A basic research for various therapeutic modalities of refarctive correction for irregular astigmatism

• Project/Area Number: 18591919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: MAEDA Naoyuki Osaka University, 医学系研究科, 寄附講座教授 (00273623)
• Co-Investigator(Kenkyū-buntansha): NISHIDA Kohji 大阪大学, 医学系研究科, 助教授 (40244610) ; FUJIKASO Takashi 大阪大学, 医学系研究科, 教授 (50243233) ; TANO Yasuo 大阪大学, 医学系研究科, 教授 (80093433)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: レーシック / コンタクトレンズ / 眼内レンズ / ドライアイ / 角膜移植 / 不正乱視 / 波面収差 / 視覚の質 / 位相伝達特性

Research Abstract

不正乱視に対する治療的屈折矯正手段の基礎的研究として、波面センサーを用いて正常と涙液層異常を呈する疾患に対して測定を行ったところ、涙液層の病態に応じて特有の高次収差の経時的変化が認められ、治療においてもこれらを考慮する必要が示唆された。また、高次収差の特徴を把握するため、Zernike多項式のベクトル解析を行ったところ、各成分が収差量と軸として表現可能となり、治療の際に有用と考えられるだけでなく、角膜前、後面の高次収差の代償関係や、円錐角膜等疾患における特徴を把握した。

Research Products

• [Journal Article] Serial measurements of higher-order aberrations after blinking inpatients with dry eye. (2009)
  • Author(s): Nakagawa T, et al
  • Journal Title: Invest Ophthalmol Vis Sci 50(In press)
  • Peer Reviewed
• [Journal Article] Serial measurements of higher-order aberrations after blinking in patients with dry eye (2008)
  • Author(s): Shizuka Koh, Naoyuki Maeda, Takashi Fujikado, Yasuo Tano
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 133-138
  • Peer Reviewed
• [Journal Article] Corneal thickness change induced by dozing while wearing hydrogel and silicone hydrogel lenses (2008)
  • Author(s): Hikaru Hamano H, Naoyuki Maeda
  • Journal Title: Eye Contact Lens 34 Pages: 56-60
  • Peer Reviewed
• [Journal Article] Effects of suppression of blinking on quality of vision in borderline cases of evaporating dry eye (2008)
  • Author(s): Shizuka Koh, Naoyuki Maeda, Takashi Fujikado, Yasuo Tano
  • Journal Title: Cornea 27 Pages: 275-278
  • Peer Reviewed
• [Journal Article] Effects of internal lubricating agents of disposable soft contact lenses on higher-order aberrations after blinking (2008)
  • Author(s): Shizuka Koh, Naoyuki Maeda, Takashi Fujikado, Yasuo Tano
  • Journal Title: Eye & Contact Lens 34 Pages: 100-105
  • Peer Reviewed
• [Journal Article] Chandelier illumination to complete Descemet stripping through severe hazy cornea during Descemet-stripping automated endothelial keratoplasty (2008)
  • Author(s): Tomoyuki Inoue, Naoyuki Maeda, Yasuo Tano
  • Journal Title: J Cataract Refract Surg 34 Pages: 892-896
  • Peer Reviewed
• [Journal Article] Corneal ablation with new 193 nm solid-state laser Preliminary experiments (2008)
  • Author(s): Tomoya Nakagawa, Naoyuki Maeda, Takashi Fujikado, Yasuo Tano
  • Journal Title: J Cataract Refract Surg 34 Pages: 1019-1023
  • Peer Reviewed
• [Journal Article] Characteristics of ocular higher-order aberrations in patients with pellucid marginal corneal degeneration (2008)
  • Author(s): Yoshinori Oie, Naoyuki Maeda, Kohji Nishida, Takashi Fujikado, Yasuo Tano
  • Journal Title: J Cataract Refract Surg 34 Pages: 1928-1934
  • Peer Reviewed
• [Journal Article] Characteristics of ocular higher-order aberrations in patientswith pellucid marginal corneal degeneration (2008)
  • Author(s): Oie Y, et al
  • Journal Title: J Cataract Eefract Surg 34・11 Pages: 1928-1934
  • Peer Reviewed
• [Journal Article] Corneal ablation with new 193 nm solid-state laser Preliminaryexperiments. (2008)
  • Author(s): Nakagawa T, et al
  • Journal Title: J Cataract Refract Surg. 34・6 Pages: 1019-1023
  • Peer Reviewed
• [Journal Article] Serial measurements of higher-order aberrations after blinking inpatients with dry eye. (2008)
  • Author(s): Koh S, et. al.
  • Journal Title: Invest Ophthalmol Vis Sci 49・1 Pages: 133-138
  • Peer Reviewed
• [Journal Article] Validity of Retinal Oxygen Saturation Analysis : Hyperspectral Imaging in Visible Wavelengthwith Fundus Camera and Liquid Crystal Wavelength Tunable Filter (2007)
  • Author(s): Yoko Hirohara, Naoyuki Maeda, Takashi Fujikado
  • Journal Title: OPTICAL REVIEW 14 Pages: 151-158
  • NAID: 10019506268
  • Peer Reviewed
• [Journal Article] Magnitude and orientation of zernike terms in patients with keratoconus (2007)
  • Author(s): Ryo Kosaki, Naoyuki Maeda, Kohji Nishida, Takashi Fujikado, Yasuo Tano
  • Journal Title: Invest Ophthalmol Vis Sci. 48 Pages: 3062-3068
  • Peer Reviewed
• [Journal Article] Ultrahigh-resolution imaging of human donor cornea using full-field optical coherence tomography (2007)
  • Author(s): Masahiro Akiba, Naoyuki Maeda, Kohji Nishida, Yasuo Tano
  • Journal Title: Journal of Biomedical Optics 12(4)
  • Peer Reviewed
• [Journal Article] Optical quality of the eye degraded by time-varying wavefront aberrations with tear film dynamics (2007)
  • Author(s): Yoko Hirohara, Naoyuki Maeda, Takashi Fujikado
  • Journal Title: Jpn J Ophthalmol 51 Pages: 258-264
  • NAID: 10019830117
  • Peer Reviewed
• [Journal Article] Magnitude and orientation of zernike terms in patients with keratoconus. (2007)
  • Author(s): Kosaki R, et. al.
  • Journal Title: Invest Ophthalmol Vis Sci 48・7 Pages: 3062-3068
  • Peer Reviewed
• [Journal Article] Optical quality of the eye degraded by time-varying wavefront aberrations with tear film dynamics. (2007)
  • Author(s): Hirohara Y, et. al.
  • Journal Title: Hirohara Y, et. al. 51・4 Pages: 258-264
  • Peer Reviewed
• [Journal Article] Paradoxical increase of visual impairment with punctal occlusion in a patient with mild dry eye (2006)
  • Author(s): Shizuka Koh, Naoyuki Maeda, Takashi Fujikado, Yasuo Tano
  • Journal Title: J Cataract Refract Surg 32 Pages: 689-691
  • Peer Reviewed
• [Journal Article] Ultrasound biomicroscopic examination of acute hydrops in patients with keratoconus (2006)
  • Author(s): Tomoya Nakagawa, Naoyuki Maeda, Kohji Nishida, Yasuo Tano
  • Journal Title: Am J Ophthalmol 141 Pages: 1134-1136
  • Peer Reviewed
• [Journal Article] Wavefront analysis of eye with monocular diplopia and cortical cataract (2006)
  • Author(s): Takashi Fujikado, Naoyuki Maeda Yasuo Tano
  • Journal Title: Am J Ophthalmol 141 Pages: 1138-1140
  • Peer Reviewed
• [Journal Article] Effects of reference axes used during measurements of ocular and corneal higher-order aberrations in patients following LASIK (2006)
  • Author(s): Atsuko Takehara, Naoyuki Maeda, Sayuri Ninomiya, Takashi Fujikado
  • Journal Title: Jpn J Ophthalmol 50 Pages: 318-322
  • NAID: 10018773834
  • Peer Reviewed
• [Journal Article] Intensity analysis of Hartmann-Shack images in cataractous, keratoconic, and normal eyes to investigate light scattering (2006)
  • Author(s): Toshifumi Mihashi, Naoyuki Maeda, Takashi Fujikado
  • Journal Title: Jpn J Ophthalmol 50 Pages: 323-333
  • NAID: 10018773852
  • Peer Reviewed
• [Journal Article] Serial measurements of higher-order aberrations after blinking in normal subjects (2006)
  • Author(s): Shizuka Koh, Naoyuki Maeda, Takashi Fujikado, Yasuo Tano
  • Journal Title: Invest Ophthalmol Vis Sci. 47 Pages: 3318-24
  • Peer Reviewed
• [Journal Article] Automated keratoconus detection using height data of anterior and posterior corneal surfaces (2006)
  • Author(s): Kenichiro Bessho, Naoyuki Maeda, Takashi Fujikado, Yasuo Tano
  • Journal Title: Jpn J Ophthalmol 50 Pages: 409-416
  • NAID: 10019263507
  • Peer Reviewed
• [Journal Article] Evaluating optical quality of a bifocal soft contact lens in near vision using a Shack-Hartmann wavefront sensor (2006)
  • Author(s): Yoko Hirohara, Naoyuki Maeda, Takashi Fujikado
  • Journal Title: Optical Review 13 Pages: 396-404
  • Peer Reviewed
• [Journal Article] Serial measurements of higher-order aberrations after blinking in normal subjects. (2006)
  • Author(s): Koh S, et al.
  • Journal Title: Invest Ophthalmol Vis Sci 47・8 Pages: 3318-3324
• [Journal Article] Automated keratoconus detection using height data of anterior and posterior corneal surfaces. (2006)
  • Author(s): Bessho K, et al.
  • Journal Title: Jpn J Ophthalmol 50・5 Pages: 409-416
• [Journal Article] Effects of reference axes used during measurements of ocular and corneal higher-order aberrations in patients following LASIK. (2006)
  • Author(s): Takehara A, et al.
  • Journal Title: Jpn J Ophthalmol 50・5 Pages: 318-322
• [Journal Article] Paradoxical increase of visual impairment with punctal occlusion in a patient with mild dry eye. (2006)
  • Author(s): Koh S, et al.
  • Journal Title: J Cataract Refract Surg 32・4 Pages: 689-691
• [Presentation] Effect of corneal topography on quality of vision during RGP lens wear (2008)
  • Author(s): Naoyuki Maeda
  • Organizer: World Ophthalmology Congress 2008
  • Place of Presentation: Hong Kong, China
• [Presentation] Topographic analysis of keratoconus with pentacam (2008)
  • Author(s): Naoyuki Maeda
  • Organizer: World Ophthalmology Congress 2008
  • Place of Presentation: Hong Kong, China
• [Presentation] Corneal topography for the selection of new technology IOLs
  • Author(s): Naoyuki Maeda
  • Organizer: The 9^<th> Qingdao International Symposium of Ophthalmology
  • Place of Presentation: Qingdao, China
• [Presentation] Clinical application of Anterior Segment Scheimpflug Analysis (pentacam) in refractive surgery
  • Author(s): Naoyuki Maeda
  • Organizer: American Society of Cataract and Refractive Surgery
  • Place of Presentation: San Diego, United States
• [Presentation] Use of pentacam in cornea and refractive surgery service
  • Author(s): Naoyuki Maeda
  • Organizer: 13^<th> catholic golden symposium of Ophthalmology
  • Place of Presentation: Seoul, Korea
• [Presentation] Contact lens fitting in the patients with keratoconus
  • Author(s): Naoyuki Maeda
  • Organizer: 13^<th> catholic golden symposium of Ophthalmology
  • Place of Presentation: Seoul, Korea
• [Presentation] Current lamellar keratoplasty at Osaka University
  • Author(s): Naoyuki Maeda
  • Organizer: 13^<th> catholic golden symposium of Ophthalmology
  • Place of Presentation: Seoul, Korea
• [Presentation] Clinical application of wavefront technology as a diagnostic tool
  • Author(s): Naoyuki Maeda
  • Organizer: 96^<th> annual meeting of Korean Ophthalmological Society
  • Place of Presentation: Seoul, Korea
• [Presentation] Characteristics of corneal topography and its impact on quality of vision in patients with keratoconus
  • Author(s): Naoyuki Maeda
  • Organizer: The 96^<th> annual meeting of Korean Ophthalmological Society
  • Place of Presentation: Seoul, Korea
• [Presentation] Distinguished lecture : Anterior lamellar keratoplasty and post-operative astigmatism
  • Author(s): Naoyuki Maeda
  • Organizer: Department of Ophthalmology, Inje University, Ilsan Paik Hospital
  • Place of Presentation: Korea
• [Presentation] Clinical Application of Wavefront Technology as a Diagnostic Tool
  • Author(s): Naoyuki Maeda
  • Organizer: The 11^<th> congress of Chinese Ophthalmological Society
  • Place of Presentation: Tianjin, China,
• [Presentation] symposium : Screening of keratoconus in refractive surgery candidates
  • Author(s): Naoyuki Maeda
  • Organizer: The 11^<th> congress and 32^<nd> Indonesian Ophthalmologists Association Annual Meeting
  • Place of Presentation: Medan, Indonesia
• [Presentation] Current Trends in Dry Eye and Its Latest Treatments
  • Author(s): Naoyuki Maeda
  • Organizer: The 11^<th> congress and 32^<nd> Indonesian Ophthalmologists Association Annual Meeting
  • Place of Presentation: Medan, Indonesia
• [Presentation] The Clinical Application of Wavefront Technology as a Diagnostic Tool
  • Author(s): Naoyuki Maeda
  • Organizer: The 11^<th> congress and 32^<nd> Indonesian Ophthalmologists Association Annual Meeting
  • Place of Presentation: Medan, Indonesia
• [Book] Topcon KR-9000PW(SLACK Incorporated, Thorofare) (2006)
  • Author(s): Naoyuki Maeda
  • Publisher: Corneal topography in the wavefront era A guide for clinical application (Ed, M. Wang)