The relation of leg venous function and structure to orthostatic hypotension in humans
| Project/Area Number |
18500554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Prefectural University of Hiroshima |
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Principal Investigator |
MIURA Akira Prefectural University of Hiroshima, Dept. Health Science, Professor (30190581)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Masako Prefectural University of Hiroshima, Dept. Health Science, Assistant Professor (30336911)
FUKUBA Yoshiyuki Prefectural University of Hiroshima, Dept. Health Science, Professor (00165309)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | orthostatic hypotension / venous compliance / capillary filtration / endurance training / 起立耐性 / 下腿静脈コンプライアンス / 膝窩静脈コンプライアンス / 静脈血管収縮 |
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| Research Abstract |
BACKGROUND AND PURPOSE: Despite extensive investigation, the effects of either cardiovascular fitness or age on orthostatic remain uncertain. Calf venous compliance may be a critical factor in determining the cardiovascular stress associated with change in orthostasis. Preventing fluid shifts into the legs markedly reduces reflex responses to an orthostatic stressor. The extent to which exercise training in a previously sedentary older and young population will affect venous compliance and tolerance to the orthostatic stress is unknown. An evaluation of the compliance of the whole venous system (including venule to large vein) in human calf was developed with a venous congested plethysmography (VCPG) (Halliwill, et al., J.Appl.Physiol. 1999) which has already been used in several application studies. Utilizing the B-mode ultrasonography (US), we have proposed a similar technique for estimating the compliance in medium venous vessels (i.e., Popliteal vein) using US images, which is deri
… More
ved from the CSA-venous pressure (Pv) relationship.
Therefore, we investigate:
1. The relation of leg venous compliance to orthostatic intolerance in humans.
2. Effect of 10days successive endurance training on leg venous compliance.
Secondly, to clearly define the venous vascular function concerning venous pooling, we examined:
3. The effect of ischemic handgrip exercise on leg venous compliance in humans
4. The relationship between venous compliance and capillary filtration in the lower limb.
RESULT: Venous compliance was not different between tolerance and intolerance group. This result suggested that the leg venous compliance is not dominant determinant of the orthostatic intolerance in humans. Venous pooling decreases cardiac filling pressure and blood pressure (BP); therefore, arterial baroreceptors (carotid and aortic) and baroreceptors in the cardiopulmonary region must adapt to maintain BP over a fairly wide range of hemodynamic conditions. And no change in calf venous compliance was found after 10 days successive of endurance training (60 min, 40% peak Vo2). Under the sympathetic stimulation (sympatho-excitatory stimulation) induced by the ischemic handgrip exercise to fatigue followed post-exercise ischemia. Compared to the control, the calf volume was consistently smaller under the sympathetic stimulation. The venous compliance at lower Pv was significantly lower. These data shows to existence of sympathetic venous vascular regulation in humans. In addition, there is negative correlation was observed between venous compliance and capillary filtration in the lower limb. Less
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Effects of femoral Vascular occlusion on ventilatory responses during recovery from exercise in human2007
Author(s)
Yoshiyuki, Fukuba, Asami, Kitano, Naoyuki, hayashi, Takayoshi, Yoshida, Hatumi, Ueoka, Masako, Yamaoka, Endo, Akira, Miura
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Journal Title
Respiratory Physiology & Neurobiology 155
Pages: 29-34
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Central circulatory and peripheral 02 extraction change as interactive facilitators of pulmonary 02 uptake during a repeated high-intensity exercise protocol in humans2007
Author(s)
Yoshiyuki, Fukuba, Masako, Yamaoka, Endo, Yukie, Ohe, Yuiko, Hirotoshi, Asami, Kitano, Chiaki, Shiragiku, Akira, Miura, Osamu, Fukuda, Hatsmi, Ueoka, Motohiko, Miyachi
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Journal Title
European Journal of Applied Physiology 99
Pages: 361-369
Description
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[Journal Article] Thigh muscle activation distribution and pulmonary Vo2 kinetics during moderate, heavy, and very heavy cycling exercise in humans2007
Author(s)
Masako, Endo, Mayumi, Kobayakawa, Ryuta, Kinugasa, Shinya, kuno, Hiroshi, Akima, Harry B., Rossiter, Akira, Miura, Yoshivuki, Fukuba
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Journal Title
American Jurnal of Applied Physiology 293
Pages: 812-820
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 起立性定血圧に対する下肢静脈伸展性の関与2007
Author(s)
三浦 朗, 梶原 尚子, 大平 祐季, 江藤 幸, 山岡 雅子, 福場 良之
Organizer
第20回日本トレーニング科学会
Place of Presentation
東京大学(東京)
Year and Date
2007-11-18
Description
「研究成果報告書概要(和文)」より
Related Report
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