| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Research Abstract |
We examined uterine artery flow velocity waveforms in 1500 pregnant women at 16 to 23 weeks of gestation, during April 2003 to March 2008. We also took 10m1 of blood from 1358, 916 and 365 pregnant women at 20 to 23, 28 to 29, and 37 weeks of gestation, respectively, and centrifuged the blood, and stored the serums and plasmas at -20 C until the examination of placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1). We obtained the following 3 main results during 2 years.
1. We investigated 587 pregnant cohorts, and examined the effects of the high notch depth index (NDI) of the uterine flow velocity waveforms around 20 weeks of gestation and blood pressure levels around 20 week of gestation on the later occurrence of preeclampsia. The sensitivities of high NDI and the existence of prehypertension (>130/85 mmHg)/hypertension were 53% and 63%, respectively. The combination of both markers resulted in the increase of sensitivity (84%)
2. We investigated 261 singleton
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pregnant cohorts, who were examined uterine artery flow velocity waveforms at 16 to 23 weeks of gestation, and in whom serum levels of P1GF and sFlt-1 twice at both 16 to 23 and 27 to 29 weeks of gestation. In women with high NDI at mid-gestation, the serum levels of P1GF were significantly low. In addition, the incidence rates of high sFlt-1 levels at around 28 weeks of gestation and the later occurrence of preeclampsia were significantly higher in women with both high NDI and low P1GF levels, than those with both low NDI and high P1GF, those with both low NDI and low P1GF, and those with both high NDI and high P1GF, respectively.
3. We established the normal reference values of serum soluble endoglin (sEng) from 20 to 38 weeks of gestation, using serums taken three times at 20 to 23, 27 to 29 and 36 to 38 weeks of gestation in 85 normal pregnant women. We found that all the women (25/25) with early onset preeclampsia showed high sEng (≧ 95% of the reference ranges of sEng during pregnant period), and all the women (5/5) with later occurrence of early onset preeclampsia showed high sEng at 16 to 23 weeks of gestation. Less
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