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Identification of transcription factors of contractile element of bronchial smooth muscle and its change in activity at airway hyperresponsiveness

Research Project

Project/Area Number 18590246
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionHoshi University

Principal Investigator

MISAWA Miwa  Hoshi University, Sch. of Pharm., Dept. of Pharmacol, Professor (20061294)

Co-Investigator(Kenkyū-buntansha) CHIBA Yoshihiko  Hoshi University, Sch. of Pharm., Dept. of Pharmacol, Assistant professor (00287848)
SAKAI Hiroyasu  Hoshi University, Sch. of Pharm., Dept. of Pharmacol, Research Associate (00328923)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,830,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsbronchial asthma / airway hyperesponsiveness / Ca^<2+> sensitization / RhoA / transcription factor / statins / geranylgeranylation / 気道過敏性 / lovastatin / glucocorticoid / CPI-17 / Il-13 / STAT6
Research Abstract

The mechanisms of pathogenesis of airway hyperresponsiveness(AHR) in allergic bronchial asthma were investigated pharmacologically and molecular biologically. The following results were obtained.
1. The contractile responsiveness to endothelin-1(ET-1) was increased in the bronchi isolated from rats subjected with repeated antigen challenges. In the augmented ET-1-induced contractility an increase in Ca^<2+> sensitization phenomenon was involved ; phosphorylations(activations) of CTI-17 and myosin light chain kinase were enhanced. 2. The expressions and activations of matrix metalloproteinase(MMP)-12 mRNA and protein of bronchial muscle were increased by repeated antigen challenges, suggesting that MMP-12 is responsible for ABR. 3. The probable transcription factors in bronchial smooth muscle which are activated by antigen exposure were examined covering it using nuclear extraction of the muscle by the method of protein/DNA array method. Among the transcription factors activated by exposuring antigen, it was found that USF-1, Sp1, NF-El, STAT5 and STAT6 are the transcription factors that have potency to bind to the elements of RhoA promoter area 4. Interleukin-13 was demonstrated to induce AHR through the transcription factor STAT6. 5. Lovastatin, one of the statins, when administered in vivo, inhibited the AHR in rats generated by repeated antigen challenges ex they It was shown that at that time, lovastatin also inhibited the translocation of RhoA to cell membrane. These findings suggest that statins may be effective for improvement of AHR in patients with bronchial asthma. 6. It was also suggested that glucocorticoids exert effectiveness for bronchial asthma by inhibiting the RhoA upregulation seen in the bronchial smooth muscle at antigen-exposure.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (98 results)

All 2008 2007 2006

All Journal Article (31 results) (of which Peer Reviewed: 14 results) Presentation (66 results) Book (1 results)

  • [Journal Article] Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma2008

    • Author(s)
      Chiba, Y., Arima, J., Sakai, H. and Misawa, M.
    • Journal Title

      Am.J.Physiol.Lung Cell.Mol.Physiol 294

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholne2008

    • Author(s)
      Sakai, H., Yamamoto, M., Chiba, Y. and Misawa, M.
    • Journal Title

      J.Smooth Muscle Res. 44

      Pages: 9-16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Glucocorticoids ameliorate antigen-induced bronchial smooth muscle hyperresponsiveness by inhibiting upregulation or RhoA in rats2008

    • Author(s)
      Chiba, Y., Goto.K., Hiraha-ra, M., Sakai, H. and Misawa, M.
    • Journal Title

      J.Pharmacol.Sci. 43

      Pages: 615-625

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Glucocorticoids inhibited airway hyperresponsiveness through downregulation of CPI-17 in bronchial smooth muscle2008

    • Author(s)
      Goto, K., Chiba, Y., Sakai, H. and Misawa, M.
    • Journal Title

      Eur.J.Pharmacol (In print)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] RhoA-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contaction2008

    • Author(s)
      Hanazaki, M., Yokoyama, M., Morita, K., Kohjitani, A., Sakai, H., Chiba, Y. and Misawa, M.
    • Journal Title

      Anesthesia & Analgesia 106

      Pages: 1765-1771

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma.2008

    • Author(s)
      Chiba, Y., Arima, J., Sakai, H., Misawa, M.
    • Journal Title

      Am, J. Physiol. Lung Cell. Mol. Physiol. 294

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholne.2008

    • Author(s)
      Sakai, H., Yamamoto, M., Chiba, Y., Misawa, M.
    • Journal Title

      J. Smooth Muscle Res. 44

      Pages: 9-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Glucocorticoids ameliorate antigen-induced bronchial smooth muscle hyper-responsiveness by inhibiting upregulation of RhoA in rats.2008

    • Author(s)
      Chiba, Y., Goto. K., Hiraha-ra, M., Sakai, H., Misawa, M.
    • Journal Title

      J. Pharmacol. Sci. 43

      Pages: 615-625

    • NAID

      10024320036

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Glucocorticoids inhibited airway hyperresponsiveness through downregulation of CPI-17 in bronchial smooth muscle.2008

    • Author(s)
      Goto, K., Chiba, Y., Sakai, H., Misawa, M.
    • Journal Title

      Eur. J. Pharmacol (In print)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] RhoA-kinase inhibitors augment the inhibitoryeffect of propofol on rat bronchial smooth muscle contaction.2008

    • Author(s)
      Hanazaki, M., Yokoyama, M., Morita, K., Kohjitani, A., Sakai, H., Chiba, Y., Misawa, M.
    • Journal Title

      Anesthesia & Analgesia 106

      Pages: 1765-1771

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Bronchial Asthma and Bronchial Smooth Muscle Hyperresponsiveness.2008

    • Author(s)
      Chiba, Y., Misawa, M.
    • Journal Title

      Medical Bio(Ohmsa) 5(2)

      Pages: 44-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Lovastatin inhibits bronchial hyperresponsiveness by reducingRhoA signaling in rat allergic asthma.2008

    • Author(s)
      Chiba, Y., Arima, J., Sakai, H.and Misawa, M.
    • Journal Title

      Am.J.Physiol.Lung Cell.Mol.Physiol 294

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Probable involvement of epsilon-isoform of protein kinase C inrat bronchial smooth musde contraction induced by acetylchone2008

    • Author(s)
      Sakai, H., Yamamoto, M., Chiba, Y.and Misawa, M.
    • Journal Title

      J.Smooth Musde Res 44

      Pages: 9-16

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glucoconicoids ameliorate anbigen-induced bronchial smooth musde hyperresponsiveness by inhibiting upregulation or RhoA in rats2008

    • Author(s)
      Chiba, Y., Goto. K., Hhrahara, M., Sakai, H.and Misawa, M.
    • Journal Title

      J.Pharmacol.Sci 43

      Pages: 615-625

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glucocorticoids inhibited airway hyperresponsiveness throughdownregUlation of CPI-17 in bronchial smooth muscle2008

    • Author(s)
      Goto, K., Chiba, Y., Sakai, H.and Misawa, M.
    • Journal Title

      Eur.J.Pharmacol (In print)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RhoA-kinase(ROcK)inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contaction2008

    • Author(s)
      Hanazaki, M., Yokoyama, M., Morita, K., Kohjitani, A., Sakai, H., Chiba, Y and Misawa, M.
    • Journal Title

      Anesthesia & Analgesia (In print)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo2007

    • Author(s)
      Chiba, Y., Oshita, M., Sakai, H. and Misawa, M.
    • Journal Title

      J.Smooth Muscle Res. 43

      Pages: 139-144

    • NAID

      110006404994

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Increase in the expression of matrix metalloproteinase-12 in the airways of rats with allergic bronchial asthma2007

    • Author(s)
      Chiba, Y., Yu, Y., Sakai, H., and Misawa, M.
    • Journal Title

      Biol.Pharm.Bull. 30

      Pages: 318-323

    • NAID

      110006162851

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvements of cystei-nyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized ratsin vivo.2007

    • Author(s)
      Chiba, Y., Oshita, M., Sakai, H., Misawa, M.
    • Journal Title

      J. Smooth Muscle Res. 43

      Pages: 139-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Increase in the expression of matrix metalloproteinase-12 in the airways of rats with allergic bronchial asthma.2007

    • Author(s)
      Chiba, Y., Yu, Y., Sakai, H., Misawa, M.
    • Journal Title

      Biol. Pharm. Bull. 30

      Pages: 318-323

    • NAID

      110006162851

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo2007

    • Author(s)
      Chiba, Y., Oshita, M., Sakai, H.and Misawa, M.
    • Journal Title

      J.Smooth Muscle Res 43

      Pages: 139-144

    • NAID

      110006404994

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase in the expression of matrix metalloproteinase-12 in the airways of ratswith allergic bronchial asthma2007

    • Author(s)
      Chiba, Y., Yu, Y., Sakai, H.and Misawa, M.
    • Journal Title

      Biol.Pharm.Bull 30

      Pages: 318-323

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase in the expression of matrix metalloproteinase-12 in the airways of rats with allergic bronchial asthma2007

    • Author(s)
      Chiba, Y., Yu, Y., Sakai, H., Misawa, M.
    • Journal Title

      Biol. Pharm. Bull. 30

      Pages: 318-323

    • NAID

      110006162851

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Increased expression of inducible nitric oxide synthase in nasal mucosae of guinea pigs with induced allergic rhinitis2006

    • Author(s)
      Chiba, Y., Matsuo, K., Sakai, H., Misawa, M.
    • Journal Title

      Am. J. Rhinol. 20

      Pages: 336-341

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparison of norepinephrine responsiveness of mucosal veins in vivo with that of isolated mucosal tissue in vitro in guinea pig nasal mucosa2006

    • Author(s)
      Chiba, Y., Oshita, M., Matsuo, K., Sakai, H., Misawa, M.
    • Journal Title

      Am. J. Rhinol. 20

      Pages: 349-352

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice2006

    • Author(s)
      Chiba, Y., Kurotani, R., Kusakabe, T., Miura, T., Link, B.W., Misawa, M
    • Journal Title

      Am. J. Respir. Crit. Care Med. 173

      Pages: 958-964

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of Rho kinase in endothelin-1-induced phosphorylation of CPI-17 in rat bronchial smooth muscle2006

    • Author(s)
      Sakai, H., Chiba, Y., Misawa, M.
    • Journal Title

      Pulm. Pharmacol. Ther. (Epub)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D_4-induced relaxation of isolated guinea pig nasal mucosa2006

    • Author(s)
      Chiba, Y., Matsuo, K., Sakai, H., Abe, K., Misawa, M.
    • Journal Title

      Nitric Oxide 15

      Pages: 142-147

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impaired norepinephrine-mediated contraction of isolated nasal mucosa in guinea pigs with allergic rhinitis2006

    • Author(s)
      Chiba, Y., Matsuo, K., Sakai, H., Misawa, M.
    • Journal Title

      Am. J. Rhinol. 20

      Pages: 477-479

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Augmentation of endothelin-1-induced phosphoryation of CPI-17 and myosin light chain in bronchial smooth muscle from airway hyperresponsive rats2006

    • Author(s)
      Sakai, H., Chiba, Y., Misawa, M.
    • Journal Title

      Biol. Pharm. Bull. 29

      Pages: 1897-1899

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs2006

    • Author(s)
      Chiba, Y., Matsuo, K., Sakai, H., Abe, K., Misawa, M.
    • Journal Title

      Auris Nasus Larynx (Epub)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Change in the expression of matrix metalloproteinase-12 in airways of rats with allergic bronchial asthma.2008

    • Author(s)
      Todoroki, M., Chiba, Y., Sakai, H., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RACK1as a binding partner for CPI-17 in bronchial smooth muscle.2008

    • Author(s)
      Tanabe, M., Chiba, Y., Kimura, S., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of actin polymerization in antigen-induced airway hyperresponsiveness in rats.2008

    • Author(s)
      Kozutsumi, Y., Chiba, Y., Sakai, H., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of cigarette smoke exposure on airway responsiveness in C57BL/6J mice.2008

    • Author(s)
      Matsuuchi, N., Ushikubo, H., Fujita, A., Sakai, H., Chiba, Y., Kamei, J., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of cigarette smoke-induced bronchial muscle hyperresponsiveness in rats depends on tar and nicotine contents.2008

    • Author(s)
      Fujita, A., Ushikubo, H., Chiba, Y., Sakai, H., Kamei, J., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of inhibitors of RhoA geranylgeranylation on antigen-induced airway hyperresponsiveness in mice.2008

    • Author(s)
      Sato S., Chiba, Y., Sakai, H., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of sphingosine-1-phosphate(S1P) in airway hyperresponsiveness observed in murine allergic bronchial asthma.2008

    • Author(s)
      Takeuchi, H., Chiba, Y., Sakai, H., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Augmented sodium nitroprusside-venodilatation of nasal mucosa in vivo in rats with allergic rhinitis.2008

    • Author(s)
      Uto, F., Enzaka, J., Oshita, M., Sakai, H., Chiba, Y., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of a specific matrix metalloproteinase-12 inhibitor on the pathogenesis of allergic bronchial asthma.2008

    • Author(s)
      Yu, Y., Chiba, Y., Sakai, H., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Increased expression of a sisintegrin and metalloproteinase 8 in mice with allergic vronchial asthma.2008

    • Author(s)
      Onoda, S., Chiba, Y., Sakai, H., Hattori, Y., Maitani, Y., Kimura, S., Misawa, M.
    • Organizer
      In The 81st Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第312報):培養ヒト気管支平滑筋細胞における各種SOCS分子種の発現に対するIL-13の効果2008

    • Author(s)
      西田 雄一、千葉 義彦、轟 倫子、三澤 美和
    • Organizer
      第118回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第313報):アレルギー性気管支喘息モデルマウスの気道過敏性および気道炎症発現に及ぼすlovastatinの効果2008

    • Author(s)
      佐藤 駿介、千葉 義彦、三澤 美和
    • Organizer
      第118回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第314報):培養ヒト気管支平滑筋細胞でのRhoAタンパ質発現におけるTNFα/NFkB経路およびIL-13/STAT6経路の関与2008

    • Author(s)
      後藤 久充子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第118回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道平滑筋におけるカルシウム感受性調節機構と麻酔薬2008

    • Author(s)
      花崎 元彦、横山 正尚、森田 潔、糀谷 淳、千葉 義彦、三澤 美和
    • Organizer
      第118回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 重症度の異なる二種類のラット褥瘡モデルの開発とその応用[シンポジウム]2008

    • Author(s)
      牛久 保裕子、千葉 義彦、三澤 美和
    • Organizer
      第118回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第311報):培養ヒト気管支平滑筋細胞におけるTNFα/NFkB誘発RhoA upregulationに対するprednisoloneの効果2008

    • Author(s)
      後藤 久充子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット褥瘡部皮膚組織における L-arghinine 代謝酵素の発現変化2008

    • Author(s)
      木村 有希、古川 晃次、牛久 保裕子、酒井 寛泰医、千葉 義彦、三澤 美和
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Change in the expression of matrix metalloproteinase-12 in airways of rats with allergic bronchiall asthma2008

    • Author(s)
      Todoroki, M., Chiba, Y., Sakai, H.and Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.302):RACK1 as a binding partner for CPI-17 in bronchial smooth muscle2008

    • Author(s)
      Tanabe, M., Chiba, Y., Kimura, S. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.303):Involvement of actin polymerization in antigen-induced airway hyperresponsiveness in rats2008

    • Author(s)
      Kozutsumi, Y., Chiba, Y., Salmi, H., & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.304):Effects of cigarette smoke exposure on airway responsiveness in C57BL/6Jmice2008

    • Author(s)
      Matsuuchi, N., Ushikubo, H., Fujita, A., Sakai, H., Chiba, Y., Kamei, J.& Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.305):Development of cigarette smoke-induced bronchial muscle hyperresponsiveness in rats depends on tar and nicotine contents2008

    • Author(s)
      Fujita, A., Ushikubo, H., Chiba, Y., Sakai, H., Kamei, J. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.306):Effect of inhibitors of RhoA geranylgeranylation on antigen-induced airway hyperresponsiveness in mice2008

    • Author(s)
      Sato S., Chiba, Y., Sakai, H.& Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.307):The role of sphingosine-1-phosphate (S1P) in airway hyperresponsiveness observed in murine allergic bronchial asthma2008

    • Author(s)
      Takeuchi, H., Chiba, Y., Sakai, H. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.308):Augmented sodium nitroprusside-induced venodilatation of nasal mucosa in vivo in rats with allergic rhinitis2008

    • Author(s)
      Uto, F., Enzaka, J., Oshita, M., Sakai, H., Chiba, Y.& Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.309):Effect of a specific matrix metalloproteinase-12 inhibitor on the pathogenesis of allergic bronchial asthma2008

    • Author(s)
      Yu, Y., Chiba, Y., Sakai, H., & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on the respiratory tract (Rept.310):Increased expression of a disintegrin and metalloproteinase 8 in mice with allergic bronchial asthma2008

    • Author(s)
      Onoda, S., Chiba, Y., Sakai, H., Hattori, Y., Maitani, Y., Kimura, S. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological studies on pressure ulcer (Rept.8):A new animal model of severe pressure ulcer using Wistar rats2008

    • Author(s)
      Kusano, R., Ushikubo, H., Sakai, H., Chiba, Y.& Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第311報):培養ヒト気管支平滑筋細胞におけるTNFα/NFκ誘発RhoA upregulationに対するprednisoloneの効果2008

    • Author(s)
      後藤 久充子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット褥瘡部皮膚組織におけるL-arginine代謝酵素の発現変化2008

    • Author(s)
      木村 有希、古川 晃次、牛久保 裕子、酒井 寛泰医、千葉 義彦、三澤 美和
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Change in the expression of matrix metalloproteinase-12 in airways of rats with allergic bronchial asthma2008

    • Author(s)
      Todoroki, M., Chiba, Y., Sakai, H. and Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacological studies on the respiratory tract(Rept.302):RACKl as a binding partner for CPI-17 in bronchial smooth muscle2008

    • Author(s)
      Tanabe, M., Chiba, Y., Kimura, S. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacological studies on the respiratory tract(Rept.303):Involvement of actin polymerization in antigen-induced airway hyperresponsiveness in rats.2008

    • Author(s)
      Kozutsumi, Y. Chiba, Y., Sakai, H., & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacological studies on the respiratory tract(Rept.304):Effects of cigarette smoke exposure on airway responslveness in C57BL/6J mice2008

    • Author(s)
      Matsuuchi, N., Ushikubo, H., Fujita, A., Sakai, H., Chiba, Y., Kamei, J. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacologial studies on the respiratory tract(Rept.305):Development of cigarette smoke-induced bronchial muscle hyperresponsiveness in rats depends on tar and nicotine contents2008

    • Author(s)
      Fujita, A., Ushikubo, H., Chiba, Y., Sakai, H., Kamei, J. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacological studies on the respiratory tract(Rept.306):Effect of inhibitors of RhoA geranylgeranylation on antigen-induced airway hyperresponsiveness in mice2008

    • Author(s)
      Sato S., Chiha, Y., Sakai, H. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacological studies on the respiratory tract(Rept.307):The role of sphingosine-1-phosphate(SIP) in airway hyperresponsiveness observed in murine allergic bronchial asthma2008

    • Author(s)
      Takeuchi, H., Chiba, Y., Sakai, H. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phamacological studies on the respiratory tract(Rept.308):Augmented sodium nitroprusside-induced venodilatation of nasal mucosa in vivo in rats with allergic rhinitis2008

    • Author(s)
      Uto, F., Enzaka, J., Oshita, M., Sakai, H., Chiba, Y. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacological studies on the respiratory tract(Rept.309):Effect of a specific matrix metalloproteinase-12inhibitor on the pathogenesis of allergic bronchial asthma2008

    • Author(s)
      Yu, Y., Chiba, Y., Sakai, H, & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacological studies on the respiratory tract(Rept.310):Increased expression of a disintegrin and metalloproteinase 8 in mice with allergic bronchial asthma2008

    • Author(s)
      Onoda, S., Chiba, Y., Sakai, H., Hattori, Y., Maitani, Y., Kimura, S. & Misawa, M
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pharmacological studies on pressure ulcer(Rept.8):A new animal model of severe pressure ulcer using Wistar rats2008

    • Author(s)
      Kusano, R., Ushikubo, H., Sakai, H., Chiba, Y. & Misawa, M.
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] TNF-α 誘発 RhoA pregulation における NF-kBの関与2007

    • Author(s)
      後藤 久充子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第1回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第299報):アレルギー性気管支喘息モデルマウスの肺組織において抗原チャレンジにより活性化されるSTATsの同定2007

    • Author(s)
      轟 倫子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第117回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第300報):培養ヒト気管支平滑筋細胞のRhoAタンパク質発現におけるTNF-α/NF-kB系の関与2007

    • Author(s)
      後藤 久充子、千葉 義彦、三澤 美和
    • Organizer
      第117回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第296報):アレルギー性気管支喘息マウスの肺組織におけるmatrix metalloproteinase-12発現の変化2007

    • Author(s)
      余 穎妍、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第51回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第297報):アレルギー性気管支喘息マウスの肺組織におけるADAM8発現の変化2007

    • Author(s)
      小野田 智、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第51回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第298報):3系統マウスにおけるタバコ主流煙誘発気道過敏性の発症とRhoAの変動2007

    • Author(s)
      松内 則秀、牛久 保裕子、藤田 亜希子、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      第51回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第295報):培養ヒト気管支平滑筋におけるIL-4およびIL-13により活性化されるSTATsの同定2007

    • Author(s)
      轟 倫子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第9回応用薬理シンポジウム
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 褥瘡の薬理学的研究(第7報):ラット褥瘡モデルの褥瘡発症・治癒過程における肥満細胞の関与2007

    • Author(s)
      古川 晃次、小林安 里奈、牛久 保裕子、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      第9回日本褥瘡学会学術大会
    • Place of Presentation
      前橋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第293報):Prednisoloneによる抗原誘発気道過敏性抑制機序におけるIL-13/STAT6経路の関与2007

    • Author(s)
      後藤 久充子、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      第116回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第294報):IL-4およびIL-13により培養ヒト気管支平滑筋細胞で活性化されるSTATsの検討2007

    • Author(s)
      轟 倫子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第116回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第291報):ステロイドによる気道過敏性抑制はSTAT6活性化阻害を介する2007

    • Author(s)
      後藤 久充子、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第292報):マウスアレルギー性気管支喘息時の肺組織におけるinterleukin-13受容体(ILー13Ralpha1)mRNA発現の増加2007

    • Author(s)
      千葉 義彦、小野田 智、轟 倫子、中沢 修司、酒井 寛泰、服部 喜之、米谷 芳枝、三澤 美和
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 褥瘡の薬理学的研究(第6報):ラット褥瘡部組織におけるMMP-9/TIMP-1バランスの変化2007

    • Author(s)
      牛久保 裕子、木崎 早矢香、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TNF-α誘発RhoA pregulationにおけるNF-κBの関与2007

    • Author(s)
      後藤 久充子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第1回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 気道の薬理学的研究(第300報):培養ヒト気管支平滑筋細胞のRhoAタンパク質発現におけるTNF-α/NF-κB系の関与2007

    • Author(s)
      後藤 久充子、千葉 義彦、三澤 美和
    • Organizer
      第117回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 気道の薬理学的研究(第297報):アレルギー性気管支喘息マウスの肺組織におけるN)AM8発現の変化2007

    • Author(s)
      小野田 智、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第51回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 気道の薬理学的研究(第295報):培養ヒト気管支平滑筋におけるIL-4およびIL-13により活性化されるSTATsの同定.2007

    • Author(s)
      轟 倫子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第9回応用薬理シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 褥瘡の薬理学的研究(第5報):新規褥瘡モデルの褥瘡部皮膚組織中MMP-9の動態とその関連物質の変化2006

    • Author(s)
      木崎 早矢香、牛久保 裕子、小林安 里奈、三澤 美和
    • Organizer
      第8回日本褥瘡学会学術集会
    • Place of Presentation
      さいたま市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第284報):抗原誘発気道過敏性発現に対するglucocorticoidsの効果2006

    • Author(s)
      後藤 久充子、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      第8回応用薬理シンポジウム
    • Place of Presentation
      千葉市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第285報):Lovastain 前処置による RhoA 活性化と気道過敏性の抑制2006

    • Author(s)
      有馬 順子、千葉 義彦、酒井 寛泰、三澤 美和
    • Organizer
      第8回応用薬理シンポジウム
    • Place of Presentation
      千葉市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第286報):抗原誘発鼻粘膜過敏性時の鼻粘膜における血管拡張反応とNO産生の変化2006

    • Author(s)
      遠坂 純、大下 未知子、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      第8回応用薬理シンポジウム
    • Place of Presentation
      千葉市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第287報):タバコ主流煙吸入暴露によるラットでの気道過敏性の証明2006

    • Author(s)
      小松 魅侑爾、牛久保 裕子、村田 真彦、松内 則秀、亀井 淳三、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      第8回応用薬理シンポジウム
    • Place of Presentation
      千葉市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第288報):タバコ主流煙吸入暴露ラットではin vivo及びin vitroで気道過敏性が発症する2006

    • Author(s)
      小松 魅侑爾、牛久保 裕子、村田 真彦、松内 則秀、亀井 淳三、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      第115回日本薬理学会関東部会
    • Place of Presentation
      高崎市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第289報):Acetylcholine誘発気管支平滑筋収縮におけるアクチン重合反応の関与2006

    • Author(s)
      酒井 寛泰、小堤 友理、千葉 義彦、三澤 美和
    • Organizer
      第115回日本薬理学会関東部会
    • Place of Presentation
      高崎市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 気道の薬理学的研究(第290報):抗原誘発鼻粘膜過敏性時のNO誘発鼻粘膜静脈弛緩反応の亢進とK^+channelの関与2006

    • Author(s)
      遠坂 純、大下 未知子、酒井 寛泰、千葉 義彦、三澤 美和
    • Organizer
      第115回日本薬理学会関東部会
    • Place of Presentation
      高崎市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] メディカルバイオ2008

    • Author(s)
      千葉 義彦、三澤 美和
    • Publisher
      株式会社オーム社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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