GENETICAND BIOCHEMICAL BIOMARICERSFOR DIAGNOSIS FORAUTISM
| Project/Area Number |
18591142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
NARITA Masaaki Mie University, GRADUATE SCHOOL OF MEDICINE, PROFESSOR (80302404)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Shinya UNIVERSITY OF TSUKUBA, GRADUATE SCHOOL OF COMPREHENSIVE HUMAN SCIENCES, 教授 (60251005)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | autism / model animal / バイオマーカー / BDNF / セロトニン |
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| Research Abstract |
Autism is thought to occur from early embryonic stage. Biomarkers for diagnosis of autism is necessary. In the field of autism basic research, chemicals including thalidomide(THAL) and valproic acid(VPA) are known to induce autism when taken at early gestational stage in human. We have previously established autism model rats by exposing THAL or VPA to embryonic(E) day 9 rats(Pediatr Res, 52 ; 576 : 2002, Int J Dev Neurosci, 23 ; 287 : 2005). Migration disorder of serotonergic(5-HT) neurons was observed in the adult.
Previously, we have found that brain-derived neurotrophic factor(BDNF) and neurotrophins-4(NT-4) are useful for the diagnostic biomarkers for autism. In this research, we found that BDNF and NT-4 are also useful for the subtype classification of autism in clinics. Also, dramatic delay of serotonergic development was observed in the embryos of autism model rats. Expression of sonic hedgehog(shh) were perturbed in the embryos of autism rats using whole mount in situ hybridization and real time PCR technique.
These results indicate that two potential autism-inducing teratogens, THAL and VPA, may disrupt early 5-HT neuronal development in the embryos through the perturbation of shh signal pathway, and thus may cause irreversible changes observed in the adult.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein2006
Author(s)
LaDu, Mary Jo, Stine, W Blaine, Jr, Narita, Masaaki, Getz, Godfrey S, Reardon, Catherine A, Bu, Guojun
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Journal Title
Biochemistry 45(2)
Pages: 381-390
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[Journal Article] Neuropathological alternation of aquaporin 1 immunoreactive enteric neurons in the streptozotocin-induced diabetic rats
Author(s)
Eriko, Ishihara, Masato, Nagahama, Naruse, Satoru, Reiji, Semba, Toshihiro, Miura, Masaru, Usami, Masaaki, Narita
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Journal Title
Autonomic Neuroscience ; Basic and Clinical (in press)
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 必ず支援に役立つ神経科学2007
Author(s)
成田正明、成田奈緒子
Organizer
日本発達障害学会第42回研究大会
Place of Presentation
山口
Year and Date
2007-08-05
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 小児疾患とセロトニン2007
Author(s)
成田正明
Organizer
第54回兵庫県神経疾患懇話会
Place of Presentation
神戸なりた
Year and Date
2007-04-07
Description
「研究成果報告書概要(和文)」より
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