Antigen removal in grafts and induction of accommodation for overcoming ABO incompatibility

• Project/Area Number: 18591407
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya University
• Principal Investigator: KOBAYAHSI Takaaki Nagoya University, School of Medicine, Professor (70314010)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Koji Nagoya University, University Hospital, Associate Professor (90362251) ; TAKEDA Shin Nagoya University, Graduate School of Medicine, Associate Professor (20314015) ; ONISHI Akira National Institute of Agrobiological Sciences, Group Director (30414890) ; MARUYAMA Shoichi Nagoya University, Hospital, Associate Professor (10362253) ; OGAWA Haruko Obihiro University of Agriculture and Veterinary Medicine, National Research Center for Protozoan Diseases, Associate Professor (10400079)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,420,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: ABO blood group / Antigen / Antibody / Antibody-mediated rejection / Accommodation / Endo-β-galactosidase / Organ transplantation

Research Abstract

We attempted to develop the comprehensive treatment to overcome ABO incompatibility which is a high risk factor for antibody-mediated rejection in organ transplantation. (1) Recombinant ABase(rABase) derived from clostridium perfringens, which effectively releases A/B antigen, was produced in E. coil BL-21. rABase removed about 90% of A antigen(Ag) and B Ag on human RBC. In vivo infusion of rABase into a blood type A baboon demonstrated a marked reduction(87-97%) of A Ag in the kidney and liver. Excised baboon kidney(Blood type B) was perfused with cold UW solution +/-purified rABase and then preserved 4h at 4℃. B Ag in glomeruli were reduced to 49% at 1h and 6% at 4h. A novel strategy was suggested using ABase would include enzymatic digestion of AB Ag during cold storage after organ retrieval and/or repeated in vivo infusion into the recipient until accommodation developed. (2) Human decay accelerating factor(hDAF) and thrombomodulin genes were introduced into porcine aortic endothelial cells. The capacity of activated protein C production, clotting time of human plasma and mRNA of Tissue Factor and Plasminogen Activator Inhibitor-1 were investigated. Inhibition of endothelial activation by complement regulatory protein and control of coagulation by thrombomodulin are considered to be essential for both prevention of rejection and induction of accommodation. (3) We established the assay to determine stimulation index(S.I) for cell cycle-related protein mRNA expression as immune function monitoring. We are planning to elucidate the significance of monitoring by measuring the blood from the recipients after transplantation.

Research Products

• [Journal Article] Relation between human decay-accelerating factor(hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for xenotransplantation (2007)
  • Author(s): Liu. D, Kobayashi T, Onishi A, Furusawa T, Iwamoto T, Suzuki S, Miwa Y, Nagasaka T, Maruyama S, Kadomatsu K, Uchida K, Nakao A
  • Journal Title: Xenotransplantation 14 Pages: 67-73
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prophylactic treatment of antibody-mediated rejection with high-dose mizoribine and pharmacokinetic study (2007)
  • Author(s): Liu D, Kobayashi T, Nagasaka T, Miwa Y, Ma Y, Yokoyama I, Kuzuya T, Oikawa T, Morozumi K, Uchida K, Nakao A.
  • Journal Title: Transplant International 30 Pages: 365-370
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Alternative strategy for overcoming ABO incompatibility (2007)
  • Author(s): Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, LiY-T, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.
  • Journal Title: Transplantation 83 Pages: 1284-1286
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice. (2007)
  • Author(s): Yamamoto K, Kojima T, Takeshita K, Matsushita T, Takamatsu J
  • Journal Title: Thrombosis Research 120 Pages: 143-144
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure. (2007)
  • Author(s): Ozaki T, Anas C, Maruyama S, Yamamoto T, Yasuda K, Morita Y, Ito Y, Gotoh M, Yuzawa Y, Matsuo S.
  • Journal Title: Nephrol Dial Transplant 23 Pages: 110-119
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity : value of highly expressed hDAF for xenotransplantation (2007)
  • Author(s): Liu. D, Kobayashi, T, Onishi, A, Furusawa, T, Iwamoto, T, Suzuki, S, Miwa, Y, Nagasaka, T, Maruyama, S, Kadomatsu, K, Uchida, K, Nakao, A
  • Journal Title: Xenotransplantation 14 Pages: 67-73
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prophylactic treatment of antibody-mediated rejection with high-dose mizoribine and pharmacokinetic study (2007)
  • Author(s): Liu, D, Kobayashi, T, Nagasaka, T, Miwa, Y, Ma, Y, Yokoyama, I, Kuzuya, T, Oikawa, T, Morozumi, K, Uchida, K, Nakao, A
  • Journal Title: Transplant International 30 Pages: 365-370
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Alternative strategy for overcoming ABO incompatibility (2007)
  • Author(s): Kobayashi, T, Liu, D, Ogawa, H, Miwa, Y, Nagasaka, T, Maruyama, S, Li, Y-T, Onishi, A, Kuzuya, T, Kadomatsu, K, Uchida, K, Nakao, A
  • Journal Title: Transplantation 83 Pages: 1284-1286
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice. (2007)
  • Author(s): Yamamoto, K, Kojima, T, Takeshita, K, Matsushita, T, Takamatsu, J
  • Journal Title: Thrombosis Rsearch 120 Pages: 143-144
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure (2007)
  • Author(s): Ozaki, T, Anas, C, Maruyama, S, Yamamoto, T, Yasuda, K, Morita, Y, Ito, Y, Gotoh, M, Yuzawa, Y, Matsuo, S
  • Journal Title: Nephrol Dial Transplant 23 Pages: 110-119
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical value of HLA antibody monitoring after renal transplantation (2007)
  • Author(s): Kobayashi T, Kohara S, Miwa Y, Nagasaka T, Goto N, Katayama A, Uchida K, Nakao A
  • Journal Title: Clinical Transplants 2006 chapter 29 Pages: 385-388
• [Journal Article] Alternative strategy for overcoming ABO incompatibility (2007)
  • Author(s): Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li Y-T, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.
  • Journal Title: Transplantation 83 Pages: 1284-1286
  • Peer Reviewed
• [Journal Article] HLA抗体と腎移植:移植後産生されたHLA抗体について (2007)
  • Author(s): 小林孝彰
  • Journal Title: Organ Biology 14 Pages: 337-349
• [Journal Article] Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity : value of highly expressed hDAF for xenotransplantation (2007)
  • Author(s): Liu.D, Kobayashi T, Onishi A, Furusawa T, Iwamoto T, Suzuki S, Miwa Y, Nagasaka T, Maruyama S, Kadomatsu K, Uchida K, Nakao A
  • Journal Title: Xenotransplantation 14 Pages: 67-73
• [Journal Article] Prophylactic treatment of antibody-mediated rejection with high-dose mizoribine and pharmacokinetic study (2007)
  • Author(s): Liu D.Kobayashi T, Nagasaka T, Miwa Y, Ma Y, Yokoyama I, Kuzuya T, Oikawa T, Morozumi K, Uchida K, Nakao A.
  • Journal Title: Transplant International 30 Pages: 365-370
• [Journal Article] Standardization of the assay method for anti-A/B antibody titers and its problems (2006)
  • Author(s): Kobayashi T
  • Journal Title: International Congress Series 1292 Pages: 3-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A series of surveys on assay for anti-A/B antibody by Japanese Society for ABO incompatible transplantation (2006)
  • Author(s): Kobayashi T
  • Journal Title: Xenotransplantation 13 Pages: 136-140
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] MMFのPharmacodynamics解析によるモニタリングの確立-MTT assayとフローサイトメトリー(FCM)の比較- (2006)
  • Author(s): 倉田洋子、葛谷孝文、小林孝彰、三輪祐子、打田 和冶、中尾 昭公、亀井浩行、松葉和久、鍋島俊隆
  • Journal Title: 移植 41 Pages: 351-355
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ABO血液型不適合移植攻略のための新補助療法 (2006)
  • Author(s): 小林孝彰
  • Journal Title: 移植 41 Pages: 573-576
  • NAID: 10024371400
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Standardization of the assay method for anti-A/B antibody titers and its problems (2006)
  • Author(s): Kobayashi, T
  • Journal Title: International Congress Series 1292 Pages: 3-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A series of surveys on assay for anti-A/B antibody by Japanese Society for ABO incomipatible transplantation (2006)
  • Author(s): Kobayashi, T, Saito, K
  • Journal Title: Xenotransplantation 13 Pages: 136-140
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Establishment of pharmacodynamic monitoring of MMF-Comparison between MTT assay and flow cytometry- (2006)
  • Author(s): Yoko, Kurata, Takafumi, Kuzuya, Takaaki, Kobayashi, Yuko, Miwa, Kazuharu, Uchida, Akimasa, Nakao, Hiroyuki, Kamei, Kazuhisa, Matsuba, Toshitaka, Nabeshima
  • Journal Title: Transplant 41
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel approach to adjuvant therapy for overcoming ABO incompatible transplantation (2006)
  • Author(s): Takaaki, Kobayashi
  • Journal Title: Transplant 41
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glycobiology relating to xenotransplantation (2006)
  • Author(s): Kobayashi T, Ezzelarab M
  • Journal Title: Current opinion in organ transplantation 11 Pages: 154-159
• [Journal Article] A series of surveys on assay for anti-A/B antibody by Japanese Society for ABO incompatible transplantation (2006)
  • Author(s): Kobayashi T, Saito K
  • Journal Title: Xenotransplantation 13 Pages: 136-140
• [Journal Article] The Cartagena protocol on biosafety : implications for xenotransplantation (2006)
  • Author(s): Kobayahsi T, Yamanouchi K
  • Journal Title: Xenotransplantation 13 Pages: 10-11
• [Journal Article] Is absoprtion profile of cyclosporine really important for effective immunosuppression ? (2006)
  • Author(s): Ma Y, Kobayashi T, Kuzuya T, Liu D, Nagasaka T, Yokoyama I, Miwa Y, Morozumi K, Oikawa T, Uchida K, Nakao A
  • Journal Title: Biological Pharmaceutical Bulletin 29 Pages: 336-342
• [Journal Article] MMFのPharmacodynamics解析によるモニタリングの確立-MTT assayとフローサイトメトリー(FCM)の比較- (2006)
  • Author(s): 倉田洋子, 葛谷孝文, 小林孝彰, 三輪祐子, 打田 和冶, 中尾 昭公, 亀井浩行, 松葉和久, 鍋島俊隆
  • Journal Title: 移植 41 Pages: 351-355
• [Presentation] Related Versus Unrelated Living Donor ABO-Incompatible Kidney Transplantation: Are Spousal Living Donors a Good Source of Kidneys for ABO-Incompatible Living Transplantation? (2007)
  • Author(s): Uchida K, Katayama A, Nagasaka T, Goto N, Morozumi K, Takeda A, Goto Y, Kobayashi T, Nakao A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Reduction of Blood Group A/B Antigen Expression in Organ by In Vivo Infusion of endo-β-Galactosidase. (2007)
  • Author(s): Kobayashi T, DaGe Liu, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Yu-The Li, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nkao A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Beneficial Fffect of Human DAF and Thrombomodulin Expression in Pig Endothelial Cells on Coagulation Control. (2007)
  • Author(s): Miwa Y, Kobayashi T, Yamamoto K, Nagasaka T, DaGe Liu, Kuzuya T, Onishi A, Kadomatsu K, Uchida K, Nakao A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pig kidney expressing both endo-beta-galactosidase C and hDAF prevented hyperacute rejection in baboon without antibody removal (2007)
  • Author(s): T. Kobayashi, A. Onishi, D. Liu, T. Nagasaka, Y. Miwa, A. Katayama, S. Maruyama, M. Iwamoto, K. Uchida, A. Nakao
  • Organizer: CTS一IPITA-IXA 2007 Joint Conference
  • Place of Presentation: Minneapolis(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Successful removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-beta-galacgtosidase(ABase) (2007)
  • Author(s): T. Kobayashi, H. Ogawa, D. Liu, T. Nagasaka, Y. Miwa, A. Katayama, S. Maruyama, Y-T. Li, A. Onishi, K. Uchida
  • Organizer: CTS-IPITA-IXA 2007 Joint Conference
  • Place of Presentation: Minneapolis(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Significance of human DAF and thrombomodulin gene transfer for coagulation control in pig to human xenotransplantation (2007)
  • Author(s): Y. Miwa, K. Yamamoto, A. Katayama, T. Nagasaka, A. Onishi, M. Iwamoto, K. Kadomatsu, K. Uchida, A. Nakao, T. Kobayashi
  • Organizer: CTS-IPITA-IXA 2007 Joint Conference
  • Place of Presentation: Minneapolis(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Related Versus Unrelated Living Donor ABO-Incompatible Kidney Transplantation : Are Spousal Living Donors a Good Source of Kidneys for ABO-Incompatible Living Transplantation (2007)
  • Author(s): Uchida, K, Katayama, A, Nagasaka, T, Goto, N, Morozumi, K, Takeda, A, Goto, Y, Kobayashi, T, Nakao, A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Reduction of Blood Group A/B Antigen Expression in Organ by In Vivo Infusion of endo- β-Galactosidase (2007)
  • Author(s): Kobayashi, T, DaGe, Liu, Ogawa, H, Miwa, Y, Nagasaka, T, Maruyama, S, Yu-The, Li, Onishi, A, Kuzuya, T, Kadomatsu, K, Uchida, K, Nkao, A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Beneficial Fffect of Human DAF and Thrombomodulin Expression in Pig Endothelial Cells on Coagulation Control (2007)
  • Author(s): Miwa, Y, Kobayashi, T, Yamamoto, K, Nagasaka, T, DaGe, Liu, Kuzuya, T, Onishi, A, Kadomatsu, K, Uchida, K, Nakao, A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pig kidney expressing both endo-beta-galactosidase C and hDAF prevented hyperacute rejection in baboon without antibody removal (2007)
  • Author(s): T. Kobayashi, A. Onishi, D. Liu, T. Nagasaka, Y. Miwa, A. Katayama, S. Maruyama, M. Iwamoto, K. Uchida, A. Nakao
  • Organizer: CTS-IPITA-IXA 2007 Joint Conference
  • Place of Presentation: Minneapolis (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Successful removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-beta-galacgtosidase (ABase) (2007)
  • Author(s): T. Kobayashi, H. Ogawa, D. Liu, T. Nagasaka, Y. Miwa, A. Katayama, S. Maruyama, Y-T. Li, A. Onishi, K. Uchida
  • Organizer: CTS-IPITA-IXA 2007 Joint Conference
  • Place of Presentation: Minneapolis (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Significance of human DAF and thrombomodulin gene transfer for coagulation control in pig to human xenotransplantation (2007)
  • Author(s): Y. Miwa, K. Yamamoto, A. Katayama, T. Nagasaka, A. Onishi, M. Iwamoto, K. Kadomatsu, K. Uchida, A. Nakao, T. Kobayashi
  • Organizer: CTS-IPITA-IXA2007 Joint Conference
  • Place of Presentation: Minneapolis (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Excellent Results in ABO-Incompatible Living Donor Renal Transplant Using Cyclophosphamide. (2007)
  • Author(s): Nagasaka T, Katayama A, Goto N, Goto Y, Sato T, Matsuoka S, Tominaga Y, Takeda A, Morozumi K, Kobayashi T, Uchida K
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco (USA)
• [Presentation] Related Versus Unrelated Living Donor ABO-Incompatible Kidney Transplantation: Are Spousal Living Donors a Good Source of Kidneys for ABO-Incomopatible Living Transplantation? (2007)
  • Author(s): Uchida K, Katayama A, Nagasaka T, Goto N, Morozumi K, Takeda A, Goto Y, Kobayashi T, Nakao A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco (USA)
• [Presentation] Reduction of Blood Group A/B Antigen Expression in Organ by In Vivo Infusion of endo-β-Galactosidase. (2007)
  • Author(s): Kobayashi T, DaGe Liu, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Yu-The Li, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nkao A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco (USA)
• [Presentation] Beneficial Fffect of Human DAF and Thrombomodulin Expression in Pig Endothelial Cells on Coagulation Control. (2007)
  • Author(s): Miwa Y, Kobayashi T, Yamamoto K, Nagasaka T, Dace Liu, Kuzuya T, Onishi A, Kadomatsu K, Uchida K, Nakao A
  • Organizer: American Transplant Congress 2007
  • Place of Presentation: San Francisco (USA)
• [Presentation] Pig kidney expressing both endo-beta-galactosidase C and hDAF Prevented hyperacute rejection in baboon without antibody removal (2007)
  • Author(s): T. Kobayashi, A. Onishi, D. Liu, T. Nagasaka, Y. Miwa, A. Katayama, S. Maruyama, M. Iwamoto, K. Uchida, A. Nakao
  • Organizer: CTS-IPITA-IXA 2007 Joint Conference
  • Place of Presentation: Minneapolis (USA)
• [Presentation] Significance of human DAF and thrombomodulin gene transfer for coagulation control in pig to human xenotransplantation (2007)
  • Author(s): Y. Miwa, K. Yamamoto, A. Katayama, T. Nagasaka, A. Onishi, M. Iwamoto, K. Kadomatsu, K. Uchida, A. Nakao, T. Kobayashi
  • Organizer: CTS-IPITA-IXA 2007 Joint Conference
  • Place of Presentation: Minneapolis (USA)
• [Presentation] Alternative strategy for overcoming ABO incompatibility (2006)
  • Author(s): Kobayashi T, Liu D, Miwa Y, Ogawa H, Kadomatsu K, Li Y-T, Nagasaka T, Maruyama S, Kuzuya T, Onishi A, Uchida K, Nakao A
  • Organizer: World Transplant Congress 2006
  • Place of Presentation: Boston(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Relation between hDAF expression level in pig cells and inhibition of human serum anti-pig cytotoxicity (2006)
  • Author(s): Liu D, Kobayashi T, Onishi A, Furusawa T, Iwamoto M, Suzuki S, Miwa Y, Nagasaka T, Maruyama S, Uchida K, Nakao A.
  • Organizer: World Transplant Congress 2006
  • Place of Presentation: Boston(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Excellent outcome in ABO-incompatible living donor kidney transplantation with the modified immunosuppression: the use of basiliximab/cyclop hosphamide instead of antilymphocyte globulin/cyclophosphamide. (2006)
  • Author(s): Uchida K, Katayama A, Nagasaka T, Goto N, Takeda A, Morozumi K, Kobayashi T, Nakao A.
  • Organizer: World Transplant Congress 2006
  • Place of Presentation: Boston(USA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Alternative strategy for overcoming ABO incompatibility (2006)
  • Author(s): Kobayashi, T, Liu, D, Miwa, Y, Ogawa, H, Kadomatsu, K, Li, Y-T, Nagasaka, T, Maruyama, S, Kuzuya, T, Onishi, A, Uchida, K, Nakao, A
  • Organizer: World Transplant Congress 2006
  • Place of Presentation: Boston (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Relation between hDAF expression level in pig cells and inhibition of human serum anti-Dig cytotoxirity (2006)
  • Author(s): Liu, D, Kobayashi, T, Onishi, A, Furusawa, T, Iwamoto, M, Suzuki, S, Miwa, Y, Nagasaka, T, Maruyama, S, Uchida, K, Nakao, A
  • Organizer: World Transplant Congress 2006
  • Place of Presentation: Boston (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Excellent outcome in ABO-incompatible living donor kidney transplantation with the modified immunosuppression : the useof basiliximab/cyclophosphamide instead of antilymphocyte globulin/cyclophosnhamide (2006)
  • Author(s): Uchida, K, Katayama, A, Nagasaka, T, Goto, N, Takeda, A, Morozumi, K, Kobayashi, T, Nakao, A
  • Organizer: World Transplant Congress 2006
  • Place of Presentation: Boston (USA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] New strategy for ABO incompatible transplantation-2006 (2006)
  • Author(s): Takaaki, Kobayahsi, Kazuhide, Saito
  • Organizer: Nihon Igakukan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] New strategy for ABO incompatible transplantation-2007 (2006)
  • Author(s): Takaaki, Kobayahsi, Kazuhide, Saito
  • Organizer: Nihon Igakukan
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] ABO血液型不適合移植の新戦略-2007- (2007)
  • Author(s): 小林孝彰、齋藤和英
  • Total Pages: 86
  • Publisher: 日本医学館
  • Description: 「研究成果報告書概要(和文)」より
• [Book] ABO血液型不適合移植の新戦略-2007- (2007)
  • Author(s): 片山 昭男、打田 和治、後藤 憲彦、長坂 隆治、佐藤 孔信、宇野 暢晃、佐藤 哲彦、松岡 慎、冨永 芳博、前田 佳哉輔、山岸 優雅、酒井 薫、小野田 浩、堀家 敬司、武田 朝美、両角 國男、永井 琢人、後藤 芳充、小林 孝彰、中尾 昭公
  • Total Pages: 86
  • Publisher: 日本医学館
• [Book] ABO血液型不適合移植の新戦略-2006- (2006)
  • Author(s): 小林孝彰、齋藤和英
  • Total Pages: 76
  • Publisher: 日本医学館
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 腎移植の進歩 わが国の現状と今後の展望 編集 日本腎臓学会渉外・企画委員会/腎移植推進委員会 異動移植の現状と展望(p244-257) (2006)
  • Author(s): 小林孝彰
  • Total Pages: 290
  • Publisher: 東京医学社