| Project/Area Number |
18591291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SUMITANI Satsuki The University of Tokushima, Medical and Dental Hospital, Lecturer (90346594)
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| Co-Investigator(Kenkyū-buntansha) |
HRADA Masafumi The University of Tokushima, Faculty of Meducune, Professer (20228654)
UENO Shu-ich The University of Tokushima, Faculty of Meducune, Professer (80232768)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | glutamate / GABA / MRS / mood disorder / anxiety disorder / OCD |
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| Research Abstract |
To investigate the abnormalities of neural function or metabolism in mental disorders, we measured the neurochemical changes in the anterior cingulate (ACC) and bilateral basal ganglia by using high magnetic field (3 Tesla) proton magnetic resonance spectroscopy (MRS) in the patients of mood disorders and anxiety disorders. Especially, we examined changes of the level of amino acid neurotransmitter such as glutamate and gamma amino butyric acid (GABA).
Obsessive-compulsive disorder (OCD) patients had significantly reduced levels of N-acetyl aspertate (NAA) and glutamate (Glu) in the ACC compared to matched controls. NAA levels in the right basal ganglia in OCD patients were higher than those in the left basal ganglia. No differences were found in levels of GABA between OCD patients and controls. Panic disorder patients had significantly higher levels of Glx (glutamate+glutamine) in the right basal ganglia compared to controls. Major depression patients had significantly reduced levels of Glu in the ACC compared to controls.
In the present study we found specific changes of amino acid neurotransmitters in each disorder, although these findings are preliminary that need further study with more samples.
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