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Exploration of new biological marker of the health effects caused by environmental pollutants using genomic and proteomic analyses

Research Project

Project/Area Number 18590559
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionThe University of Tokushima

Principal Investigator

ARISAWA Kokichi  The University of Tokushima, Institute of Health Biosciences, Graduate School, Professor (30203384)

Co-Investigator(Kenkyū-buntansha) ROKUTAN Kazuhito  The University of Tokushima, Institute of Health Biosciences, Graduate School, Professor (10230898)
UEMURA Hirokazu  The University of Tokushima, Institute of Health Biosciences, Graduate School, Lecturer (50346590)
HIYOSHI Mineyoshi  The University of Tokushima, Institute of Health Biosciences, Graduate School, Assistant Professor (30363162)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsCd-exposed population / Stress chip / Cluster analysis / Carbon tetrachloride / Liver injury / Proteomic analysis / Relative quantification of proteins / ビスフェノールA曝露マウス
Research Abstract

(1) Changes in gene expression of peripheral blood cells from women exposed to environmental cadmium
The objective of this study was to examine the effects of environmental cadmium (Cd) exposure on the gene expression profile of peripheral blood cells using an original cDNA microarray. The study population consisted of 20 female residents in a Cd-polluted area (mean age=68.7 years, Cd-exposed group) and 20 female residents in a non-Cd polluted area individually matched for age (control group).The mRNA levels of the Cd-exposed subjects were compared with those of respective controls. Median Cd concentrations in blood (3.55 μg/l) and urine (8.27 μg/g cr.)from the Cd-exposed group were 1.9-2.4 times higher than those of the control group. In cDNA microarray analysis, 137 up-regulated (>1.20-fold) and 80 down-regulated genes (<0.84-fold) were identified. Further, the authors chose 17 genes which were positively correlated with Cd concentrations in blood or urine, or which were involved in i … More mportant biological functions, and performed real-time PCR analysis. Significantly or marginally significantly increased expression was observed for CASP9, TNFRSF1B, GPX3, HYOU1, SLC3A2, SLC19A1, SLC35A4, CYP4F12, ITGAL and MT2, and significantly decreased expression was noted for BCL2A1 and COX7B. Increased expression of genes involved in protection against oxidative stress, apoptosis through the mitochondrial pathway and transporters were the characteristic features. Expression levels of SLC19A1 were positively correlated with Cd concentrations in blood and urine (r>0.5), suggesting that this was a candidate marker gene in low level exposure to environmental Cd.
(2)Introduction of proteomic approach to environmental medicine
Recent progress in life science technology and the availability of much information on genes obtained by genome analysis has enabled us to analyze the changes of proteins on a large scale. Sets of proteins are called proteomes, and proteomics is the scientific field of proteome analysis including differential, post translational modification and interaction analyses. Various proteomic techniques, particularly two-dimensional gel electrophoresis (2-DE), mass spectrometry, protein chip methods, and surface plasmon resonance (SPR), are very useful for acquiring proteomes in cells, tissues and body fluid, and for analyzing interactions between a protein and other biofactors including proteins. A proteomic approach is also useful for determining biomarkers of diseases and key proteins involved in various stages of metabolism such as differentiation, cell cycle and apoptosis. Environmental pollutants including endocrine disruptors inhibit activities of various organs in wild animals and humans. Proteomic approaches could be very useful tools for elucidating the mechanisms of damage caused by environmental pollutants. We reviewed the application of a proteomic approach to the field of environmental medicine. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (58 results)

All 2008 2007 2006 Other

All Journal Article (31 results) (of which Peer Reviewed: 15 results) Presentation (22 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Circulating osteoprotegerin associates with age and systolic blood pressure but not with lipid profile or fasting glucose in postmenopausal women.2008

    • Author(s)
      Uemura H, et. al.
    • Journal Title

      Menopause 15

      Pages: 180-184

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Growth of head circumference in autistic infants during the first year of life.2008

    • Author(s)
      Fukumoto A, et. al.
    • Journal Title

      Journal of Autism and Developmental Disorders 38

      Pages: 411-418

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Circulating profiles of osteoprotegerin and soluble receptor activator of nuclear factor κB ligand in postmenopausal women.2008

    • Author(s)
      Uemura H, et. al.
    • Journal Title

      Journal of Endocrinological Investigation 31

      Pages: 163-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Growth of head circumference in autistic infants during the first year of life2008

    • Author(s)
      Fukumoto, A
    • Journal Title

      Journal of Autism and Developmental Disorders 38(3)

      Pages: 411-418

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Circulating profiles of osteoprotegerin and soluble receptor activator of nuclear factor KB ligand in postmenopausal women2008

    • Author(s)
      Uemura, H
    • Journal Title

      Journal of Endocrinological Investigation 31(2)

      Pages: 163-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Circulating osteoprotegerin associates with age and systolic blood pressure but not with lipid profile or fasting glucose in postmenopausal women2008

    • Author(s)
      Uemura, H
    • Journal Title

      Menopause 15(1)

      Pages: 180-184

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cadmium-induced renal dysfunction and mortality in two cohorts: disappearance of the association in a generation born later.2007

    • Author(s)
      Arisawa K, et. al.
    • Journal Title

      Toxicology Letters 169

      Pages: 214-221

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cause-specific mortality and cancer incidence rates in relation to urinary β2-microglobulin: 23-year follow-up study in a cadmium-polluted area.2007

    • Author(s)
      Arisawa K, et. al.
    • Journal Title

      Toxicology Letters 173

      Pages: 168-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dietary intake of tin in Japan, and the effects on intake of canned food and beverage consumption.2007

    • Author(s)
      Shimbo S, et. al.
    • Journal Title

      Food Additives and Contaminants 24

      Pages: 535-545

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cause-specific mortality and cancer incidence rates in relation to urinary 82-microglobulin : 23-year follow-up study in a cadmium-polluted area2007

    • Author(s)
      Arisawa, K
    • Journal Title

      Toxicology Letters 173(3)

      Pages: 168-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cadmium-induced renal dysfunction and mortality in two cohorts : disappearance of the association in a generation born later2007

    • Author(s)
      Arisawa, K
    • Journal Title

      Toxicology Letters 169(3)

      Pages: 214-221

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dietary intake of tin in Japan, and the effects on intake of canned food and beverage consumption2007

    • Author(s)
      Shimbo, S
    • Journal Title

      Food Additives and Contaminants 24(5)

      Pages: 535-545

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cadmium-induced renal dysfunction and mortality in two cohorts: disappearance of the association in a generation born later2007

    • Author(s)
      Arisawa K, et. al.
    • Journal Title

      Toxicology Letters 169

      Pages: 214-221

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cause-specific mortality and cancer incidence rates in relation to urinary β2-microglobulin:23-year follow-up study in a cadmium-polluted area2007

    • Author(s)
      Arisawa K, et. al.
    • Journal Title

      Toxicology Letters 173

      Pages: 168-174

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary intake of tin in Japan,and the effects on intake of canned food and beverage consumption2007

    • Author(s)
      Shimbo S, et. al.
    • Journal Title

      Food Additives and Contaminants 24

      Pages: 535-545

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human T-cell lymphotropic virus type-1 infection and risk of cancer: 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan.2006

    • Author(s)
      Arisawa K, et. al.
    • Journal Title

      Cancer Science 97

      Pages: 535-539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A lack of significant association between the electropherotype or G-serotype of the infecting strain and disease severity of rotavirus gastroenteritis.2006

    • Author(s)
      Nakagomi O, et. al.
    • Journal Title

      Archives of Virology 151

      Pages: 1947-1960

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A high incidence of intussusception in Japan as studied in a sentinel hospital over a 25-year period (1978-2002).2006

    • Author(s)
      Nakagomi T, et. al.
    • Journal Title

      Epidemiology and Infection 134

      Pages: 57-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 環境医学領域におけるプロテオミクスの導入.2006

    • Author(s)
      日吉峰麗, 他.
    • Journal Title

      日本衛生学雑誌 61

      Pages: 393-399

    • NAID

      10018256506

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ダイオキシンの健康リスクと食の安全.2006

    • Author(s)
      有澤孝吉.
    • Journal Title

      遺伝 別冊 食の安全科学 19

      Pages: 116-121

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Human T-cell lymphotropic virus type-1 infection and risk of cancer : 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan2006

    • Author(s)
      Arisawa, K
    • Journal Title

      Cancer Science 97(6)

      Pages: 935-939

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A lack of significant association between the electropherotype or G-serotype of the infecting strain and disease severity of rotavirus gastroenteritis2006

    • Author(s)
      Nakagomi, O
    • Journal Title

      Archives of Virology 150(10)

      Pages: 1947-1960

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A high incidence of intussusception in Japan as studied in a sentinel hospital over a 25-year period(1978-2002)2006

    • Author(s)
      Nakagomi, T
    • Journal Title

      Epidemiology and Infection 134(1)

      Pages: 57-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Introduction of proteomic approach to environmental medicine2006

    • Author(s)
      Hiyoshi, M
    • Journal Title

      Japanese Journal of Hygiene 61(4)

      Pages: 393-399

    • NAID

      10018256506

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 環境医学領域におけるプロテオミクスの導入.2006

    • Author(s)
      日吉 峰麗
    • Journal Title

      日本衛生学雑誌 61

      Pages: 393-399

    • NAID

      10018256506

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Human T-cell lymphotropic virus type-1 infection and risk of cancer : 15.4 year longitudinal study among atomic bomb survivors in Nagasaki,Japan.2006

    • Author(s)
      Arisawa K, et al.
    • Journal Title

      Cancer Science 97(6)

      Pages: 935-939

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A lack of significant association between the electropherotype or G-serotype of the infecting strain and disease severity of rotvirus gastroenteritis.2006

    • Author(s)
      Nakagomi, O, et al.
    • Journal Title

      Archives of Virology

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A high incidence of intussusception in Japan as studied in a sentinel hospital over a 25-year period(1978-2002).2006

    • Author(s)
      Nakagomi, T, et al.
    • Journal Title

      Epidemiology and Infection 134(1)

      Pages: 57-61

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth of head circumference in autistic infants during the first year of life.

    • Author(s)
      Fukumoto A, et. al.
    • Journal Title

      Journal of Autism and Developmental Disorders (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating profiles of osteoprotegerin and soluble receptor activator of nuclear factor κB ligand in postmenopausal women.

    • Author(s)
      Uemura H, et. al.
    • Journal Title

      Journal of Endocrinological Investigation (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cadmium-induced renal dysfunction and mortality in two cohorts : disappearance of the association in a generation born later.

    • Author(s)
      Arisawa K, et al.
    • Journal Title

      Toxicology Letters (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 日本の一般環境におけるダイオキシン曝露と高血圧、高脂血症、甲状腺疾患、アレルギー性鼻炎との有病状況との関係の検討.2008

    • Author(s)
      上村 浩一, 他.
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] カドミウム曝露群における血液中白血球での遺伝子発現の変動とその影響について.2008

    • Author(s)
      嵩下 賢, 他.
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Associations of environmental exposure to dioxins with hypertension, hyperlipidemia, thyroid disease and allergic coryza among general inhabitants in Japan2008

    • Author(s)
      Uemura, H
    • Organizer
      The 78th Annual Meeting of the Japanese Society for Hygiene
    • Place of Presentation
      Kumamoto
    • Year and Date
      2008-03-31
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Alteration of gene expression and health effects of environmental cadmium exposure2008

    • Author(s)
      Dakeshita, S
    • Organizer
      The 78th Annual Meeting of the Japanese Society for Hygiene
    • Place of Presentation
      Kumamoto
    • Year and Date
      2008-03-31
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 日本の一般環境におけるダイオキシン曝露と高血圧、高脂血症、甲状腺疾患、アレルギー性鼻炎との有病状況との関係の検討2008

    • Author(s)
      上村 浩一, 他
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] カドミウム曝露群における血液中白血球での遺伝子発現の変動とその影響について2008

    • Author(s)
      嵩下 賢, 他
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2008-03-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] Associations of cadmium-induced low molecular weight proteinuria with cancer mortality and cancer incidence rate2008

    • Author(s)
      Arisawa, K
    • Organizer
      The 77th Annual Meeting of the Japanese Society for Hygiene
    • Place of Presentation
      Osaka
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Body burden of dioxins in generalinhabitants in Japan-An investigation of blood levels of dioxins2008

    • Author(s)
      Uemura, H
    • Organizer
      The 77th Annual Meeting of the Japanese Society for Hygiene
    • Place of Presentation
      Osaka
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Proteomic analysis of liver proteins in CCl_4-induced liver injury in rats2008

    • Author(s)
      Hiyoshi, M
    • Organizer
      The 77th Annual Meeting of the Japanese Society for Hygiene
    • Place of Presentation
      Osaka
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dietary intake of dioxins among Japanese population estimated by duplicate portion analysis:low proportion of adults whose long-term intake exceeded the tolerable daily intake2007

    • Author(s)
      Arisawa K, et. al.
    • Organizer
      DIOXIN 2007 International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Associations of low levels exposure to dioxins with prevalent diabetes in Japanese general population2007

    • Author(s)
      Uemura H, et. al.
    • Organizer
      DIOXIN 2007 International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The survey on the accumulation of dioxins in humans-dioxin concentration of general environmental inhabitants in Japan and intake survey through diet2007

    • Author(s)
      Hasegawa M, et. al.
    • Organizer
      DIOXIN 2007 International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dietary intake of dioxins among Japanese population estimated by duplicate portion analysis : low proportion of adults whose long-term intake exceeded the tolerable daily intake2007

    • Author(s)
      Arisawa, K
    • Organizer
      Dioxin 2007 International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Associations of low levels exposure to dioxins with prevalent diabetes in Japanese general population2007

    • Author(s)
      Uemura, H
    • Organizer
      Dioxin 2007 International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The survey on the accumulation of dioxins in humans dioxin concentration of general environmental inhabitants in Japan and intake survey through diet2007

    • Author(s)
      Hasegawa, M
    • Organizer
      Dioxin 2007 International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dietary intake of dioxins among Japanese population estimated by duplicate portion analysis: low proportion of adults whose long-term intakeexceeded the tolerable daily intake.2007

    • Author(s)
      Arisawa K, et. al.
    • Organizer
      Dioxin 2007International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Associations of low levels exposure to dioxins with prevalent diabetes in Japanese general population.2007

    • Author(s)
      Uemura H, et. al.
    • Organizer
      DIOXIN 2007 International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] The survey on the accumulation of dioxins in humans-dioxin concentration of general environmental inhabitants in Japan and intake survey through diet.2007

    • Author(s)
      Hasegawa M, et. al.
    • Organizer
      DIOXIN 2007 International Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] カドミウムによる低分子量蛋白尿とがん死亡率およびがん罹患率.2007

    • Author(s)
      有澤 孝吉, 他.
    • Organizer
      第77回日本衛生学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 日本の一般環境におけるダイオキシン類の人体への蓄積状況〜血液中のダイオキシン類濃度の検討〜.2007

    • Author(s)
      上村 浩一, 他.
    • Organizer
      第77回日本衛生学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 四塩化炭素曝露により誘導した肝傷害モデルラットにおける肝臓内タンパク質変動解析.2007

    • Author(s)
      日吉 峰麗, 他.
    • Organizer
      第77回日本衛生学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationships between circulating osteoprotegerin and the risk factors of vascular disorders in postmenopausal women2007

    • Author(s)
      Uemura, H
    • Organizer
      The 3rd Scientific Meeting of the Asian Pacific Menopause Federation (APMF)
    • Place of Presentation
      Taipei
    • Year and Date
      2007-03-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 遺伝 別冊 食の安全科学 192006

    • Author(s)
      有澤 孝吉
    • Total Pages
      6
    • Publisher
      ダイオキシンの健康リスクと食の安全.
    • Related Report
      2006 Annual Research Report
  • [Book] 国際感染症と公衆衛生感染の疫学.

    • Author(s)
      有澤 孝吉.
    • Publisher
      医科細菌学改訂第4版、南江堂(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 医科細菌学改訂第4版、南江堂

    • Author(s)
      有沢 孝吉
    • Publisher
      国際感染症と公衆衛生感染の疫学
    • Related Report
      2007 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.hosp.med.tokushima-u.ac.jp/university/servlet/index?level=4&reference=0/10001/3/30003/20007

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.hosp.med.tokushima-u.ac.jp/university/servlet/index?level=4&reference=0/10001/3/30003/20007

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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