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Clinicoimmunopathological study on autoinflammatory syndrome

Research Project

Project/Area Number 18590524
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionShinshu University

Principal Investigator

MASUMOTO Junya  Shinshu University, 医学部, 講師 (20334914)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,910,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords臨床 / 免疫 / 病理 / 細菌 / シグナル伝達 / 免疫学 / 病理学
Research Abstract

細胞内病原体受容体のNOD蛋白質の変異による自己炎症性疾患の病態を解析することで、炎症を制御するインフラマソームの機能を詳細に描き出すことができ、その制御の異常によって自己炎症性疾患が発症することが裏付けられた。今回の研究でインフラマソームの果たす炎症制御への役割が類推できたことで、炎症性疾患の予防や治療への応用が可能になると考えられる。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (38 results)

All 2009 2008 2007 2006

All Journal Article (25 results) (of which Peer Reviewed: 15 results) Presentation (13 results)

  • [Journal Article] Interleukin-1β suppression in Nod2-defect Blau syndrome2009

    • Author(s)
      Masumoto J, Yamazaki T, Ohta K, Nakayama J, Agematsu K
    • Journal Title

      Arthritis and Rheumatism (印刷中)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis2009

    • Author(s)
      Kobayashi M, Hoshino H, Masumoto J, Fukushima M, Suzawa K, 他
    • Journal Title

      Inflammatory Bowel Disease 15-5

      Pages: 697-706

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity ofulcerative colitis2009

    • Author(s)
      Kobayashi M, Hoshino H, Masumoto J, Fukushima M, Suzawa K, 他
    • Journal Title

      Inflammatory Bowel Disease 15

      Pages: 697-706

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1βsuppression in Nod2-defect Blau syndrome2009

    • Author(s)
      Masumoto J, Yamazaki T, Ohta K, Nakayama J. Agematsu K
    • Journal Title

      Arthritis and Rheuniatism (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice2008

    • Author(s)
      Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, 他
    • Journal Title

      Circulation 117巻

      Pages: 3079-307

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nod2とCrohn病2008

    • Author(s)
      増本純也, 長谷川瑞穂, 猪原直弘
    • Journal Title

      炎症と免疫 16巻・5号

      Pages: 592-593

    • Related Report
      2008 Final Research Report
  • [Journal Article] 家族性地中海熱の分子メカニズムと臨床像2008

    • Author(s)
      山崎崇志, 増本純也, 上松一永
    • Journal Title

      日本小児科学会会誌 112巻・号

      Pages: 1358-1368

    • NAID

      10024462926

    • Related Report
      2008 Final Research Report
  • [Journal Article] 家族性地中海熱の分子病態2008

    • Author(s)
      増本純也, 篠崎康治, 上松一永
    • Journal Title

      炎症と免疫 16巻・2号

      Pages: 149-157

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Journal Article] Nod-like receptorの機能から考える「自己炎症性疾患」の分子病態2008

    • Author(s)
      増本純也, 長谷川瑞穂, 猪原直弘
    • Journal Title

      小児リウマチ 1巻・1号

      Pages: 51-56

    • Related Report
      2008 Final Research Report
  • [Journal Article] Anakinra improves sensory deafness in a Japanese patient with Muckle-Wells syndrome, possibly by inhibiting the cryopyrin inflammasome2008

    • Author(s)
      Yamazaki T, Masumoto J, Agematsu K, Sawai N, Kobayashi S, 他
    • Journal Title

      Arthritis and Rheumatism 58巻・3号

      Pages: 864-868

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein. an inflammasome adaptor molecule, in neointimal formation after vascularinjury in mice2008

    • Author(s)
      Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumotol, 他
    • Journal Title

      Circulation 117

      Pages: 3079-3087

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anakinra improves sensory deafness in a Japanese patient with Muckle-Wells syndrome, possibly by inhibiting the cryopyrin inflammasome.2008

    • Author(s)
      Yamazaki T, Masumoto J, Agematsu K, Sawai N, Kobayashi S, 他.
    • Journal Title

      Arthritis and Rheumatism 58巻・3号

      Pages: 864-868

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of the immunohistochemical staining of cleaved-caspase-3, an activated form of caspase-3, in gliomas2007

    • Author(s)
      Kobayashi T, Masumoto J, Tada T, Hongo K, Nomiyama K, Nakayama J
    • Journal Title

      Clinical Cancer Research 13巻・13号

      Pages: 3868-3874

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The molecular mechanism of autoinflammatory disease-lessons from the function of NOD protein families-2007

    • Author(s)
      Masumoto J, Hasegawa M, Inohara N
    • Journal Title

      Japanese Journal of Clinical 30巻・2号

      Pages: 68-77

    • NAID

      10019495134

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nodl-mediated immune responses2007

    • Author(s)
      Hasegawa M, Kawasaki A, Yang K, Fujimoto Y, Masumoto J, Breukink E, 他.
    • Journal Title

      Journal of Biological Chemistry 282巻・16号

      Pages: 11757-11764

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The molecular mechanism of autoinflammatory disease-lessons from the function of NOD protein families-2007

    • Author(s)
      Masumoto J, Hasegawa M, Inohara N.
    • Journal Title

      Japanese Journal of Clinical Immunology 30巻・2号

      Pages: 68-77

    • NAID

      10019495134

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses2007

    • Author(s)
      Hasegawa M, Kawasaki A, Yang K, Fujimoto Y, Masumoto J, Breukink E他
    • Journal Title

      Journal of Biological Chemistry 282巻・16号

      Pages: 11757-11764

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prognostic significance of the immunohistochemical staining of cleaved-caspase-3, an activated form of caspase-3, in gliomas2007

    • Author(s)
      Kobayashi T, Masumoto J, Tada T, Hongo K, Nomiyama K, Nakayama J他
    • Journal Title

      Clinical Cancer Research (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 『NOD蛋白質』の機能から考える自己炎症疾患発症の分子メカニズム2007

    • Author(s)
      増本純也, 長谷川瑞穂, 猪原直弘
    • Journal Title

      日本臨床免疫学会雑誌 (印刷中)

    • NAID

      10019495134

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of the ASC expression in response to LPS stimulation is related to IL-8 secretion in the human intestinal mucosa2006

    • Author(s)
      Masumoto J, Kobayashi H, Nakamura T, Kaneko Y, Ota H, 他
    • Journal Title

      Biochemical and Biophysical Research Communications 346巻・3号

      Pages: 968-973

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo2006

    • Author(s)
      Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, 他
    • Journal Title

      Journal of Experimental Medicine 203巻・1号

      Pages: 203-213

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes2006

    • Author(s)
      Ozoren N, Masumoto J, Franchi L, Kanneganti TD, Body-Malapel M, 他
    • Journal Title

      Journal of Immunology 176巻・7号

      Pages: 4337-4342

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo2006

    • Author(s)
      Masumoto J, Yang K, Varmbally S, Hasegawa M, Tomlins SA, Qiu S他
    • Journal Title

      Journal of Experimental Medicine 203巻・1号

      Pages: 203-213

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes2006

    • Author(s)
      Ozoren N, Masumoto J, Franchi L, Kanneganti TD, Body-Malapel M, Erturk I他
    • Journal Title

      Journal of Immunology 176巻・7号

      Pages: 4337-4342

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of the ASC expression in response to LPS stimulation is related to IL-8 secretion in the human intestinal mucosa2006

    • Author(s)
      Masumoto J, Kobayashi H, Nakamura T, Kaneko Y, Ota H, Hasegawa M他
    • Journal Title

      Biochemical and Biophysical Research Communications 346巻・3号

      Pages: 968-973

    • Related Report
      2006 Annual Research Report
  • [Presentation] インフラマソーム機能の異常による自己炎症性疾患の解析と分子標的薬による治療効果2008

    • Author(s)
      増本純也, 山崎崇志, 上松一永, 勝山努, 本田孝行
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] アナキンラはインフラマゾームを阻害してマックルウェルズ症候群患者の感音性難聴を改善した2008

    • Author(s)
      増本純也, 山崎崇志, 重村倫成, 上松一永, 小池健一
    • Organizer
      社団法人日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺扁平上皮癌におけるクライオパイリンの発現2008

    • Author(s)
      柏倉隆一, 増本純也, 宮崎祐子, 下條康代, 小林幸弘, 本田孝行, 中山淳
    • Organizer
      社団法人日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] アナキンラはインフラマゾームを阻害してマックルウェルズ症候群患者の感音性難聴を改善した2008

    • Author(s)
      増本純也, 山崎崇志, 重村倫成, 上松一永, 小池健一
    • Organizer
      社団法人日本薬学会第128年会(横浜)
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肺扁平上皮癌におけるクライオパイリンの発現2008

    • Author(s)
      柏倉隆一, 増本純也, 宮崎祐子, 下條康代, 小林幸弘, 本田孝行, 中山淳
    • Organizer
      社団法人日本薬学会第128年会(横浜)
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Application of immunohistochemistry for study of ASC-related molecules in diseases(Invited speaker)2007

    • Author(s)
      Masumoto J, Nakayama J
    • Organizer
      第48回日本組織細胞化学会総会(第8回日中合同組織細胞化学セミナー)/第39回日本臨床分子形態学会総会
    • Place of Presentation
      山梨県甲府市総合市民会館
    • Related Report
      2008 Final Research Report
  • [Presentation] Application of immunohistochemistry for study of ASC-related molecules in diseases(Invited speaker)2007

    • Author(s)
      Masumoto J, Nakayama J
    • Organizer
      第48回日本組織細胞化学会総会(第8回日中合同組織細胞化学セミナー>/第39回日本臨床分子形態学会総会
    • Place of Presentation
      山梨県甲府市総合市民会館
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞内菌体受容体NODと炎症性疾患の解析(学会賞受賞講演)2006

    • Author(s)
      増本純也
    • Organizer
      第53回日本臨床検査医学会学術集会
    • Place of Presentation
      弘前 ; 弘前市民会館・弘前文化センター・ホテルニューキャッスル
    • Year and Date
      2006-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] マックル-ウェルズ症候群(MWS)と末梢血単核球免疫応答2006

    • Author(s)
      増本純也, 山崎崇志, 上松一永, 佐野健司, 勝山努
    • Organizer
      第53回日本臨床検査医学会学術集会
    • Place of Presentation
      弘前 ; 弘前市民会館・弘前文化センター・ホテルニューキャッスル
    • Year and Date
      2006-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Muckle-Wells症候群の1女児例2006

    • Author(s)
      山崎崇志, 重村倫成, 小池健一, 上松一永, 増本純也, 安井耕三, 澤井信邦, 小林真二
    • Organizer
      第16回日本小児リウマチ学会総会・学術総会
    • Place of Presentation
      松本 ; 信州大学旭研究棟
    • Year and Date
      2006-10-06
    • Related Report
      2008 Final Research Report
  • [Presentation] NOD蛋白質の機能から考える「自己炎症疾患」発症の分子メカニズム2006

    • Author(s)
      増本純也
    • Organizer
      第16回日本小児リウマチ学会総会・学術総会
    • Place of Presentation
      松本 ; 信州大学旭研究棟
    • Year and Date
      2006-10-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo2006

    • Author(s)
      Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA 他
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Year and Date
      2006-06-18
    • Related Report
      2008 Final Research Report
  • [Presentation] クローン病消化管粘膜からの_異常なIL-8とTNF-αの産生2006

    • Author(s)
      増本純也、太田浩良、佐野健司、勝山努
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      新宿 ; 京王プラザホテル
    • Year and Date
      2006-04-30
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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