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Tailor-made chemotherapy for non-small cell lung cancers

Research Project

Project/Area Number 18591553
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKagawa University

Principal Investigator

LIU Dage  Kagawa University, Faculty of Medicine, Research Associate (30314941)

Co-Investigator(Kenkyū-buntansha) HUANG Cheng-long  Kagawa University, Faculty of Medicine, Associate professor (10271511)
ISHIKAWA Shinya  Kagawa University, Faculty of Medicine, Research Associate (20363210)
YOKOMISE Hiroyasu  Kagawa University, Faculty of Medicine, Professor (80231728)
UENO Masaki  Kagawa University, Faculty of Medicine, Associate professor (30322267)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordslung cancer / chemotherapy / TS / OPRT / DPD / 5-FU / EGFR / gefitinib
Research Abstract

In order to improve the clinical outcome of patients with non-small cell lung cancer (NSCLC), we have been performing "tailor-made chemotherapy", the selection of the effective chemotherapy treatment based on evaluation of biomarkers associated with chemo-responsiveness (Huang, et. Al., Future Oncol 2006).Biomarkers associated with 5-FU responsiveness are its target enzyme TS, activating enzyme OPRT, and catabolic enzyme DPD. We have found that low TS expression, high OPRT expression, and low DPD expression are independent good prognostic factors in NSCLC patients postoperatively treated with oral 5-FU (Nakano, et. Al., Br J Cancer 2006). On the other hand, because epidermal growth factor receptor (EGFR) gene mutations are reported to be associated with responsiveness of EGFR-specific TKIs, we developed the clinically useful protocol to evaluate the EGFR gene mutations (Liu, et. Al.,〓ncol Rep 2006). In addition, we performed comprehensive studies on the tumor suppressor gene p53, which is involved in tumor apoptosis (Huang, et. Al., Future Oncol 2007). Consequently, we demonstrated a reduced expression of HAUSP to be associated with the downregulation of the p53 protein and its targets, such as p21 and bax (Masuya, et. Al., J Pathol 2006). Furthermore, regarding the apoptosis inhibitor survivin, we have found that the E2F1 over-expression is associated with the TS and Survivin expression (Clin Cancer Res 2007), and that splicing variants of Survivin have different biological functions associated with carcinogenesis (Nakano, et. Al., Br J Cancer 2008).Comprehensive analysis using cDNA microarray assays revealed the Wnt pathway to be associated with carcinogenesis. In addition, we found that the intratumoral Wntl expression is a poor prognostic factor of NSCLC patients, through the induction of its targets, such as c-Myc and MMP-7 (Liu, et. Al., Lung Cancer 2007; Nakashima, et. Al., Oncol Rep 2008).

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (19 results)

All 2008 2007 2006

All Journal Article (17 results) (of which Peer Reviewed: 7 results) Presentation (2 results)

  • [Journal Article] Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients2008

    • Author(s)
      Takashi Nakashima, et. al.
    • Journal Title

      Oncology Reports 19

      Pages: 203-209

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Wntl overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients2008

    • Author(s)
      Nakashima, T, Liu, D, et. al.
    • Journal Title

      Oncology Reports 19(1)

      Pages: 203-209

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The clinical significance of splice variants and subcellular localization of survivin in non-small cell lung cancers2008

    • Author(s)
      Jun Nakano, et. al.
    • Journal Title

      British Journal of Cancer (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt1 overexpression associated with tumor proliferation and a poor Prognosis in non-small cell lung cancer patients2008

    • Author(s)
      Takashi Nakashima, et. al.
    • Journal Title

      Oncology Reports 19

      Pages: 203-209

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of matrix metalloproteinase-7(MMP-7)correlates with tumor proliferation,and a poor prognosis in non-small cell lung cancer2007

    • Author(s)
      Dage Liu, et. al.
    • Journal Title

      Lung Cancer 58

      Pages: 384-391

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non-small cell lung cancer2007

    • Author(s)
      Cheng-long Huang, et. al.
    • Journal Title

      Clinical Cancer Research 13

      Pages: 6938-6946

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Overexpression of matrix metalloproteinase-7(MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer2007

    • Author(s)
      Liu, D, et. al.
    • Journal Title

      Lung Cancer 58(3)

      Pages: 384-391

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non-small cell lung cancer2007

    • Author(s)
      Huang, C, Liu, D, et. al.
    • Journal Title

      Clinical Cancer Research 13(23)

      Pages: 6938-6946

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A useful protocol for analyses of mutations of the epidermal growth factor receptor gene2007

    • Author(s)
      Liu, D, et. al.
    • Journal Title

      Oncology Reports 15(6)

      Pages: 1503-1505

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] E2F1 overexpression correlates with thymidylate synthase and survivingene expressions and tumor proliferation in non-small cell lung cancer2007

    • Author(s)
      Cheng-long Huang, et. al.
    • Journal Title

      Clinical Cancer Research 13

      Pages: 6938-6946

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A useful protocol for analyses of mutations the epidermal growth Factor receptor gene2006

    • Author(s)
      Dage Liu, et. al.
    • Journal Title

      Oncology Reports 15

      Pages: 1503-1505

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A useful protocol for analyses of mutations of the epidermal growth factor receptor gene2006

    • Author(s)
      Dage Liu, et al.
    • Journal Title

      Oncology Reports 15・6

      Pages: 1503-1505

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT2006

    • Author(s)
      Jun Nakano, et al.
    • Journal Title

      British Journal of Cancer 95・5

      Pages: 607-615

    • Related Report
      2006 Annual Research Report
  • [Journal Article] tailor-made chemotherapy for non-small cell lung cancer patients2006

    • Author(s)
      Cheng-long Huang, et al.
    • Journal Title

      Future Oncology 2・2

      Pages: 289-299

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Therapeutic strategy based on biological markers for non-small-cell lung cancers2006

    • Author(s)
      Cheng-long Huang, et al.
    • Journal Title

      Enhancer-Biotherapy of Cancer 4・1

      Pages: 19-21

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE22006

    • Author(s)
      Cheng-long Huang, et al.
    • Journal Title

      Oncogene 25・49

      Pages: 6480-6488

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways2006

    • Author(s)
      Daiki Masuya, et al.
    • Journal Title

      Journal of Pathology 208・5

      Pages: 724-732

    • Related Report
      2006 Annual Research Report
  • [Presentation] 非小細胞肺癌におけるWnt1及びWnt5aの腫瘍内発現とVEGF-A発現との関連2007

    • Author(s)
      劉 大革
    • Organizer
      第24回日本呼吸器外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-05-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The intratumoral expressions of Wntl and Wnt5a correlate with VEGF-A expression in non-small cell lung cancer2007

    • Author(s)
      Liu, D, et. al.
    • Organizer
      24th Annual Meeting of Japanese Association for Chest Surgery
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-05-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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