neuroscience Society(Symposium)
  • Place of Presentation: Kyoto.
  • Year and Date: 2006-07-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Visualization of nitric oxide signaling inducing input-specific and frequency-dependent long-term potentiation of paranllel-fiber-Purkinje cell synapses in the mouse cerebellum (2006)
  • Author(s): Kakizawa S., Namiki, S., Hirose, K. & Iino, M
  • Organizer: 5th Forum of European Neuroscience
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2006-07-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Visualization of nitric oxide signaling inducing input-specific and frequency-dependent long-term potentiation of parallel-fiber-Purkinje cell synapses in the mouse cerebellum (2006)
  • Author(s): Kakizawa. S., Namiki, S., Hirose, K. & Iino, M.
  • Organizer: The 5th Forum of European Neuroscience
  • Place of Presentation: Vienna, Austria.
  • Year and Date: 2006-07-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Metabotropic glutamate receptor-mediated postsynaptic inositol- 1, 4, 5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF (2006)
  • Author(s): Furutani, K, Okubo, Y., Kakizawa, S. & Iino, M
  • Organizer: 5th Forum of European Neuroscience
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2006-07-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Metabotropic glutamate receptor-mediated postsynaptic inositol-1, 4, 5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF (2006)
  • Author(s): Furutani, K., Okubo, Y., Kakizawa. S. & Iino, M.
  • Organizer: The 5th Forum of European Neuroscience
  • Place of Presentation: Vienna, Austria.
  • Year and Date: 2006-07-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 新ホルモンハンドブック(浦野 明央ら編、南江堂) (2007)
  • Author(s): 柿澤 昌
  • Publisher: 「神経栄養因子」
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 新ホルモンハンドブック(浦野 明央ら編、南江堂) (2007)
  • Author(s): 柿澤 昌
  • Publisher: 神経栄養因子
• [Book] 新ホルモンハンドブック「神経栄養因子」 「(浦野 ら 編)」 (2007)
  • Author(s): 柿澤 昌
  • Publisher: 南江堂(印刷中)
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://calcium.cmp.m.u-tokyo.ac.jp/papers.html
• [Remarks]
  • URL: http://calcium.cmp.m.u-tokyo.ac.jp/papers.html