Neck cooling against epileptic discharges-study in rat model
| Project/Area Number |
18590947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIGETO Hiroshi Kyushu University, Neurological Institute, Department of Neurophysiology, Lecturer (50335965)
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| Co-Investigator(Kenkyū-buntansha) |
TANIWAKI Takayuki Kurume University, 医学部, Professor (80284496)
KIKUCHI Hitoshi Kyushu University Hospital, 大学病院, Lecturer (60322765)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥2,780,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Epilepsy / Cooling / Neck cooling / Animal model / Electrical stimulation / Direct current stimulation / 脳冷却 / キンドリング |
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| Research Abstract |
Objective : Instead of excision of the focus of intractable epilepsy, we test the efficacy of neck cooling in rat animal model.
Methods : (1) Use a thermoelectric Peltier chip, measure the temperature change of the device. (2) After 15 minutes contact of circulating frozen ethylene glycol direct to rat's neck, measure the deep brain temperature (6 rats). (3) Compare the threshold of afterdischarges (ADs) between cooling and non-cooling neck groups (7 rats). (4) As a substitution of cooling methods, direct current stimulation (DC, 2mA 3s) was supplied to the wide flat electrodes (5mm X 5mm) directly on the left hippocampal cortex. ADs threshold induced at left hippocampal were compared (10 trials).
Results : (1) Cooling Peltier chip could not induce overall cooling because of heat radiation side. (2) Cooling was not statistically significant using circulating frozen ethylene glycol (Cooled 29.0±0.7℃, Non-cooled 30.3±0.7℃). (3) Threshold and duration of ADs were not different (Threshold ; Cooled 2.0±0.7mA, Non-cooled 1.9±0.4mA). (4) DC provided raise of ADs threshold (With DC 3.7±2.7mA, without DC 2.3±1.2mA, p= 0.0149).
Conclusion : We could not obtain satisfactory result using neck cooling. As a substitution of cooling method, DC directly on cortex provides reduction of epileptic activity.
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Report
(3 results)
Research Products
(86 results)
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[Journal Article] てんかんの分類2008
Author(s)
重藤寛史, 飛松省三
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Journal Title
Clinical neuroscience 24
Pages: 29-32
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] Age-related alterations of the functional interactions within the basal ganglia and cerebellar motor loops in vivo.2007
Author(s)
Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J, Tobimatsu S.
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Journal Title
Neuroimage 36
Pages: 1263-1276
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Age-related alterations of the functional interactions within the basal ganglia and cerebellar motor loops in vivo2007
Author(s)
Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J, Tobimatsu S
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Journal Title
Neuroimage 36
Pages: 1263-1276
Related Report
Peer Reviewed
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[Journal Article] Functional network of the basal ganglia and cerebellar motor loops in vivo : different activation patterns between self-initiated and externally triggered movements.2006
Author(s)
Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J, Tobimatsu S.
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Journal Title
Neuroimage 31
Pages: 745-753
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Presentation] 九州大学病院におけるてんかんモニタリングデータの一元管理.2007
Author(s)
酒田あゆみ, 森岡隆人, 橋口公章, 吉田史章, 重藤寛史, 吉良龍太郎, 大塩麻夕, 藤本明子, 栢森裕三, 佐々木富男, 康東天
Organizer
日本てんかん外科学会
Place of Presentation
福岡
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] てんかんモニタリングシステムの構築と今後の展望.2006
Author(s)
酒田あゆみ, 大塩麻夕, 泉裕美, 前田トモ子, 小柳さく代, 森岡隆人, 重藤寛史, 吉良龍太郎, 橋口公章, 吉田史章, 高瀬敬一郎, 鳥巣浩幸, 実藤雅文.
Organizer
九州てんかん研究会
Place of Presentation
福岡
Year and Date
2006-07-01
Description
「研究成果報告書概要(和文)」より
Related Report
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