| Project/Area Number |
18590922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KIKUCHI Seiji Hokkaido University, Grad. School of Med., Lecture (10271660)
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| Co-Investigator(Kenkyū-buntansha) |
INOKO Hidetoshi TokaiUniv, Grad. School of Med., Professor (10101932)
YABE Ichiro Hokkaido University, Grad. School of Med., Associate Prof. (60372273)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | multiple sclerosis / genes / susceptible genes |
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| Research Abstract |
We studied the association between DRB1^*1501, DPB1^*0501, or DPB1^*0301 and Japanese patients in the groups of optic-spinal form multiple sclerosis (OSMS) or multiple sclerosis except for OSMS (MS). As a result, the frequencies of DPB1^*0501 is much higher in OSMS than those in controls. All OSMS were negative for DPB1^*0301 while 19% of the MS were positive for the allele. In DPB1^*0301-negatives, the frequencies of DPB1^*0501 in OSMS and MS were similar, but both were higher than in the controls. We reviewed some disorders of the idiopathic inflammatory demyelinating disorders spectrum, and our recent findings on the fulminant nature of each attack and the expansion of each lesion, which we called attack-related severity in Japanese MS. From our findings and the literature, attack-related severity appears to be a third important factor, in addition to lesion distribution and clinical course. Introduction of the third axis produces a three-dimensional space for a better understanding of the heterogeneous characteristics of 'MS' syndrome, and can advance treatment strategies for these disorders. It is also suggested that a group with longitudinally extensive spinal cord lesion (LESL) may be associated with genes of CTLA-4 and HLA-DP. Furthermore, we got the results that the MS group without oligoclonal band is associated with HLA-DRB1^*0405, not HLA-DRB1^*1501.
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