Clinicoimmunopathological study on autoinflammatory syndrome

• Project/Area Number: 18590524
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Shinshu University
• Principal Investigator: MASUMOTO Junya Shinshu University, 医学部, 講師 (20334914)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,910,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥510,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 臨床 / 免疫 / 病理 / 細菌 / シグナル伝達 / 免疫学 / 病理学

Research Abstract

細胞内病原体受容体のNOD蛋白質の変異による自己炎症性疾患の病態を解析することで、炎症を制御するインフラマソームの機能を詳細に描き出すことができ、その制御の異常によって自己炎症性疾患が発症することが裏付けられた。今回の研究でインフラマソームの果たす炎症制御への役割が類推できたことで、炎症性疾患の予防や治療への応用が可能になると考えられる。

Research Products

• [Journal Article] Interleukin-1β suppression in Nod2-defect Blau syndrome (2009)
  • Author(s): Masumoto J, Yamazaki T, Ohta K, Nakayama J, Agematsu K
  • Journal Title: Arthritis and Rheumatism (印刷中)
  • Peer Reviewed
• [Journal Article] GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis (2009)
  • Author(s): Kobayashi M, Hoshino H, Masumoto J, Fukushima M, Suzawa K, 他
  • Journal Title: Inflammatory Bowel Disease 15-5 Pages: 697-706
  • Peer Reviewed
• [Journal Article] GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity ofulcerative colitis (2009)
  • Author(s): Kobayashi M, Hoshino H, Masumoto J, Fukushima M, Suzawa K, 他
  • Journal Title: Inflammatory Bowel Disease 15 Pages: 697-706
  • Peer Reviewed
• [Journal Article] Interleukin-1βsuppression in Nod2-defect Blau syndrome (2009)
  • Author(s): Masumoto J, Yamazaki T, Ohta K, Nakayama J. Agematsu K
  • Journal Title: Arthritis and Rheuniatism (In press)
  • Peer Reviewed
• [Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice (2008)
  • Author(s): Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, 他
  • Journal Title: Circulation 117巻 Pages: 3079-307
  • Peer Reviewed
• [Journal Article] Nod2とCrohn病 (2008)
  • Author(s): 増本純也, 長谷川瑞穂, 猪原直弘
  • Journal Title: 炎症と免疫 16巻・5号 Pages: 592-593
• [Journal Article] 家族性地中海熱の分子メカニズムと臨床像 (2008)
  • Author(s): 山崎崇志, 増本純也, 上松一永
  • Journal Title: 日本小児科学会会誌 112巻・号 Pages: 1358-1368
  • NAID: 10024462926
• [Journal Article] 家族性地中海熱の分子病態 (2008)
  • Author(s): 増本純也, 篠崎康治, 上松一永
  • Journal Title: 炎症と免疫 16巻・2号 Pages: 149-157
• [Journal Article] Nod-like receptorの機能から考える「自己炎症性疾患」の分子病態 (2008)
  • Author(s): 増本純也, 長谷川瑞穂, 猪原直弘
  • Journal Title: 小児リウマチ 1巻・1号 Pages: 51-56
• [Journal Article] Anakinra improves sensory deafness in a Japanese patient with Muckle-Wells syndrome, possibly by inhibiting the cryopyrin inflammasome (2008)
  • Author(s): Yamazaki T, Masumoto J, Agematsu K, Sawai N, Kobayashi S, 他
  • Journal Title: Arthritis and Rheumatism 58巻・3号 Pages: 864-868
  • Peer Reviewed
• [Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein. an inflammasome adaptor molecule, in neointimal formation after vascularinjury in mice (2008)
  • Author(s): Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumotol, 他
  • Journal Title: Circulation 117 Pages: 3079-3087
  • Peer Reviewed
• [Journal Article] Anakinra improves sensory deafness in a Japanese patient with Muckle-Wells syndrome, possibly by inhibiting the cryopyrin inflammasome. (2008)
  • Author(s): Yamazaki T, Masumoto J, Agematsu K, Sawai N, Kobayashi S, 他.
  • Journal Title: Arthritis and Rheumatism 58巻・3号 Pages: 864-868
  • Peer Reviewed
• [Journal Article] Prognostic significance of the immunohistochemical staining of cleaved-caspase-3, an activated form of caspase-3, in gliomas (2007)
  • Author(s): Kobayashi T, Masumoto J, Tada T, Hongo K, Nomiyama K, Nakayama J
  • Journal Title: Clinical Cancer Research 13巻・13号 Pages: 3868-3874
  • Peer Reviewed
• [Journal Article] The molecular mechanism of autoinflammatory disease-lessons from the function of NOD protein families- (2007)
  • Author(s): Masumoto J, Hasegawa M, Inohara N
  • Journal Title: Japanese Journal of Clinical 30巻・2号 Pages: 68-77
  • NAID: 10019495134
  • Peer Reviewed
• [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nodl-mediated immune responses (2007)
  • Author(s): Hasegawa M, Kawasaki A, Yang K, Fujimoto Y, Masumoto J, Breukink E, 他.
  • Journal Title: Journal of Biological Chemistry 282巻・16号 Pages: 11757-11764
  • Peer Reviewed
• [Journal Article] The molecular mechanism of autoinflammatory disease-lessons from the function of NOD protein families- (2007)
  • Author(s): Masumoto J, Hasegawa M, Inohara N.
  • Journal Title: Japanese Journal of Clinical Immunology 30巻・2号 Pages: 68-77
  • NAID: 10019495134
  • Peer Reviewed
• [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses (2007)
  • Author(s): Hasegawa M, Kawasaki A, Yang K, Fujimoto Y, Masumoto J, Breukink E他
  • Journal Title: Journal of Biological Chemistry 282巻・16号 Pages: 11757-11764
• [Journal Article] Prognostic significance of the immunohistochemical staining of cleaved-caspase-3, an activated form of caspase-3, in gliomas (2007)
  • Author(s): Kobayashi T, Masumoto J, Tada T, Hongo K, Nomiyama K, Nakayama J他
  • Journal Title: Clinical Cancer Research (印刷中)
• [Journal Article] 『NOD蛋白質』の機能から考える自己炎症疾患発症の分子メカニズム (2007)
  • Author(s): 増本純也, 長谷川瑞穂, 猪原直弘
  • Journal Title: 日本臨床免疫学会雑誌 (印刷中)
  • NAID: 10019495134
• [Journal Article] Regulation of the ASC expression in response to LPS stimulation is related to IL-8 secretion in the human intestinal mucosa (2006)
  • Author(s): Masumoto J, Kobayashi H, Nakamura T, Kaneko Y, Ota H, 他
  • Journal Title: Biochemical and Biophysical Research Communications 346巻・3号 Pages: 968-973
  • Peer Reviewed
• [Journal Article] Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo (2006)
  • Author(s): Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, 他
  • Journal Title: Journal of Experimental Medicine 203巻・1号 Pages: 203-213
  • Peer Reviewed
• [Journal Article] Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes (2006)
  • Author(s): Ozoren N, Masumoto J, Franchi L, Kanneganti TD, Body-Malapel M, 他
  • Journal Title: Journal of Immunology 176巻・7号 Pages: 4337-4342
  • Peer Reviewed
• [Journal Article] Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo (2006)
  • Author(s): Masumoto J, Yang K, Varmbally S, Hasegawa M, Tomlins SA, Qiu S他
  • Journal Title: Journal of Experimental Medicine 203巻・1号 Pages: 203-213
• [Journal Article] Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes (2006)
  • Author(s): Ozoren N, Masumoto J, Franchi L, Kanneganti TD, Body-Malapel M, Erturk I他
  • Journal Title: Journal of Immunology 176巻・7号 Pages: 4337-4342
• [Journal Article] Regulation of the ASC expression in response to LPS stimulation is related to IL-8 secretion in the human intestinal mucosa (2006)
  • Author(s): Masumoto J, Kobayashi H, Nakamura T, Kaneko Y, Ota H, Hasegawa M他
  • Journal Title: Biochemical and Biophysical Research Communications 346巻・3号 Pages: 968-973
• [Presentation] インフラマソーム機能の異常による自己炎症性疾患の解析と分子標的薬による治療効果 (2008)
  • Author(s): 増本純也, 山崎崇志, 上松一永, 勝山努, 本田孝行
  • Organizer: 第55回日本臨床検査医学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-28
• [Presentation] アナキンラはインフラマゾームを阻害してマックルウェルズ症候群患者の感音性難聴を改善した (2008)
  • Author(s): 増本純也, 山崎崇志, 重村倫成, 上松一永, 小池健一
  • Organizer: 社団法人日本薬学会第128年会
  • Place of Presentation: 横浜
• [Presentation] 肺扁平上皮癌におけるクライオパイリンの発現 (2008)
  • Author(s): 柏倉隆一, 増本純也, 宮崎祐子, 下條康代, 小林幸弘, 本田孝行, 中山淳
  • Organizer: 社団法人日本薬学会第128年会
  • Place of Presentation: 横浜
• [Presentation] アナキンラはインフラマゾームを阻害してマックルウェルズ症候群患者の感音性難聴を改善した (2008)
  • Author(s): 増本純也, 山崎崇志, 重村倫成, 上松一永, 小池健一
  • Organizer: 社団法人日本薬学会第128年会(横浜)
  • Place of Presentation: パシフィコ横浜
• [Presentation] 肺扁平上皮癌におけるクライオパイリンの発現 (2008)
  • Author(s): 柏倉隆一, 増本純也, 宮崎祐子, 下條康代, 小林幸弘, 本田孝行, 中山淳
  • Organizer: 社団法人日本薬学会第128年会(横浜)
  • Place of Presentation: パシフィコ横浜
• [Presentation] Application of immunohistochemistry for study of ASC-related molecules in diseases(Invited speaker) (2007)
  • Author(s): Masumoto J, Nakayama J
  • Organizer: 第48回日本組織細胞化学会総会(第8回日中合同組織細胞化学セミナー)/第39回日本臨床分子形態学会総会
  • Place of Presentation: 山梨県甲府市総合市民会館
• [Presentation] Application of immunohistochemistry for study of ASC-related molecules in diseases(Invited speaker) (2007)
  • Author(s): Masumoto J, Nakayama J
  • Organizer: 第48回日本組織細胞化学会総会(第8回日中合同組織細胞化学セミナー>/第39回日本臨床分子形態学会総会
  • Place of Presentation: 山梨県甲府市総合市民会館
• [Presentation] 細胞内菌体受容体NODと炎症性疾患の解析(学会賞受賞講演) (2006)
  • Author(s): 増本純也
  • Organizer: 第53回日本臨床検査医学会学術集会
  • Place of Presentation: 弘前 ; 弘前市民会館・弘前文化センター・ホテルニューキャッスル
  • Year and Date: 2006-11-09
• [Presentation] マックル-ウェルズ症候群(MWS)と末梢血単核球免疫応答 (2006)
  • Author(s): 増本純也, 山崎崇志, 上松一永, 佐野健司, 勝山努
  • Organizer: 第53回日本臨床検査医学会学術集会
  • Place of Presentation: 弘前 ; 弘前市民会館・弘前文化センター・ホテルニューキャッスル
  • Year and Date: 2006-11-09
• [Presentation] Muckle-Wells症候群の1女児例 (2006)
  • Author(s): 山崎崇志, 重村倫成, 小池健一, 上松一永, 増本純也, 安井耕三, 澤井信邦, 小林真二
  • Organizer: 第16回日本小児リウマチ学会総会・学術総会
  • Place of Presentation: 松本 ; 信州大学旭研究棟
  • Year and Date: 2006-10-06
• [Presentation] NOD蛋白質の機能から考える「自己炎症疾患」発症の分子メカニズム (2006)
  • Author(s): 増本純也
  • Organizer: 第16回日本小児リウマチ学会総会・学術総会
  • Place of Presentation: 松本 ; 信州大学旭研究棟
  • Year and Date: 2006-10-06
• [Presentation] Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo (2006)
  • Author(s): Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA 他
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Year and Date: 2006-06-18
• [Presentation] クローン病消化管粘膜からの_異常なIL-8とTNF-αの産生 (2006)
  • Author(s): 増本純也、太田浩良、佐野健司、勝山努
  • Organizer: 第95回日本病理学会総会
  • Place of Presentation: 新宿 ; 京王プラザホテル
  • Year and Date: 2006-04-30