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Approach to find the susceptible genes for multiple sclerosis

Research Project

Project/Area Number 18590922
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionHokkaido University

Principal Investigator

KIKUCHI Seiji  Hokkaido University, Grad. School of Med., Lecture (10271660)

Co-Investigator(Kenkyū-buntansha) INOKO Hidetoshi  TokaiUniv, Grad. School of Med., Professor (10101932)
YABE Ichiro  Hokkaido University, Grad. School of Med., Associate Prof. (60372273)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsmultiple sclerosis / genes / susceptible genes
Research Abstract

We studied the association between DRB1^*1501, DPB1^*0501, or DPB1^*0301 and Japanese patients in the groups of optic-spinal form multiple sclerosis (OSMS) or multiple sclerosis except for OSMS (MS). As a result, the frequencies of DPB1^*0501 is much higher in OSMS than those in controls. All OSMS were negative for DPB1^*0301 while 19% of the MS were positive for the allele. In DPB1^*0301-negatives, the frequencies of DPB1^*0501 in OSMS and MS were similar, but both were higher than in the controls. We reviewed some disorders of the idiopathic inflammatory demyelinating disorders spectrum, and our recent findings on the fulminant nature of each attack and the expansion of each lesion, which we called attack-related severity in Japanese MS. From our findings and the literature, attack-related severity appears to be a third important factor, in addition to lesion distribution and clinical course. Introduction of the third axis produces a three-dimensional space for a better understanding of the heterogeneous characteristics of 'MS' syndrome, and can advance treatment strategies for these disorders. It is also suggested that a group with longitudinally extensive spinal cord lesion (LESL) may be associated with genes of CTLA-4 and HLA-DP. Furthermore, we got the results that the MS group without oligoclonal band is associated with HLA-DRB1^*0405, not HLA-DRB1^*1501.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (14 results)

All 2008 2007 2006

All Journal Article (14 results) (of which Peer Reviewed: 7 results)

  • [Journal Article] Therapeutic potential of vitamin D for multiple sclerosis2008

    • Author(s)
      Niino M
    • Journal Title

      Current medicinal chemistry 15

      Pages: 499-505

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of vitamin D for multiple sclerosis.2008

    • Author(s)
      Niino M
    • Journal Title

      Current medicinal chemistry 15

      Pages: 499-505

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Therapeutic potential ofvitamin D for multiple sclerosis.2008

    • Author(s)
      Niino M
    • Journal Title

      Current medicinal chemistry 15

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A three-dimensional approach for understanding the spectrum of idiopathic inflammatory demyelinating disorders: Importance of the "attack-related severity axis".2007

    • Author(s)
      Fukazawa T
    • Journal Title

      Multiple Sclerosis 13

      Pages: 199-207

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications.2007

    • Author(s)
      Niino M
    • Journal Title

      Expert review of neurotherapeutics 7

      Pages: 1175-1188

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Recent advanced in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications.2007

    • Author(s)
      Niino M
    • Journal Title

      Expert review of neurotherapeutics 7

      Pages: 1175-1188

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recent advances in genetic analysis of multiple sclerosis: genetic associatins and theraeudc implications.2007

    • Author(s)
      Niino M
    • Journal Title

      Expert review of neurotherapeutics 7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A three-dimensional approach for understanding the spectrum of idiopathic inflammatory demyelinating disorders : Importance of the "attack-related severity axis".2007

    • Author(s)
      Fukazawa T
    • Journal Title

      Multiple Sclerosis (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] HLA-DPB1^*0501 is not uniquely associated with opticospinal multiple sclerosis in Japanese patients. Important roleof DPB1^*0301.2006

    • Author(s)
      Fukazawa T
    • Journal Title

      Multiple Sclerosis 12

      Pages: 19-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] APOE epsilon variation in multiple sclerosis and disease severity some answers.2006

    • Author(s)
      Burwick R M
    • Journal Title

      Neurology 66

      Pages: 1373-1383

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] HLA-DPB1^*0501 is not uniquely associated with opticospinal multiple sclerosis in Japanese patients. Important role of DPB1^*0301.2006

    • Author(s)
      Fukazawa T
    • Journal Title

      Multiple Sclerosis 12

      Pages: 19-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] APOE epsilon variation in multiple sclerosis and disease severity: some answers.2006

    • Author(s)
      Burwick R M
    • Journal Title

      Neurology 66

      Pages: 1373-1383

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] HLA-DPB1 0501 is not uniquely associated with opticospinal multiple sclerosis in Japanese patients. Important role of DPB1 0301.2006

    • Author(s)
      Fukazawa T
    • Journal Title

      Multiple Sclerosis 12

      Pages: 19-23

    • Related Report
      2006 Annual Research Report
  • [Journal Article] APOE epsilon variation in multiple sclerosis and disease severity : some answers.2006

    • Author(s)
      Burwick R M
    • Journal Title

      Neurology 66

      Pages: 1378-1383

    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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