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Study of new immunosuppressive strategy and kinetics for ABO incompatible transplantation

Research Project

Project/Area Number 18591401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

KAWAGISHI Naoki  Tohoku University, Tohoku University Hospital, Assistant Professor (00333807)

Co-Investigator(Kenkyū-buntansha) DOI Hideyuki  Tohoku University Hospital, 病院, Associate Professor (90188839)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,790,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsincompatible / liver transplantation / rejection / kidney transplantation / 腎臓移植
Research Abstract

In Japan, the shortage of grafts has encouraged us to perform living donor liver transplantation (LDLT) across the ABO blood barrier. To decide the treatment for an ABO-I recipient, the amount of anti-AB antibody (Ab) is very important. At present, the quantity of anti-AB Ab is represented by the agglutination titer. We developed an enzyme linked immunosorbent assay (ELISA) to measure anti-AB Ab, and assessed its usefulness in clinical practice in this study.
In this report, we describe a novel ELISA we have developed to measure anti-histo-blood group Ab in patients subjected to LDLT, which uses synthetic carbohydrate blood group antigens. We assessed the correlation between optical density (O.D.) determined by ELISA and agglutination titers, and considered the possibility of using ELISA in clinical cases. (Tohoku Journal of Experimental Medicine, 211; 359-367,2007) And'' in another study we experienced 9 recipients who underwent apheresis to eliminate allogeneic antibodies, out of 101 LDLT patients. We focused d on the indication and the efficacy of apheresis as extracorporeal immunomodulation for the elimination of antibodies in patients undergoing LDLT. The long-term follow-up was also investigated. (Therapeutic Apheresis and Dialysis; 11(5):319-32.4, 2007) In conclusion, our ELISA method is useful to detect changes in individually anti-A/B Ab and may have the possibility of using ELISA in clinical cases.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (7 results)

All 2007

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] The Management of Anti-allogeneic Antibody Elimination by Apheresis in Living Donor Liver Transplantation2007

    • Author(s)
      Naoki Kawagishi, et a1.
    • Journal Title

      Therapeutic Apheresis and Dialysis 11

      Pages: 319-324

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Development of a Novel ELISA for Detection of Anti-A and Anti-B Antibodies in Recipients of ABO-Incompatible Living Donor Liver Grafts2007

    • Author(s)
      Akefumi Satoh, Naoki Kawagishi, et. al.
    • Journal Title

      Tohoku J Exp Med 211

      Pages: 359-367

    • NAID

      130004459555

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The Management of Anti-allogeneic Antibody Elimination by Apheresis in Living Donor Liver Transplantation2007

    • Author(s)
      Naoki Kawagishi, et. al.
    • Journal Title

      Therapeutic Apheresis and Dialysis 11

      Pages: 319-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Development of a Novel ELISA for Detection of Anti-A and Anti-B Antibodies in Recipients of ABO-Incompatible Living Donor Liver Grafts2007

    • Author(s)
      Akefumi Sato, Naoki Kawagishi et. al.
    • Journal Title

      Tohoku J Exp Med 211(4)

      Pages: 359-367

    • NAID

      130004459555

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development of a Novel ELISA for Detection of Anti-A and Anti-B Antibodies in Recipients of ABO-Incompatible Living Donor Liver Grafts.2007

    • Author(s)
      Akefumi Satoh, Naoki Kawagishi, et al.
    • Journal Title

      Tohoku Journal of Experimental Medicine in press

    • NAID

      130004459555

    • Related Report
      2006 Annual Research Report
  • [Presentation] LONG-TERM OUTCOME OF ABO-INCOMPATIBLE LIVING DONOR LIVER TRANSPLANTATION IN A SINGLE CENTER EXPERIENCE2007

    • Author(s)
      Naoki Kawagishi
    • Organizer
      European Society of Organ Transplantation
    • Place of Presentation
      プラハ
    • Year and Date
      2007-09-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] LONG-TERM OUTCOME OF ABO-INCOMPATIBLE LIVING DONOR LIVER TRANSPLANTATION IN A SINGLE CENTER EXPERIENCE2007

    • Author(s)
      Naoki Kawagishi
    • Organizer
      European Society of Organ Transplantation
    • Place of Presentation
      Prague, Czech Republi
    • Year and Date
      2007-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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