| Project/Area Number |
18560267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
電力工学・電気機器工学
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| Research Institution | Yamagata University |
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Principal Investigator |
MINAMITANI Yasushi Yamagata University, Graduate School of Science and Engineering, Associate Professor (10323172)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHIYAMA Yoshio Yamagata University, Graduate School of Science and Engineering, Professor (50144209)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
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| Keywords | Cancer / Cell / Nucleus / Ultra-short pulse electric field / Pulsed electromagnetic wave / apoptosis / 細胞・核 |
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| Research Abstract |
Nanosecond and sub-nanosecond high voltage pulses can provide new applications. A cancer treatment by an ultra-short pulse high electric field is one of them. High power pulsed electromagnetic wave has been proposed to apply the high electric field for that treatment. This work focuses on the design of a compact high power pulsed electromagnetic wave generator using a nanosecond pulse power generator for the cancer treatment. In this study, a L-C inversion circuit was employed for the pulsed power generator to obtain a voltage waveform with a single frequency for applying an antenna. A water gap switch and a water capacitor were used for L-C inversion circuit to obtain the frequency of hundreds MHz, because the water gap switch has a low inductance property and the loop inductance of the circuit can be made small using the same medium for the capacitor and the switch. By using the water gap switch and the water capacitor for the L-C inversion circuit, the pulsed voltage had the frequency element of 250 MHz. The electromagnetic wave was radiated underwater by the loop antenna in this experiment. Water was used for a simplest phantom of tissues because tissues have much water inside. The intensity of electric field was measured at 10 kV of applying voltage to the radiating antenna. Ameasuring antenna put at 0.15 from the radiating antenna caught the electric field intensity of 112 kV/m A focusing bowl was equipped on the radiating antenna to obtain higher electric field. The peak electric field intensity is 11.3 kV/cm at a focal point. The area of the electric field intensity over 10.8 kV/cm is 5 mm, 5 mm and 3 mm on the direction of the radiating axis, the other horizontal axis and the axis in depth direction around the focal point, respectively.
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