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Identification of glucocorticoid target genes involved in visceral obesity

Research Project

Project/Area Number 18590997
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionUniversity of Hyogo

Principal Investigator

KAJI Hidesuke  University of Hyogo, College of Nursing Art & Science, Professor (90224401)

Co-Investigator(Kenkyū-buntansha) FUKANO Chika  University of Hyogo, College of Nursing Art & Science, Assistant Professor (00405367)
TANIDA Keiko  University of Hyogo, College of Nursing Art & Science, Senior Assistant Professor (60405371)
KIMURA Yukari  University of Hyogo, College of Nursing Art & Science, Associate (80438259)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,850,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsadipocyte / glucocorticoid / RNA interference (RNAi) / metabolic syndrome (MetS) / single nuculeotide polymorphism (SNP) / CCAAT / enhancer binding protein 8 (C / EBPδ) / neuropeptide Y (NPY) / NPY type 2 receptor (NPY2R) / ニューロペプチドY2受容体 / メタボリックシンドローム / 内臓肥満 / 1塩基多型 / 遺伝子転写調節 / 脂肪細胞分化 / RNA干渉 / C / EBPδ / SNP / 血圧高値 / 脂質代謝異常 / 空腹時高血糖
Research Abstract

We investigated to clarify whether connective tissue growth factor, emerin, and calpain 1 are essential for the initial step of adipocyte differentiation, since glucocorticoid is very important for adipocyte differentiation, and mRNA expressions of these 3 molecules are induced by cocktail with dexamethasone during the initial adipocyte differentiation from 3T3-L1 cells, and they have their human ortholog as well as glucocorticoid responsive element on their 5'-flanking region of the gene. The RNA interference in each mRNA expression failed to change the adipocyte differentiation, suggesting that these molecules, at least by each single molecule, are not essential for the initial step of the adipocyte differentiation.
Next, the association between metabolic syndrome (MetS) and CCAAT/enhancer binding protein δ (C/EBPδ) was investigated after informed consent in 172 persons for health checkup. It has been reported in the study using C/EBPδ knockout mouse that C/EBPδ mRNA induction by gluc … More ocorticoid during the initial adipocyte differentiation from 3T3-L1 cells is essential for visceral obesity. Our result indicated for the first time that genotype C/T in SNP rs15955 was more prevalent in dyslipidemia as well as impaired glucose tolerance (IGT) among phenotypes of MetS.
Furthermore, neuropeptide Y (NPY)/NPY type 2 receptor (NPY2R) pathway is recently reported to be involved in high fat and sucrose diet-induced visceral obesity under certain stresses with stimulated glucocorticoid secretion. Therefore, we tested the association between MetS (IDF Asia criteria) and the 5'-flanking region of NPY2R gene SNPs with high minor allele frequency in Asian population. In 317 persons for health checkup participated in this study after informed consent, genotype '17 in SNP rs6857715 was more prevalent in MetS and IGT. Genotype AA in SNP rs6857530 was more prevalent in IGT. Further functional studies of the transcriptional control of these SNP regions will be required for the development of prevention strategy and drug discovery for MetS. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (68 results)

All 2008 2007 2006

All Journal Article (40 results) (of which Peer Reviewed: 22 results) Presentation (19 results) Book (9 results)

  • [Journal Article] Genetic variations at the CCAAT/Enhancer-binding protein δ are associated with metabolic phenotypes in the Japanese population2008

    • Author(s)
      Kaji H, Fukano C, imura Y Takiguchi E, anida K
    • Journal Title

      Metabolic Syndrome and Related Disorders 6

      Pages: 24-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes2008

    • Author(s)
      Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, IidaK Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K.
    • Journal Title

      FEBS Lett 582(5)

      Pages: 573-578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Low serum IGF-I/GH ratio is associated with abnormal glucose tolerance in acromegaly2008

    • Author(s)
      Fukuoka H, Takahashi Y, Iida K, Kaji H(8/9), et. al.
    • Journal Title

      Hormone Research 69

      Pages: 165-171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexsamethasone-induced expressions of muscle-snecific ubiauitin lieases. Atrogin-1 and MuRF12008

    • Author(s)
      Yamamoto D, Ikeshita N, Matsubara T, Tasaki H, Kaji H(9/11), et. al.
    • Journal Title

      Life Sciences 82

      Pages: 460-466

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of mPOU(Brn-5),a class VI POU protein,in the gene expression of Pit-1 as well as PRL2008

    • Author(s)
      Toda K, Yamamoto D, Fumoto M, Ikeshita N, Kali H(9/11), et. al.
    • Journal Title

      Molecular and Cellular Endocrinology 280

      Pages: 20-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic variations at the CCAAT/Enhancer-binding protein 6 areassociated with metabolic phenotypes in the Japanese population2008

    • Author(s)
      Kaji H, Fukano C, Kimura Y, Takiguchi E, Tanida, K
    • Journal Title

      Metabolic Syndrome and Related Disorders 6

      Pages: 24-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes2008

    • Author(s)
      Takahashi M, Takahashi Y, Takahashi K, Zolotaryov, FN, Hong, KS, Kitazawa R, IidaK, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara, K
    • Journal Title

      FEBS Lett 582(5)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Low serum IGF-I/GH ratio is associated with abnormal glucose tolerance in acromegaly2008

    • Author(s)
      Fukuoka H, Takahashi Y, Iida K, Kaji, H(8/9), et. al.
    • Journal Title

      Hormone Research 69

      Pages: 165-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexsamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF12008

    • Author(s)
      Yamamoto D, Ikeshita N, Matsubara T, Tasaki H, Kaji, H(9/11), et. al.
    • Journal Title

      Life Sciences 82

      Pages: 460-466

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of mPOU(Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL2008

    • Author(s)
      Toda K, Yamamoto D, Fumoto M, Ikeshita N, Kaji, H(9/11), Okimura Y, et. al.
    • Journal Title

      Molecular and Cellular Endocri nology 280

      Pages: 20-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of mPOU(Brn-5),a class VI POU protein,in the gene expression of Pit-1 as well as PRL2008

    • Author(s)
      Toda K, Yamamoto D, Fumoto M, Ikeshita N, Kaji H(9/11), et. al.
    • Journal Title

      Molecular and Cellular Endocrinology 280

      Pages: 20-29

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GHRP-2,a GHS-R agonist,directly acts on myocytes to attenuate the dexsamethasone-induced expressions of muscle-specific ubiquitin ligases,Atrogin-1 and MuRF12008

    • Author(s)
      Yamamoto D, Ikeshita N, Matsubara T, Tasaki H, Kaji H(9/11), et. al.
    • Journal Title

      Life Sciences 82

      Pages: 460-466

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variations at the CCAAT/Enhancer-binding protein δ are associated with metabolic phenotypes in the Japanese population2008

    • Author(s)
      Kaji H, Fukano C, Kimura Y, Takiguchi E, Tanida K
    • Journal Title

      Metabolic Syndrome and Related Disorders 6

      Pages: 24-31

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity2007

    • Author(s)
      Takahashi M, Takahashi Y, Takahashi K, Kaji H(8/9), et. al.
    • Journal Title

      Biochem Biophys ResCommun 364

      Pages: 1037-1042

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamnine. method2007

    • Author(s)
      Imanaka M, Iida K, Nishizawa H, Fukuoka H, Takeno R, Kaii H(10/11), et. al.
    • Journal Title

      Internal Medicine 46

      Pages: 1577-1583

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hormone replacement therapy and vascular risk disorders in adult hypopituitarism2007

    • Author(s)
      Kaji H, Iida K, Takahashi Okimura Y, Chihara K
    • Journal Title

      Endocrine Journal 54

      Pages: 239-245

    • NAID

      10019478618

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] プレクリニカルクッシング症候群を伴った副腎皮質癌の1例2007

    • Author(s)
      竹野 亮子、飯田 啓二、井上 喜文, 加治 秀介(10/12)千原 和夫, 他
    • Journal Title

      日本内分泌学会雑誌 83

      Pages: 158-160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 2A型VHL病の1家系におけるVHL遺伝子解析2007

    • Author(s)
      今中 真理、飯田 啓二、高橋 健太郎、置村 康彦、加治 秀介(11/12), 他
    • Journal Title

      日本内分泌学会雑誌 83

      Pages: 174-177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Health needs of patients with chronic diseases who lived through the Great Hanshin Earthquake2007

    • Author(s)
      Mori K, Ugai K, Nonami Y, Kirimura T, Kondo C, Nakamura T, Motoki E, Kaii H
    • Journal Title

      Disaster Management & Response 5・1

      Pages: 8-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats2007

    • Author(s)
      Yamamoto D, Ikehashi N, Daito R, Herningtyas EH, Toda K, Kaji H(9/11), Okimura Y, et. al.
    • Journal Title

      Regulatory Peptides 138

      Pages: 141-144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency2007

    • Author(s)
      Takahashi Y, Iida K, Takahashi K, Yoshioka S, Kaji H(14/16), et. al.
    • Journal Title

      Gastroenterology 132-3

      Pages: 938-943

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity2007

    • Author(s)
      Takahashi M, Takahashi Y, Takahashi K, Kaji, H(8/9), et. al.
    • Journal Title

      Biochem Biophys Res Commun 364

      Pages: 1037-1042

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method2007

    • Author(s)
      Imanaka M, Iida K, Nishizawa H, Fukuoka H, Takeno R, Kaji, H(10/11), et. al.
    • Journal Title

      Internal Medicine 46

      Pages: 1577-1583

    • NAID

      130000076004

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hormone replacement therapy and vascular risk disorders in adult hypopituitarism2007

    • Author(s)
      Kaji H, Iida K, Takahashi Y, Okimura Y, Chihara, K
    • Journal Title

      Endocrine Journal 54

      Pages: 239-245

    • NAID

      10019478618

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Health needs of patients with chronic diseases who lived through the Great Hanshin Earthquake2007

    • Author(s)
      Mori K, Ugai K, Nonami Y, Kirimura T, Kondo C, Nakamura T, Motoki E, Kaji, H
    • Journal Title

      Disaster Management & Response 5(1)

      Pages: 8-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neither intravenous nor intracerebroventricular Administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats2007

    • Author(s)
      Yamamoto D, Ikehashi N, Daito R, Herningtyas, EH, Toda K, Kaji, H(9/11), Okimura Y, et. al.
    • Journal Title

      Regulatory Peptides 138

      Pages: 141-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency2007

    • Author(s)
      Takahashi Y, Iida K, Takahashi K, Yoshioka S, Kaji, H(14/16), et. al.
    • Journal Title

      Gastroenterology 132-3

      Pages: 938-943

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hormone replacement therapy and vascular risk disorders in adult hypopituitarism.2007

    • Author(s)
      Kaji H, Iida K, Takahashi Y, Okimura Y, Chihara K
    • Journal Title

      Endocrine Journal 54

      Pages: 239-245

    • NAID

      10019478618

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method2007

    • Author(s)
      Imanaka M, Iida K, Nishizawa H, Fukuoka, H, Takeno R, Kaji H(10/11), et. al.
    • Journal Title

      Internal Medicine 46

      Pages: 1577-1583

    • NAID

      130000076004

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity2007

    • Author(s)
      Takahashi M, Takahashi Y, Takahashi K, Kaji H(8/9), et. al.
    • Journal Title

      Biochemical and Biophysical Research Communications 364

      Pages: 1037-1042

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2A型VHL病の1家系におけるVHL遺伝子解析2007

    • Author(s)
      今中 真理、飯田 啓二、高橋 健太郎 置村 康彦、加治 秀介(11/12), 他
    • Journal Title

      日本内分泌学会雑誌 83

      Pages: 174-177

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency2007

    • Author(s)
      Takahashi Y, Iida K, Takahashi K, Yoshioka S, Fukuoka H, Takeno R, Imanaka M, Nishikawa H, Takahashi M, Seo Y, Hayashi Y, Kondo T, Okimura Y, Kaji H, Kitazawa R, Chihara K
    • Journal Title

      Gastroenterology 132・3

      Pages: 938-943

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH,PRL,TSH and ACTH in rats.2007

    • Author(s)
      Yamamoto D, Ikehashi N, Daito R, Herningtyas EH, Toda K, Takahashi K, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y
    • Journal Title

      Regulatory Peptides 138

      Pages: 141-144

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Health needs patients with chronic diseases who lived through the Great Hanshin Earthquake2007

    • Author(s)
      Mori K, Ugai K, Nonami Y, Kirimura T, Kondo C, Nakamura T, Motoki E, Kaji H
    • Journal Title

      Disaster Management & Response 5・1

      Pages: 8-13

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The N131S mutation in the von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas2006

    • Author(s)
      Imanaka M, Iida K, Takahashi K, Tsuji K, Nishizawa H., Fukaoka H, Takeno R, Takahashi Y, Okimura Y, Kaii H, Chihara K
    • Journal Title

      Endocrine Journal 53

      Pages: 819-827

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemaneioma2006

    • Author(s)
      Takahashi K, Iida K, Kaji H(9/10), Chihara K, et. al.
    • Journal Title

      Internal Medicine 45

      Pages: 265-269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The N131S mutation in the von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas2006

    • Author(s)
      Imanaka M, Iida K, Takahashi K, Tsuji K, Nishizawa, H., Fukaoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara, K
    • Journal Title

      Endocrine Journal 53

      Pages: 819-827

    • NAID

      10020612693

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma2006

    • Author(s)
      Takahashi K, Iida K, Kaji, H(9/10), Chihara K, et. al.
    • Journal Title

      Internal Medicine 45

      Pages: 265-269

    • NAID

      130000076543

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma2006

    • Author(s)
      Takahashi K, Iida K, Okimura Y, Takahashi Y, Naito J, Nishikawa S, Kadowaki S, Iguchi G, Kaji H, Chihara K
    • Journal Title

      Internal Medicine 45

      Pages: 265-269

    • NAID

      130000076543

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The N131S mutation in von Hippel-Lindau gene in a Japanese family with pheochromocytoma and hemangioblastomas.2006

    • Author(s)
      Imanaka M, Iida K, Takahashi K, Tsuji K, Nishikawa, Fukaoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara K
    • Journal Title

      Endocrine Journal 53

      Pages: 819-827

    • NAID

      10020612693

    • Related Report
      2006 Annual Research Report
  • [Presentation] スプライシング異常が確認できたGitelman症候群の1例2008

    • Author(s)
      飯田 啓二、野津 寛大、高橋 裕、加治 秀介(5/8)千原 和夫, 他
    • Organizer
      日本内分泌学会(第18回臨床内分泌代謝Update)
    • Place of Presentation
      高知
    • Year and Date
      2008-03-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 妊娠中毒症、糖尿病を契機に診断されたクッシング症候群の1例2008

    • Author(s)
      今中 真理、飯田 啓二、内藤 純子、加治 秀介(10/12)千原 和夫, 他
    • Organizer
      日本内分泌学会(第18回臨床内分泌代謝Update)
    • Place of Presentation
      高知
    • Year and Date
      2008-03-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 成長ホルモン受容体拮抗剤により著明に耐糖能が改善した先端巨大症の1例2007

    • Author(s)
      高橋 裕、飯田 啓二、福岡 秀規、加治 秀介(8/10)春日 雅人, 他
    • Organizer
      第44回日本糖尿病学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 変異Propl S156insTはDNA結合性を保持するが、転写活性を欠く2007

    • Author(s)
      池下 伸子、川岸 万佑子、芝原 優美, 加治 秀介(9/11)置村 康彦, 他
    • Organizer
      第34回日本神経内分泌学会
    • Place of Presentation
      前橋
    • Year and Date
      2007-08-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 変異Prop1 S156insTはDNA結合性を保持するが、転写活性を欠く2007

    • Author(s)
      池下 伸子、川岸 万佑子、芝原 優美 加治 秀介(9/11)置村 康彦, 他
    • Organizer
      第34回日本神経内分泌学会
    • Place of Presentation
      前橋
    • Year and Date
      2007-08-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 日本人下垂体機能低下症患者のQOL評価質問紙(JAHQ)の完成と臨床知見2007

    • Author(s)
      石井 均、山城 小百合、島津 章、加治 秀介(7/9)沖 隆, 他
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 新規ケモカイン、メタボカイン1はインスリン感受性と脂質代謝を改善する2007

    • Author(s)
      高橋 路子、高橋 裕、高橋 健一、加治 秀介(12/19)、千原 和夫, 他
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Graves病寛快に伴い糖尿病の著明な改善がみられた1例2007

    • Author(s)
      今中 真理、高橋 健太郎、飯田 啓二、加治 秀介(10/12)千原 和夫, 他
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 低身長児で報告された変異Prop1 S156insTの機能解析2007

    • Author(s)
      池下 伸子、川岸 万佑子、芝原 優美、加治 秀介(10/12)置村 康彦, 他
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] IGF-I stimulates reactive oxygen species (ROS) production,thereby affecting insulin sensitivity in adipocytes2007

    • Author(s)
      Fukuoka H, TakahashiY, Iida K, Kaji H(11/12), et. al.
    • Organizer
      The Endocrine Society's 89th Annual Meeting
    • Place of Presentation
      Toronto,Canada
    • Year and Date
      2007-06-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IGF-I stimulates reactive oxygen species(ROS) production, thereby affecting insulin sensitivity in adipocytes2007

    • Author(s)
      Fukuoka, H., Takahashi, Y., Iida, K., Kaji, H.(11/12), et. al.
    • Organizer
      The Endocrine Society's 89th Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2007-06-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IGF-I stimulates reactive oxyen species (ROS)production, thereby affecting insulin sensitivity in adipocytes2007

    • Author(s)
      Fukuoka H, Takahashi Y, Iida K, Kaji H(11/12), et. al.
    • Organizer
      The Endocrine Society's 89^<th> Annual Meeting,
    • Place of Presentation
      Toronto,Canada
    • Year and Date
      2007-06-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] A metabolic syndrome model for adult growth hormone deficiency in GH-deficient spontaneous dwarf rat2006

    • Author(s)
      Takahashi, Y., Yoshioka, S., Kaji, H(17/18), Chihara, K., et. al.
    • Organizer
      The Third International Congress of GRS and IGF Society
    • Place of Presentation
      Kobe
    • Year and Date
      2006-11-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Growth hormone increase FoxOl protein levels and the expression of its target genes in adipose tissue2006

    • Author(s)
      Fukuoka, H., Takahashi, Y., Okimura, Y., Kaji, H(10/11)., Chihara, K., et. al.
    • Organizer
      The Third International Congress of GRS and IGF Society
    • Place of Presentation
      Kobe
    • Year and Date
      2006-11-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Growth hormone increase FoxO1 protein levels and the expression of its target genes in adipose tissue2006

    • Author(s)
      Fukuoka, H., Takahashi, Y., Okimura, Y., Kaji, H.(10/11), Chihara, K., et. al.
    • Organizer
      The Third International Congress of GRS and IGF Society
    • Place of Presentation
      Kobe
    • Year and Date
      2006-11-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Difference in the frequency of polymorphism in the growth hormone receptor gene between Japanese and Caucasian populations2006

    • Author(s)
      Iida, K., Takahashi, Y., Kaji, H., Okimura, Y., Nose, O., Chihara, K.
    • Organizer
      The Endocrine Society's88th Annual Meeting
    • Place of Presentation
      Boston,USA
    • Year and Date
      2006-06-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Difference in the frequency of polymorphism in the growth hormone receptor gene between Japanese and Caucasian populations2006

    • Author(s)
      Iida, K., Takahashi, Y., Kaji, H., Okimura, Y., Nose, O., Chihara, K
    • Organizer
      The Endocrine Society's88th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2006-06-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] cDNAマイクロアレイを用いた骨格筋、骨における成長ホルモン標的遺伝子の解析2006

    • Author(s)
      吉岡 嗣朗、高橋 裕、福岡 秀規、工藤 工、高橋 健太郎、飯田 啓二、加治 秀介、置村 康彦、千原 和夫
    • Organizer
      第79回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2006-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] GH,PRL.TSH欠乏を特徴とする後天性複合下垂体機能低下症PIT1自己抗体の検出2006

    • Author(s)
      竹野 亮子、高橋 裕、加治 秀介(11/12)、千原 和夫, 他
    • Organizer
      第79回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 臨床検査データブックコンパクト版第4版2007

    • Author(s)
      加治 秀介
    • Total Pages
      16
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] 臨床検査データブック2007-20082007

    • Author(s)
      加治 秀介
    • Total Pages
      29
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] 成人生長ホルモン分泌不全症の臨床Chapter3-C, 5-B-3)2006

    • Author(s)
      加治 秀介
    • Total Pages
      13
    • Publisher
      メディカルビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] インフォームドコンセントのための図説シリーズ先端巨大症5.治療 (3)薬物療法2006

    • Author(s)
      加治 秀介
    • Total Pages
      6
    • Publisher
      医薬ジャーナル社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 臨床病態学2 2下垂体の異常 1下垂体腫瘍2006

    • Author(s)
      加治 秀介
    • Total Pages
      5
    • Publisher
      NOUVELL HIROKAWA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Book] 災害看護学習テキスト慢性疾患患者2006

    • Author(s)
      森 菊子、鵜飼 和浩、加治 秀介、野並 葉子
    • Total Pages
      8
    • Publisher
      日本看護協会出版社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 成人成長ホルモン分泌不全症の臨床(Chapter 3-C,5-B-3)2006

    • Author(s)
      加治 秀介
    • Total Pages
      13
    • Publisher
      メディカルビュー社
    • Related Report
      2006 Annual Research Report
  • [Book] インフォームドコンセントのための図説シリーズ 先端巨大症 5.治療 (3)薬物療法2006

    • Author(s)
      加治 秀介
    • Total Pages
      6
    • Publisher
      医薬ジャーナル社
    • Related Report
      2006 Annual Research Report
  • [Book] 災害看護 学習テキスト 慢性疾患患者2006

    • Author(s)
      森菊子, 鵜飼和浩, 加治 秀介, 野並葉子
    • Total Pages
      8
    • Publisher
      日本看護協会出版
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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